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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Quantifying Live Microbial Load in Human Saliva Samples over Time Reveals Stable Composition and Dynamic Load

    Publication
    Evaluating microbial community composition through next-generation sequencing has become increasingly accessible. However, metagenomic sequencing data sets provide researchers with only a snapshot of a dynamic ecosystem and …
  2. Accurate precision cosmology with redshift unknown gravitational wave sources

    Publication
    Gravitational waves can provide an accurate measurement of the luminosity distance to the source, but cannot provide the source redshift unless the degeneracy between mass and redshift can …
  3. Production and Persistence of Extreme Two-temperature Plasmas in Radiative Relativistic Turbulence

    Publication
    Turbulence is a predominant process for energizing electrons and ions in collisionless astrophysical plasmas, and thus is responsible for shaping their radiative signatures (luminosity, spectra, and variability). To …
  4. Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial

    Publication
    With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized …
  5. Investigating the representation of uncertainty in neuronal circuits

    Publication
    Skilled behavior often displays signatures of Bayesian inference. In order for the brain to implement the required computations, neuronal activity must carry accurate information about the uncertainty of …
  6. MIPP-Seq: Ultra-sensitive rapid detection and validation of low-frequency mosaic mutations.

    Publication
  7. Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank.

    Publication
  8. Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1

    Publication
    The rise of antibiotic resistance calls for new therapeutics targeting resistance factors such as the New Delhi metallo-β-lactamase 1 (NDM-1), a bacterial enzyme that degrades …
  9. Mapping parameter spaces of biological switches

    Publication
    Since the seminal 1961 paper of Monod and Jacob, mathematical models of biomolecular circuits have guided our understanding of cell regulation. Model-based exploration of the functional capabilities …
  10. Mapping parameter spaces of biological switches

    Publication
    Since the seminal 1961 paper of Monod and Jacob, mathematical models of biomolecular circuits have guided our understanding of cell regulation. Model-based exploration of the functional capabilities …
  11. Early pandemic experiences of autistic adults: Predictors of psychological distress.

    Publication
  12. NeuroSCORE: A genome-wide omics-based model to identify candidate disease genes of the central nervous system.

    Publication
  13. Programmable hyperbolic polaritons in van der Waals semiconductors

    Publication
    The propagation of light within a material is usually well defined, with the propagation described by scattering and dispersion. In artificially designed metamaterials and in anisotropic layered materials …
  14. Implanting and Recycling Neuropixels Probes for Recordings in Freely Moving Mice

    Publication
    Recording neural activity in unrestricted animals is necessary to unravel the neural basis of ethological behaviors. Recently, Neuropixels probes have made important strides in improving yield and lowering …
  15. Chiral crystals self-knead into whorls

    Publication
    The competition between thermal fluctuations and potential forces is the foundation of our understanding of phase transitions and matter in equilibrium. Driving matter out of equilibrium allows for …
  16. Spatial modulation of visual responses arises in cortex with active navigation

    Publication
    During navigation, the visual responses of neurons in mouse primary visual cortex (V1) are modulated by the animal's spatial position. Here we show that this spatial modulation …
  17. Sensitivity analysis for the stationary distribution of reflected Brownian motion in a convex polyhedral cone.

    Publication
    Reflected Brownian motion (RBM) in a convex polyhedral cone arises in a variety of applications ranging from the theory of stochastic networks to mathematical finance, and under general …
  18. Tunable chiral symmetry breaking in symmetric Weyl materials

    Publication
    Asymmetric Weyl semimetals, which possess an inherently chiral structure, have different energies and dispersion relations for left- and right-handed fermions. They exhibit certain effects not found in …
  19. Systems Neuroscience of Natural Behaviors in Rodents

    Publication
    Animals evolved in complex environments, producing a wide range of behaviors, including navigation, foraging, prey capture, and conspecific interactions, which vary over timescales ranging from milliseconds to days …
  20. The psychiatric phenotypes of 1q21 distal deletion and duplication.

    Publication
  21. Transcriptome-wide transmission disequilibrium analysis identifies novel risk genes for autism spectrum disorder.

    Publication
  22. DYNAMICS OF HEADING AND CHOICE-RELATED SIGNALS IN THE PARIETO-INSULAR VESTIBULAR CORTEX OF MACAQUE MONKEYS

    Publication
    … from other multisensory cortical areas. We find that vestibular cortex activity reflects a dynamically changing combination of sensory and choice signals, with both similarities and notable differences …
  23. Continuous whole-body 3D kinematic recordings across the rodent behavioral repertoire.

