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September 30, 2024… University of Washington Anselmo Rivera Johns Hopkins University Gwen Roter University of Wisconsin–Madison Gloria Shen University of Washington Alishba Silat University of Texas at Dallas Ilana … -
September 25, 2024… the guidance of Art Director Samuel Velasco “These articles resulted from more than 60 hours of interviews with more than 30 quantum gravity researchers,” said Staff Writer … -
New ScientistAstronomer Jo Dunkley is planning to use the Simons Observatory to snare evidence for inflation, the theory that the universe expanded at incredible speed after its birth.
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Funded WorkDecades of research have documented abnormal white matter integrity1–4 and reduced axonal conduction velocities5, 6 in people with idiopathic and syndromic autism spectrum disorder (ASD).
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Funded WorkMany kinases have been linked to monogenic subtypes of autism spectrum disorder (ASD), but their role in the mechanisms underlying disease etiology is not well understood.
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Funded WorkA large subset of genes associated with autism are transcription factors or epigenetic regulators whose disruption causes broad dysregulation of gene expression during all stages of brain development.
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September 23, 2024Simons Collaboration on the Global Brain investigators and their colleagues imaged a large portion of the fruit fly brain as the insect performed various activities. The findings may … -
September 19, 2024Timothy Berkelbach, co-director of the Initiative for Computational Catalysis. The American Chemical Society (ACS) today announced that Initiative for Computational Catalysis (ICC) Co-Director Timothy Berkelbach will … -
September 19, 2024A new paper unravels the mysteries of a bizarre physical state known as the pseudogap, which has close ties to the sought-after state called high-temperature superconductivity … -
Funded WorkUBE3A is an imprinted gene that encodes an E3 ubiquitin ligase (also known as UBE3A) associated with two developmental disorders.
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September 18, 2024Researchers will build a new breed of AI-powered tools to find the needles of discovery lurking in vast haystacks of astronomical data. -
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September 17, 2024The Blavatnik Family Foundation and the New York Academy of Sciences (NYAS) today announced Flatiron Research Fellow Aavishkar Patel as a finalist in the Blavatnik Regional Awards for … -
September 16, 2024The Society for Neuroscience (SfN) announced today that Center for Computational Neuroscience (CCN) director Eero Simoncelli will receive its prestigious Swartz Prize, which it annually awards to “an … -
September 13, 2024On January 25–26, 2024, SFARI welcomed researchers to a workshop to discuss SFARI Gene and other existing databases and other tools focused on different aspects of autism … -
Funded WorkIndividuals with autism spectrum disorder (ASD) process information differently from neurotypical individuals.
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Funded WorkThe genetic architecture of autism spectrum disorder (ASD) includes rare protein-truncating variants with large effect sizes as well as common variation conferring much smaller effect sizes.
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Funded WorkAggression is the most common reason for hospitalization in children with autism spectrum disorder (ASD).
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Funded WorkThe current proposal entails a series of significant conceptual and technological advances.
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Funded WorkIn this project, Michael Piper and colleagues plan to analyze how H3K36 methylation impacts neural stem cell development and subsequent brain function, using transgenic mouse models lacking the …
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Funded WorkDisruption of cortical excitatory and inhibitory neuron development has been implicated in autism spectrum disorder (ASD) by postmortem brain analyses and ASD risk genes.
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September 12, 2024… (SIAM) and the American Mathematical Society. He received the Martin Kruskal Prize from SIAM in 2018 for his work on nonlinear waves and coherent structures. Founded in … -
Stony Brook UniversityStony Brook University’s Simons STEM Scholars Program celebrated the signing of its second cohort (S2) of students this past May at the Simons Foundation’s Flatiron Institute …
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September 11, 2024… beyond. Host Paul Middlebrooks takes a close look at how advances in artificial intelligence are opening new avenues for studying biological brains and how a better understanding … -
Funded WorkMissense variants are the most abundant type of protein-altering variants in coding regions in the genome.
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Funded WorkGenetics play a prominent role in autism, as nearly 1,000 genes have been nominated as contributors in the form of point mutations, single gene deletions and chromosomal …
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September 10, 2024… Wan Rutgers University, Newark Mu-Tao Wang Columbia University Changyou Wang Purdue University Xiaowei Wang Rutgers University, Newark Weinan Wang University of Oklahoma Jaroslaw Wlodarczyk Purdue University … -
Funded WorkCopy number variations (CNVs) of the human 16p11.2 genetic locus are associated with a number of neurodevelopmental and psychiatric conditions.
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Funded WorkChronic sleep disruption is a major comorbidity seen in more than 80 percent of children with autism spectrum disorder (ASD).
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Funded WorkAutism spectrum disorders (ASD) are characterized by difficulties in social decision-making, posing a significant challenge for individuals with ASD.
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Funded WorkThe primary goal of human genetics is to understand the relationship between DNA sequence variation and disease.
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Funded WorkIndividuals with X-linked CDKL5 deficiency disorder (CDD) exhibit many features common to autism spectrum disorder (ASD), including increased risk of seizures, cognitive impairment and altered sensory sensitivity.
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Funded WorkWhile autism spectrum disorder (ASD) is highly heterogeneous in etiology and severity, the majority of autistic individuals exhibit an array of co-morbid symptoms, including aberrant reactivity to …
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Funded WorkMutations in chromatin regulators have emerged as a major cause of autism spectrum disorder (ASD).
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August 28, 2024Physicist Riccardo Rossi has received the 2024 Hermann Kümmel Early Achievement Award in Many-Body Physics for his groundbreaking research in computational quantum field theory. The award, established … -
August 28, 2024… and legislative staff. The fellows also met with staff leaders at the Simons Foundation, who are primary funders of the fellowship, after which they participated in an … -
August 26, 2024The new estimates of the parameters that form the basis of the standard model of cosmology are far more precise than previous approaches using the same galaxy distribution … -
August 22, 2024The ripples in space-time caused by the death of massive spinning stars could be within the limits of detection of projects like LIGO and Virgo, new simulations … -
August 19, 2024In 2014, scientists observed X-ray activity from distant galaxies that was thought to be the first evidence of dark matter decay — a landmark discovery that could significantly … -
August 15, 2024… treatment of monogenic syndromes associated with autism Cleyton Sobrinho, Ph.D. 2024 SFARI Fellow University of Connecticut Project: Disordered breathing in autism: screen for central and peripheral … -
August 14, 2024SFARI is pleased to announce the release of genetic data for 119 Autism BrainNet brain tissue samples, including whole genome and whole exome data. -
July 30, 2024The Simons Foundation is pleased to announce the establishment of the Simons Collaboration on Moduli of Varieties, directed by James McKernan at the University of California, San Diego … -
July 30, 2024… supercurrents, potentially revolutionizing various fields and significantly impacting society. -
OnOfficeThe new HQ of documentary production company Sandbox Films speaks to New York’s status as a cinematic icon as well as the old-school glamour of Hollywood …
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Funded WorkRecognizing others’ moods, emotions and intentions from facial expressions lies at the core of human interpersonal communication and social engagement.
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Orchestration of synaptic gene regulation by H3K27me3-dependent modulation of chromatin architecture
Funded WorkChromatin-regulatory genes are among the most common classes of genes mutated in autism spectrum disorder (ASD) and intellectual disability (ID). -
Funded WorkAbout two-thirds of children with autism spectrum disorder (ASD) experience severe sleep disturbances.
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Funded WorkMost forms of autism spectrum disorder (ASD) are thought to be caused by disruptions in molecular processes involved in gene regulation or synaptic function.