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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis.

    Publication
  2. Supramammillary regulation of locomotion and hippocampal activity

    Publication
  3. Supramammillary regulation of locomotion and hippocampal activity

    Publication
  4. The Clustering of Orbital Poles Induced by the LMC: Hints for the Origin of Planes of Satellites

    Publication
    A significant fraction of Milky Way (MW) satellites exhibit phase-space properties consistent with a coherent orbital plane. Using tailored N-body simulations of a spherical MW halo …
  5. Neurodevelopmental outcomes at one year in offspring of mothers who test positive for SARS-CoV-2 during pregnancy.

    Publication
  6. Motile dislocations knead odd crystals into whorls

    Publication
    The competition between thermal fluctuations and potential forces governs the stability of matter in equilibrium, in particular the proliferation and annihilation of topological defects. However, driving matter out …
  7. Restoring Shank3 in the rostral brainstem of shank3ab-/- zebrafish autism models rescues sensory deficits.

    Publication
  8. Transforming representations of movement from body- to world-centric space

    Publication
    When an animal moves through the world, its brain receives a stream of information about the body's translational velocity from motor commands and sensory feedback signals. These …
  9. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Publication
    We systematically compare the contributions of two dopaminergic and two cholinergic ascending populations to a spatial short-term memory task in rats. In ventral tegmental area dopamine (VTA …
  10. Building an allocentric travelling direction signal via vector computation

    Publication
    Many behavioural tasks require the manipulation of mathematical vectors, but, outside of computational models1-7, it is not known how brains perform vector operations. Here we show how …
  11. Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila

    Publication
    In most animals, the oocyte is the largest cell by volume. The oocyte undergoes a period of large-scale growth during its development, prior to fertilization. At first …
  12. Computational mechanisms of distributed value representations and mixed learning strategies

    Publication
    Learning appropriate representations of the reward environment is challenging in the real world where there are many options, each with multiple attributes or features. Despite existence of alternative …
  13. Methods for inferring neural circuit interactions and neuromodulation from local field potential and electroencephalogram measures.

    Publication
  14. Preference for biological motion is reduced in ASD: Implications for clinical trials and the search for biomarkers.

    Publication
  15. A Late-Time Galaxy-Targeted Search for the Radio Counterpart of GW190814

    Publication
    GW190814 was a compact object binary coalescence detected in gravitational waves by Advanced LIGO and Advanced Virgo that garnered exceptional community interest due to its excellent localization and …
  16. A Comparison of Circumgalactic Mg ii Absorption between the TNG50 Simulation and the MEGAFLOW Survey

    Publication
    The circumgalactic medium (CGM) contains information on gas flows around galaxies, such as accretion and supernova-driven winds, which are difficult to constrain from observations alone. Here, we …
  17. Algorithms for solving high dimensional PDEs: from nonlinear Monte Carlo to machine learning

    Publication
    In recent years, tremendous progress has been made on numerical algorithms for solving partial differential equations (PDEs) in a very high dimension, using ideas from either nonlinear (multilevel …
  18. Learning and attention increase visual response selectivity through distinct mechanisms

    Publication
    Selectivity of cortical neurons for sensory stimuli can increase across days as animals learn their behavioral relevance and across seconds when animals switch attention. While both phenomena occur …
  19. Final Targeting Strategy for the Sloan Digital Sky Survey IV Apache Point Observatory Galactic Evolution Experiment 2 North Survey

    Publication
    The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is a dual-hemisphere, near-infrared (NIR), spectroscopic survey with the goal of producing a chemodynamical mapping of …
  20. Exercise plasma boosts memory and dampens brain inflammation via clusterin

    Publication
    Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration1. The cognitive benefits of physical exercise are tied to an …
  21. Supervised Multisensory Calibration Signals Are Evident in VIP But Not MSTd

    Publication
    Multisensory plasticity enables our senses to dynamically adapt to each other and the external environment, a fundamental operation that our brain performs continuously. We searched for neural correlates …
  22. A New Classification Model for the ZTF Catalog of Periodic Variable Stars

    Publication
    Using the second data release from the Zwicky Transient Facility (ZTF, Bellm et al. 2019), Chen et al. (2020) created a ZTF Catalog of Periodic Variable Stars (ZTF …
  23. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans.

