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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Simons Foundation Announces 2026–2027 Class of SURFiN Fellows

    October 14, 2026
    The 93 undergraduate students will receive invaluable, hands-on research experience in nearby Simons Foundation-supported neuroscience labs.
  2. Applications Open for 2027 Fellows-to-Faculty Award Program

    October 13, 2026
    The program supports talented early-career scientists as they transition to tenure-track faculty positions. Submit your application by January 13, 2027.
  3. Former SFARI Investigator Karl Deisseroth Wins 2026 Nobel Prize

    October 5, 2026
    Deisseroth wins the award, along with Peter Hegemann and Georg Nagel, for discoveries leading to the development of optogenetics — a technique that uses light to control cellular signals.
  4. Funding Awarded for 16 Courses and Conferences in Autism and Neuroscience

    September 22, 2026
    The events selected for funding include a training program for African autism researchers, a computational neuroscience forum and a conference supporting open-science tools in neurophysiology.
  5. Now Available: Largest-Ever Whole-Genome Sequencing Dataset for Autism Research

    September 8, 2026
    … genotype-phenotype studies.” The data are available to approved researchers via SFARI Base. Please contact [email protected] with any questions.
  6. New Omics Data Available From Autism BrainNet

    September 3, 2026
    Autism BrainNet (ABN) announces the release of genetic data from the laboratories of Tomasz Nowakowski and Stephan Sanders. This release includes omics data from studies of postmortem brain …
  7. Genes Linked to Early Childhood Temperament Also Influence Autism and ADHD Risk

    August 31, 2026
    … distinction lets researchers separate genetics from environment. A sibling with more of the genetic variants linked to a trait, such as shyness, tended to score higher on …
  8. Autistic and Nonautistic Youth Successfully Leverage Same Social Learning Strategies

    August 20, 2026
    … understanding between autistic and nonautistic people. The difficulty that each group has in reading the other runs deeper than a simple skills gap. Much of it stems …
  9. Long-Read Whole Genome Sequencing Data Available for Autism Research

    August 10, 2026
    The data include PacBio long-read whole genome sequencing data for 110 individuals from 37 families participating in the SPARK autism research study.
  10. Fragile X Syndrome Impairs Cooperation in Rats

    August 5, 2026
    … competition for space. This same separation also makes it possible to study brain activity during cooperation without that physical complication. It offers researchers a more direct way …
  11. Simons Searchlight July 2026 Update: New Autism Phenotypic Data Available

    August 4, 2026
    Simons Searchlight, a program of the Simons Foundation Autism Research Initiative (SFARI), announces the release of new de-identified participant data available to qualified researchers. This release includes …
  12. Applications Open for Autism Genetics Workshops

    August 3, 2026
    These workshops seek to support research that applies emerging genomic technologies and artificial intelligence approaches to develop a more comprehensive understanding of autism’s genetic architecture.
  13. Announcing the Recipients of the 2026 Fellows-to-Faculty Awards

    July 31, 2026
    The Simons Foundation is pleased to announce the 2026 class of its Fellows-to-Faculty program. The program supports talented early-career scientists and their research visions as …
  14. How Mathematical Modeling Identified Subclasses of Autism

    June 23, 2026
    … work.”
  15. SFARI Sex Differences Collaborations Convene for Fourth Annual Meeting

    June 18, 2026
    … reported that measures of gene expression and chromatin accessibility across the genome followed patterns specific to the XX or XY status of an individual cell, regardless of …
  16. SFARI Hosts 2026 Investigator Meeting

    June 15, 2026
    The Simons Foundation Autism Research Initiative held its annual investigator meeting on March 16–18, 2026, in New York City.
  17. SFARI To Fund Patient Advocacy Group Conferences and Travel Awards for Scientists

    June 15, 2026
    SFARI plans to support 17 meetings organized by patient advocacy groups within the Simons Searchlight community.
  18. Acetylcholine Helps Dopamine Reward Hard Work

