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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. The Quantum Plumber

    May 6, 2022
    Sitting at the juncture of quantum physics and fluid dynamics, Flatiron Institute physicist Nikita Kavokine has been called a “quantum plumber” for having discovered the specifics of how …
  2. Science Sandbox Holds Inaugural Awardee Summit

    May 3, 2022
    For the first time, the community of Science Sandbox awardees convened for a two-day summit at the Simons Foundation
  3. Quanta Magazine’s New Podcast, ‘The Joy of Why,’ Ponders the Big Questions

    May 2, 2022
    … Powers and The Joy of x. Quanta Magazine is an award-winning, editorially independent publication launched by the Simons Foundation to illuminate big ideas in science and …
  4. Integration of electrophysiological and transcriptomic signatures of cognitive resilience in the hippocampus using patch-seq

    Funded Work
    As we age, most individuals will experience normal declines in cognitive abilities, including memory.
  5. Altered Immune Molecules During Pregnancy and in the Umbilical Cord at Birth Predict Later Autism Diagnoses

    April 29, 2022
    Ian Lipkin, Mady Hornig and colleagues showed that levels of immune molecules in mothers during pregnancy and in cord blood at birth are highly predictive of later autism …
  6. Synaptic Imbalance and Disrupted Homeostatic Plasticity in Cortical Circuits of Chd8 Haploinsufficient Mice

    April 29, 2022
    Laura Andreae, M. Albert Basson and collaborators showed that Chd8 haploinsufficiency in mice was linked to changes in excitation/inhibition balance and disrupted homeostatic plasticity of prefrontal circuits.
  7. SFARI Autism Rat Models Consortium Awardees Announced

    April 29, 2022
    SFARI is pleased to announce that it intends to fund seven grants in response to the Autism Rat Models Consortium request for applications.
  8. Alterations in Sound Processing in Cntnap2 Rats Provide Insights Into Mechanisms of Language-Related Disorders

    April 29, 2022
    SFARI Investigator Susanne Schmid and colleagues showed that loss of Cntnap2 in rats leads to immature-like delays in auditory cortex sound processing and overactive auditory neurons.
  9. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    April 28, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  10. Searching for Shapes in Neural Activity

    April 28, 2022
    Massive neural recordings combined with advanced analyses can distill insight from enigmatic data. How far can these tools take us?
  11. Computers Have Memories, Too

    April 27, 2022
    Sometimes computer crashes occur because a computer program looks for something that no longer exists. This is a problem that Simons Junior Fellow Sebastian Wolff wants to solve.
  12. 2022 Autism BrainNet Appreciation Award: Recipients Announced

    April 26, 2022
    Autism BrainNet announces the recipients of the 2022 Autism BrainNet Appreciation Award, an initiative that recognizes outstanding partners and collaborators for their dedication to advancing brain tissue research …
  13. INSYNC-AS Inaugural Meeting Discusses the Therapeutic Landscape for Angelman Syndrome

    April 19, 2022
    A joint project of the Foundation for Angelman Syndrome Therapeutics (FAST) and SFARI, the International Angelman Syndrome Research Council (INSYNC-AS) held its inaugural meeting on July 9 …
  14. Biological and Machine Intelligence: Connecting the Dots

    April 19, 2022
    At the intersection of neuroscience, computer science and theoretical physics, Flatiron Institute neuroscientist SueYeon Chung is working to understand the inner workings of the brain — and along the …
  15. New Genetic Analyses Provide Estimates of De Novo Mutations in Low– and High–Risk Families With Autism

    April 18, 2022
    Ivan Iossifov, Michael Wigler and colleagues provided a detailed comparison of simplex and multiplex families with autism, supporting the view that de novo mutations are a more frequent …
  16. Watch: Andrea Alù on Controlling Light and Sound Using Metamaterials

    April 18, 2022
    CUNY’s Andrea Alù describes how metamaterials — materials engineered to have properties not found in nature — are paving the way for a wide range of technological advancements, from …
  17. Simons Foundation Partners With Institute of International Education’s Scholar Rescue Fund

    April 14, 2022
    The partnership will support fellowships for threatened scholars in mathematics, computer science and theoretical physics.
  18. David Spergel Receives NASA’s Exceptional Public Service Medal

    April 13, 2022
    On April 13, NASA has awarded Simons Foundation president David Spergel its Exceptional Public Service Medal, in a virtual ceremony telecast. The award cites Spergel’s “outstanding leadership …
  19. COVID-19 Pregnancy Registry of Immune ResponSes and Maternal Microbiome (COVID PRISM)

    Funded Work
    The potential impact of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the developing fetal brain is not yet understood.
  20. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    April 4, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  21. The role of feedback in speech in autism: The missing perceptuomotor link

    Funded Work
    Over the past few decades, there have been significant gains made in modern communication technology, yet there exists a huge gap in the application of these technologies to …
  22. Investigating neural oscillations in early autism with innovative wearable MEG

    Funded Work
    Atypical brain activity and connectivity are well demonstrated in older children and adults with autism spectrum disorder (ASD), but it is unknown when these changes first appear.
  23. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    March 29, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  24. Cracking the Neural Code in Humans

    March 29, 2022
    The ability to record neural activity from populations of single cells in the human brain is expanding. What will these efforts reveal about neural dynamics?
  25. Watch: Building the Ultimate Brain Map

    March 29, 2022
    In efforts to construct a map of neural connections in the brain, researchers at the Flatiron Institute’s Center for Computational Neuroscience are turning to an unlikely source …
  26. Characterizing sleep physiology in autism: A path from genes to treatment

    Funded Work
    Research on the functions of sleep has produced a wealth of evidence that sleep rhythms play an evolutionarily conserved role in the consolidation of multiple forms of memory.
  27. What Actually Happens When We Experience Inflammation?

