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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. MEG/EEG Part 2: Analysis, Application and Interpretation

    Lecture
    … they afford, especially in the field of neuropsychiatric disorders, in which disruptions of neural systems, circuitry and connectivity may be implicated. The talk will focus on the …
  2. Why Prove Theorems?

    Lecture
    Since at least the time when it was understood that the circumference of a circle is pi multiplied by its diameter, the applications of mathematics have raced on …
  3. Learning to move

    Lecture
    On 3 December 2014, Karen E. Adolph discussed how infants learn to generate and control their movements by adapting to environmental and social factors.
  4. Learning to Move

    Lecture
    Basic motor skills such as looking, reaching and walking do not simply appear as the result of maturation. Rather, infants must learn to move. Learning entails discovering new …
  5. December 3, 2014: Learning to Move

    Event
    December 3, 2014, 4:30-6:30 p.m. EST Gerald D. Fischbach Auditorium at the Simons Foundation 160 Fifth Avenue, New York, NY In this lecture, Karen …
  6. Topology and Complexity

    Lecture
    Topology, the "rubber sheet geometry", studies properties that do not change when objects are pulled and stretched. Accepting somewhat fuzzy input, it is the part of mathematics typically …
  7. Celebrating the Mathematics of Maxim Kontsevich

    Lecture
    A day to explore Maxim Kontsevich's contributions to the field of mathematics.
  8. Belief Propagation Algorithms with Applications to Cancer Genomics

    Lecture
    In this talk, Christian Borgs will give an introduction to belief propagation, discuss how the accuracy of belief propagation has been rigorously established, and present recent applications to …
  9. MEG/EEG Part 1: Acquisition, Modeling and Localization

    Lecture
    … principle, ideally suited for the noninvasive investigation of dynamics in cortical networks. However, localizing MEG activity is not a trivial task. Mislocalization of activity affects subsequent estimates …
  10. Geometric and Multiscale Methods for Statistical Learning

    Lecture
    In this lecture, Mauro Maggioni will discuss a family of ideas, algorithms and results for learning from high-dimensional data.
  11. Microbiota and the host immune system in autism

    Lecture
    On 29 October 2014, Dan Littman described how intestinal bacteria affect immune system cell functioning, potentially contributing to systemic inflammation and autism.
  12. Dialogue of the Microbiota with the Host Immune System: Implications for Inflammatory Disease and Autism

    Lecture
    In this lecture, Dan Littman will describe how intestinal commensal bacteria shape functions of immune system cells that prevent invasion by pathogenic microbes but can also contribute to …
  13. MoSAIC Math + Art Festival

    Lecture
    The MoSAIC Festival includes a variety of hands-on workshops, lectures, a mathematical art exhibit, short films and an area for informal exchange. It is designed to be …
  14. 2014 MPS Annual Meeting

    Conference
    … established the best current bounds to the restriction problem. Extending this work, he and Katz essentially solved one of the most well-known problems in incidence geometry …
  15. Numerical Quantum Simulations of Realistic Materials

    Lecture
    Simulating quantum mechanics on classical computers appears at first to require exponential computational resources, yet at the same time rapid progress is being made in accurate simulations of …
  16. Urban Social Science Au Naturel

    Lecture
    The enormous amount of information that is now available about cities and the people who live in them offers intriguing opportunities for better understanding human behavior. That understanding …
  17. Testing the Cortical Column Conjecture

    Lecture
    In his talk, Carey Priebe will present the conjecture that neurons in the neocortex are connected in a graph that exhibits motifs representing repeated processing modules.
  18. The social brain: Understanding autism

    Lecture
    On 23 September 2014, Nancy Kanwisher discussed the functional architecture of the social brain as an avenue for considering which functions are affected and which are preserved in …
  19. The Social Brain: A Hypothesis Space for Understanding Autism

    Lecture
    In this talk, Nancy Kanwisher will consider the functional architecture of the social brain in typical subjects as an avenue for considering which functions are affected and which …
  20. Strategies to Prolong Vision in Inherited Forms of Blindness

    Lecture
    In the disease retinitis pigmentosa (RP), disease genes directly cause the dysfunction and death of rod photoreceptors, the photoreceptor type that mediates vision in dim light, causing night …
  21. Complex Data Visualization: Approach and Application

    Lecture
    This Biotech Symposium will focus on the visualization and representation of analytic results from complex data sets.
  22. Living with Uncertainty but Still Learning: Anti-Abortion Democrats, Jimmy Carter Republicans and the Missing Leap Day Babies

    Lecture
    Andrew Gelman will illustrate this concept with various examples from his recent research and discuss more generally how statistical methods can help or hinder the scientific process.
  23. Simons Collaboration on the Many Electron Problem Annual Meeting 2014

    Conference
    … 1:00 – 1:25 PM Benchmarks: how well do our methods work? | E. Gull View Slides 1:25 – 2:15 PM Short Talks | J. LeBlanc; G. Chan …
  24. November 6, 2013: Infants’ Grasp of Others’ Intentions: The Development of Social Understanding

    Lecture
  25. Symposium on Evidence in the Natural Sciences

    Event
    … armamentarium that it is easy to think they are part of the eternal firmament of physics. But they, like the objects and laws they helped establish, are …
  26. Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders?

