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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish

    Publication
    Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities and differences of these representations across species are not well …
  2. Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

    Publication
    Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1-3. Cerebrospinal fluid (CSF) makes up …
  3. Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice.

    Publication
  4. All-sky search for gravitational wave emission from scalar boson clouds around spinning black holes in LIGO O3 data

    Publication
    This paper describes the first all-sky search for long-duration, quasi-monochromatic gravitational-wave signals emitted by ultralight scalar boson clouds around spinning black holes using data …
  5. Neurofeedback through the lens of reinforcement learning

    Publication
    Despite decades of experimental and clinical practice, the neuropsychological mechanisms underlying neurofeedback (NF) training remain obscure. NF is a unique form of reinforcement learning (RL) task, during which …
  6. GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging

    Publication
    Optical imaging of calcium signals in the brain has enabled researchers to observe the activity of hundreds-to-thousands of individual neurons simultaneously. Current methods predominantly use morphological …
  7. Saturated reconstruction of living brain tissue.

    Publication
  8. Oxytocin attenuates microglial activation and restores social and non-social memory in the APP/PS1 mouse model of Alzheimer's disease.

    Publication
  9. Engineered protein–iron oxide hybrid biomaterial for MRI-traceable drug encapsulation

    Publication
    Labeled protein-based biomaterials have become popular for various biomedical applications such as tissue-engineered, therapeutic, and diagnostic scaffolds. Labeling of protein biomaterials, including with ultrasmall superparamagnetic iron …
  10. The GALAH+ survey: Third data release

    Publication
    The ensemble of chemical element abundance measurements for stars, along with precision distances and orbit properties, provides high-dimensional data to study the evolution of the Milky Way …
  11. The geometry of domain-general performance monitoring in the human medial frontal cortex

    Publication
    Controlling behavior to flexibly achieve desired goals depends on the ability to monitor one's own performance. It is unknown how performance monitoring can be both flexible, to …
  12. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits

    Publication
    Parvalbumin-positive (PV+) interneurons play a critical role in maintaining circuit rhythm in the brain, and their reduction is implicated in autism spectrum disorders. Animal studies demonstrate that …
  13. An Aligned Orbit for the Young Planet V1298 Tau b

    Publication
    The alignment of planetary orbits with respect to the stellar rotation preserves information on their dynamical histories. Measuring this angle for young planets help illuminate the mechanisms that …
  14. Spectrally accurate solutions to inhomogeneous elliptic PDE in smooth geometries using function intension

    Publication
    We present a spectrally accurate embedded boundary method for solving linear, inhomogeneous, elliptic partial differential equations (PDE) in general smooth geometries, focusing in this manuscript on the Poisson …
  15. On the dimensionality of behavior

    Publication
    There is a growing effort in the “physics of behavior” that aims at complete quantitative characterization of animal movements under more complex, naturalistic conditions. One reaction to the …
  16. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Publication
    Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) have been implicated in the extinction of drug associations, as well as related plasticity in medium spiny neurons (MSNs). However …
  17. On the dimensionality of behavior

    Publication
    There is a growing effort in the “physics of behavior” that aims at complete quantitative characterization of animal movements under more complex, naturalistic conditions. One reaction to the …
  18. Robust and interpretable denoising via deep learning

    Publication
    In the past decade, convolutional neural networks (CNN) have achieved state-of-the-art results in denoising. The goal of this work is to advance our understanding of …
  19. Flexible sensory information processing through targeted stochastic co-modulation

    Publication
    … task-informative. Overall, these results provide a new framework for how intelligent systems can flexibly and robustly adapt to changes in task structure by adjusting information routing …
  20. Effects of foveation on early visual representations

    Publication
    … This allows us to investigate to what extent the change in perception across the visual field can be accounted for by well-understood models of low-level …
  21. A common framework for discriminability and perceived intensity of sensory stimuli

    Publication
    The perception of sensory attributes is often quantified through measurements of discriminability (the ability to detect small stimulus changes), as well as through direct judgements of appearance or …
  22. Few-Femtosecond Dynamics of Free-Free Opacity in Optically Heated Metals

    Publication
  23. Nonequilibrium phase transition in a driven-dissipative quantum antiferromagnet

    Publication
  24. Polaritonic Hofstadter Butterfly and Cavity-Control of the Quantized Hall Conductance

    Publication
  25. An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes

    Publication
    There is a need for better classification and understanding of tumor-infiltrating lymphocytes (TILs). Here, we applied advanced functional genomics to interrogate 9,000 human tumors and multiple …
  26. Second-order magnetic responses in quantum magnets: Magnetization under ac magnetic fields

    Publication
  27. Superconductivity and Antiferromagnetism in NdNiO

    Publication
    We perform a comparative 2 2 real space cluster DMFT study on minimal models for NdNiO
  28. Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through cAMP/PKA pathway.

