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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCN Researcher SueYeon Chung Named McKnight Scholar

    June 8, 2026
    … joining the Flatiron Institute, Chung was a postdoctoral research scientist at Columbia University’s Center for Theoretical Neuroscience. Before that, she was a fellow in computation in …
  2. CCN Director Eero Simoncelli Elected to National Academy of Sciences

    April 29, 2026
    Eero Simoncelli, director of the Flatiron Institute’s Center for Computational Neuroscience (CCN), has been elected to the National Academy of Sciences. He joins 119 national and 25 …
  3. Biological Brains Inspire a New Building Block for Artificial Neural Networks

    January 26, 2026
    While artificial intelligence systems have advanced tremendously in recent years, they still lag behind the performance of real brains in reliability and efficiency. A new type of computational …
  4. A Tug-of-War Explains a Decades-Old Question About How Bacteria Swim

    January 8, 2026
    Bacteria tails rotate counterclockwise to propel the bacteria through liquid environments and clockwise to change direction. Previous research has suggested that the direction of the spin depends on …
  5. CCN’s SueYeon Chung Named a ‘Rising Star in Neuroscience’

    November 15, 2025
    The Transmitter — an editorially independent publication of the Simons Foundation — has selected Flatiron Institute neuroscientist SueYeon Chung as one of its 2025 Rising Stars in Neuroscience. The awards …
  6. Simons Foundation Now Accepting Applications for Workshop on Canonical Cortical Computations

    November 13, 2025
    The Center for Computational Neuroscience (CCN) at the Flatiron Institute and the Simons Foundation Neuroscience Collaborations invite applications to participate in a workshop aimed at developing a potential …
  7. Mapping Mouse Brains Points to How Autism Can Affect Expectation Updating

    October 23, 2025
    A new study finds that mice with variants in autism-associated genes have difficulty flexibly updating their expectations. The mice relied more on frontal brain areas associated with …
  8. CCN Research Scientist Alex Williams Named McKnight Scholar

    June 23, 2025
    The McKnight Endowment Fund for Neuroscience has selected Associate Research Scientist Alex Williams of the Flatiron Institute’s Center for Computational Neuroscience as a 2025 McKnight Scholar. The …
  9. CCN’s NeuroRSE Group Hosts Two Software Workshops

    February 25, 2025
    The NeuroRSE group at the Flatiron Institute’s Center for Computational Neuroscience (CCN) recently hosted two software workshops that taught scientists how to analyze neuroscience data using new …
  10. CCN Director Eero Simoncelli Awarded Swartz Prize

    September 16, 2024
    The Society for Neuroscience (SfN) announced today that Center for Computational Neuroscience (CCN) director Eero Simoncelli will receive its prestigious Swartz Prize, which it annually awards to “an …
  11. New Computational Model of Real Neurons Could Lead to Better AI

    June 24, 2024
    The new model developed by researchers at the Flatiron Institute proposes that biological neurons have more control over their surroundings than previously thought, something that could be replicated …
  12. Two Neuroscience Laws Governing How We Sense the World Finally United After 67 Years

    June 17, 2024
    Neuroscientists at the Flatiron Institute and New York University developed a new theoretical framework that describes our ability to both absolutely and relatively gauge the properties of sensory …
  13. Amin Nejatbakhsh Named Leon Levy Scholar in Neuroscience

    May 29, 2024
    … program is an initiative of the Leon Levy Foundation, which supports the preservation, understanding and expansion of knowledge, with a focus on the ancient world, arts and …
  14. CCM and CCN Researchers Awarded Outstanding Paper Award at the International Conference on Learning Representations

    May 7, 2024
    The International Conference on Learning Representations (ICLR) honored Center for Computational Neuroscience (CCN) research fellow Florentin Guth, CCN guest researcher Zahra Kadkhodaie, Center for Computational Mathematics (CCM) distinguished …
  15. Neuroscientist SueYeon Chung Awarded Sloan Research Fellowship

    February 20, 2024
    The Alfred P. Sloan Foundation has awarded neuroscientist SueYeon Chung one of its prestigious research fellowships. The honor recognizes “early-career researchers whose creativity, innovation, and research accomplishments …
  16. All Five Flatiron Centers Represented at the Conference on Neural Information Processing Systems (NeurIPS)

    December 8, 2023
    For the first time, the five Flatiron Institute research centers (astrophysics, biology, mathematics, neuroscience and quantum physics), as well as its Scientific Computing Core and the Foundation Models …
  17. Learning Better: Improving the Efficiency of Deep Learning Models

