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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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  • Research News
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  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Topology and Complexity

November 19, 2014

Results

  1. Building an AI That Understands the Universe

    June 23, 2026
    … a single DNA mutation could have ripple effects throughout the body) remains out of reach for many models. The first iteration of the Polymathic AI model can …
  2. These New AI Models Are Trained on Physics, Not Words, and They’re Driving Discovery

    December 9, 2025
    While popular AI models such as ChatGPT are trained on language or photographs, new models created by researchers at the Flatiron Institute and other members of the Polymathic …
  3. CCA Senior Research Scientist Shirley Ho Named an AI2050 Senior Fellow by Schmidt Sciences

    November 5, 2025
    The fellowships support scholars on the cutting edge of developing AI to benefit humankind.
  4. New Datasets Will Train AI Models To Think Like Scientists

    December 2, 2024
    The Polymathic AI team has released two massive datasets for training artificial intelligence models to tackle problems across scientific disciplines. The datasets include data from dozens of sources …
  5. Astrophysicists Use AI To Precisely Calculate Universe’s ‘Settings’

    August 26, 2024
    The new estimates of the parameters that form the basis of the standard model of cosmology are far more precise than previous approaches using the same galaxy distribution …
  6. Scientists Begin Building AI for Scientific Discovery Using Tech Behind ChatGPT

    October 9, 2023
    … ask questions that they wouldn’t be able to ask without the models we’re producing.” ChatGPT has well-known limitations when it comes to accuracy (for …
  7. Shirley Ho Named a Finalist for the 2023 Blavatnik National Awards for Young Scientists

    July 26, 2023
    … joined NYU as a research professor of physics. The Blavatnik Family Foundation and the New York Academy of Sciences will celebrate Ho alongside the other finalists and …
  8. Artificial Intelligence Predicts Which Planetary Systems Will Survive

    July 13, 2020
    Machine-learning methods can predict the long-term stability of planetary configurations 100,000 times faster than previous approaches.
  9. The First AI Simulation of the Universe Is Fast and Accurate — and Even Its Creators Don’t Know How It Works

    June 26, 2019
    The new model can envision universes with unique parameters, such as extra dark matter, even without receiving training data in which those parameters varied.

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