    June 11, 2026
    … 6852 (2023) PubMed Liu C. et al. Science 375, 1378–1385 (2022) PubMed Krok A.C. et al. Nature 621, 543–549 (2023) PubMed Chantranupong L. et …
  19. How an Autism-Associated Gene Keeps Synapses Stable

    June 9, 2026
    Epilepsy and intellectual disability often occur alongside autism spectrum disorder (ASD), and researchers have long suspected that these conditions share common biological roots.
  20. Protein Levels, Not Just Transcripts, Hold Clues to Autism

    May 26, 2026
    … forming connections with other neurons, making it genetically vulnerable. The same research team had previously identified this window as a time of heightened autism risk using an …
  21. Now Accepting Applications for Workshops on Quantitative Behavioral Phenotyping in Autism

    May 14, 2026
    The Simons Foundation Autism Research Initiative will hold three workshops aimed at developing a multiyear collaborative effort in quantitative behavioral analysis of individuals with autism.
  22. Unbiased Approaches to Quantifying Motor and Other Visible Behaviors in Humans With Autism

    May 11, 2026
    On January 22–23, 2026, SFARI held a workshop to explore advanced quantitative phenotyping methods for capturing visible behaviors, including motor phenotypes.
  23. New Ideas: Applications Open for Exploratory Autism Research Grants

    April 29, 2026
    To enable bold and innovative new directions in autism research, the Simons Foundation Autism Research Initiative (SFARI) welcomes applications for its recently launched New Ideas grant program. These …
  24. New Ideas RFA: Perspectives

    April 29, 2026
    … rigor, proposals are evaluated on how clearly they articulate their relevance to autism and related NDDs. We encourage applicants to familiarize themselves with the current landscape of …
  25. Announcing the Recipients of the 2025 Data Analysis Awards

    April 21, 2026
    The Simons Foundation Autism Research Initiative (SFARI) is funding 16 projects through its 2025 Data Analysis awards. This award is designed to encourage the use of large, publicly …
  26. Altered Corticotectal Circuitry Shapes Contextual Sensory Processing in a Mouse Model of Autism

    April 6, 2026
    … learning-related differences in sensory function. By revealing how disrupted cortical–midbrain communication interferes with the flexible interpretation of environmental cues, this work offers a framework for …
  27. 2026 SFARI Sex Differences Collaborations Announced

    April 2, 2026
    These awards support interdisciplinary research into the sex bias associated with autism and its underlying biological mechanisms.
  28. Using the Linear References From the Pangenome To Discover Missing Autism Variants

    April 1, 2026
    … SVs4, making it difficult to identify those relevant to disease. Comparing variants within families and against hundreds of long-read reference pangenomes allowed the team to filter …
  29. Age at Autism Diagnosis Linked to Distinct Genetic Profiles

    March 11, 2026
    Recent SFARI-funded research challenges the idea that autism represents a single condition driven by a uniform set of genetic risk factors. Instead, the results support a developmental …
  30. Applications Open for 2026–2027 Undergraduate Research Fellowships in Neuroscience

    March 10, 2026
    The Simons Foundation is now accepting applications from undergraduate students to participate in its Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) program for the 2026–2027 academic year …
  31. Choroid Plexus Secretion Regulates CSF Proteome and Alters Brain Development

    March 5, 2026
    SFARI-funded research demonstrates that activating serotonergic 5HT2c receptors leads to an increase in intracellular calcium, early-response gene expression and elevated protein secretion into cerebrospinal fluid.
  32. Applications for Conferences and Courses Awards in Neuroscience Now Open

    March 4, 2026
    … PAG-organized conference, you can explore the Conference Grant Support for Rare Neurodevelopmental Disorder Communities Participating in Simons Searchlight RFA. Applicants must submit a letter of intent …
  33. Multimodal Approach Reveals How Autism-Linked Genes Shape Primate Prefrontal Cortex Development

