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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. A quasar-based supermassive black hole binary population model: implications for the gravitational-wave background

    Publication
    The nanohertz gravitational wave background (GWB) is believed to be dominated by GW emission from supermassive black hole binaries (SMBHBs). Observations of several dual active galactic nuclei (AGN …
  2. Black Hole Flares: Ejection of Accreted Magnetic Flux through 3D Plasmoid-mediated Reconnection

    Publication
    Magnetic reconnection can power bright, rapid flares originating from the inner magnetosphere of accreting black holes. We conduct extremely high-resolution (5376 × 2304 × 2304 cells) general-relativistic magnetohydrodynamics …
  3. Baryonic feedback biases on fundamental physics from lensed CMB power spectra

    Publication
    Upcoming measurements of the small-scale primary cosmic microwave background (CMB) temperature and polarization power spectra (TT/TE/EE) are anticipated to yield transformative constraints on new physics …
  4. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

    Publication
    Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations …
  5. Neural Circuits for Dynamics-Based Segmentation of Time Series

    Publication
    The brain must extract behaviorally relevant latent variables from the signals streamed by the sensory organs. Such latent variables are often encoded in the dynamics that generated the …
  6. Black hole–galaxy scaling relations in FIRE: the importance of black hole location and mergers

    Publication
    The concurrent growth of supermassive black holes (SMBHs) and their host galaxies remains to be fully explored, especially at high redshift. While often understood as a consequence of …
  7. Tracing Birth Properties of Stars with Abundance Clustering

    Publication
    To understand the formation and evolution of the Milky Way disk, we must connect its current properties to its past. We explore hydrodynamical cosmological simulations to investigate how …
  8. Connectome-wide mega-analysis reveals robust patterns of atypical functional connectivity in autism.

    Publication
  9. Migration and Mixing in the Galactic Disc from Encounters between Sagittarius and the Milky Way

    Publication
    Stars born on near-circular orbits in spiral galaxies can subsequently migrate to different orbits due to interactions with non-axisymmetric disturbances within the disc such as bars …
  10. Lapses in perceptual decisions reflect exploration

    Publication
    Perceptual decision-makers often display a constant rate of errors independent of evidence strength. These 'lapses' are treated as a nuisance arising from noise tangential to the decision …
  11. Proximity labeling identifies a repertoire of site-specific R-loop modulators.

    Publication
  12. Fluorescence imaging of large-scale neural ensemble dynamics

    Publication
    Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of thousands of individual neurons, identified genetically or by their connectivity, across multiple brain areas and for …
  13. GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder.

    Publication
  14. A speech planning network for interactive language use

    Publication
    During conversation, people take turns speaking by rapidly responding to their partners while simultaneously avoiding interruption1,2. Such interactions display a remarkable degree of coordination, as gaps between …
  15. Neurophotonic tools for microscopic measurements and manipulation: status report

    Publication
    Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics …
  16. Understanding topological defects in fluidized dry active nematics

    Publication
    Dense assemblies of self-propelling rods (SPRs) may exhibit fascinating collective behaviors and anomalous physical properties that are far away from equilibrium. Using large-scale Brownian dynamics simulations …
  17. Transcriptional regulation of neural stem cell expansion in the adult hippocampus

    Publication
    Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors (TFs) in RGLs integrate physiological signals to dictate self …
  18. The PETSc Community Is the Infrastructure

    Publication
    The communities who develop and support open source scientific software packages are crucial to the utility and success of such packages. Moreover, these communities form an important part …
  19. Self-reported parkinsonism features in older autistic adults: A descriptive study.

    Publication
  20. A cortico-cortical pathway targets inhibitory interneurons and modulates paw movement during locomotion in mice.

    Publication
  21. On the Origin of Coulomb Pseudopotential: Two Wrongs Make a "Right"

    Publication
  22. Topological band inversion in HgTe(001): surface and bulk signatures from photoemission

    Publication
  23. Chiral surface superconductivity in half-Heusler semimetals

    Publication
  24. Pair Density Wave Order from Electron Repulsion

    Publication
  25. Dirac electron under periodic magnetic field: Platform for fractional Chern insulator and generalized Wigner crystal

    Publication
  26. Origin of Model Fractional Chern Insulators in All Topological Ideal Flatbands: Explicit Color-entangled Wavefunction and Exact Density Algebra

    Publication
  27. Bipolaronic superconductivity out of a Coulomb gas

    Publication
  28. Coupling of Magnetic Phases at Nickelate Interfaces

    Publication
  29. Planckian behavior of cuprate superconductors: Reconciling the scaling of optical conductivity with resistivity and specific heat

    Publication
  30. Origin and fate of the pseudogap in the doped Hubbard model

    Publication
  31. Scalable neural quantum states architecture for quantum chemistry

    Publication
  32. Toward Neural Network Simulation of Variational Quantum Algorithms

    Publication
  33. Evidence of a 2D Electron Gas in a Single-Unit-Cell of Anatase TiO2 (001)

    Publication
  34. A density-matrix renormalization group algorithm for simulating quantum circuits with a finite fidelity

    Publication
  35. Supermoiré low-energy effective theory of twisted trilayer graphene

    Publication
  36. On the potentially transformative role of auxiliary-field quantum Monte Carlo in quantum chemistry: A highly accurate method for transition metals and beyond

    Publication
  37. Unidirectional subsystem symmetry in a hole-doped honeycomb-lattice Ising magnet

    Publication
  38. The Generalized Green's function Cluster Expansion: A Python package for simulating polarons

    Publication
  39. Generalization and Overfitting in Matrix Product State Machine Learning Architectures

    Publication
  40. Absence of localization in interacting spin chains with a discrete symmetry

    Publication
  41. Bose-Einstein condensation in honeycomb dimer magnets and Yb

    Publication
  42. Triple electron–electron–proton excitations and second-order approximations in nuclear–electronic orbital coupled cluster methods

    Publication
  43. Geometry of the Phase Retrieval Problem: Graveyard of Algorithms

    Publication
    Recovering the phase of the Fourier transform is a ubiquitous problem in imaging applications from astronomy to nanoscale X-ray diffraction imaging. Despite the efforts of a multitude …
  44. RidgeSketch: A Fast Sketching Based Solver for Large Scale Ridge Regression

    Publication
    We propose new variants of the sketch-and-project method for solving large scale ridge regression problems. First, we propose a new momentum alternative and provide a theorem …
  45. Pandemic Control, Game Theory, and Machine Learning

    Publication
    Game theory has been an effective tool in the control of disease spread and in suggesting optimal policies at both individual and area levels. In this AMS Notices …
  46. Generative modeling via tensor train sketching

    Publication
  47. Spin-orbit induced equilibrium spin currents in materials

    Publication
  48. Emergence of a low-energy excitonic state in single layer WS2 with 1H/1T phase mixture

    Publication
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