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Bringing people and ideas together to fund, conduct, and share transformative science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. A Reanalysis of Public Galactic Bulge Gravitational Microlensing Events from OGLE-III and IV

    Publication
    Modern surveys of gravitational microlensing events have progressed to detecting thousands per year. Surveys are capable of probing Galactic structure, stellar evolution, lens populations, black hole physics, and …
  2. Modulation of inhibitory communication coordinates looking and reaching

    Publication
    Looking and reaching are controlled by different brain regions and are coordinated during natural behaviour1. Understanding how flexible, natural behaviours such as coordinated looking and reaching are controlled …
  3. Reward signals in the cerebellum: Origins, targets, and functional implications

    Publication
    The cerebellum has long been proposed to play a role in cognitive function, although this has remained controversial. This idea has received renewed support with the recent discovery …
  4. Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task

    Publication
    Understanding the complexities of behavior is necessary to interpret neurophysiological data and establish animal models of neuropsychiatric disease. This understanding requires knowledge of the underlying information-processing structure …
  5. Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task.

    Publication
  6. Error rate reduction of single-qubit gates via noise-aware decomposition into native gates

    Publication
  7. The contributions of rare inherited and polygenic risk to ASD in multiplex families.

    Publication
  8. A Standard Siren Cosmological Measurement from the Potential GW190521 Electromagnetic Counterpart ZTF19abanrhr

    Publication
    The identification of the electromagnetic counterpart candidate ZTF19abanrhr to the binary black hole merger GW190521 opens the possibility to infer cosmological parameters from this standard siren with a …
  9. Wavelet Moments for Cosmological Parameter Estimation

    Publication
    Extracting non-Gaussian information from the non-linear regime of structure formation is key to fully exploiting the rich data from upcoming cosmological surveys probing the large-scale …
  10. Direct Discriminative Decoder Models for Analysis of High-Dimensional Dynamical Neural Data

    Publication
    … modalities of neural data, make it a powerful tool for high-dimensional neural data analysis. We also introduce an extension of these methods, called the discriminative-generative …
  11. Direct Discriminative Decoder Models for Analysis of High-Dimensional Dynamical Neural Data

    Publication
    … modalities of neural data, make it a powerful tool for high-dimensional neural data analysis. We also introduce an extension of these methods, called the discriminative-generative …
  12. Implications of the Milky Way travel velocity for dynamical mass estimates of the Local Group

    Publication
    The total mass of the Local Group (LG) is a fundamental quantity that enables interpreting the orbits of its constituent galaxies and placing the LG in a cosmological …
  13. A network model of glymphatic flow under different experimentally-motivated parametric scenarios

    Publication
    Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain delivers nutrients, clears metabolic waste, and causes edema formation. Brain-wide imaging cannot resolve PVSs, and …
  14. Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences

    Publication
    Neurons in the hippocampus exhibit a striking selectivity for specific combinations of sensory features, forming representations that are thought to subserve episodic memory. Even during completely novel experiences …
  15. MR spectroscopy frequency and phase correction using convolutional neural networks

    Publication
    Purpose: To introduce a novel convolutional neural network (CNN)-based approach for frequency-and-phase correction (FPC) of MR spectroscopy (MRS) spectra to achieve fast and accurate FPC …
  16. Dynamics of Drosophila endoderm specification

    Publication
    During early Drosophila embryogenesis, a network of gene regulatory interactions orchestrates terminal patterning, playing a critical role in the subsequent formation of the gut. We utilized CRISPR gene …
  17. Priority coding in the visual system

    Publication
    Although we are continuously bombarded with visual input, only a fraction of incoming visual events is perceived, remembered or acted on. The neural underpinnings of various forms of …
  18. Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures

    Publication
    Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and neurodegenerative diseases. In the present study, we used limited proteolysis–mass spectrometry (LiP–MS) to …
  19. Chaotic and Clumpy Galaxy Formation in an Extremely Massive Reionization-era Halo

    Publication
    The SPT0311-58 system at z=6.900 is an extremely massive structure within the reionization epoch, and offers a chance to understand the formation of galaxies in …
  20. Resilience integrates concepts in aging research

    Publication
    Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of …
  21. Blind demixing methods for recovering dense neuronal morphology from barcode imaging data

    Publication
    Cellular barcoding methods offer the exciting possibility of 'infinite-pseudocolor' anatomical reconstruction-i.e., assigning each neuron its own random unique barcoded 'pseudocolor,' and then using these pseudocolors …
  22. KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice

    Publication
    … cognitive deficits. We demonstrate that brain engagement through cognitive stimulation induces metabolic remodeling of the hippocampus that was acutely recapitulated by the longevity factor klotho, mediated by …
  23. Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19

    Publication
    … infections in young adults, including potential targets for developing new therapies and prognostic tests.
  24. Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons

    Publication
    The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they coordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin …
  25. Gut enterochromaffin cells are critical drivers of visceral pain and anxiety.

