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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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  • Presidential Lectures
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. From Ring to Keyhole: Modeling How Tissues Mold the Fruit Fly’s Gut

    November 17, 2025
    Researchers at the Flatiron Institute’s Center for Computational Biology and their collaborators from Princeton University and the Max Planck Institute in Dresden, Germany, use experimental and computational …
  2. Support for Ukrainian Scientists Keeps Research and Collaboration Alive

    June 8, 2025
    Simons Foundation grants are helping the Ukrainian research community keep going and maintain their work in the face of the ongoing war. More than 430 grantees are receiving …
  3. Why Don’t Disease-Linked Genetic Mutations Always Result in Disease? A Study in Fruit Flies Offers New Clues

    March 13, 2023
    By harnessing both experimental and computational methods, researchers have identified a significant role for randomness in disease manifestation.
  4. Simons Foundation Providing Support to Researchers in Ukraine

    January 25, 2023
    … other members of the Simons Foundation staff. Ultimately, the Simons Foundation accepted every application it received and extended the application period as many scientists lost power and …
  5. A ‘Forest Fire’ Model of Cell Division Can Explain Clonal Dominance in Developing Tissue

    December 14, 2021
    A new study reveals that communication between cells encasing the developing fruit fly egg chamber induces unequal cell division, shedding light on a fundamental biological process.
  6. Fruit Fly Egg Takes an Active Hand in Its Own Growth, Highlighting Parallels to Mammals

    March 22, 2021
    … the sheet of follicle cells that surrounds it. “These two tissue types need to grow together, and later, the follicle cells that stay over the nurse cells …
  7. Computing the Egg: The Effort To Calculate Biological Development

    July 10, 2020
    … something similar about the fiery bodies racing across the sky until some bold thinkers cracked the patterns. As a reproducible and evolvable system subject to cutting-edge …
  8. Bioengineer Stanislav Shvartsman Heads CCB’s New Developmental Dynamics Group

    November 1, 2019
    The ovaries of female fruit flies contain ovarioles that serve as egg-making assembly lines. This image shows the cross-sections of 10 ovarioles from different fruit flies …

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