    Publication
  24. Regional, layer, and cell-type-specific connectivity of the mouse default mode network.

    Publication
  25. Ab initio electronic density in solids by many-body plane-wave auxiliary-field quantum Monte Carlo calculations

    Publication
  26. Charge density wave and superconductivity in the disordered Holstein model

    Publication
  27. Impression learning: Online predictive coding with synaptic plasticity

    Publication
    Early sensory areas in the brain are faced with a task analogous to the scientific process itself: given raw data, they must extract meaningful information about its underlying …
  28. In silico prediction of annihilators for triplet–triplet annihilation upconversion via auxiliary-field quantum Monte Carlo

    Publication
    … platinum octaethylporphyrin (PtOEP) sensitizer. The BTD framework thus represents a new class of annihilators for TTA upconversion. Its chemical functionalization, guided by the computational tools utilized herein …
  29. Moiré heterostructures as a condensed-matter quantum simulator

    Publication
    Twisted van der Waals heterostructures have latterly received prominent attention for their many remarkable experimental properties, and the promise that they hold for realising elusive states of matter …
  30. Robustness of the microtubule network self-organization in epithelia

    Publication
    Robustness of biological systems is crucial for their survival, however, for many systems its origin is an open question. Here, we analyze one subcellular level system, the microtubule …
  31. Lower Airway Dysbiosis Affects Lung Cancer Progression

    Publication
    In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly occurs, and ex vivo models support that some of these bacteria can trigger host transcriptomic …
  32. New role for circuit expansion for learning in neural networks

    Publication
    Many sensory pathways in the brain include sparsely active populations of neurons downstream from the input stimuli. The biological purpose of this expanded structure is unclear, but it …
  33. Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

    Publication
    Direct electrical stimulation can modulate the activity of brain networks for the treatment of several neurological and neuropsychiatric disorders and for restoring lost function. However, precise neuromodulation in …
  34. SFARI genes and where to find them; classification modelling to identify genes associated with autism spectrum disorder from RNA-seq data.

    Publication
  35. From heterogeneous datasets to predictive models of embryonic development

    Publication
    Modern studies of embryogenesis are increasingly quantitative, powered by rapid advances in imaging, sequencing, and genome manipulation technologies. Deriving mechanistic insights from the complex datasets generated by these …
  36. Detailed clinical and psychological phenotype of the X-linked HNRNPH2-related neurodevelopmental disorder.

    Publication
  37. Whole-genome analysis of de novo and polymorphic retrotransposon insertions in autism spectrum disorder.

    Publication
  38. PIGH deficiency can be associated with severe neurodevelopmental and skeletal manifestations.

    Publication
  39. Maternal immune activation in mice disrupts proteostasis in the fetal brain.

    Publication
  40. The logic of developing neocortical circuits in health and disease.

    Publication
  41. Large mosaic copy number variations confer autism risk.

    Publication
  42. The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing.

    Publication
  43. Cerebral gray and white matter hemodynamic function across the adult lifespan

    Publication
    Arterial spin labeling (ASL) magnetic resonance imaging (MRI) has become a popular approach for studying cerebral hemodynamic function in a range of neurovascular disorders and has recently been …
  44. Online analysis of microendoscopic 1-photon calcium imaging data streams

    Publication
    In vivo calcium imaging through microendoscopic lenses enables imaging of neuronal populations deep within the brains of freely moving animals. Previously, a constrained matrix factorization approach (CNMF-E …
  45. Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

    Publication
    Neural circuits generate representations of the external world from multiple information streams. The navigation system provides an exceptional lens through which we may gain insights about how such …
  46. Excessive formation and stabilization of dendritic spine clusters in the MECP2 duplication syndrome mouse model of autism.

    Publication
  47. Measurement, manipulation and modeling of brain-wide neural population dynamics

    Publication
    Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical …
  48. Multiscale low-dimensional motor cortical state dynamics predict naturalistic reach-and-grasp behavior

    Publication
    Motor function depends on neural dynamics spanning multiple spatiotemporal scales of population activity, from spiking of neurons to larger-scale local field potentials (LFP). How multiple scales of …
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