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  1. Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction.

    Publication

  2. Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells

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    During late embryonic development of the cerebral cortex, the major class of cortical output neurons termed subcerebral projection neurons (SCPN; including the predominant population of corticospinal neurons, CSN …

  3. Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes

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    State-of-the-art silicon probes for electrical recording from neurons have thousands of recording sites. However, due to volume limitations there are typically many fewer wires carrying …

  4. Differences in the number of de novo mutations between individuals are due to small family-specific effects and stochasticity.

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  5. Mapping the research domain criteria social processes constructs to the social responsiveness scale.

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  6. Tight distance-dependent estimators for screening two-center and three-center short-range Coulomb integrals over Gaussian basis functions

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  7. Design and realization of topological Dirac fermions on a triangular lattice

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  8. From high-T

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  9. Quantum sampling algorithms, phase transitions, and computational complexity

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  10. Quantum Sampling Algorithms for Near-Term Devices

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  11. Absorption Spectra of Solids from Periodic Equation-of-Motion Coupled-Cluster Theory

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  12. Tree tensor-network real-time multiorbital impurity solver: Spin-orbit coupling and correlation functions in Sr

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  13. Investigation of photon emitters in Ce-implanted hexagonal boron nitride

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  14. Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity

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    Neural activity sculpts circuit wiring in many animals. In vertebrates, patterned spontaneous network activity (PaSNA) generates sensory maps and establishes local circuits.1-3 However, it remains unclear …

  15. utr.annotation: A tool for annotating genomic variants that could influence post-transcriptional regulation.

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  16. Atypical genomic cortical patterning in autism with poor early language outcome.

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  17. Distinct ensembles in the noradrenergic locus coeruleus evoke diverse cortical states.

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  18. Developmental and temporal characteristics of clonal sperm mosaicism.

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  19. Reduced sensory habituation in autism and its correlation with behavioral measures.

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  20. Chemical evidence for planetary ingestion in a quarter of Sun-like stars

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    Stellar members of binary systems are formed from the same material, therefore they should be chemically identical. However, recent high-precision studies have unveiled chemical differences between the …

  21. Chronically implantable LED arrays for behavioral optogenetics in primates

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    Optogenetic methods have been widely used in rodent brains, but remain relatively under-developed for nonhuman primates such as rhesus macaques, an animal model with a large brain …

  22. Rates of contributory de novo mutation in high and low-risk autism families.

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  23. What is the dynamical regime of cerebral cortex?

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    Many studies have shown that the excitation and inhibition received by cortical neurons remain roughly balanced across many conditions. A key question for understanding the dynamical regime of …

  24. Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility.

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  25. Expression of genes in the 16p11.2 locus during development of the human fetal cerebral cortex.

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  26. Association of polygenic liability for autism with face-sensitive cortical responses from infancy.

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  27. Dendritic integration dysfunction in neurodevelopmental disorders.

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  28. Sleep problems in children with ASD and gene disrupting mutations.

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  29. Decoding locomotion from population neural activity in moving C. elegans

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    We investigated the neural representation of locomotion in the nematode C. elegans by recording population calcium activity during movement. We report that population activity more accurately decodes locomotion …

  30. Full-length isoform transcriptome of the developing human brain provides further insights into autism.

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  31. Toward performance-portable PETSc for GPU-based exascale systems

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    The Portable Extensible Toolkit for Scientific computation (PETSc) library delivers scalable solvers for nonlinear time-dependent differential and algebraic equations and for numerical optimization. The PETSc design for …

  32. Attenuated activation of pulmonary immune cells in mRNA-1273–vaccinated hamsters after SARS-CoV-2 infection

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    The mRNA-1273 vaccine is effective against SARS-CoV-2 and was granted emergency use authorization by the FDA. Clinical studies, however, cannot provide the controlled response to …

  33. NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

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    Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived …

  34. The grid code for ordered experience

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    Entorhinal cortical grid cells fire in a periodic pattern that tiles space, which is suggestive of a spatial coordinate system. However, irregularities in the grid pattern as well …

  35. What is the dynamical regime of cerebral cortex?

    Publication
    Many studies have shown that the excitation and inhibition received by cortical neurons remain roughly balanced across many conditions. A key question for understanding the dynamical regime of …

  36. Topological braiding and virtual particles on the cell membrane

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    Braiding of topological structures in complex matter fields provides a robust framework for encoding and processing information, and it has been extensively studied in the context of topological …

  37. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

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    … chromosome gene expression (3 genes), adjusted for age at death and education, was associated with neuropathological tau burden at the genome-wide level in men but not …

  38. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice

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    Executing memory-guided behavior requires storage of information about experience and later recall of that information to inform choices. Awake hippocampal replay, when hippocampal neural ensembles briefly reactivate …

  39. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

    Publication
    … gene expression (3 genes), adjusted for age at death and education, was associated with neuropathological tau burden at the genome-wide level in men but not women …

  40. A phase II randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of arbaclofen administered for the treatment of social function in children and adolescents with autism spectrum disorders: Study protocol for AIMS-2-TRIALS-CT1.

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  41. Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse neocortex.

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  42. A Holistic Review of a Galactic Interaction

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    Our situation as occupants of the Milky Way (MW) Galaxy, bombarded by the Sagittarius dwarf galaxy, provides an intimate view of physical processes that can lead to the …

  43. Evaluating the Arrhenius equation for developmental processes

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    The famous Arrhenius equation is well suited to describing the temperature dependence of chemical reactions but has also been used for complicated biological processes. Here, we evaluate how …

  44. From complex datasets to predictive models of embryonic development

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    Modern studies of embryogenesis are increasingly quantitative, powered by rapid advances in imaging, sequencing and genome manipulation technologies. Deriving mechanistic insights from the complex datasets generated by these …

  45. latentcor: An R Package for estimating latent correlations from mixed data types

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    We present `latentcor`, an R package for correlation estimation from data with mixed variable types. Mixed variables types, including continuous, binary, ordinal, zero-inflated, or truncated data are …

  46. A Biologically Plausible Neural Network for Multichannel Canonical Correlation Analysis

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    Cortical pyramidal neurons receive inputs from multiple distinct neural populations and integrate these inputs in separate dendritic compartments. We explore the possibility that cortical microcircuits implement canonical correlation …

  47. Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

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    Neuropsychiatric disorders are often accompanied by cognitive impairments/intellectual disability (ID). It is not clear whether there are converging mechanisms underlying these debilitating impairments. We found that many …

  48. GABAB receptor agonist R-baclofen reverses altered auditory reactivity and filtering in the Cntnap2 knock-out rat.

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