    February 12, 2026
    SFARI-funded research finds that RAPGEF4 is a key molecular regulator orchestrating prefrontal cortical maturation in primates.
  34. Simons Searchlight February 2026 Update: New Phenotypic Data Available

    February 5, 2026
    The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce a new data release from Simons Searchlight aimed at improving the scientific understanding of autism.
  35. Human Assembloid Model Reveals Region-Specific Effects of an Epilepsy-Linked Mutation

    February 5, 2026
    SFARI-funded research demonstrates that SCN8A mutations underlying DEE-13 disrupt both cortical and hippocampal networks, but in distinct ways.
  36. 2025 Autism Rat Consortium Meeting Held in New York City

    January 13, 2026
    On September 29, 2025, the SFARI Autism Rat Consortium (ARC) held its annual meeting in the Usher Institute of the University of Edinburgh. This year’s event brought …
  37. Simons Searchlight at 15: A Researcher’s Guide

    December 18, 2025
    Simons Searchlight offers open-source data and tools to researchers worldwide who study autism and related neurodevelopmental conditions.
  38. Autism and Neuroscience Innovators: Awardees Share Their Research at the Annual Retreat

    December 15, 2025
    … has shown that this inhibitory synchronicity is indeed a driver of seizure vulnerability. Mapping the Senses of Internal Organs Fellows-to-Faculty member Chen Ran, an assistant …
  39. Fellows-to-Faculty Alum Gabriela Rosenblau Dives Deep Into Social Learning in Autism

    December 11, 2025
    … fellowship encouraged you to collaborate with people in different fields? Absolutely. Once a year or twice a year, for as long as you’re a grantee, you …
  40. Fellows-to-Faculty Alum Tomasz Nowakowski Studies Human Cortical Development

    December 8, 2025
    … other Simons Investigators. For example, I collaborate with Stephan Sanders on analyses of human postmortem brain tissue profiling. I collaborate with Omer Bayraktar to further understand which …
  41. Performance on a Specialized Video Game Distinguishes Children With Autism From Those With ADHD and Neurotypical Development

    November 20, 2025
    … Autism Spectr. Disord. 87, 101840 (2021) PubMed
  42. Cis-Regulation Therapy Rescues SCN2A-Related Neurological Dysfunction

    November 19, 2025
    … Neurosci. 27, 1864–1879 (2024) PubMed Karczewski K.J. et al. Nature 581, 434–443 (2020) PubMed Howe K.L. et al. Ensembl 2021. Nucleic Acids Res …
  43. Two Simons Foundation Investigators Elected to the National Academy of Medicine

    November 3, 2025
    This year’s new cohort of National Academy of Medicine members includes two investigators funded by the Simons Foundation. Election to the academy “recognizes individuals who have demonstrated …
  44. Mapping Mouse Brains Points to How Autism Can Affect Expectation Updating

    October 23, 2025
    A new study finds that mice with variants in autism-associated genes have difficulty flexibly updating their expectations. The mice relied more on frontal brain areas associated with …
  45. Announcing the Recipients of the Autism and Neuroscience Conferences and Courses Awards

    October 1, 2025
    … linking genes and behavior. The magnitude of this problem requires communal efforts among scientists working on different organisms and systems. Creating such synergy served as a motivation …
  46. Simons Foundation Announces Latest Class of SURFiN Fellows

    September 29, 2025
    This program provides highly motivated undergraduates with opportunities to gain first-hand research experience and career development.
  47. Simons Foundation Announces Recipients of 2025 Fellows-to-Faculty Awards

    September 16, 2025
    The awards help senior postdoctoral researchers with fresh perspectives on autism and neuroscience transition to tenure-track faculty positions.
  48. Announcing the Recipients of the Autism Rat Models Consortium 2.0 Awards

    August 18, 2025
    The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce the recipients of its Autism Rat Models Consortium 2.0 grants. This grant program will expand on …
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