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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCA Seminar (Adam Showman)

    Seminar
    The Atmospheric Circulation of hot Jupiters Over 3500 planets have been discovered around other stars, many of which orbit extremely close-in, where they receive enormous stellar fluxes …
  2. CCA Seminar (Evan Schneider Talk)

    Seminar
    Title: Simulating Galactic Winds on Supercomputers Using Cholla Abstract: Galactic winds are a ubiquitous feature of rapidly star-forming galaxies. Observations have revealed these outflows to be complex …
  3. Nanotechnology for Massively-Parallel, Multi-Physical Interrogation of Brain Activity

    Lecture
    We are still far from elucidating how complex assemblies of neurons — that is, brain circuits — interact to process information. In this lecture, Michael Roukes will outline the immense …
  4. SFARI Society for Neuroscience 2016 Social

    Social
    Join the SFARI science team and leaders in the autism research community for an informal evening of food, drink, conversation and mingling on 14 November 2016 in San …
  5. Galaxy Formation Collaboration Meeting

    Meeting
    By invite only, please contact Rachel Somerville for questions.
  6. Randomness

    Lecture
    Humanity has pondered the meaning and utility of randomness for millennia. A computational theory of randomness, developed in the past three decades, reveals (perhaps counterintuitively) that very little …
  7. How immune cells help wire the brain: Implications for autism and psychiatric illness

    Lecture
    On 2 November 2016, Beth Stevens discussed recent work that implicates brain immune cells, called microglia, in sculpting of synaptic connections during development and their relevance to autism …
  8. How Immune Cells Help Wire the Brain: Implications for Autism and Psychiatric Illness

    Lecture
    In this lecture, Dr. Beth Stevens will discuss recent work that implicates brain immune cells, called microglia, in sculpting of synaptic connections during development and their relevance to …
  9. CCA Seminar (Elad Talk)

    Seminar
    The topic of my talk is: “Recent advances in moving mesh and its application to the G2 gas cloud” Abstract: I will give a very brief introduction to …
  10. Solar Convection

    Lecture
    Katepalli Sreenivasan will describe what is known about the convective phenomena in the sun, using results from basic turbulence modeling, numerical simulations, as well as helioseismology.
  11. Curiosity’s Search for Ancient Habitable Environments at Gale Crater, Mars

    Lecture
    The Mars Science Laboratory rover, Curiosity, was built to search for and explore habitable environments. In this lecture, John Grotzinger will review Curiosity’s latest discoveries and describe …
  12. 2016 MPS Annual Meeting

    Event
    … University. He likes to study simply stated problems with a geometric flavor, often with the aid of graphical user interfaces and other computer programs that he writes …
  13. GAIA Sprint Workshop

    Event
    By Invite Only – Please contact David Hogg if you have any questions regarding this event.
  14. SCGB NY-Area Postdoc Meeting Series

    SCGB
    Speakers: Kanaka Rajan, Biophysics Theory Fellow, Lewis-Sigler Institute, Princeton University Recurrent network models of evidence accumulation Michel A. Picardo, Postdoc, Neuroscience institute, New York University Population-level …
  15. CCA Seminar (Licia Verde Talk)

    Seminar
    Precision cosmology: now what? The standard cosmological model has been established and its parameters are now measured with unprecedented precision. However, there is a big difference between modelling …
  16. CCA Seminars (Jeremy Kepner Talk)

    Seminar
    “Enabling Scale-Up, Scale-Out, and Scale-Deep for Big Data” Dr. Jeremy Kepner / MIT Lincoln Laboratory Fellow / MIT Lincoln Laboratory Supercomputing Center Head Big Data volume …
  17. CCA Seminar (Kris Sigurdson Talk)

    Seminar
    … coupling.
  18. Tuberous Sclerosis: Shedding light on the neural circuitry of autism

    Lecture
    On 5 October 2016, Mustafa Sahin presented an update on translational research in Tuberous Sclerosis Complex.
  19. Tuberous Sclerosis: Shedding Light on the Neural Circuitry of Autism

    Lecture
    Genetic disorders with high penetrance of autism symptoms provide an opportunity to investigate the cellular and circuitry abnormalities underlying autism spectrum disorder. Mustafa Sahin studies the basis of …
  20. CCA Seminar (Mark Dijkstra Talk)

    Seminar
    Speaker Mark Djikstra Wine & Cheese to follow 4pm-5pm
  21. The Monster at the Heart of our Galaxy

    Lecture
    In this lecture, Dr. Andrea Ghez will discuss the latest developments in the study of black holes, specifically how the environment around the black hole at the center …
  22. Metagenomic DNA Sequencing to Detect and Diagnose Infections

    Lecture
    Next-generation sequencing has the power to decode DNA in a matter of hours, but doctors still diagnose infections using methods developed decades ago. This lecture will describe …
  23. CCA Seminar

    Seminar
    Please contact [email protected] to be added to participant list.
  24. Statistical Astronomy Group Meeting

    Meeting
    Scientists interested in making cosmological measurements meet to discuss projects in progress, with a focus on measurement processes, data analysis, and statistical inference. Please contact ([email protected] …
  25. Sleep in autism spectrum disorders: A window to etiology, diagnosis and treatment

    Lecture
    On 7 September 2016, Ruth O'Hara discussed the field’s current understanding of sleep in autism spectrum disorder.
  26. Sleep in Autism Spectrum Disorders: A Window to Etiology, Diagnosis and Treatment

