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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Simons Foundation Announces 2024 Class of Neuroscience Undergraduate Research Fellows

    September 30, 2024
    … University of Washington Anselmo Rivera Johns Hopkins University Gwen Roter University of Wisconsin–Madison Gloria Shen University of Washington Alishba Silat University of Texas at Dallas Ilana …
  2. Quanta Magazine Unravels Space and Time in Ambitious New Series

    September 25, 2024
    … the guidance of Art Director Samuel Velasco “These articles resulted from more than 60 hours of interviews with more than 30 quantum gravity researchers,” said Staff Writer …
  3. The Astrophysicist Who May be About to Discover How the Universe Began

    New Scientist
    Astronomer Jo Dunkley is planning to use the Simons Observatory to snare evidence for inflation, the theory that the universe expanded at incredible speed after its birth.
  4. Oligodendrocyte dysfunction in mouse models of autism

    Funded Work
    Decades of research have documented abnormal white matter integrity1–4 and reduced axonal conduction velocities5, 6 in people with idiopathic and syndromic autism spectrum disorder (ASD).
  5. Cell-specific phosphoproteomic profiling in a mouse model of autism linked to a dysregulated kinase

    Funded Work
    Many kinases have been linked to monogenic subtypes of autism spectrum disorder (ASD), but their role in the mechanisms underlying disease etiology is not well understood.
  6. Retrospective longitudinal characterization of gene expression changes in mouse models of autism

    Funded Work
    A large subset of genes associated with autism are transcription factors or epigenetic regulators whose disruption causes broad dysregulation of gene expression during all stages of brain development.
  7. High-Energy Motion Activates Nearly All Neurons in Fruit Fly Brain, Study Finds

    September 23, 2024
    Simons Collaboration on the Global Brain investigators and their colleagues imaged a large portion of the fruit fly brain as the insect performed various activities. The findings may …
  8. Flatiron Initiative for Computational Catalysis Co-Director Timothy Berkelbach Receives 2025 ACS Award in Pure Chemistry

    September 19, 2024
    Timothy Berkelbach, co-director of the Initiative for Computational Catalysis. The American Chemical Society (ACS) today announced that Initiative for Computational Catalysis (ICC) Co-Director Timothy Berkelbach will …
  9. Mysteries of the Bizarre ‘Pseudogap’ in Quantum Physics Finally Untangled

    September 19, 2024
    A new paper unravels the mysteries of a bizarre physical state known as the pseudogap, which has close ties to the sought-after state called high-temperature superconductivity …
  10. Harnessing functional variant analysis for the targeted design of inhibitors of UBE3A

    Funded Work
    UBE3A is an imprinted gene that encodes an E3 ubiquitin ligase (also known as UBE3A) associated with two developmental disorders.
  11. NSF and Simons Foundation Launch 2 AI Institutes To Help Astronomers Understand the Cosmos

    September 18, 2024
    Researchers will build a new breed of AI-powered tools to find the needles of discovery lurking in vast haystacks of astronomical data.
  12. Analysis of lateral gene transfer rates

    Funded Work
  13. Flatiron Research Fellow Aavishkar Patel Named Finalist for Blavatnik Regional Award for Young Scientists

    September 17, 2024
    The Blavatnik Family Foundation and the New York Academy of Sciences (NYAS) today announced Flatiron Research Fellow Aavishkar Patel as a finalist in the Blavatnik Regional Awards for …
  14. CCN Director Eero Simoncelli Awarded Swartz Prize

    September 16, 2024
    The Society for Neuroscience (SfN) announced today that Center for Computational Neuroscience (CCN) director Eero Simoncelli will receive its prestigious Swartz Prize, which it annually awards to “an …
  15. SFARI Gene Workshop Touches on the Future of Autism Gene Databases

    September 13, 2024
    On January 25–26, 2024, SFARI welcomed researchers to a workshop to discuss SFARI Gene and other existing databases and other tools focused on different aspects of autism …
  16. Putting genes associated with autism in their neurobiological context by transcriptomic and proteomic analyses

