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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Decoding excitation-inhibition imbalance from neuroimaging data in autism

    Funded Work
    Imbalance between excitatory and inhibitory signals in the brain (i.e., E/I imbalance) has long been theorized as one of the primary pathophysiological explanations behind autism.
  2. An Inclusive Theater Company Embraces Science

    October 31, 2023
    How Chickenshed NYC are artfully integrating STEAM concepts into their programming.
  3. Learning Better: Improving the Efficiency of Deep Learning Models

    October 31, 2023
    Flatiron Research Fellow Brett Larsen is developing better ways to train deep learning models.
  4. High-resolution proteome mapping in the developing human cerebral cortex to uncover mutationally convergent pathways in autism

    Funded Work
    Genetic alterations in autism spectrum disorder (ASD) ultimately manifest at the protein level.
  5. Fusing Insights From Computer Science and Pure Mathematics

    October 30, 2023
    Simons Junior Fellow Michael Chapman studies the connections between complexity theory and approximations of algebraic structures.
  6. How Do Our Brains Classify Similar Objects? New Theory Works Out the Details

    October 26, 2023
    With a new computational model, Flatiron Institute researchers have made big steps in understanding how our brains classify. This advance could improve efficiency in artificial neural networks.
  7. Taking a Fresh Look at the Cosmos

    October 16, 2023
    Astrophysicist Shy Genel is leveraging machine learning to reveal the most basic properties of the universe.
  8. Promoting functional brain maintenance – insights from successful agers

    Funded Work
    As we age, our bodies and brains decline.
  9. SFARI 2023 Winter Pilot Awardees Announced

    October 12, 2023
    SFARI is pleased to announce that it intends to fund 9 grants in response to the 2023 Winter Pilot Award request for applications.
  10. Scientists Begin Building AI for Scientific Discovery Using Tech Behind ChatGPT

    October 9, 2023
    … ask questions that they wouldn’t be able to ask without the models we’re producing.” ChatGPT has well-known limitations when it comes to accuracy (for …
  11. Simons Foundation Announces Second Class of Pivot Fellowship Recipients

    October 6, 2023
    … the marine ecosystem and ultimately the climate. Rachel Collin As a marine biologist with expertise in aquatic invertebrates, Rachel Collin focuses on documenting tropical biodiversity and understanding …
  12. Bursts of Star Formation Explain Mysterious Brightness at Cosmic Dawn

    October 5, 2023
    … galaxy comes from the most massive stars,” Faucher-Giguère says. “Because more-massive stars burn at a higher speed, they are shorter-lived. They rapidly use up …
  13. Announcing “In The Path of Totality”

    October 3, 2023
    A new initiative to celebrate and support work around the April 8, 2024 total solar eclipse.
  14. Researchers Create First-Ever Map of a Single Animal’s Early Visual System

    September 28, 2023
    A team of scientists at the Flatiron Institute and their colleagues have mapped out the entire early visual system — from eyes to neurons — for a tiny parasitic wasp …
  15. Simons Foundation Announces Next Class of Neuroscience Undergraduate Research Fellows

    September 26, 2023
    … Vy Nguyen University of Utah Ana Carolina Odebrecht Vergne de Abreu University of Essex Brenner Philbrook University of Washington Luisa Quispe Brandeis University Aya Sahib University of …
  16. How Do Our Neurons Change When We Encounter New Things?

    September 26, 2023
    Simons Junior Fellow Lynn Yap fuses expertise in neuroscience with chemistry to understand how our brains detect and encode new information.
  17. On the Cosmological and Particle Physics Implications of the String Swampland

    Funded Work
    Cumrun Vafa will seek to find the universal features that distinguish the string landscape from the swampland by studying solutions to string equations.
  18. Science Sandbox: Changing our Visual Identity

    September 19, 2023
    While our logo is going away, our mission to support boundary-pushing science engagement will stay the same.
  19. Simons Foundation Unveils New Logo and Visual Identity

    September 18, 2023
    … internal research division devoted to computational science, the Flatiron Institute, also received its own revised logo as part of the refresh, one closely related to the new …
  20. CBIOMES Director Mick Follows Wins 2023 A.G. Huntsman Award

    September 14, 2023
    The A.G. Huntsman Foundation has selected Mick Follows as the recipient of the 2023 A.G. Huntsman Award. Follows is a professor of oceanography at MIT and …
  21. Simons Investigator Simon Brendle Awarded Breakthrough Prize in Mathematics

    September 14, 2023
    The Breakthrough Prize Foundation has named Simon Brendle the winner of the 2024 Breakthrough Prize in mathematics for his work in the field of differential geometry. Brendle is …
  22. Simons Society of Fellows Junior Fellow Oliver Philcox Awarded New Horizons Prize

    September 14, 2023
    On September 14, the Breakthrough Prize Foundation named Oliver Philcox as one of the winners of the 2024 New Horizons Prize in Physics. The honor recognizes early-career …
  23. New $50 Million Institute Aims To Use the Power of Math to Model, Predict Biological Processes

    September 14, 2023
    The National Institute for Theory and Mathematics in Biology will bring together mathematical and biological scientists to make new advances in challenging and potentially high-reward research areas.
  24. Simons Foundation Announces 13 Recipients of 2023 Independence Awards

