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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Quantifying the role of antiferromagnetic fluctuations in the superconductivity of the doped Hubbard model

    Publication
  2. Temperature Dependence of Spin and Charge Orders in the Doped Two-Dimensional Hubbard Model

    Publication
  3. Full-frequency dynamical Bethe–Salpeter equation without frequency and a study of double excitations

    Publication
  4. Dark-Exciton Driven Energy Funneling into Dielectric Inhomogeneities in Two-Dimensional Semiconductors

    Publication
  5. Deep Learning the Functional Renormalization Group

    Publication
  6. Deconvolving the components of the sign problem

    Publication
  7. Full Configuration Interaction Excited-State Energies in Large Active Spaces from Subspace Iteration with Repeated Random Sparsification

    Publication
  8. Near-Exact Nuclear Gradients of Complete Active Space Self-Consistent Field Wave Functions

    Publication
  9. Coexistence of Even- and Odd-Frequency Superconductivity in Correlated Multi-Orbital Systems with Spin-Orbit Coupling

    Publication
  10. Dynamical Mean Field Studies of Infinite Layer Nickelates: Physics Results and Methodological Implications

    Publication
  11. Interfacial charge transfer and persistent metallicity of ultrathin SrIrO3/SrRuO3 heterostructures

    Publication
  12. Frequency-dependent Inter-pseudospin Solutions to Superconducting Strontium Ruthenate

    Publication
  13. Substituents affect the mechanism of photochemical E-Z isomerization of diarylethene triazoles via adiabatic singlet excited state pathway or via triplet excited state

    Publication
  14. Photocatalytic water oxidation on SrTiO

    Publication
  15. Strain-tuned topological phase transition and unconventional Zeeman effect in ZrTe5 microcrystals

    Publication
  16. Twofold van Hove singularity and origin of charge order in topological kagome superconductor CsV3Sb5

    Publication
  17. Common microscopic origin of the phase transitions in Ta

    Publication
  18. Perturbational Complexity by Distribution Mismatch: A Systematic Analysis of Reinforcement Learning in Reproducing Kernel Hilbert Space

    Publication
    Most existing theoretical analysis of reinforcement learning (RL) is limited to the tabular setting or linear models due to the difficulty in dealing with function approximation in high …
  19. Economic growth and happiness in China: A Bayesian multilevel age-period-cohort analysis based on the CGSS data 2005–2015

    Publication
    This paper introduces a Bayesian multilevel model based on the age-period-cohort framework to examine Chinese happiness. Using 8 waves of the Chinese General Social Survey (CGSS …
  20. Autism screening at 18 months of age: A comparison of the Q-CHAT-10 and M-CHAT screeners.

    Publication
  21. Solving Fredholm second-kind integral equations with singular right-hand sides on non-smooth boundaries

    Publication
    A numerical scheme is presented for the solution of Fredholm second-kind boundary integral equations with right-hand sides that are singular at a finite set of boundary …
  22. Robust regression with compositional covariates

    Publication
    Many high-throughput sequencing data sets in biology are compositional in nature. A prominent example is microbiome profiling data, including targeted amplicon-based and metagenomic sequencing data. These …
  23. How exponentially ill-conditioned are contiguous submatrices of the Fourier matrix?

    Publication
    Linear systems involving contiguous submatrices of the discrete Fourier transform (DFT)matrix arise in many applications, such as Fourier extension, superresolution, and coherent diffraction imaging. We show that …
  24. Circulating klotho is elevated in cerebrospinal fluid, but not serum, among KLOTHO KL-VS allele carriers at risk for Alzheimer’s disease

    Publication
    … heterozygotic and homozygotic carriers of the KLOTHO KL-VS allele. Serum levels are lower than CSF and did not differ by genotype. Klotho specimen source should be …
  25. Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks.

    Publication
  26. ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.

    Publication
  27. Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study.

    Publication
  28. MYT1L-associated neurodevelopmental disorder: Description of 40 new cases and literature review of clinical and molecular aspects.

    Publication
  29. Imputing cognitive impairment in SPARK, a large autism cohort.

    Publication
  30. Advancing methodologies to improve RRB outcome measures in autism research: Evaluation of the RBS-R.

    Publication
  31. Cognitive profiles of children with autism spectrum disorder with parent-reported extraordinary talents and personal strengths.

    Publication
  32. Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice.

    Publication
  33. DeepHAM: A Global Solution Method for Heterogeneous Agent Models with Aggregate Shocks

    Publication
    An efficient, reliable, and interpretable global solution method, the Deep learning-based algorithm for Heterogeneous Agent Models (DeepHAM), is proposed for solving high dimensional heterogeneous agent models with …
  34. Disruption of Brainstem Structural Connectivity in REM Sleep Behavior Disorder Using 7 Tesla Magnetic Resonance Imaging

    Publication
    Background: Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is one of the earliest manifestations of α synucleinopathies. Brainstem pathophysiology underlying REM sleep behavior disorder has been …
  35. Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling

    Publication
    Whether and how the pathogenic disruptions in endosomal trafficking observed in Alzheimer's disease (AD) are linked to its anatomical vulnerability remain unknown. Here, we began addressing these …
  36. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

    Publication
    Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes, parvalbumin-expressing (PV+) and somatostatin-expressing (SST …
  37. Excitatory/inhibitory imbalance in autism: The role of glutamate and GABA gene-sets in symptoms and cortical brain structure.

    Publication
  38. All-sky search for short gravitational-wave bursts in the third Advanced LIGO and Advanced Virgo run

    Publication
    This paper presents the results of a search for generic short-duration gravitational-wave transients in data from the third observing run of Advanced LIGO and Advanced Virgo …
  39. Multifrequency inverse obstacle scattering with unknown impedance boundary conditions using recursive linearization

    Publication
    … reconstructions for many complicated geometries and impedance functions, a number of interesting open questions remain regarding the convergence behavior of the approach. We present numerical experiments that …
  40. Make war not love: The neural substrate underlying a state-dependent switch in female social behavior

    Publication
    Female mice exhibit opposing social behaviors toward males depending on their reproductive state: virgins display sexual receptivity (lordosis behavior), while lactating mothers attack. How a change in reproductive …
  41. FlyWire: online community for whole-brain connectomics

    Publication
    Due to advances in automated image acquisition and analysis, whole-brain connectomes with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated reconstructions …
  42. Direct Measurement of Cerebrospinal Fluid Production in Mice

    Publication
    The emerging interest in brain fluid transport has prompted a need for techniques that provide an understanding of what factors regulate cerebrospinal fluid (CSF) production. Here, we describe …
  43. A transcriptional rheostat couples past activity to future sensory responses

    Publication
    Animals traversing different environments encounter both stable background stimuli and novel cues, which are thought to be detected by primary sensory neurons and then distinguished by downstream brain …
  44. Spatial maps in piriform cortex during olfactory navigation

    Publication
    Odours are a fundamental part of the sensory environment used by animals to guide behaviours such as foraging and navigation1,2. Primary olfactory (piriform) cortex is thought to …
  45. FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons.

    Publication
  46. APOGEE Chemical Abundance Patterns of the Massive Milky Way Satellites

    Publication
    The SDSS-IV Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey has obtained high-resolution spectra for thousands of red giant stars distributed among the massive satellite galaxies …
  47. Environmental carcinogens disproportionally mutate genes implicated in neurodevelopmental disorders.

    Publication
  48. Virally encoded connectivity transgenic overlay RNA sequencing (VECTORseq) defines projection neurons involved in sensorimotor integration.

    Publication
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