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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Parking Cars, Rolling Balls, and Falling Cats: The Concept of Holonomy

    Lecture
    … theory and particle physics. In this talk, I’ll describe some basic aspects of this concept, starting with simple physical problems and illustrating the ideas using familiar …
  2. Climate Projections over North America in the Coming Decades

    Lecture
    Earth’s climate trajectory over the next few decades will be influenced by human-induced climate change and by internally generated variability in the climate system. Clara Deser …
  3. New genetic insights into autism

    Lecture
    On 25 April 2013, Matthew State discussed genetic discoveries in autism research and the challenges that lie ahead.
  4. New Genetic Insights into the Pathophysiology of Autism Spectrum Disorders

    Lecture
    The genetics and genomics of autism spectrum disorders have reached a tipping point. The recent focus on de novo mutations has led to systematic, highly productive gene discovery …
  5. Water: Climate's Great Orchestrator

    Lecture
    The mighty water molecule is responsible for much of what we know about climate and climate change, and even more of what we don’t know. In this …
  6. Climate Feedbacks: Magnitude and Uncertainty in Global Warming

    Lecture
    This lecture presented by Brian J. Soden outlines our understanding of the main feedback processes in the climate system and how they impact both the magnitude of future …
  7. Non-Archimedean and Tropical Geometry (2013)

    Symposia
    March 31-April 6, 2013 Organizers: Matt Baker and Sam Payne This symposium will focus on setting a clear agenda for future developments in the related fields of …
  8. The Most Random of All Possible Worlds

    Lecture
    Andrei Okounkov presents a talk about the law of large numbers, in its various manifestations. This is a real cornerstone of probability, which states that a random system …
  9. Hurricanes: Present and Future

    Lecture
    Some 90 tropical cyclones develop each year. In this lecture, Professor Kerry Emanuel will review the theory of tropical cyclones and how it informs observed variability. He will …
  10. Autism, Oxytocin, and Neural Signaling

    Lecture
    Genetics tells us that abnormal synaptic and nuclear proteins are often at the root of major neuropsychiatric disorders. Autism, a prominent and often debilitating disorder of the brain …
  11. The Kardar-Parisi-Zhang Equation and Universality Class (2013)

    Symposia
    … universality of the KPZ equation. The new well-posedness theory should provide a route to proving scaling limits to the KPZ equation for a wider class of …
  12. Probability & Intuition

    Lecture
    Probability theory was devised in order to understand gambling, but now is the underpinning of statistics, without which we would be clueless in our complex society.  Yet probability …
  13. Simons Symposium on Quantum Entanglement (2013)

    Symposia
    … Millis, Simons Foundation Robert Myers, Perimeter Institute Hirosi Ooguri, Caltech Masaki Oshikawa, University of Tokyo Joe Polchinski, KITP Subir Sachdev, Harvard University Eva Silverstein, Stanford University Julian …
  14. Resting State fMRI

    Lecture
    Resting-state functional magnetic resonance imaging (fMRI) has been used to identify consistent functional patterns in neurotypical individuals, as well as changes in neurologic and psychiatric diseases.
  15. January 31, 2013: Resting State fMRI

    Event
    January 31, 2013, 12:30-5:30 p.m. EST Gerald D. Fischbach Auditorium at the Simons Foundation 160 Fifth Avenue, New York, NY This Biotech Symposium will …
  16. Mathematics of Planet Earth 2013 Simons Public Lecture Series

    Lecture
    This comprehensive and accessible series features some of today’s most pressing issues. This series will not only inform the public about the connection between math and sustainability …
  17. New Directions in Approximation Algorithms (2013)

    Symposia
    … Princeton University Boaz Barak Microsoft Research, New England Julia Chuzhoy Toyota Technological Institute at Chicago Uriel Feige Weizmann Institute Michel X. Goemans MIT Venkatesan Guruswami Carnegie Mellon …
  18. Animation, Teeth and Skeletons

    Lecture
    The talk describes (dis)similarity distances between pairs of two-dimensional surfaces (embedded in three-dimensional space) that use both local structures and global information in the surfaces.
  19. The Mathematics of Mind and Brain

    Lecture
    The mind and brain can be thought of as computational systems — but what kinds of computations do they carry out, and what kinds of mathematics can best characterize …
  20. Knot Homologies and BPS States (2012)

    Symposia
    … Hill Robbert Dijkgraaf Universiteit van Amsterdam Davide Gaiotto Institute for Advanced Study Sergei Gukov California Institute of Technology Mikhail Khovanov Columbia University Peter Kronheimer Harvard University Ciprian …
  21. What Has the Brain Evolved to Know About the Natural Olfactory World?

