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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Fermionic Wave Functions from Neural-Network Constrained Hidden States

    Publication
    We introduce a systematically improvable family of variational wave functions for the simulation of strongly correlated fermionic systems. This family consists of Slater determinants in an augmented Hilbert …
  2. Tuning the Fermi Liquid Crossover in Sr

    Publication
  3. Seebeck coefficient in a cuprate superconductor: particle-hole asymmetry in the strange metal phase and Fermi surface transformation in the pseudogap phase

    Publication
  4. Sachdev-Ye-Kitaev Models and Beyond: A Window into Non-Fermi Liquids

    Publication
  5. Dynamical mean field theory of moiré bilayer transition metal dichalcogenides: phase diagram, resistivity, and quantum criticality

    Publication
  6. Unveiling the underlying interactions in Ta2NiSe5 from photo-induced lifetime change

    Publication
  7. Inter-orbital singlet pairing in Sr

    Publication
  8. Minimally Entangled Typical Thermal States Algorithms for Finite Temperature Matsubara Green Functions

    Publication
  9. Toward Confined Carbyne with Tailored Properties

    Publication
  10. Mott insulating states with competing orders in the triangular lattice Hubbard model

    Publication
  11. Skewed Non-Fermi Liquids and the Seebeck Effect

    Publication
  12. Long-lived phonon polaritons in hyperbolic materials

    Publication
  13. Quantum Criticality in Twisted Transition Metal Dichalcogenides

    Publication
  14. Fizeau Drag in Graphene Plasmonics

    Publication
  15. Energy Landscape analysis of metal-insulator transitions: theory and application to Ca

    Publication
  16. Quantum embedding methods for correlated excited states of point defects: Case studies and challenges

    Publication
  17. Neuron-Glia Signaling Regulates the Onset of the Antidepressant Response

    Publication
  18. Asynchronous, contagious and digital aging

    Publication
    Aging has largely been defined by analog measures of organ and organismal dysfunction. This has led to the characterization of aging processes at the molecular and cellular levels …
  19. An integral equation method for the simulation of doubly-periodic suspensions of rigid bodies in a shearing viscous flow

    Publication
    With rheology applications in mind, we present a fast solver for the time-dependent effective viscosity of an infinite lattice containing one or more neutrally buoyant smooth rigid …
  20. Complex interplay between cognitive ability and social motivation in predicting social skill: A unique role for social motivation in children with autism.

    Publication
  21. A prefrontal social circuit vulnerable to juvenile social isolation.

    Publication
  22. PsychENCODE and beyond: Transcriptomics and epigenomics of brain development and organoids.

    Publication
  23. Effect sizes of deletions and duplications on autism risk across the genome.

    Publication
  24. Polygenicity in psychiatry-like it or not, we have to understand it.

    Publication
  25. Motor impairment increases in children with autism spectrum disorder as a function of social communication, cognitive and functional impairment, repetitive behavior severity, and comorbid diagnoses: A SPARK study report.

    Publication
  26. Neuronal correlates of strategic cooperation in monkeys.

    Publication
  27. SCN2A-developmental and epileptic encephalopathies: Challenges to trial-readiness for non-seizure outcomes.

    Publication
  28. A genetics-first approach to dissecting the heterogeneity of autism: Phenotypic comparison of autism risk copy number variants.

    Publication
  29. Eliciting language samples for analysis (ELSA): A new protocol for assessing expressive language and communication in autism.

    Publication
  30. Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders.

    Publication
  31. Emotion dysregulation is substantially elevated in autism compared to the general population: Impact on psychiatric services.

    Publication
  32. ARDD 2020: from aging mechanisms to interventions

    Publication
    Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as …
  33. Accurate analytic model for the weak lensing convergence one-point probability distribution function and its autocovariance

    Publication
    The one-point probability distribution function (PDF) is a powerful summary statistic for non-Gaussian cosmological fields, such as the weak lensing (WL) convergence reconstructed from galaxy shapes …
  34. Polaritonic Chemistry: Collective Strong Coupling Implies Strong Local Modification of Chemical Properties

    Publication
    Polaritonic chemistry has become a rapidly developing field within the last few years. A multitude of experimental observations suggest that chemical properties can be fundamentally altered and novel …
  35. Sampling-based inference of the primordial CMB and gravitational lensing

    Publication
    The search for primordial gravitational waves in the Cosmic Microwave Background (CMB) will soon be limited by our ability to remove the lensing contamination to B-mode polarization …
  36. H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives.

    Publication
  37. Multiregional communication and the channel modulation hypothesis

    Publication
    Multiregional communication is important to understanding the brain mechanisms supporting complex behaviors. Work in animals and human subjects shows that multiregional communication plays significant roles in cognitive function …
  38. Modeling molecular development of breast cancer in canine mammary tumors

    Publication
    Understanding the changes in diverse molecular pathways underlying the development of breast tumors is critical for improving diagnosis, treatment, and drug development. Here, we used RNA-profiling of …
  39. Modeling molecular development of breast cancer in canine mammary tumors

    Publication
    Understanding the changes in diverse molecular pathways underlying the development of breast tumors is critical for improving diagnosis, treatment, and drug development. Here, we used RNA-profiling of …
  40. Supplying the sleeping brain

    Publication
    uring sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals.
  41. Supplying the sleeping brain

    Publication
    During sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals.
  42. NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans

    Publication
    Comprehensively resolving neuronal identities in whole-brain images is a major challenge. We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a neuronal polychromatic …
  43. A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

    Publication
    Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed …
  44. Direct Measurement of Cerebrospinal Fluid Production in Mice

    Publication
    The emerging interest in brain fluid transport has prompted a need for techniques that provide an understanding of what factors regulate cerebrospinal fluid (CSF) production. Here, we describe …
  45. Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

    Publication
    The complement component 4 (C4) gene is linked to schizophrenia and synaptic refinement. In humans, greater expression of C4A in the brain is associated with an increased risk …
  46. A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila

    Publication
    Aggression involves both sexually monomorphic and dimorphic actions. How the brain implements these two types of actions is poorly understood. We have identified three cell types that regulate …
  47. Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation

    Publication
    Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that …
  48. Comparative many-body study of Pr

    Publication
    We study the many-body electronic structure of the stoichiometric and electron-doped trilayer nickelate Pr
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