    Publication
  29. Simple and statistically sound recommendations for analysing physical theories

    Publication
    Physical theories that depend on many parameters or are tested against data from many different experiments pose unique challenges to statistical inference. Many models in particle physics, astrophysics …
  30. Analysis of a repetitive language coding system: Comparisons between fragile X syndrome, autism, and Down syndrome.

    Publication
  31. Clarity increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue.

    Publication
  32. Autism and the criminal justice system: An analysis of 93 cases.

    Publication
  33. Neurodevelopmental profile of HIVEP2-related disorder.

    Publication
  34. Nutrition, longevity and disease: From molecular mechanisms to interventions

    Publication
    Diet as a whole, encompassing food composition, calorie intake, and the length and frequency of fasting periods, affects the time span in which health and functional capacity are …
  35. Multiple-Allele MHC Class II Epitope Engineering by a Molecular Dynamics-Based Evolution Protocol

    Publication
    Epitopes that bind simultaneously to all human alleles of Major Histocompatibility Complex class II (MHC II) are considered one of the key factors for the development of improved …
  36. PatchWarp: Corrections of non-uniform image distortions in two-photon calcium imaging data by patchwork affine transformations

    Publication
    Complex distortions on calcium imaging often impair image registration accuracy. Here, we developed a registration algorithm, PatchWarp, to robustly correct slow image distortion for calcium imaging data. PatchWarp …
  37. All-optical interrogation of neural circuits in behaving mice

    Publication
    Recent advances combining two-photon calcium imaging and two-photon optogenetics with computer-generated holography now allow us to read and write the activity of large populations of …
  38. Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits.

    Publication
  39. A direct measurement of the distance to the Galactic center using the kinematics of bar stars

    Publication
    The distance to the Galactic center R0 is a fundamental parameter for understanding the Milky Way, because all observations of our Galaxy are made from our heliocentric reference …
  40. A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up or down scaling.

    Publication
  41. Methylphenidate as a causal test of translational and basic neural coding hypotheses

    Publication
    Most systems neuroscience studies fall into one of two categories: basic science work aimed at understanding the relationship between neurons and behavior, or translational work aimed at developing …
  42. Vitruvion: A Generative Model of Parametric CAD Sketches

    Publication
    Parametric computer-aided design (CAD) tools are the predominant way that engineers specify physical structures, from bicycle pedals to airplanes to printed circuit boards. The key characteristic of …
  43. Rare CNVs and phenome-wide profiling: A tale of brain-structural divergence and phenotypical convergence.

    Publication
  44. The relationship between age, metallicity, and abundances for disk stars in a simulated Milky Way galaxy

    Publication
    Observations of the Milky Way's low-α disk show that at fixed metallicity, [Fe/H], several element abundance, [X/Fe], correlate with age, with unique slopes and …
  45. Large-scale discovery of novel neurodevelopmental disorder-related genes through a unified analysis of single-nucleotide and copy number variants.

    Publication
  46. Breaking baryon-cosmology degeneracy with the electron density power spectrum

    Publication
    Uncertain feedback processes in galaxies affect the distribution of matter, currently limiting the power of weak lensing surveys. If we can identify cosmological statistics that are robust against …
  47. Longitudinal two-photon calcium imaging with ultra-large cranial window for head-fixed mice

    Publication
    Neural activity is heterogeneous across different cortical areas and can change during learning. Here, we describe a protocol for longitudinal in vivo two-photon calcium imaging with an …
  48. An Empirical Representation of a Physical Model for the ISM [C ii], CO, and [C i] Emission at Redshift 1 ≤ z ≤ 9

    Publication
    Sub-millimeter emission lines produced by the interstellar medium (ISM) are strong tracers of star formation and are some of the main targets of line intensity mapping (LIM …
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