    Lecture
    Most sensory stimuli in the natural world exhibit strong statistical regularities. A proposed general principle of sensory neuroscience is that the brain’s circuitry is designed to take …
  22. New Technologies for Measuring Neural Circuit Dynamics

    Lecture
    A talk on recent advances in methods and instrumentation that combine genetically encoded molecular sensors, optical imaging and virtual-reality systems to measure neural-circuit dynamics in the …
  23. Geometry Over Non-Closed Fields (2012)

    Symposia
    … Foundations Dan Abramovich Logarithmic stable maps (PDF) Chanyang Xu Irreducibility and degenerate fibers of Fano fibrations (PDF) Burt Totaro The integral Hodge conjecture for threefolds (PDF) Constructing …
  24. Taking the Universe's Baby Picture

    Lecture
    While significant progress has been made on key cosmological questions, many remain unanswered: What happened during the first moments of the big bang? What is dark energy? What …
  25. Analysis of Boolean Functions: New Directions and Applications (2012)

    Symposia
    … Probabilistic Existence of Rigid Combinatorial Objects Informal Discussions Thursday, February 9 Tali Kaufmann Locally Testable Codes and Expanders Parikshit Gopalan The Short Code Open Problem Session II …
  26. Quantum Physics Beyond Simple Systems: Complex Dynamics, Decoherence, Topology and Information (2012)

    Symposia
    … physics. Participants Igor Aleiner Columbia University Boris Altshuler Columbia University Piet Brouwer Dahlem Center for Complex Quantum Systems Sankar Das Sarma University of Maryland Vladimir Falko Lancaster …
  27. Quantum Mechanics and Space-Time in the 21st Century

    Lecture
    Nima Arkani-Hamed's research has shown how the extreme weakness of gravity, relative to other forces of nature, might be explained by the existence of extra dimensions …
  28. Controlling Quantum Coherence: Toward New Paradigms of Computation

    Lecture
    This talk describes experimental progress toward controlling quantum mechanical coherence and entanglement in a solid-state environment.
  29. Beautiful Thoughts from Ugly Neurons

    Lecture
    This talk is based on mathematical and computational studies of neural network models. Understanding the range of dynamic phenomena in such models provides a basis for thinking about …
  30. The Regulation of Fidelity in the Transmission of Genetic Information from Parent to Offspring

    Lecture
    The evolution of organisms requires the generation of some diversity in the offspring and then the selection of the fittest in the present environment from among this diversity …
  31. Merging Mind and Machine: Creating technology to reconnect the brain to action

    Lecture
    This talk discusses progress in developing devices that can restore lost functions of the nervous system following disease or injury, in particular the development of a brain computer …
  32. Computational Perspectives on Social Phenomena at Global Scales

    Lecture
    Analyzing the collective behavior and social interactions of hundreds of millions of people with powerful computational techniques offers a radically new perspective on fundamental questions in the social …
  33. The Missing Circuits: Studying Entire Brains

    Lecture
    Fundamental gaps remain in our understanding of animal brains, especially human brains, in comparison with other organ systems in the body. One of these gaps is our very …
  34. Attention Deficits in Autism

    SFARI Workshop
    Overview Children with autism often have behaviors that suggest problems with attention. It is unclear whether this attention deficit causes the other symptoms of autism or is a …
  35. When and How Can We Compute Approximately Optimal Solutions to Intractable Computational Problems?

    Lecture
    Can efficient algorithms find approximately optimal solutions? The classical theory of NP-completeness didn't address or preclude this possibility.
  36. Unbiased Reconstruction of Mammalian Regulatory Networks

    Lecture
    This talk presents a strategy based on systematic gene perturbation and innovative multiplex detection to derive regulatory networks in mammalian cells.
  37. Fluctuations, Information and Survival: Some Lessons from Bacteria

    Lecture
    Bacteria have developed an astonishing panoply of survival strategies in varying environments. This talk describes some recent experimental and theoretical studies connected with microbial behavior.
  38. Normalization as a Canonical Neural Computation

    Lecture
    This talk presents the normalization model of neural computation and elaborates the hypothesis that dysfunctions of normalization may be associated with schizophrenia, amblyopia, epilepsy, and autism spectrum disorders.
  39. Strategic Behavior and the Science of Social Networks

    Lecture
    The modern ability to carefully measure large-scale social networks has driven new empirical studies and theoretical models of growth, dynamics, influence, and collective behavior in such systems.
  40. The Power and Weakness of Randomness (When You are Short on Time)

    Lecture
    Man has grappled with the meaning and utility of randomness for centuries. This talk describes two main aspects of the research on randomness with respect to the theory …
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