    Lecture
    Dr. Ruth O’Hara will present on the field’s current understanding of sleep in autism spectrum disorder.
  27. SCGB NY-Area Postdoc Meeting Series

    SCGB
    Speakers: Ashok Litwin-Kumar, Postdoc, Center for Theoretical Neuroscience, Columbia University Optimal connectivity for random and learned neural representations Antonio H. Lara, Postdoc, Department of Neuroscience, Columbia University …
  28. Conference on Shocks and Particle Acceleration in Novae and Supernovae

    Conference
    … Indrek Vurm Columbia University Fred Walter Stony Brook University Jennifer Weston Columbia University Bob Williams Space Telescope Science Institute Bill Wolf UC Santa Barbara
  29. SCGB NY-Area Postdoc Meeting Series

    SCGB
    Speakers: Matthew Kaufman, Churchland Lab, Cold Spring Harbor Mapping mouse cortex with spontaneous correlations in calcium imaging. Athena Akrami, Brody Lab, Princeton Parametric working memory - trial history vs …
  30. Imaging Life at High Spatiotemporal Resolution

    Lecture
    In this lecture, Eric Betzig will describe advanced optical tools being developed to help scientists delve deeper into the complexity of biological systems.
  31. Universality Phenomena in Machine Learning, and Their Applications

    Lecture
    A canonical task in machine learning is to fit a model to a dataset. Sanjeev Arora will describe models fitted to real-life datasets, which display randomlike properties …
  32. Contemporary Supercomputing: Opportunities for Science and Challenges for Computer Engineering

    Lecture
    In this lecture, Thomas Schulthess will show how recent developments in architecture have moved us away from traditional abstractions, forcing software development and mathematical algorithms to acknowledge the …
  33. One brain, many genomes: Somatic mutation and genomic variability in human cerebral cortex

    Lecture
    On 27 April 2016, Christopher Walsh reviewed recent work on ‘somatic mutations’ — de novo mutations that are present in some brain cells but not in all cells of …
  34. One Brain, Many Genomes: Somatic Mutation and Genomic Variability in Human Cerebral Cortex

    Lecture
    Christopher Walsh will review recent work on ‘somatic mutations’ — de novo mutations that are present in some brain cells but not in all cells of the body — in …
  35. 2016 Conference on Theory & Biology

    Conference
    … very different outcomes; thus we turn to biochemical switches like the G2/M cell cycle transition switch. To compare networks with different structures and levels of complexity …
  36. Integrability and Universality in Probability

    Lecture
    In this lecture, Alexei Borodin will illustrate how these two concepts work together in examples from random matrices to random interface growth.
  37. Geometry Over Nonclosed Fields (2016)

    Symposia
    … Lefschetz theorems (mostly) over finite fields 6:00 – 7:00 PM Alena Pirutka: Rationality in families and quadric bundles (Slides PDF) 8:00 – 9:30 PM Dinner …
  38. Einstein's Blunder Undone

    Lecture
    In this talk, Robert Kirshner will show how we discovered cosmic acceleration and present evidence that we live in a universe that is only 4 percent ordinary matter …
  39. Geometric Aspects of the Trace Formula (2016)

    Symposia
    … Nicolas Templier Cornell University Yakov Varshavsky Hebrew University Jean-Loup Waldspurger Institute de Mathematiques de Jussieu-Paris Rive Gauche « Back to Simons Symposia
  40. Analysis of Boolean Functions (2016)

    Symposia
    … 7:30 – 10:30 AM Breakfast 10:30 – 10:55 AM G. Schechtman: Embedding Pythagorean powers of hypercubes in hypercubes 10:55 – 11:20 AM M. Rudelson …
  41. Development begins before birth: Prenatal research relevant to autism

    Lecture
    On 30 March 2016, Catherine Monk described her lab’s fetal origins of adult disease studies that focus on women in the perinatal period and fetal and infant …
  42. Development Begins Before Birth: Prenatal Research Relevant to Autism

    Lecture
    In this lecture, Catherine Monk will describe her lab’s studies on women in the perinatal period and fetal and infant neurobehavioral development.
  43. What Can Genetics Tell Us About Autism Spectrum Disorder?

    Lecture
    This talk will outline the current state of genetics research in autism, highlight some of the key findings that remain to be discovered, and consider how these findings …
  44. The Fourth Dimension of Transcriptional Networks: TIME

    Lecture
    In this lecture, Dr. Gloria Coruzzi will focus on time — building predictive network models based on time-series transcriptome data, and perturbing transcription networks in time.
  45. The Formation of Structure in the Cosmos

    Lecture
    In this lecture, Juna Kollmeier will take you on a cosmic journey, starting with the infant universe and explain the current thinking about how “structure” emerges from this …
  46. Determining Multimodal Imaging Biomarkers for Parkinson's Disease

    Lecture
    In this lecture, F. DuBois Bowman will discuss how he and his colleagues are working to identify functional or anatomical properties of the brain that reliably distinguish individuals …
  47. Simons Collaboration on the Many Electron Problem Annual Meeting 2016

    Conference
    … regime of low-lying excited states, accessed by using different trial wavefunctions to fix the nodes. Lucas demonstrated both test calculations for small molecules and good results …
  48. A Molecular Geneticist's Approach to Understanding the Fly Brain

    Lecture
    In this lecture, Gerald Rubin will discuss efforts to develop and apply the tools that will be required for a comprehensive analysis of the anatomy and function of …
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