    Funded Work
    Individuals with autism spectrum disorder (ASD) process information differently from neurotypical individuals.
  17. Determining how rare and common variants interact and contribute to risk for autism

    Funded Work
    The genetic architecture of autism spectrum disorder (ASD) includes rare protein-truncating variants with large effect sizes as well as common variation conferring much smaller effect sizes.
  18. Neural circuits of frustration and aggression

    Funded Work
    Aggression is the most common reason for hospitalization in children with autism spectrum disorder (ASD).
  19. Restoration of KCC2 expression as a potential therapeutic avenue to treat autism spectrum disorder

    Funded Work
    The current proposal entails a series of significant conceptual and technological advances.
  20. What is the common factor driving brain overgrowth in autism? Investigating the relationship between epigenetic marks and neural stem cell proliferation

    Funded Work
    In this project, Michael Piper and colleagues plan to analyze how H3K36 methylation impacts neural stem cell development and subsequent brain function, using transgenic mouse models lacking the …
  21. Charting the emergence of excitatory and inhibitory neuronal lineages in organoid models of autism

    Funded Work
    Disruption of cortical excitatory and inhibitory neuron development has been implicated in autism spectrum disorder (ASD) by postmortem brain analyses and ASD risk genes.
  22. The Simons Society of Fellows Welcomes Senior Fellows William Bialek and Michael Weinstein

    September 12, 2024
    … (SIAM) and the American Mathematical Society. He received the Martin Kruskal Prize from SIAM in 2018 for his work on nonlinear waves and coherent structures. Founded in …
  23. Forging Future Leaders: Simons STEM Scholars Second Cohort Kicks Off Academic Journey

    Stony Brook University
    Stony Brook University’s Simons STEM Scholars Program celebrated the signing of its second cohort (S2) of students this past May at the Simons Foundation’s Flatiron Institute …
  24. The Transmitter Partners With World Wide Neuro and Brain Inspired, Building on Mission to Inform, Connect Neuroscience Community

    September 11, 2024
    … beyond. Host Paul Middlebrooks takes a close look at how advances in artificial intelligence are opening new avenues for studying biological brains and how a better understanding …
  25. Triangulation of missense variant impact through multimodal modeling and functional assays

    Funded Work
    Missense variants are the most abundant type of protein-altering variants in coding regions in the genome.
  26. Cell village-based detection of shared molecular and cellular defects across autism risk factors

    Funded Work
    Genetics play a prominent role in autism, as nearly 1,000 genes have been nominated as contributors in the form of point mutations, single gene deletions and chromosomal …
  27. 2024 Travel Support for Mathematicians Awardees Announced

    September 10, 2024
    … Wan Rutgers University, Newark Mu-Tao Wang Columbia University Changyou Wang Purdue University Xiaowei Wang Rutgers University, Newark Weinan Wang University of Oklahoma Jaroslaw Wlodarczyk Purdue University …
  28. 16p11.2 copy number variant effects on transcriptome-metabolome coupling

    Funded Work
    Copy number variations (CNVs) of the human 16p11.2 genetic locus are associated with a number of neurodevelopmental and psychiatric conditions.
  29. Early life sleep disruption as a risk factor for autism

    Funded Work
    Chronic sleep disruption is a major comorbidity seen in more than 80 percent of children with autism spectrum disorder (ASD).
  30. Neural basis of social decision-making in autism mouse models

    Funded Work
    Autism spectrum disorders (ASD) are characterized by difficulties in social decision-making, posing a significant challenge for individuals with ASD.
  31. Improving the prediction of nonsense-mediated decay outcomes for protein-truncating variants associated with autism

    Funded Work
    The primary goal of human genetics is to understand the relationship between DNA sequence variation and disease.
  32. Mechanisms of disrupted cortical functional connectivity in a mouse model of CDKL5 deficiency disorder

    Funded Work
    Individuals with X-linked CDKL5 deficiency disorder (CDD) exhibit many features common to autism spectrum disorder (ASD), including increased risk of seizures, cognitive impairment and altered sensory sensitivity.
  33. Understanding oral texture feeding issues in mouse models of autism

    Funded Work
    While autism spectrum disorder (ASD) is highly heterogeneous in etiology and severity, the majority of autistic individuals exhibit an array of co-morbid symptoms, including aberrant reactivity to …
  34. Does ectopic expression of germline genes during brain development contribute to autism?

