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  1. A Toy Model for the Time–Frequency Structure of Fast Radio Bursts: Implications for the CHIME/FRB Burst Dichotomy

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    We introduce a toy model for the time-frequency structure of fast radio bursts (FRB), in which the observed emission is produced as a narrowly-peaked intrinsic spectral …

  2. Higher-order Van Hove singularity in magic-angle twisted trilayer graphene

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  3. When ions break the law

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  4. Moiré engineering of spin--orbit coupling in twisted platinum diselenide

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  5. Excited-state band structure mapping

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  6. Fluorescence lifetime imaging microscopy (FLIM) detects differences in metabolic signatures between euploid and aneuploid human blastocysts

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    Can non-invasive imaging with fluorescence lifetime imaging microscopy (FLIM) detect metabolic differences in euploid versus aneuploid human blastocysts? FLIM has identified significant metabolic differences between euploid and …

  7. Nature of the bonded-to-atomic transition in liquid silica to TPa pressures

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    First-principles calculations and analysis of the thermodynamic, structural, and electronic properties of liquid SiO

  8. Nonadiabatic Born Effective Charges in Metals and the Drude Weight

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    In insulators, Born effective charges describe the electrical polarization induced by the displacement of individual atomic sublattices. Such a physical property is at first sight irrelevant for metals …

  9. Transverse instability and universal decay of spin spiral order in the Heisenberg model

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  10. Fluctuation-induced quantum friction in nanoscale water flows

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  11. Novel stimuli evoke excess activity in the mouse primary visual cortex

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    o explore how neural circuits represent novel versus familiar inputs, we presented mice with repeated sets of images with novel images sparsely substituted. Using two-photon calcium imaging …

  12. Towards practical holographic coherent diffraction imaging via maximum likelihood estimation

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    A new algorithmic framework is developed for holographic coherent diffraction imaging (HCDI) based on maximum likelihood estimation (MLE). This method provides superior image reconstruction results for various practical …

  13. Co-evolution of massive black holes and their host galaxies at high redshift: discrepancies from six cosmological simulations and the key role of JWST

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    Experimental Particle Physics has been at the forefront of analyzing the world's largest datasets for decades. The HEP community was among the first to develop suitable software …

  14. Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

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    Recent advances in multi-electrode array technology have made it possible to monitor large neuronal ensembles at cellular resolution in animal models. In humans, however, current approaches restrict …

  15. Sparse connectivity for MAP inference in linear models using sister mitral cells

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    Sensory processing is hard because the variables of interest are encoded in spike trains in a relatively complex way. A major goal in studies of sensory processing is …

  16. Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits.

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  17. Is there an association between prenatal testosterone and autistic traits in adolescents?

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  18. Precise genome editing across kingdoms of life using retron-derived DNA.

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  19. Neurogenetic disorders across the lifespan: From aberrant development to degeneration.

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  20. Using the Clinical Global Impression Scale to assess social communication change in minimally verbal children with autism spectrum disorder.

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  21. Parenting stress in caregiver-mediated interventions for toddlers with autism: An application of quantile regression mixed models.

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  22. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

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    We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three …

  23. Prolonged and Pervasive Perturbations in the Composition of the Southern Hemisphere Midlatitude Lower Stratosphere From the Australian New Year’s Fires

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    The 2019/2020 Australian New Year’s wildfires injected record amounts of smoke and biomass burning products into the lower stratosphere. The Aura Microwave Limb Sounder (MLS) tracked …

  24. Meeting Report: Aging Research and Drug Discovery

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    Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is …

  25. Large-scale neural recordings call for new insights to link brain and behavior

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    Neuroscientists today can measure activity from more neurons than ever before, and are facing the challenge of connecting these brain-wide neural recordings to computation and behavior. In …

  26. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    Publication
    We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three …

  27. The role of state uncertainty in the dynamics of dopamine

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    Reinforcement learning models of the basal ganglia map the phasic dopamine signal to reward prediction errors (RPEs). Conventional models assert that, when a stimulus predicts a reward with …

  28. Nano-spectroscopy of excitons in atomically thin transition metal dichalcogenides

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    Excitons play a dominant role in the optoelectronic properties of atomically thin van der Waals (vdW) semiconductors. These excitons are amenable to on-demand engineering with diverse control …

  29. Autism spectrum disorder trios from consanguineous populations are enriched for rare biallelic variants, identifying 32 new candidate genes.

