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  1. Neural mechanisms of persistent aggression

    Publication
    While aggression is often conceptualized as a highly stereotyped, innate behavior, individuals within a species exhibit a surprising amount of variability in the frequency, intensity, and targets of …

  2. Stellar Abundance Maps of the Milky Way Disk

    Publication
    To understand the formation of the Milky Way's prominent bar it is important to know whether stars in the bar differ in the chemical element composition of …

  3. Studying Interstellar Turbulence Driving Scales using the Bispectrum

    Publication
    We demonstrate the utility of the bispectrum, the Fourier three-point correlation function, for studying driving scales of magnetohydrodynamic (MHD) turbulence in the interstellar medium. We calculate the …

  4. Cortical activation during cooperative joint actions and competition in children with and without an autism spectrum condition (ASC): An fNIRS study.

    Publication

  5. Boundary layers of accretion discs: wave-driven transport and disc evolution

    Publication
    Astrophysical objects possessing a material surface (white dwarfs, young stars, etc.) may accrete gas from the disc through the so-called surface boundary layer (BL), in which the …

  6. Turning points in the age–metallicity relations – created by late satellite infall and enhanced by radial migration

    Publication
    The present-day age–metallicity relation (AMR) is a record of the star formation history of galaxies, as this traces the chemical enrichment of the gas over time …

  7. Dissociable cellular and genetic mechanisms of cortical thinning at different life stages.

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  8. The link between autism and sex-specific neuroanatomy, and associated cognition and gene expression.

    Publication

  9. The relevance of the interpersonal theory of suicide for predicting past-year and lifetime suicidality in autistic adults.

    Publication

  10. Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a novel cost-benefit foraging task.

    Publication

  11. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

    Publication
    A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a …

  12. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  13. Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

    Publication
    The loss of skeletal muscle function with age, known as sarcopenia, significantly reduces independence and quality of life and can have significant metabolic consequences. Although exercise is effective …

  14. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  15. Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity

    Publication
    We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from ∼250 × 140 × 90 μm3 of electron microscopic images, including pyramidal and non-pyramidal neurons …

  16. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Publication
    Motor behaviors are often planned long before execution but only released after specific sensory events. Planning and execution are each associated with distinct patterns of motor cortex activity …

  17. Treatment of a genetic brain disease by CNS-wide microglia replacement

    Publication
    Hematopoietic cell transplantation after myeloablative conditioning has been used to treat various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain presumably due to poor …

  18. Cortical ensembles orchestrate social competition through hypothalamic outputs

    Publication
    Most social species self-organize into dominance hierarchies1,2, which decreases aggression and conserves energy3,4, but it is not clear how individuals know their social rank. We …

  19. The effect of autistic traits on disembedding and mental rotation in neurotypical women and men.

    Publication

  20. Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration

    Publication
    SignificanceNeurodegenerative diseases are poorly understood and difficult to treat. One common hallmark is lysosomal dysfunction leading to the accumulation of aggregates and other undegradable materials, which cause damage …

  21. Developmental and evolutionary constraints on olfactory circuit selection

    Publication
    SignificanceIn this work, we explore the hypothesis that biological neural networks optimize their architecture, through evolution, for learning. We study early olfactory circuits of mammals and insects, which …

  22. Dimensional characterizations of gender diversity are associated with higher polygenic propensity for cognitive performance in a neurodiverse sample.

    Publication

  23. Controlling the shape and topology of two-component colloidal membranes

    Publication
    Changes in the geometry and topology of self-assembled membranes underlie diverse processes across cellular biology and engineering. Similar to lipid bilayers, monolayer colloidal membranes have in-plane …

  24. Deconstructing gastrulation at single-cell resolution

    Publication
    Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets, which are driven by cell divisions, cell shape changes, and cell intercalations. Each of …

  25. Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases.

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  26. Visual consciousness dynamics in adults with and without autism.

    Publication

  27. Thermodynamically consistent coarse-graining of polar active fluids

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    We introduce a closure model for coarse-grained kinetic theories of polar active fluids. Based on a thermodynamically consistent, quasi-equilibrium approximation of the particle distribution function, the …

  28. Exploring the Sgr–Milky Way–disk Interaction Using High-resolution N-body Simulations

    Publication
    The ongoing merger of the Sagittarius (Sgr) dwarf galaxy with the Milky Way is believed to strongly affect the dynamics of the Milky Way's disk. We present …

  29. Weighing the Galactic disk using phase-space spirals

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    In this fourth article on weighing the Galactic disk using the shape of the phase-space spiral, we have tested our method on a billion particle three-dimensional …

  30. Accuracy of power spectra in dissipationless cosmological simulations

    Publication
    We exploit a suite of large emph{N}-body simulations (up to N=40963) performed with Abacus, of scale-free models with a range of spectral indices n …

  31. Similarities behind the high- and low-α disc: small intrinsic abundance scatter and migrating stars

    Publication
    The detailed age-chemical abundance relations of stars measure time-dependent chemical evolution. These trends offer strong empirical constraints on nucleosynthetic processes, as well as the homogeneity of …

  32. Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

    Publication
    A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols have been optimized for optimal cell …

  33. SETBP1 variants outside the degron disrupt DNA-binding and transcription independent of protein abundance to cause a heterogeneous neurodevelopmental disorder.

    Publication

  34. Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms

    Publication
    Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and ATAC-seq resource …

  35. Modeling multiscale causal interactions between spiking and field potential signals during behavior

    Publication
    … the NHP datasets.Significance.This multiscale causality method can reveal the directed functional interactions across spatiotemporal scales of brain activity to inform basic science investigations and neurotechnologies.

  36. Putting in the Erk: Growth factor signaling and mesoderm morphogenesis

    Publication
    It has long been known that FGF signaling contributes to mesoderm formation, a germ layer found in triploblasts that is composed of highly migratory cells that give rise …

  37. Enhanced clamshell swimming with asymmetric beating at low Reynolds number

    Publication
    A single flexible filament can be actuated to escape from the scallop theorem and generate net propulsion at low Reynolds number. In this work, we study the dynamics …

  38. Neuroticism drives associations between repetitive behaviors and depression in autistic adults.

    Publication

  39. Autism in gifted youth is associated with low processing speed and high verbal ability.

    Publication

  40. Molecular hallmarks of heterochronic parabiosis at single-cell resolution

    Publication
    The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality1. Although an increasing number of interventions show promise for …

  41. Mapping spatial frequency preferences across human primary visual cortex

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    Neurons in primate visual cortex (area V1) are tuned for spatial frequency, in a manner that depends on their position in the visual field. Several studies have examined …

  42. Debye source representations for type-I superconductors, I: The static type I case

    Publication

  43. How Cross-Link Numbers Shape the Large-Scale Physics of Cytoskeletal Materials

    Publication
    Cytoskeletal networks are the main actuators of cellular mechanics, and a foundational example for active matter physics. In cytoskeletal networks, motion is generated on small scales by filaments …

  44. Feedforward and feedback interactions between visual cortical areas use different population activity patterns

    Publication
    Brain function relies on the coordination of activity across multiple, recurrently connected brain areas. For instance, sensory information encoded in early sensory areas is relayed to, and further …

  45. EphB1 controls proper long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells.

    Publication

  46. A Transparent Window into Early-type Stellar Variability

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    Subsurface convection zones are ubiquitous in early-type stars. Driven by narrow opacity peaks, these thin convective regions transport little heat but play an important role in setting …

  47. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse.

    Publication

  48. Maternal mid-gestational and child cord blood immune signatures are strongly associated with offspring risk of ASD.

    Publication