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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Funded Work

Our funded projects advance discovery across mathematics, the physical and life sciences, neuroscience, and autism.

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  1. Inter-regional interactions underlying the decision to act, at spiking resolution

    Funded Work
    The adaptive value of cognition manifests in decisions not only about how to act but also about when to act.
  2. Single-neuron-resolution population dynamics in human Broca’s area and motor cortex when preparing and producing speech

    Funded Work
    Speech is a highly sophisticated, uniquely human behavior.
  3. How does the brain predict the future? Large-scale neural calcium imaging, two-photon optogenetic and deep neural network studies of future prediction across 11 neocortical areas in behaving mice

    Funded Work
    Prediction of the future and mental simulation of experiences are key to many forms of cognition and sensory processing.
  4. Computation timescales as an organizing principle of large-scale cortical dynamics during decision-making

    Funded Work
    The ability to make decisions lies at the core of cognition, but much remains unknown about its underlying neural mechanisms.
  5. Using brain-machine interfaces to identify and manipulate computational principles of learning

    Funded Work
    Learning a complex motor skill like playing tennis or a music instrument requires changes in connections between many neurons in the brain.
  6. Dissection of inter-area interactions of motor circuits

    Funded Work
    Behaviors are known to arise from numerous neurons communicating with each other within and across brain areas.
  7. Communication among sensorimotor cortices: Where state space meets biology

    Funded Work
    Movement is the primary way animals interact with the world.
  8. Investigating symbol-like reasoning in the brain: Neural mechanisms of compositional action planning

    Funded Work
    Humans and other animals can rapidly solve new problems — such as imitating a dance from a single observation — by adaptively combining components from prior knowledge to generate new …
  9. Theory-driven approaches to identify minimal circuits for susceptibility and resilience

    Funded Work
    Individuals vary widely in the types of behavioral transitions they undergo in response to adverse environmental conditions.
  10. Brainwide dynamics of a social interaction

    Funded Work
    Communication is a fundamental aspect of life among animals, and yet we lack a comprehensive understanding of the underlying neural mechanisms.
  11. Neural Circuit Dynamics for Sequence and Variability

    Funded Work
    Songbirds produce a complex, learned sequential behavior that shares features with the most intriguing human behaviors, such as speech, musical performance and even thinking and planning.
  12. Neural circuit dynamics underlying sequence and variability

    Funded Work
    Some of our most complex behavior, such as speaking, swimming or playing the piano, can be understood by breaking the behavior down into a sequential succession of learning …
  13. Computation-through-dynamics as a framework to link brain and behavior

    Funded Work
    The human brain is a daunting object: It contains nearly 100 billion neurons, each one linked to roughly 10,000 other neurons, making 100 trillion total connections in …
  14. Multi-regional neuronal dynamics of memory-guided flexible behavior

    Funded Work
    Our brains are able to store information about the world for several seconds after it was acquired, for example the shape and identity of an animal that disappeared …
  15. Discovering repeating neural motifs representing sequenced behavior

    Funded Work
    Imagine a tennis player hitting a forehand, but in slow-motion: There is anticipatory footwork, alignment of the body, preparation of the racquet, the wind-up and swing …
  16. Neural mechanisms of context dependent cognitive behavior

    Funded Work
    Context matters when making a decision.
  17. Neural computations for visual form processing and form-based cognition

    Funded Work
    When deciding whether to eat an apple, you might focus on its color, firmness and smell.
  18. Outer brain and inner brain: computational principles and interactions

    Funded Work
    Loosely speaking, we all have two brains.
  19. Dynamical computation in populations -- analysis and theory

    Funded Work
    The brain has a remarkable ability to choose appropriate actions in the face of an ever-changing environment.
  20. Leveraging dynamical smoothness to predict motor cortex population activity

    Funded Work
    Animals often move in response to the senses.
  21. Neural dynamics of a multi-timescale social behavior

    Funded Work
    The brain of any animal has to operate on multiple timescales at once.
  22. Plasticity of global brain dynamics: tunable neural integration

    Funded Work
    In the last few years, powerful experimental techniques that can monitor the activity of many neurons at once have generated a new field of neuroscience — ‘neural dynamics’ — which …
  23. International brain lab

