Search

What are you looking for?

  1. Delayed motor learning in a 16p11.2 deletion mouse model of autism is rescued by locus coeruleus activation.

    Publication

  2. The role of GABAergic signalling in neurodevelopmental disorders.

    Publication

  3. In Silico: Where Next?

    Publication

  4. The factor structure of the macaque social responsiveness scale-revised predicts social behavior and personality dimensions.

    Publication

  5. Exons as units of phenotypic impact for truncating mutations in autism.

    Publication

  6. Geometric deep learning enables 3D kinematic profiling across species and environments.

    Publication

  7. Explaining face representation in the primate brain using different computational models

    Publication
    Understanding how the brain represents the identity of complex objects is a central challenge of visual neuroscience. The principles governing object processing have been extensively studied in the …

  8. Coupling of activity, metabolism and behaviour across the Drosophila brain

    Publication
    Coordinated activity across networks of neurons is a hallmark of both resting and active behavioural states in many species1-5. These global patterns alter energy metabolism over seconds …

  9. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

    Publication
    Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells without affecting healthy cells and avoiding tumor escape …

  10. CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation.

    Publication

  11. Astrophysics Milestones for Pulsar Timing Array Gravitational-wave Detection

    Publication
    The NANOGrav Collaboration reported strong Bayesian evidence for a common-spectrum stochastic process in its 12.5-yr pulsar timing array dataset, with median characteristic strain amplitude at …

  12. A Space Mission to Map the Entire Observable Universe using the CMB as a Backlight

    Publication
    This Science White Paper, prepared in response to the ESA Voyage 2050 call for long-term mission planning, aims to describe the various science possibilities that can be …

  13. MHCEpitopeEnergy, a Flexible Rosetta-Based Biotherapeutic Deimmunization Platform

    Publication
    As non-“self” macromolecules, biotherapeutics can trigger an immune response that can reduce drug efficacy, require patients to be taken off therapy, or even cause life-threatening reactions …

  14. Low rank compression in the numerical solution of the nonequilibrium Dyson equation

    Publication
    We propose a method to improve the computational and memory efficiency of numerical solvers for the nonequilibrium Dyson equation in the Keldysh formalism. It is based on the …

  15. Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice.

    Publication

  16. A normative model representing autistic individuals amidst autism spectrum disorders phenotypic heterogeneity.

    Publication

  17. Tissue-specific enhancer functional networks for associating distal regulatory regions to disease

    Publication
    Systematic study of tissue-specific function of enhancers and their disease associations is a major challenge. We present an integrative machine-learning framework, FENRIR, that integrates thousands of …

  18. Tissue-specific enhancer functional networks for associating distal regulatory regions to disease.

    Publication

  19. The Galaxy Progenitors of Stellar Streams around Milky Way-mass Galaxies in the FIRE Cosmological Simulations

    Publication
    Stellar streams record the accretion history of their host galaxy. We present a set of simulated streams from disrupted dwarf galaxies in 13 cosmological simulations of Milky Way …

  20. Coordinated postnatal maturation of striatal cholinergic interneurons and dopamine release dynamics in mice.

    Publication

  21. Geometric deep learning enables 3D kinematic profiling across species and environments

    Publication
    Comprehensive descriptions of animal behavior require precise three-dimensional (3D) measurements of whole-body movements. Although two-dimensional approaches can track visible landmarks in restrictive environments, performance drops …

  22. Attractor dynamics gate cortical information flow during decision-making

    Publication
    Decisions are held in memory until enacted, which makes them potentially vulnerable to distracting sensory input. Gating of information flow from sensory to motor areas could protect memory …

  23. Molecular mechanisms underlying cellular effects of human MEK1 mutations

    Publication
    Terminal regions of Drosophila embryos are patterned by signaling through ERK, which is genetically deregulated in multiple human diseases. Quantitative studies of terminal patterning have been recently used …

  24. Modeling transcriptional regulation of model species with deep learning

    Publication
    To enable large-scale analyses of regulatory logic in model species, we developed DeepArk, a set of deep learning models of the cis-regulatory codes of four widely …

  25. The Hubbard model on the Bethe lattice via variational uniform tree states: metal-insulator transition and a Fermi liquid

    Publication
    We numerically solve the Hubbard model on the Bethe lattice with finite coordination number z=3, and determine its zero-temperature phase diagram. For this purpose, we introduce …

  26. Genetic vulnerability of exposures to antenatal maternal treatments in 1- to 2-month-old infants.

    Publication

  27. Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders.

