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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Genome-wide surveillance of transcription errors in response to genotoxic stress

    Publication
    Mutagenic compounds are a potent source of human disease. By inducing genetic instability, they can accelerate the evolution of human cancers or lead to the development of genetically …
  2. Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults

    Publication
    Background and purpose: Cerebral white matter signal abnormalities (WMSAs) are a significant radiological marker associated with brain and vascular aging. However, understanding their clinical impact is limited because …
  3. Sex differences in scores on standardized measures of autism symptoms: A multisite integrative data analysis.

    Publication
  4. Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders.

    Publication
  5. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes

    Publication
    Background: Identification of new genetic variants that modify Alzheimer's disease (AD) risk will elucidate novel targets for curbing the disease progression or delaying symptom onset. Objective: To …
  6. A design framework for actively crosslinked filament networks

    Publication
    Living matter moves, deforms, and organizes itself. In cells this is made possible by networks of polymer filaments and crosslinking molecules that connect filaments to each other and …
  7. A mechanical model of blastocyst hatching

    Publication
    We develop a continuum mechanics model of blastocyst hatching. The blastocyst and the zona pellucida are modeled as concentric thick-walled initially spherical shells embedded in a viscous …
  8. Stochastic Solutions for Linear Inverse Problems using the Prior Implicit in a Denoiser

    Publication
    Deep neural networks have provided state-of-the-art solutions for problems such as image denoising, which implicitly rely on a prior probability model of natural images. Two …
  9. Nonlinear nanoelectrodynamics of a Weyl metal

    Publication
  10. Anti-Poiseuille Flow: Increased Vortex Velocity at Superconductor Edges

    Publication
  11. Calculation of Metallocene Ionization Potentials via Auxiliary Field Quantum Monte Carlo: Towards Benchmark Quantum Chemistry for Transition Metals

    Publication
  12. Exotic Superfluid Phases in Spin Polarized Systems on Optical Lattices

    Publication
  13. Precision Many-Body Study of the Berezinskii-Kosterlitz-Thouless Transition and Temperature-Dependent Properties in the Two-Dimensional Fermi Gas

    Publication
  14. Stripes and spin-density waves in the doped two-dimensional Hubbard model: ground state phase diagram

    Publication
  15. Correlation-consistent Gaussian basis sets for solids made simple

    Publication
  16. Tunable Cr4+ Molecular Color Centers

    Publication
  17. Approximating matrix eigenvalues by subspace iteration with repeated random sparsification

    Publication
  18. Full-frequency GW without frequency

    Publication
  19. Anharmonic Lattice Dynamics from Vibrational Dynamical Mean-Field Theory

    Publication
  20. A simplified GW/BSE approach for charged and neutral excitation energies of large molecules and nanomaterials

    Publication
  21. Triplet superconductivity from non-local Coulomb repulsion in Sn/Si(111)

    Publication
  22. Hierarchy of Ideal Flatbands in Chiral Twisted Multilayer Graphene Models

    Publication
  23. Van Hove tuning of AV3Sb5 kagome metals under pressure and strain

    Publication
  24. Fractional Quantum Hall States on CP2 Space

    Publication
  25. Continuous-variable neural-network quantum states and the quantum rotor model

    Publication
    We initiate the study of neural-network quantum state algorithms for analyzing continuous-variable lattice quantum systems in first quantization. A simple family of continuous-variable trial wavefunctons …
  26. Overcoming barriers to scalability in variational quantum Monte Carlo

    Publication
    The variational quantum Monte Carlo (VQMC) method received significant attention in the recent past because of its ability to overcome the curse of dimensionality inherent in many-body …
  27. The effects of strain in multi-orbital superconductors: the case of Sr

    Publication
  28. Thermalization of dilute impurities in one dimensional spin chains

    Publication
  29. Markovian baths and quantum avalanches

    Publication
  30. Digital quantum simulation of NMR experiments

    Publication
  31. Platform tailored co-design of gate-based quantum simulation

    Publication
  32. Ab-initio investigation of Er3+ defects in tungsten disulfide

    Publication
  33. Defect Polaritons from First Principles

    Publication
  34. Simple Exchange-Correlation Energy Functionals for Strongly Coupled Light-Matter Systems based on the Fluctuation-Dissipation Theorem

    Publication
  35. Cavity-Modulated Proton Transfer Reactions

    Publication
  36. Polaritonic Unitary Coupled Cluster for Quantum Computations

    Publication
  37. Linear free energy relationships in electrostatic catalysis

    Publication
  38. Robust Pipek–Mezey Orbital Localization in Periodic Solids

    Publication
  39. Rotational g factors and Lorentz forces of molecules and solids from density-functional perturbation theory

    Publication
  40. Topology invisible to eigenvalues in obstructed atomic insulators

    Publication
  41. Gapless electronic topology without free-electron counterpart

    Publication
  42. Staggered Pseudo Magnetic Field in Twisted Transition Metal Dichalcogenides: Physical Origin and Experimental Consequences

    Publication
  43. Cavity-modified unimolecular dissociation reactions via intramolecular vibrational energy redistribution

    Publication
  44. Magic angle conditions for twisted 3D topological insulators

    Publication
  45. Shining light on the microscopic resonant mechanism responsible for cavity-mediated chemical reactivity

    Publication
  46. Error Rate Reduction of Single-Qubit Gates via Noise-Aware Decomposition

    Publication
  47. Ab initio linear-response approach to vibro-polaritons in the cavity Born-Oppenheimer approximation

    Publication
  48. Charge self-consistent electronic structure calculations with dynamical mean-field theory using Quantum ESPRESSO, Wannier90 and TRIQS

    Publication
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