    Funded Work
    A central goal of neuroscience is to decode the brain activity responsible for decisions and actions.
  24. Cortical mechanisms of multistable perception

    Funded Work
    Some visual patterns can be seen in more than one way, like the famous Necker cube which reverses its 3D orientation spontaneously.
  25. Communication between neural populations: circuits, coding, and behavior

    Funded Work
    Every time we open our eyes, we take in far too much visual information for our brains to fully process.
  26. Neural substrates of behavior and action selection in model organisms

    Funded Work
    Our group is helping Rafael Yuste’s lab to pioneer the use of Hydra vulgaris, a small, freshwater polyp that attaches itself to underwater surfaces in lakes, rivers …
  27. Theory of distributed persistent activity in large-scale brain circuits

    Funded Work
    Working memory, the ability to temporarily hold and manipulate pieces of information in our minds, is crucial for thinking and flexible behavior.
  28. Remapping across time, space and region

    Funded Work
    We take it for granted that we can distinguish similar events yet still group them together as being similar.
  29. Dissecting navigation and the general logic of episodic state computation

    Funded Work
    Imagine you are rowing a boat in a river.
  30. Integrative approaches to understanding whole-brain computation

    Funded Work
    The human brain is composed of billions of neurons.
  31. The representation of internal state in the fly brain

    Funded Work
    Our interaction with the world is influenced by our internal state.
  32. Single-trial visual familiarity memory acquisition

    Funded Work
    We’ve all experienced a sense of familiarity—that vague sense that we’ve met someone, been in a room, or seen a movie before—even if we …
  33. Corticocortical signaling between populations of neurons

    Funded Work
    How the human brain’s nearly 100 billion neurons interact with each other to give rise to cognition, emotion, and action is a total mystery.
  34. Circuit mechanisms of social cognitive computations

    Funded Work
    While we may take for granted social tasks such as inferring what others are thinking and feeling, or predicting someone’s next move, they pose considerable processing challenges …
  35. Neural dynamics for a cognitive map in the macaque brain

    Funded Work
    The ability of the human brain to form a complex memory of an event experienced just a single time is astounding—and that memory can be stored and …
  36. Dense mapping of dynamics onto structure in the c. elegans brain

    Funded Work
    In the human brain, billions of neurons wired into networks sense the environment; process, store, and retrieve information; and produce thoughts and behavior.
  37. Understanding visual object coding in the macaque brain

    Funded Work
    When we perceive a face, we see multiple aspects, such as its location in space, its overall 3-D shape, and the color of the lips and eyes.
  38. Neural circuit dynamics during cognition

    Funded Work
    How does the activity of neurons give rise to cognitive phenomena such as short-term memory or decision-making?
  39. Network properties and plasticity in high- and low-gain cortical states

    Funded Work
    Neural networks in the brain have their own intrinsic activity independent of incoming sensory stimuli.
  40. Toward computational neuroscience of global brains

    Funded Work
    Neural pathways are composed of hundreds, thousands, or millions of neurons.
  41. The latent dynamical structure of mental activity

    Funded Work
    The human brain is composed of billions of neurons.
  42. Decoding internal state to predict behavior

    Funded Work
    The behavioral repertoire of any animal is ultimately determined by the activity of its brain cells.
  43. Population dynamics across pairs of cortical areas in learning and behavior

    Funded Work
    The activity of neurons in the brain represents external sensory stimuli, internal cognitive states, and plans for upcoming motor behavior.
  44. Large-scale cortical and thalamic networks that guide oculomotor decisions

    Funded Work
    The cerebral cortex—the outermost, wrinkled layer of our brains—contains a variety of brain areas that are connected to form neural networks.
  45. How the basal ganglia forces cortex to do what it wants

    Funded Work
    It is well established that multiple brain areas are involved in generating movements, yet individual brain areas are often studied in isolation.
  46. Neural computation of innate defensive behavioral decisions

    Funded Work
    In general, our actions are not mere reflexes in response to external stimuli.
  47. Probing recurrent dynamics in prefrontal cortex

    Funded Work
    We all know that our thoughts change from moment to moment.
  48. Neural encoding and decoding of policy uncertainty in the frontal cortex

    Funded Work
    Imagine an autumn day.
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