    March 28, 2022
    Inflammation is a crucial part of our response to infection. Simons Junior Fellow Ashley Chui is working to uncover exactly how critical proteins in our cells support this …
  28. Simons Foundation Funds Center for Computational Physical Chemistry at NYU

    March 21, 2022
    … professorships, offer graduate student fellowships and run a summer school series for high school students aimed at introducing them to the field of computational physical chemistry. An …
  29. New Model Shows How Cilia Make Waves

    March 17, 2022
    By building a biophysical model that incorporates real-world biological complexity, scientists discover important links between the nanometer-sized motors that power a cell’s cilia and the …
  30. High-throughput molecular and connectivity autism variant phenotyping in vivo using single-cell, single-virion genomic technologies

    Funded Work
    Mutations in genes involved in synaptic function have been identified as risk factors for autism spectrum disorder (ASD), yet how risk-alleles encoding ubiquitous synaptic proteins affect the …
  31. Targeted restoration of chromatin regulators as therapeutic interventions for autism

    Funded Work
    Autism spectrum disorder (ASD) has a complex genetic landscape with many highly penetrant risk genes which individually affect a small proportion of individuals with a spectrum of clinical …
  32. COVID-19 Outcomes in Mother-Infant Pairs (COMP Study): A longitudinal study of immunopathogenesis and neurodevelopmental outcomes in children exposed to SARS CoV-2 in utero

    Funded Work
    The massive outbreak of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has spread rapidly around the …
  33. Generation C: The impact of maternal COVID-19 infection and inflammation on risk for autism spectrum disorder

    Funded Work
    The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected hundreds of million individuals globally.
  34. Neuromuscular mechanisms of motor impairments associated with autism

    Funded Work
    Autism spectrum disorder (ASD) affects one in 59 children in the United States.
  35. Molecular signatures and reversibility in mouse models of Jordan's syndrome

    Funded Work
    PPP2R5D is a high-confidence (category 1) autism spectrum disorder (ASD) risk gene and the 13th most significantly neurodevelopmental disorder-associated gene in the genome.
  36. Modeling deficiencies in the chromatin modifying enzyme EHMT1 during human neurogenesis using multipurpose degron alleles

    Funded Work
    Loss-of-function mutations in repressive chromatin modifying enzymes such as euchromatic histone methyltransferase 1 (EHMT1) are frequent causes of neurodevelopmental conditions, including autism spectrum disorder (ASD).
  37. RNA-binding proteins in autism

    Funded Work
    Post-transcriptional regulation of mRNAs plays a major role in determining the proteome and thus cell fate.
  38. Elucidating how the autism risk gene CPEB4 regulates cortical neuron development

    Funded Work
    Autism spectrum disorder (ASD) is a set of conditions arising during neural development.
  39. Development and validation of an online webcam-based performance measurement battery for autism spectrum disorders

    Funded Work
    There are currently no available evaluation tools specifically designed for online, rapid and repeated evaluation of multiple neurobehavioral domains important to people with autism spectrum disorder (ASD) and …
  40. Copy number variation and pathogenic variant analyses of SPARK exomes

    Funded Work
    The objective of this one-year Director Award is to continue pathogenic copy number variation (CNV) discovery for exomes generated as part of the SPARK Consortium (the initial …
  41. Center for Computational Neuroscience Celebrates Opening

    March 14, 2022
    … group leaders, research scientists, postdoctoral fellows, computational engineers and support staff. Simoncelli sees the center as “living at the nexus” of three endeavors and communities: systems neuroscience …
  42. The Simons Society of Fellows Welcomes Latest Class of Junior Fellows

    March 11, 2022
    The Simons Foundation is delighted to announce the 2022 class of Junior Fellows in the Simons Society of Fellows. These 12 researchers are outstanding early-career scientists and …
  43. Pathogenic insight into autism from novel mapping of behavioral dynamics in the infant-caregiver dyad from 0 to 6 months

    Funded Work
    From birth, infants and their caregivers engage in mutually adaptive and mutually reinforcing interactions that serve as the platform and catalyst for development of the social brain and …
  44. Actimetry-based study of sleep traits in autism spectrum disorder

    Funded Work
    Autism spectrum disorder (ASD) is a complex, heritable and highly heterogeneous neurodevelopmental condition characterized by challenges in the core areas of reciprocal social communication as well as the …
  45. Inter-regional interactions underlying the decision to act, at spiking resolution

    Funded Work
    The adaptive value of cognition manifests in decisions not only about how to act but also about when to act.
  46. It From Qubit and the Gravity of a Quantum Universe

    March 8, 2022
    Now in its penultimate year, the Simons Collaboration on Quantum Fields, Gravity and Information has made a solid case for using quantum computing principles to understand spacetime, black …
  47. Deep insights into microbial interactions through high-resolution observations and modeling

    Funded Work
  48. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    March 3, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
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