    Publication

  28. An epigenetically distinct subset of children with autism spectrum disorder resulting from differences in blood cell composition.

    Publication

  29. The Geometry of Information Coding in Correlated Neural Populations

    Publication
    Neurons in the brain represent information in their collective activity. The fidelity of this neural population code depends on whether and how variability in the response of one …

  30. Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

    Publication
    Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce …

  31. Fast multipole methods for evaluation of layer potentials with locally-corrected quadratures

    Publication
    While fast multipole methods (FMMs) are in widespread use for the rapid evaluation of potential fields governed by the Laplace, Helmholtz, Maxwell or Stokes equations, their coupling to …

  32. Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders.

    Publication

  33. ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

    Publication
    Background ChIP-seq combines chromatin immunoprecipitation assays with sequencing and identifies genome-wide binding sites for DNA binding proteins. While many binding sites have strong ChIP-seq ‘peak …

  34. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

    Publication
    In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size …

  35. VolPy: automated and scalable 2 analysis pipelines for voltage 3 imaging datasets

    Publication
    Voltage imaging enables monitoring neural activity at sub-millisecond and sub-cellular scale, unlocking the study of subthreshold activity, synchrony, and network dynamics with unprecedented spatio-temporal resolution …

  36. Automated and scalable analysis pipelines for voltage imaging datasets

    Publication
    Voltage imaging enables monitoring neural activity at sub-millisecond and sub-cellular scale, unlocking the study of subthreshold activity, synchrony, and network dynamics with unprecedented spatio-temporal resolution …

  37. Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCHD19 disorder.

    Publication

  38. Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

    Publication
    Cortical spreading depolarization (CSD) is a propagating wave of tissue depolarization characterized by a large increase of extracellular potassium concentration and prolonged subsequent electrical silencing of neurons. Waves …

  39. fmr1 mutation interacts with sensory experience to alter the early development of behavior and sensory coding in zebrafish.

    Publication

  40. Learning physically consistent differential equation models from data using group sparsity

    Publication
    We propose a statistical learning framework based on group-sparse regression that can be used to 1) enforce conservation laws, 2) ensure model equivalence, and 3) guarantee symmetries …

  41. The gut-brain-microbiome axis and its link to autism: Emerging insights and the potential of zebrafish models.

    Publication

  42. Mesoscale cortical dynamics reflect the interaction of sensory evidence and temporal expectation during perceptual decision-making

    Publication
    How sensory evidence is transformed across multiple brain regions to influence behavior remains poorly understood. We trained mice in a visual change detection task designed to separate the …

  43. The relationship between developmental coordination disorder and concurrent deficits in social communication and repetitive behaviors among children with autism spectrum disorder.

    Publication

  44. Variational Monte Carlo calculations of A≤4 nuclei with an artificial neural-network correlator ansatz

    Publication
    The complexity of many-body quantum wave functions is a central aspect of several fields of physics and chemistry where non-perturbative interactions are prominent. Artificial neural networks …

  45. Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

    Publication
    Direct electrical stimulation can modulate the activity of brain networks for the treatment of several neurological and neuropsychiatric disorders and for restoring lost function. However, precise neuromodulation in …

  46. Perceived helpfulness of depression treatments among young adults with autism.

    Publication

  47. Spatial memory: Place cell activity is causally related to behavior

    Publication
    A recent study using new holographic optogenetic stimulation technology has provided direct evidence that hippocampal place cell activity is sufficient to drive memory and navigation-related behaviors.

  48. Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism.

    Publication