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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. How Decision-Making Changes With Age

    March 2, 2022
    Building on decades of research on the neural circuitry of decision-making, researchers are now exploring how those circuits evolve over the life span.
  2. SFARI Hosts Workshop on Newborn Screening

    February 28, 2022
    On September 27, 2021, SFARI convened a one-day virtual workshop to explore and discuss opportunities and risks for early detection of neurodevelopmental disorders through genomic sequencing.
  3. Why the Ocean Holds the Key to Understanding Climate Change

    February 28, 2022
    By bringing the power of machine learning to climate science, Simons Junior Fellow Abigail Bodner is working to deepen our understanding of the connection between ocean processes and …
  4. Autism BrainNet: Whole-Genome Sequencing Data Now Available

    February 25, 2022
    Whole-genome sequencing data from more than 50 brains in the Autism BrainNet collection are now available for research purposes. Additional data will be released in the coming …
  5. Study Finds Placental Hormone Is Critical for Fetal Brain Development

    February 24, 2022
    Anna Penn and colleagues showed that loss of the supply of the hormone allopregnanolone (ALLO) from the placenta leads to cerebellar brain and behavioral deficits in male offspring.
  6. Human Derived 3D Brain Cultures Provide Insights Into Brain Size Changes in 16p11.2 Conditions

    February 24, 2022
    SFARI Investigators Lilia Iakoucheva and Alysson Muotri and colleagues utilized 3D organoid brain cultures to demonstrate how defects in neuron migration are affected in 16p11.2 deletion and …
  7. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    February 24, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  8. Conference Spotlight: Cosyne 2022

    February 24, 2022
    Check out these talks and workshops featuring Simons Collaboration on the Global Brain investigators and fellows.
  9. New Study Supports Role for Disruptions in Synapse Development and Function in ASD

    February 23, 2022
    SFARI Investigator Bruce Herring and colleagues showed that ASD-linked mutations in Trio and NLGN1 cause deficits in synapse development and function.
  10. Investigating mechanisms underlying perceptual integration in autism

    Funded Work
    Atypical sensory perception is widely observed in individuals with autism spectrum disorder (ASD).
  11. In Foraging Tasks, New Opportunities To Study the Brain’s Complexity

    February 23, 2022
    Systems neuroscience is seeing a renaissance in the use of complex, naturalistic tasks, such as foraging, which offer surprising new insights into the brain. But gleaning these insights …
  12. Keywords at Cosyne

    February 23, 2022
    Analysis of more than 10 years’ worth of abstracts from the annual Cosyne meeting highlights research trends in systems and computational neuroscience.
  13. Watch: Community Engagement, Down to a Science

    February 22, 2022
    How a hands-on science museum made a home in Corona, Queens through community-led programming
  14. 2022 Simons Fellows in Mathematics and Theoretical Physics Announced

    February 18, 2022
    … Michigan Rayan Saab University of California, San Diego Laurent Saloff-Coste Cornell University Michael Stillman Cornell University Vesna Stojanoska University of Illinois at Urbana-Champaign Jeffrey D …
  15. New Simons Foundation ‘Pivot’ Fellowship Enables Researchers To Explore New Fields

    February 15, 2022
    The Simons Foundation announces its new Pivot fellowship program, which provides funding for today’s brightest minds to apply their talent and expertise to a new field in …
  16. Theoretical Physicist Jennifer Cano Awarded Sloan Research Fellowship

    February 15, 2022
    The Alfred P. Sloan Foundation has named theoretical quantum physicist Jennifer Cano a 2022 Alfred P. Sloan Research Fellow in Physics. The fellowship is one of the most …
  17. Cosmologist J. Colin Hill Awarded Sloan Research Fellowship

    February 15, 2022
    The Alfred P. Sloan Foundation has awarded one of its prestigious research fellowships to cosmologist J. Colin Hill. The fellowship “recognizes and rewards outstanding early-career faculty who …
  18. Origin of Supermassive Black Hole Flares Identified: Largest-Ever Simulations Suggest Flickering Powered by Magnetic ‘Reconnection’

    February 3, 2022
    Researchers at the Flatiron Institute and their collaborators found that breaking and reconnecting magnetic field lines near the event horizon release energy from a black hole’s magnetic …
  19. ‘Quantum Friction’ Slows Water Flow Through Carbon Nanotubes, Resolving Long-Standing Fluid Dynamics Mystery

    February 2, 2022
    Flatiron Institute research fellow Nikita Kavokine and his colleagues propose that water molecules interact with electrons in the nanotube walls, so that they push and pull on one …
  20. The Challenges of Studying Elderly Animals

    January 31, 2022
    Physical and cognitive decline, along with highly variable behavior and physiological factors, complicates studies of aging.
  21. Theorists and Experimentalists Join Forces To Explore Nature’s ‘Third Kingdom’ of Particles

    January 31, 2022
    Two recent collaborations between experimental physicists and members of the Simons Collaboration on Ultra-Quantum Matter have yielded new insights into the production of the elusive particles called …
  22. Patchy Expression of Pcdh19 in Female Mice Causes Defects in Hippocampal Neuron Presynaptic Development Signaling and Memory Processing

