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  1. The glymphatic system

    Publication
    All biological processes including movement, digestion, and thought require energy, and the metabolic activity necessary to generate that energy also generates waste. Metabolic by-products, including a variety …

  2. Rats use memory confidence to guide decisions

    Publication
    Memory enables access to past experiences to guide future behavior. Humans can determine which memories to trust (high confidence) and which to doubt (low confidence). How memory retrieval …

  3. De novo variants in CACNA1E found in patients with intellectual disability, developmental regression and social cognition deficit but no seizures.

    Publication

  4. Can we make drug discovery targeting fundamental mechanisms of aging a reality?

    Publication

  5. Can we make drug discovery targeting fundamental mechanisms of aging a reality?

    Publication

  6. Attention improves information flow between neuronal populations without changing the communication subspace

    Publication
    Visual attention allows observers to change the influence of different parts of a visual scene on their behavior, suggesting that information can be flexibly shared between visual cortex …

  7. Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer's Disease Across Two Brain Regions

    Publication
    Alzheimer's disease (AD) is a pervasive neurodegenerative disorder that disproportionately affects women. Since neural anatomy and disease pathophysiology differ by sex, investigating sex-specific mechanisms in AD …

  8. Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions.

    Publication

  9. mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity.

    Publication

  10. A geometric distance to the supermassive black Hole of NGC 3783

    Publication
    The angular size of the broad line region (BLR) of the nearby active galactic nucleus (AGN) NGC 3783 has been spatially resolved by recent observations with VLTI/GRAVITY …

  11. Altered inflammatory response in FMRP-deficient microglia.

    Publication

  12. Boundary layers of accretion discs: Discovery of vortex-driven modes and other waves

    Publication
    Disk accretion onto weakly magnetized objects possessing a material surface must proceed via the so-called boundary layer (BL) - a region at the inner edge of the disk …

  13. Flexible filtering by neural inputs supports motion computation across states and stimuli

    Publication
    Sensory systems flexibly adapt their processing properties across a wide range of environmental and behavioral conditions. Such variable processing complicates attempts to extract a mechanistic understanding of sensory …

  14. Primary visual cortex straightens natural video trajectories

    Publication
    Many sensory-driven behaviors rely on predictions about future states of the environment. Visual input typically evolves along complex temporal trajectories that are difficult to extrapolate. We test …

  15. Analysis of single-excitation states in quantum optics

    Publication
    In this paper we analyze the dynamics of single-excitation states, which model the scattering of a single photon from multiple two level atoms. For short times and …

  16. Customized de novo mutation detection for any variant calling pipeline: SynthDNM.

    Publication

  17. Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosis

    Publication
    DNA damage reshapes the cellular transcriptome by modulating RNA transcription and processing. In cancer cells, these changes can alter the expression of genes in the immune surveillance and …

  18. Oligogenic combinations of rare variants influence specific phenotypes in complex disorders.

    Publication

  19. Cardiolipin prevents pore formation in phosphatidylglycerol bacterial membrane models

    Publication
    Abstract Several antimicrobial peptides, including magainin and the human cathelicidin LL-37, act by forming pores in bacterial membranes. Bacteria such as Staphylococcus aureus modify their membrane's …

  20. Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids.

    Publication

  21. All-sky Search for Continuous Gravitational Waves from Isolated Neutron Stars in the Early O3 LIGO Data

    Publication
    We report on an all-sky search for continuous gravitational waves in the frequency band 20-2000,Hz and with a frequency time derivative in the range of …

  22. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

    Publication
    Parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical …

  23. How learning unfolds in the brain: toward an optimization view

    Publication
    How do changes in the brain lead to learning? To answer this question, consider an artificial neural network (ANN), where learning proceeds by optimizing a given objective or …

  24. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

    Publication
    Parkinson's disease and related synucleinopathies are characterized by the abnormal accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of the substantia nigra. Although clinical …

  25. A multimodal cell census and atlas of the mammalian primary motor cortex

    Publication
    Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census …

  26. Cellular anatomy of the mouse primary motor cortex

    Publication
    An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can …

  27. Comparative cellular analysis of motor cortex in human, marmoset and mouse

    Publication
    The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1. Here, using high-throughput transcriptomic and epigenomic profiling of more …

  28. The COMBS Survey – III. The chemodynamical origins of metal-poor bulge stars

    Publication
    The characteristics of the stellar populations in the Galactic bulge inform and constrain the Milky Way’s formation and evolution. The metal-poor population is particularly important in …

  29. Evolving the olfactory system with machine learning

    Publication
    The convergent evolution of the fly and mouse olfactory system led us to ask whether the anatomic connectivity and functional logic of olfactory circuits would evolve in artificial …

  30. The Learning Salon: Toward a new participatory science

    Publication
    The Learning Salon is an online weekly forum for discussing points of contention and common ground in biological and artificial learning. Hosting neuroscientists, computer scientists, AI researchers, and …

  31. Bringing faint active galactic nuclei (AGNs) to light: a view from large-scale cosmological simulations

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    The sensitivity of X-ray facilities and our ability to detect fainter active galactic nuclei (AGNs) will increase with the upcoming Athena mission and the AXIS and Lynx …

  32. Rare and de novo variants in 827 congenital diaphragmatic hernia probands implicate LONP1 as candidate risk gene.

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  33. Collective oscillations of coupled cell cycles

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    Problems with networks of coupled oscillators arise in multiple contexts, commonly leading to the question about the dependence of network dynamics on network structure. Previous work has addressed …

  34. Investigating the structure of trait rumination in autistic adults: A network analysis.

    Publication

  35. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes

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  36. How rare and common risk variation jointly affect liability for autism spectrum disorder.

    Publication

  37. Characterizing mass, momentum, energy, and metal outflow rates of multiphase galactic winds in the FIRE-2 cosmological simulations

    Publication
    We characterize mass, momentum, energy and metal outflow rates of multi-phase galactic winds in a suite of FIRE-2 cosmological "zoom-in" simulations from the Feedback in …

  38. A Bayesian neural network predicts the dissolution of compact planetary systems

    Publication
    Despite over three hundred years of effort, no solutions exist for predicting when a general planetary configuration will become unstable. We introduce a deep learning architecture to push …

  39. A Bayesian neural network predicts the dissolution of compact planetary systems

    Publication
    Despite over three hundred years of effort, no solutions exist for predicting when a general planetary configuration will become unstable. We introduce a deep learning architecture to push …

  40. Nature of unconventional pairing in the kagome superconductors AV

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  41. Sensing strain-induced symmetry breaking by reflectance anisotropy spectroscopy

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  42. Optical activation and detection of charge transport between individual colour centres in diamond

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  43. Magnetic photocurrents in multifold Weyl fermions

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  44. Spatial modulation of hippocampal activity in freely moving macaques

    Publication
    The hippocampal formation is linked to spatial navigation, but there is little corroboration from freely moving primates with concurrent monitoring of head and gaze stances. We recorded neural …

  45. Computational fingerprints: Modeling interactions between brain regions as points in a function space.

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  46. Identification of neural oscillations and epileptiform changes in human brain organoids.

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  47. Brief report: Impact of COVID-19 on individuals with ASD and their caregivers: A perspective from the SPARK cohort.

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  48. Bayesian estimation of cell-type-specific gene expression with prior derived from single-cell data.

    Publication