    Funded Work
    Mutations in chromatin regulators have emerged as a major cause of autism spectrum disorder (ASD).
  35. Former CCQ Flatiron Research Fellow Riccardo Rossi Awarded 2024 Hermann Kümmel Early Achievement Award in Many-Body Physics

    August 28, 2024
    Physicist Riccardo Rossi has received the 2024 Hermann Kümmel Early Achievement Award in Many-Body Physics for his groundbreaking research in computational quantum field theory. The award, established …
  36. First Class of New York State Science Policy Fellows Announced

    August 28, 2024
    … and legislative staff. The fellows also met with staff leaders at the Simons Foundation, who are primary funders of the fellowship, after which they participated in an …
  37. Astrophysicists Use AI To Precisely Calculate Universe’s ‘Settings’

    August 26, 2024
    The new estimates of the parameters that form the basis of the standard model of cosmology are far more precise than previous approaches using the same galaxy distribution …
  38. New Detectable Gravitational Wave Source From Collapsing Stars Predicted From Simulations

    August 22, 2024
    The ripples in space-time caused by the death of massive spinning stars could be within the limits of detection of projects like LIGO and Virgo, new simulations …
  39. Hyped Signal of Decaying Dark Matter Vanishes in Updated Analysis

    August 19, 2024
    In 2014, scientists observed X-ray activity from distant galaxies that was thought to be the first evidence of dark matter decay — a landmark discovery that could significantly …
  40. Simons Foundation Announces 13 Recipients of 2024 Independence Awards

    August 15, 2024
    … treatment of monogenic syndromes associated with autism Cleyton Sobrinho, Ph.D. 2024 SFARI Fellow University of Connecticut Project: Disordered breathing in autism: screen for central and peripheral …
  41. Autism BrainNet: New Genetic Data Available

    August 14, 2024
    SFARI is pleased to announce the release of genetic data for 119 Autism BrainNet brain tissue samples, including whole genome and whole exome data.
  42. Simons Foundation Announces the Simons Collaboration on Moduli of Varieties

    July 30, 2024
    The Simons Foundation is pleased to announce the establishment of the Simons Collaboration on Moduli of Varieties, directed by James McKernan at the University of California, San Diego …
  43. Simons Foundation Announces the Simons Collaboration on New Frontiers in Superconductivity

    July 30, 2024
    … supercurrents, potentially revolutionizing various fields and significantly impacting society.
  44. The Golden Age of Hollywood is Alive and Well at Sandbox Films’ New York HQ

    OnOffice
    The new HQ of documentary production company Sandbox Films speaks to New York’s status as a cinematic icon as well as the old-school glamour of Hollywood …
  45. Developing a closed-loop framework using artificial neural networks and nonhuman primate experiments to test theories of atypical facial emotion processing in autism

    Funded Work
    Recognizing others’ moods, emotions and intentions from facial expressions lies at the core of human interpersonal communication and social engagement.
  46. Orchestration of synaptic gene regulation by H3K27me3-dependent modulation of chromatin architecture

    Funded Work
    Chromatin-regulatory genes are among the most common classes of genes mutated in autism spectrum disorder (ASD) and intellectual disability (ID).
  47. Reversing sleep and memory deficits in a mouse model of 16p11.2 deletion syndrome

    Funded Work
    About two-thirds of children with autism spectrum disorder (ASD) experience severe sleep disturbances.
  48. Linking mitochondrial metabolism and autism during human neuronal development

    Funded Work
    Most forms of autism spectrum disorder (ASD) are thought to be caused by disruptions in molecular processes involved in gene regulation or synaptic function.
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