    Lecture
    Although most people regularly tune up their cars, you probably haven’t needed to bring your brain in for a tune-up, despite the fact that the human …
  27. May 28, 2014: Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders?

    Event
    … Technological Innovation and Neurobiology of Disease awards, an NIH director’s pioneer award, the HFSP Nakasone Award, election to the American Academy of Arts and Sciences and …
  28. Probabilistic Topic Models of Text and Users

    Lecture
    Probabilistic topic models provide a suite of tools for analyzing large collections of electronic documents. A traditional topic model analyzes a collection of documents to discover its hidden …
  29. May 21, 2014: Probabilistic Topic Models of Text and Users

    Event
    … assumptions and scalable algorithms for using those assumptions to uncover hidden patterns in massive data. David Blei is associate professor of computer science at Princeton University. Blei …
  30. Big Data Analytics and a Path to Enhancing Our Understanding of Human Disease

    Lecture
    Dr. Schadt provides an overview of how his team organizes very large scale data across many different types, and then integrates these data using sophisticated mathematical algorithms to …
  31. Where is Fundamental Physics Heading?

    Lecture
    In recent decades, physicists and astronomers have discovered two beautiful standard models, one for the quantum world of extremely short distances and one for the universe as a …
  32. New approaches to treating Rett syndrome

    Lecture
    On 23 April 2014, Gail Mandel presented the complex pathology of Rett syndrome.
  33. New Insights and Approaches for Studying Rett Syndrome, an Autism-Associated Disorder

    Lecture
    A central goal in neuroscience is determining the genetic basis of neurological disorders — from autism to brain tumors. Many of these pathological states result from defects in gene …
  34. Von Neumann Machines and Molecular Darwinism

    Lecture
    In this lecture, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines …
  35. April 11, 2014: Conference on Theory & Biology

    Event
  36. 2014 Conference on Theory & Biology

    Conference
    … encountered in the environment, and the selectivity and response levels of neurons within a population that encodes those attributes. This allocation of neural resources, in turn, imposes …
  37. Transcriptional and Epigenetic Mechanisms of Depression

    Lecture
    Depression is a common, chronic, and debilitating disease. Although many patients benefit from antidepressant medications or other therapies, only about half show complete remission. Factors that precipitate depression …
  38. An attempt at redefining autism

    Lecture
    On 26 March 2014, Ami Klin presented two new infant and toddler behavioral measures of social behaviors.
  39. An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities

    Lecture
    Advances in molecular genetics have implicated a variety of genetic variations in autism, yet understanding of what these variations mean is still limited. Advances in classification of diseases …
  40. Galactic Superwinds: Beyond Phenomenology (2014)

    Symposia
    … Outflow Questions Rob Crain, Leiden Observatory Pre-SNe Stellar Winds, Intermediate Age Populations, Momentum Driving Relevance on Scales Beyond GMCs, 1051 erg/SN, Short AGN Duty Cycles …
  41. Learning With a Nontrivial Teacher

    Lecture
    Learning Using Privileged Information (LUPI) is a new paradigm that uses an intelligent agent (a ‘nontrivial teacher’) to supplement standard training data in the context of supervised learning …
  42. March 12, 2014: Learning With a Nontrivial Teacher

    Event
    … computer science and machine learning, including a general theory for minimizing the expected risk of losses using empirical data, and the widely used Support Vector Machine approach …
  43. Discrete Analysis: Beyond the Boolean Cube (2014)

    Symposia
    … Columbia University Yuri Tschinkel, Simons Foundation Thomas Vidick, MIT Avi Wigderson, IAS Julia Wolf, École Polytechnique
  44. Perspectives on Big Data in Biology

    Lecture
    This Biotech Symposium will focus on perspectives on big data in biology from leading practitioners in the field.
  45. March 7, 2014: Perspectives on Big Data in Biology

    Event
    … video below) Memorial Sloan-Kettering Cancer Center Global Alliance for Genomics and Health
  46. Genes That Regulate Sleep and Circadian Rhythms in Drosophila

    Lecture
    Circadian (~24 hour) clocks are endogenous mechanisms that time the recurring, daily activities observed in most organisms. These clocks are genetically regulated, and generate biochemical oscillations within individual …
  47. Imaging early brain development in autism

    Lecture
    On 26 February 2014, David Amaral discussed different types of altered brain development among children with autism.
  48. Neuroimaging Contributions to the Understanding of Brain Development in Autism

    Lecture
    While autism clearly involves altered function of the central nervous system, the neuropathology of the disorder remains controversial. This is due in part,to the enormous complexity of …
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