    January 28, 2022
    Hisashi Umemori and colleagues showed that X-inactivation-based patchy expression of PCDH19 causes defects in presynaptic development and signaling in the mouse hippocampus, affecting memory processes.
  23. Simons Searchlight: December 2021 Data Release

    January 28, 2022
    New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs …
  24. More Than Funding: Career Development Opportunities Abound for Bridge to Independence Fellows

    January 28, 2022
    The Bridge to Independence Award program serves as an overall scientific support system to help early-career scientists successfully launch their independent research positions. Fellows receive a commitment …
  25. SFARI Hosts Virtual Fall 2021 Science Meeting

    January 28, 2022
    In October and November 2021, SFARI held the fall 2021 science meeting virtually. Across three webinars, nine SFARI-funded researchers discussed their latest findings in autism research to …
  26. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    January 28, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  27. SFARI 2021 Director Awards Announced

    January 27, 2022
    SFARI is pleased to announce that seven Director Awards were awarded in 2021. These projects include, but are not limited to, studies that aim to develop new tools …
  28. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    January 27, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  29. Unlocking the Secrets of Neural Circuits and Development

    January 27, 2022
    From the development of neurons to how they function, Simons Junior Fellow Raffi Cohn studies every aspect of the brain’s intricate circuitry.
  30. SPARK December 2021 Update: New Phenotypic and Genomic Data Available

    January 26, 2022
    New phenotypic and genomic data are available from participants enrolled in SPARK. Currently available data include phenotypic information from 283,520 people, including more than 111,000 individuals …
  31. High-Resolution Rodent Movement Tracking Provides the Opportunity To Link Autism Risk Genes With Behavioral Presentations

    January 26, 2022
    Bence Ölveczky, Jesse Marshall and colleagues developed a new method, CAPTURE, for long-term behavioral tracking in rodents and demonstrate its utility in tracking behaviors in Fmr1-KO …
  32. Building a New Model for Neuroscience Research

    January 26, 2022
    Four years into its run, the International Brain Lab, a collaboration among 22 labs, is demonstrating a novel approach to team-based neuroscience.
  33. A Machine-Learning Framework for Prioritizing Disease-Associated Enhancers

    January 25, 2022
    Olga Troyanskaya and colleagues developed a bioinformatics framework for the identification and prioritization of disease-associated enhancers.
  34. Mathematician Bianca Viray Invites Everyone to the Table

    January 21, 2022
    A trailblazer in her research field, Bianca Viray believes that mathematics is for everyone and works tirelessly to achieve a vision of inclusivity and diversity.
  35. Updates to SFARI’s 2022 Requests for Grant Applications

    January 13, 2022
    SFARI’s requests for grant applications (RFAs) underwent a number of changes in 2021. In 2022, we will largely continue on the course set last year. There will …
  36. MAX Interrogates Scientific Advances Through Art

    January 12, 2022
    How collaborations between scientists and artists are yielding groundbreaking, moving new works.
  37. SueYeon Chung and Alex Williams Join CCN as Project Leaders

    January 10, 2022
    … population and the encoded task information. She then joined MIT as a Fellow in Computation in the department of brain and cognitive sciences. While there, Chung applied …
  38. The Largest Suite of Cosmic Simulations for AI Training Is Now Free To Download; Already Spurring Discoveries

    January 6, 2022
    The CAMELS project uses machine learning and thousands of simulations to extract secrets from the cosmos
  39. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    December 25, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  40. Ingrid Daubechies Joins Simons Foundation Board of Directors

    December 23, 2021
    The Simons Foundation is pleased to announce that mathematician and physicist Ingrid Daubechies has joined its board of directors. Daubechies is the James B. Duke Distinguished Professor of …
  41. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    December 23, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  42. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    December 22, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  43. Reaching Across the Aisle To Find the Algorithms of Vision

    December 22, 2021
    Two styles of understanding visual processing — discriminative and generative approaches — have guided researchers on separate paths for decades but are now being brought together.
  44. What’s Behind Autism’s Apparent Rise? New Book From Spectrum Explores Condition’s Prevalence

    December 22, 2021
    … Within this section, a gatefold features highlights from the “Prevalence Map” project that lives on Spectrum’s site. Under the guidance of an advisory board of autism …
  45. Untangling the Feedback Loop Between the Genome, the Brain and Evolution

    December 21, 2021
    Simons Junior Fellow Philipp Brand began his career studying genetic variation in orchid bees. Now exploring the evolutionary underpinnings of fruit fly behavior, his long-term goal is …
  46. Simons Searchlight To Host Conference on CSNK2A1, HIVEP2, MED13L and SETBP1 Genes

    December 20, 2021
    Simons Searchlight will host the CSNK2A1, HIVEP2, MED13L and SETBP1 Family and Scientific Conference on Aug 4-7, 2022, in Baltimore. Basic and clinical researchers, carriers of these …
  47. EPICC STEMulate

    Funded Work
    Community-focused program that provides extraordinary opportunities for under-recognized and underrepresented youth
  48. SFARI 2021 Pilot Awardees Announced

    December 17, 2021
    SFARI is pleased to announce that it intends to fund 17 grants in response to the 2021 Pilot Award request for applications.
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