    Publication
  24. De novo variants in the PSMC3 proteasome AAA-ATPase subunit gene cause neurodevelopmental disorders associated with type I interferonopathies.

    Publication
  25. Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.

    Publication
  26. Rapid build-up of the stellar content in the protocluster core SPT2349−56 at z = 4.3

    Publication
    The protocluster SPT2349−56 at z=4.3 contains one of the most actively star-forming cores known, yet constraints on the total stellar mass of this system …
  27. The GALAH Survey: chemical tagging and chrono-chemodynamics of accreted halo stars with GALAH+ DR3 and Gaia eDR3

    Publication
    Since the advent of Gaia astrometry, it is possible to identify massive accreted systems within the Galaxy through their unique dynamical signatures. One such system, Gaia-Sausage-Enceladus …
  28. Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics

    Publication
    Women live longer than men but experience greater disability and a longer period of illness as they age. Despite clear sex differences in aging, the impact of pregnancy …
  29. Neural optimal feedback control with local learning rules

    Publication
    A major problem in motor control is understanding how the brain plans and executes proper movements in the face of delayed and noisy stimuli. A prominent framework for …
  30. Bridging the Gap: Point Clouds for Merging Neurons in Connectomics

    Publication
    In the field of Connectomics, a primary problem is that of 3D neuron segmentation. Although deep learning-based methods have achieved remarkable accuracy, errors still exist, especially in …
  31. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

    Publication
    Knockoff-based methods have become increasingly popular due to their enhanced power for locus discovery and their ability to prioritize putative causal variants in a genome-wide analysis …
  32. Classical Novae at Radio Wavelengths

    Publication
    We present radio observations (1--40 GHz) for 36 classical novae, representing data from over five decades compiled from the literature, telescope archives, and our own programs. Our …
  33. Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation

    Publication
    Failure to reorganize the endoplasmic reticulum (ER) in mitosis results in chromosome missegregation. Here, we show that accurate chromosome segregation in human cells requires cell cycle-regulated ER …
  34. Exact Landau Level Description of Geometry and Interaction in a Flatband

    Publication
  35. Classification of Dirac points with higher-order Fermi arcs

    Publication
  36. Cortical interneurons in autism.

    Publication
  37. Gauge equivariant neural networks for quantum lattice gauge theories

    Publication
    Gauge symmetries play a key role in physics appearing in areas such as quantum field theories of the fundamental particles and emergent degrees of freedom in quantum materials …
  38. Lithium Enrichment Signatures of Planetary Engulfment Events in Evolved Stars

    Publication
    Planetary engulfment events have long been proposed as a lithium (Li) enrichment mechanism contributing to the population of Li-rich giants (A(Li) ≥ 1.5 dex). Using MESA …
  39. 16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis.

    Publication
  40. The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Publication
    The study of naturalistic social behavior requires quantification of animals' interactions. This is generally done through manual annotation-a highly time-consuming and tedious process. Recent advances in …
  41. The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Publication
    The study of naturalistic social behavior requires quantification of animals' interactions. This is generally done through manual annotation-a highly time-consuming and tedious process. Recent advances in …
  42. Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.

    Publication
  43. The diagnosis of autism: From Kanner to DSM-III to DSM-5 and beyond.

    Publication
  44. Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes.

    Publication
  45. AbacusHOD: A highly efficient extended multi-tracer HOD framework and its application to BOSS and eBOSS data

    Publication
    We introduce the AbacusHOD model and present two applications of AbacusHOD and the AbacusSummit simulations to observations. AbacusHOD is an HOD framework written in Python that is particle …
  46. Pivotal response treatment for school-aged children and adolescents with autism spectrum disorder: A randomized controlled trial.

    Publication
  47. "You must become a chameleon to survive": Adolescent experiences of camouflaging.

    Publication
  48. The impact of COVID-19 on the mental health and wellbeing of caregivers of autistic children and youth: A scoping review.

    Publication
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