    October 31, 2023
    Flatiron Research Fellow Brett Larsen is developing better ways to train deep learning models.
  18. How Do Our Brains Classify Similar Objects? New Theory Works Out the Details

    October 26, 2023
    With a new computational model, Flatiron Institute researchers have made big steps in understanding how our brains classify. This advance could improve efficiency in artificial neural networks.
  19. Researchers Create First-Ever Map of a Single Animal’s Early Visual System

    September 28, 2023
    A team of scientists at the Flatiron Institute and their colleagues have mapped out the entire early visual system — from eyes to neurons — for a tiny parasitic wasp …
  20. New Software Streamlines Neuroscience Research

    August 7, 2023
    Flatiron data scientist Billy Broderick is on a mission to make neuroscience research easier and more efficient by developing user-friendly software for analyzing and modeling data.
  21. Neuroscientist SueYeon Chung Awarded a Klingenstein-Simons Fellowship

    July 5, 2023
    The Esther A. & Joseph Klingenstein Fund has announced that neuroscientist SueYeon Chung is one of this year’s recipients of a prestigious Klingenstein-Simons Fellowship Award in Neuroscience.
  22. Looking for Patterns: Understanding How We See the World

    April 26, 2023
    At the Flatiron Institute, Tim Oleskiw combines experimental and computational methods to figure out how our visual systems work. He hopes his work can help spur advances in …
  23. Computational Model Uncovers New Insights Into How Our Brains Store Information

    March 9, 2023
    With the new model, researchers reveal how memories and learned behaviors can remain strong, even in the face of shifting neural representations.
  24. Simons Foundation Scientists Named as Sloan Research Fellows

    February 16, 2023
    The Alfred P. Sloan Foundation has awarded its prestigious research fellowship to four past and present Simons Foundation researchers. This year’s 125 fellowship recipients “represent the most …
  25. A New Era of Perception Research

    February 10, 2023
    How we perceive the world is an age-old question. Flatiron Institute researcher Jingyang Zhou is part of a new generation of scientists tackling it from a different …
  26. From Statistics to Gerbils: Learning About Neural Connections With Social Rodents

    October 17, 2022
    By learning the language of Mongolian gerbils, neurostatistician Alex Williams is studying the ways our brains’ neural circuits change over time.
  27. Searching for Shapes in Neural Activity

    April 28, 2022
    Massive neural recordings combined with advanced analyses can distill insight from enigmatic data. How far can these tools take us?
  28. Biological and Machine Intelligence: Connecting the Dots

    April 19, 2022
    At the intersection of neuroscience, computer science and theoretical physics, Flatiron Institute neuroscientist SueYeon Chung is working to understand the inner workings of the brain — and along the …
  29. Watch: Building the Ultimate Brain Map

    March 29, 2022
    In efforts to construct a map of neural connections in the brain, researchers at the Flatiron Institute’s Center for Computational Neuroscience are turning to an unlikely source …
  30. Center for Computational Neuroscience Celebrates Opening

    March 14, 2022
    … group leaders, research scientists, postdoctoral fellows, computational engineers and support staff. Simoncelli sees the center as “living at the nexus” of three endeavors and communities: systems neuroscience …
  31. SueYeon Chung and Alex Williams Join CCN as Project Leaders

    January 10, 2022
    … population and the encoded task information. She then joined MIT as a Fellow in Computation in the department of brain and cognitive sciences. While there, Chung applied …
  32. Building Computer Models That See Everything

    August 30, 2021
    Simons Junior Fellow and computational neuroscientist Kathryn Bonnen uses advanced modeling and experimental techniques to help us understand what happens inside our minds as we perceive the world …
  33. Eero Simoncelli Leads New Center for Computational Neuroscience

    January 26, 2021
    … Dmitri Chklovskii will lead the neural circuits and algorithms group, previously part of the Flatiron Institute’s Center for Computational Biology. The group aims to reverse-engineer …
  34. Open-Source Software Tracks Neural Activity in Real Time

    February 28, 2019
    The tool, called CaImAn, replaces the process of manually tracking the location and activity of neurons.
  35. Scientists Provide New Insight on How the Nose Adapts to Smells

    February 26, 2019
    First-of-its-kind study could aid research into how our sense of smell is affected by the decreasing number of neurons in our noses as we age.
  36. Neurons in Cerebellum Show Surprising Activity During Learning

    March 21, 2017
    The study, the first to look at the cerebellum’s granule cells in living animals while they learn a task, reveals that the cells not only relay sensory …

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