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  30. FOS licenses early events in stem cell activation driving skeletal muscle regeneration

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    Muscle satellite cells (SCs) are a quiescent (non-proliferative) stem cell population in uninjured skeletal muscle. Although SCs have been investigated for nearly 60 years, the molecular drivers …

  31. Cortical preparatory activity indexes learned motor memories

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    The brain's remarkable ability to learn and execute various motor behaviours harnesses the capacity of neural populations to generate a variety of activity patterns. Here we explore …

  32. The emptiness inside: Finding gaps, valleys, and lacunae with geometric data analysis

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    Discoveries of gaps in data have been important in astrophysics. For example, there are kinematic gaps opened by resonances in dynamical systems, or exoplanets of a certain radius …

  33. Variability in sampling of cortex-wide neural dynamics explains individual differences in functional connectivity and behavioral phenotype.

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  34. CHD8 regulates gut epithelial cell function and affects autism-related behaviours through the gut-brain axis.

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  35. Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish

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    Motor systems must continuously adapt their output to maintain a desired trajectory. While the spinal circuits underlying rhythmic locomotion are well described, little is known about how the …

  36. Characterization of Two 2 mm detected Optically Obscured Dusty Star-forming Galaxies

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    The 2mm Mapping Obscuration to Reionization with ALMA (MORA) Survey was designed to detect high redshift (z≳4), massive, dusty star-forming galaxies (DSFGs). Here we present two …

  37. Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities.

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  38. Astrocyte glutamate transport is modulated by motor learning and regulates neuronal correlations and movement encoding by motor cortex neurons.

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  39. Massively parallel reporter assays discover de novo exonic splicing mutants in paralogs of autism genes.

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  40. SARS-CoV-2 RNA concentrations in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases

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    Current estimates of COVID-19 prevalence are largely based on symptomatic, clinically diagnosed cases. The existence of a large number of undiagnosed infections hampers population-wide investigation of …

  41. Lateralized decrease of parvalbumin+ cells in the somatosensory cortex of ASD models is correlated with unilateral tactile hypersensitivity.

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  42. A multiscale biophysical model gives quantized metachronal waves in a lattice of beating cilia

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    Motile cilia are slender, hair-like cellular appendages that spontaneously oscillate under the action of internal molecular motors and are typically found in dense arrays. These active filaments …

  43. FMM-LU: A fast direct solver for multiscale boundary integral equations in three dimensions

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    We present a fast direct solver for boundary integral equations on complex surfaces in three dimensions using an extension of the recently introduced recursive strong skeletonization scheme. For …

  44. Engineering stability, longevity, and miscibility of microtubule-based active fluids

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    Microtubule-based active matter provides insight into the self-organization of motile interacting constituents. We describe several formulations of microtubule-based 3D active isotropic fluids. Dynamics of these …

  45. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease

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    Disruption of retromer-dependent endosomal trafficking is considered pathogenic in late-onset Alzheimer's disease (AD). Here, to investigate this disruption in the intact brain, we turn to …

  46. Mothers adapt their voice during children’s adolescent development.

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  47. Bursting Bubbles: Clustered Supernova Feedback in Local and High-redshift Galaxies

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    We compare an analytic model for the evolution of supernova-driven superbubbles with observations of local and high-redshift galaxies, and the properties of intact HI shells in …

  48. Black Hole Flares: Ejection of Accreted Magnetic Flux through 3D Plasmoid-mediated Reconnection

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    Magnetic reconnection can power bright, rapid flares originating from the inner magnetosphere of accreting black holes. We conduct extremely high resolution (5376×2304×2304 cells) general-relativistic magnetohydrodynamics …