    September 12, 2023
    … corticocerebellar perturbations Daniel Pederick, Ph.D. Stanford University SFARI BTI Fellow Project: Investigating tonotopy in autism Greta Pintacuda, D.Phil. Broad Institute, Massachusetts Institute of Technology SFARI …
  25. Interview: Tracy Drinkwater From the Seattle Universal Math Museum

    September 7, 2023
    This edition of our Science Sandbox Spotlight series features Tracy Drinkwater, president and founder of the Seattle Universal Math Museum
  26. Prenatal COVID-19 impact on autism risk in genetically susceptible families

    Funded Work
    Increased risk for autism spectrum disorder (ASD) associated with gestational fever, infections, stress and other inflammatory events and innate immune responses and dysregulation suggest the need to study …
  27. Validation of a digital movement-based measure of early social communication

    Funded Work
    Despite commonalities in core social communication traits, young children on the autism spectrum show significant phenotypic heterogeneity and variability in response to interventions focused on improving social communication.
  28. The chemical root of biocatalyst and biosynthetic logic

    Funded Work
  29. Nitrogen fixation and export

    Funded Work
  30. Advancing big data solutions for high volume image data in marine plankton ecology

    Funded Work
  31. Genetics and Artificial Intelligence for Individualized Neural Stratification (GAIINS)

    Funded Work
    Personalized medicine in autism requires stratification biomarkers because of substantial biological heterogeneity.
  32. Identifying early markers of autism in naturalistic motor behavior using high-frequency sampling

    Funded Work
    Early identification of infants at risk for autism spectrum disorder (ASD) is a huge challenge because neither genetic nor neuroimaging methods have revealed robust early pathological markers for …
  33. Capturing the Quantum Essence: Solving Simplified Models With High Precision

    September 5, 2023
    At the Flatiron Institute, computational quantum physicist Bo Xiao is working to understand the importance of materials’ fundamental properties by solving simplified mathematical models on an infinite grid.
  34. What Happened Right After the Universe Began?

    August 30, 2023
    Simons Junior Fellow Oliver Philcox uses detective skills — and math — to shed light on the interactions between physics and matter at the birth of the universe.
  35. Watch: Jennifer Cano and Cyrus Dreyer on What’s Bringing Their Fields Closer Together

    August 28, 2023
    Center for Computational Quantum Physics associate research scientists Jennifer Cano and Cyrus Dreyer navigated their careers as a couple, each focusing on a different — though increasingly connected — field.
  36. Long-term ethological monitoring of motor and social behaviors in mouse models of autism

    Funded Work
    Autism spectrum disorder (ASD) is characterized by heterogeneous phenotypes classically encompassing three domains — difficulties with social interactions, language communication challenges and an overrepresentation of stereotyped behaviors.
  37. Foundation Announces the Simons Collaboration on Perfection in Algebra, Geometry and Topology

    August 21, 2023
    The Simons Foundation is pleased to announce the establishment of the Simons Collaboration on Perfection in Algebra, Geometry and Topology, directed by Martin Olsson of the University of …
  38. Foundation Announces the Simons Collaboration on Extreme Electrodynamics of Compact Sources

    August 21, 2023
    … mechanics, to interface with the microphysical view. In this way, it is hoped to choose between several competing models and to interface with a parallel investigation involving …
  39. Foundation Announces the Simons Collaboration on Celestial Holography

    August 21, 2023
    … unrealistic, it could usefully guide the bottom-up construction of a hologram for the natural world. Fortuitously, there has been a recent explosion of complementary advances in …
  40. We Finally Know Why Quantum ‘Strange Metals’ Are So Strange

    August 17, 2023
    A new study led by the Flatiron Institute’s Aavishkar Patel has identified a mechanism that explains the unusual behavior of strange metals, considered one of the greatest …
  41. Mathematician Svitlana Mayboroda Receives the 2023 Blavatnik National Award

    August 17, 2023
    … University of Missouri in Columbia. Her research focuses on analysis and partial differential equations, particularly on the localization of waves. The Blavatnik Family Foundation and the New …
  42. SPARK July 2023 Update: New Phenotypic Data Available

    August 15, 2023
    Phenotypic data from 328,973 participants enrolled in SPARK, including 132,138 individuals with autism spectrum disorder (ASD), are now available to approved researchers. Genomic data are also …
  43. STEAM From Theory to Practice

    August 15, 2023
    How a Los Angeles-based organization is empowering youth to use STEAM concepts to be leaders in their communities.
  44. Validation of an online Neurobehavioral Evaluation Tool (NET) across large autism cohorts

    Funded Work
    Autism spectrum disorder (ASD) is an etiologically and phenotypically heterogenous condition.
  45. Role of autism risk genes in frontal-sensory cognitive control circuits in mice

    Funded Work
    Cognitive control deficits are one of the frequent challenges accompanying autism spectrum disorder (ASD).
  46. New Software Streamlines Neuroscience Research

    August 7, 2023
    Flatiron data scientist Billy Broderick is on a mission to make neuroscience research easier and more efficient by developing user-friendly software for analyzing and modeling data.
  47. Brett Dakin Joins Simons Foundation as General Counsel

    July 31, 2023
    The Simons Foundation is pleased to announce that Brett Dakin has joined the foundation as senior vice president and general counsel. As the foundation’s first chief legal …
  48. Tapping Into the Body’s Natural Electricity To Improve Treatments for Neurological Disorders

    July 31, 2023
    By combining expertise in neuroscience and engineering, Simons Junior Fellow Cynthia Steinhardt is uncovering general principles about how electricity drives the brain.
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