    Publication
  26. SLEAP: A deep learning system for multi-animal pose tracking

    Publication
    The desire to understand how the brain generates and patterns behavior has driven rapid methodological innovation in tools to quantify natural animal behavior. While advances in deep learning …
  27. Deep-learning based identification, tracking, pose estimation, and behavior classification of interacting primates and mice in complex environments

    Publication
    The quantification of behaviors of interest from video data is commonly used to study brain function, the effects of pharmacological interventions, and genetic alterations. Existing approaches lack the …
  28. Application of Pontryagin's maximum principle to quantum metrology in dissipative systems

    Publication
  29. Comment on “Origin of symmetry-forbidden high-order harmonic generation in the time-dependent Kohn-Sham formulation”

    Publication
    In their recent paper [Phys. Rev. A 103, 043106 (2021)], Zang et al. theoretically investigated high harmonic generation (HHG) in benchmark two-electron systems that are inversion symmetric …
  30. Intergenerational trauma: Parental PTSD and parent-reported child abuse subtypes differentially relate to admission characteristics in the autism inpatient collection.

    Publication
  31. CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder.

    Publication
  32. Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion

    Publication
    Running profoundly alters stimulus-response properties in mouse primary visual cortex (V1), but its effect in higher-order visual cortex is under-explored. Here we systematically investigate how …
  33. COVID-19 in pregnancy: Implications for fetal brain development.

    Publication
  34. Developmental pyrethroid exposure and age influence phenotypes in a Chd8 haploinsufficient autism mouse model.

    Publication
  35. Delineation of a novel neurodevelopmental syndrome associated with PAX5 haploinsufficiency.

    Publication
  36. Two distinct types of nodes of Ranvier support auditory nerve function in the mouse cochlea.

    Publication
  37. Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis.

    Publication
  38. Current and lifetime somatic symptom burden among transition-aged autistic young adults.

    Publication
  39. Comparing fathers’ and mothers’ perspectives about their child’s autism spectrum disorder.

    Publication
  40. Dopamine neurons evaluate natural fluctuations in performance quality

    Publication
    Many motor skills are learned by comparing ongoing behavior to internal performance benchmarks. Dopamine neurons encode performance error in behavioral paradigms where error is externally induced, but it …
  41. Glial dysregulation in human brain in fragile X-related disorders.

    Publication
  42. A general sample complexity analysis of vanilla policy gradient

    Publication
    We adapt recent tools developed for the analysis of Stochastic Gradient Descent (SGD) in non-convex optimization to obtain convergence and sample complexity guarantees for the vanilla policy …
  43. SAN: Stochastic Average Newton Algorithm for Minimizing Finite Sums

    Publication
    We present a principled approach for designing stochastic Newton methods for solving f inite sum optimization problems. Our approach has two steps. First, we re-write the stationarity …
  44. Snails across Scales: Local and Global Phase-mixing Structures as Probes of the Past and Future Milky Way

    Publication
    Signatures of vertical disequilibrium have been observed across the Milky Way's (MW's) disk. These signatures manifest locally as unmixed phase spirals in z–vz space ("snails …
  45. A Variable Clock Underlies Internally Generated Hippocampal Sequences

    Publication
    Humans have the ability to store and retrieve memories with various degrees of specificity, and recent advances in reinforcement learning have identified benefits to learning when past experience …
  46. Detecting and correcting false transients in calcium imaging

    Publication
    Population recordings of calcium activity are a major source of insight into neural function. Large datasets require automated processing, but this can introduce errors that are difficult to …
  47. Mobile elements in human population-specific genome and phenotype divergence.

    Publication
  48. A Census of the Bright z = 8.5–11 Universe with the Hubble and Spitzer Space Telescopes in the CANDELS Fields

    Publication
    We present the results from a new search for candidate galaxies at z ~ 8.5-11 discovered over the 850 arcmin^2 area probed by the Cosmic Assembly …
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