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Bringing people and ideas together to fund, conduct, and share transformative science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Inaugural SCGB 2021 Bridge to Independence Fellows Announced

    July 29, 2021
    The Simons Collaboration on the Global Brain (SCGB) is pleased to announce its inaugural class of Bridge to Independence (BTI) fellows.
  2. Exponentially Important: The Scientific Origins of PCR

    July 28, 2021
    … of being internally quantitative, meaning that you can count the absolute number of molecules that were in the starting material. That’s probably the next 20 years …
  3. Karin Öberg’s Search for the Chemical Basis of Planet Formation

    July 28, 2021
    With new tools offering an unprecedented view of a planet’s molecular building blocks, astrochemists are working to pin down the recipe for a habitable world.
  4. Watch: When Galaxies Collide

    July 27, 2021
    Galaxy clusters are some of the largest known structures in the universe. Astrophysicist Chris Hayward explains what happens when galaxies within those clusters collide.
  5. Magnetic ‘Balding’ of Black Holes Saves General Relativity Prediction

    July 27, 2021
    Magnetic fields around black holes decay quickly, report researchers from the Flatiron Institute, Columbia University and Princeton University. This finding backs up the so-called ‘no-hair conjecture …
  6. Studies of Women’s Longevity Offer Clues to Cognitive Resilience for All

    July 26, 2021
    Across animal species and human cultures, females outlive males and appear less susceptible to cognitive decline with age. Scientists are exploring these sex-linked differences to identify interventions …
  7. Rare Inherited Variants in Previously Unsuspected Genes May Confer Significant Risk for Autism

    July 26, 2021
    New study in Nature Genetics uses SPARK database to investigate variants that are less damaging than de novo mutations, but contribute almost as much risk.
  8. The Computational Quest To Make Communication Error-Free

    July 26, 2021
    Simons Junior Fellow Jarosław “Jarek” Błasiok, a theoretical computer scientist, seeks to make computers more efficient and accurate — even in the face of increasingly large datasets.
  9. Ultrafast Microscope Observes Quick-Moving Excitation That Could Be a Long Sought Phase of Matter

    July 21, 2021
    … harness this property, including in computers,” Rao says.
  10. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    July 21, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  11. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    July 21, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  12. Impaired Long–Range Communication and Reduced Anxiety–Related Behavior in Pogz Deficient Mice

    July 20, 2021
    Vikaas Sohal and John Rubenstein found that Pogz heterozygous mice exhibited reduced anxiety-related avoidance behavior and that this correlated with impaired communication between the ventral hippocampus and …
  13. SFARI Investigators and Affiliated Staff Appointed to the Interagency Autism Coordinating Committee

    July 20, 2021
    Three SFARI Investigators and the deputy director of Clinical Research Associates, LLC (an affiliate of the Simons Foundation) were recently appointed to serve on the Interagency Autism Coordinating …
  14. Pupil Responses Predict Reward Sensitivity and Autism Status

    July 19, 2021
    Vanessa Troiani and colleagues demonstrated a linear relationship between pupil dilation, reward/punishment sensitivity and individual ASD diagnostic status.
  15. A New Era in Neural Recording Part 2: A Flexible Solution

    July 19, 2021
    Flexible electrodes offer an alternative approach to silicon probes for high-density recordings. Both methods face challenges in how to best process data.
  16. A New Era in Neural Recording

    July 19, 2021
    Novel technologies to simultaneously record from hundreds to thousands of neurons over weeks and months grant access to the brain at an unprecedented resolution. Researchers are now tackling …
  17. Cellular System To Screen ASD Risk Gene Function

    July 19, 2021
    Robi Mitra and colleagues have developed a scalable CRISPR/Cas9 RNA sequencing assay in a human neuronal differentiation cell model, enabling high-throughput assessments of how repression of …
  18. Assessing signaling pathway- and brain region-specific alterations in Trio mouse models of autism

    Funded Work
    TRIO is among the genes most frequently impacted by damaging de novo mutations and rare variants in individuals with autism spectrum disorder (ASD), severe intellectual disability (ID), schizophrenia …
  19. Statistical analysis of autism phenotypic and genotypic data

    Funded Work
    Since the fall of 2008, Abba Krieger and colleagues (most prominently Andreas Buja) at the Wharton School of the University of Pennsylvania have served as statistical consultants to …
  20. Kelsey Martin To Lead the Simons Foundation Autism Research Initiative, Neuroscience Collaborations

    July 12, 2021
    … health volunteer in what is now the Democratic Republic of the Congo, and as editor and researcher for the Journal of Public Health in Africa. Her experiences …
  21. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    July 9, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  22. Record-Breaking Suite of Cosmic Simulations Aims To Identify Universe’s Parameters

    July 7, 2021
    The CAMELS project is the largest set of detailed cosmological simulations designed to train machine-learning algorithms.
  23. Exploring the integrated stress response as a driver of autism features

    Funded Work
    The integrated stress response (ISR) has recently emerged as a main causative driver of normal aging as well as a wide spectrum of cognitive disorders of vastly different …
  24. Microbial-based interventions in rodent models of autism: An exploratory study

    Funded Work
    Despite the increase in the prevalence of autism spectrum disorder (ASD), currently, there are no treatments that can effectively reverse ASD core features.
  25. Julianne Dalcanton Named Next Director of the Center for Computational Astrophysics

    July 6, 2021
    … Pasadena, California, before joining the University of Washington faculty in 1998. Dalcanton has received numerous recognitions for her work, including an Alfred P. Sloan Research Fellowship, a …
  26. David Spergel Takes the Helm as President of the Simons Foundation

    July 1, 2021
    … to have significant impacts,” he says. “In the long run, it will be the combination of the scientists we train and the transformative results we enable that …
  27. Pandemic Puts Mathematical Modeling Through Its Paces

    June 29, 2021
    … says Edholm. “How do people get infected and how do people get recovered? And how do you move through these infections and how do they propagate?” ‍ Getting …
  28. Announcing the Launch of Simons Foundation 2.0

    June 29, 2021
    … “Goodbye” but like a “See you soon.” We will remain close by and will eagerly follow this new stage of the Simons Foundation, led by David Spergel …
  29. SFARI Workshop Explores the Use of Rat Models in Autism Research

    June 28, 2021
    On April 26 and 29, 2021, SFARI and the Simons Initiative for the Developing Brain hosted a virtual workshop that focused on the use of rats as a …
  30. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    June 28, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  31. Molecular Clocks Offer New Insight Into Aging

    June 28, 2021
    Epigenetic clocks capture aging processes at the molecular level. Now, researchers grapple with how they work and what they mean.
  32. Our Cells Often Behave in Unpredictable and Unknown Ways

    June 28, 2021
    Molecular biologist and Simons Junior Fellow Naama Aviram works to understand how individual cells function — a more mysterious process than often appreciated. Beyond the sheer lure of scientific …
  33. Foundation Announces the Simons Collaboration on Learning the Universe

    June 24, 2021
    … neural-net likelihood, simulation-based or likelihood-free inference techniques that have the potential to fully exploit the enormous amount of information from upcoming observational surveys. By …
  34. Foundation Announces the Simons Collaboration on Global Categorical Symmetries

    June 24, 2021
    The Simons Foundation is pleased to announce the establishment of the Simons Collaboration on Global Categorical Symmetries, directed by Constantin Teleman of the University of California, Berkeley. This …
  35. SFARI Continues Support of Summer Undergraduate Research Program

    June 22, 2021
    In conjunction with leading universities across the county, SFARI works to provide undergraduates with an opportunity to advance their careers in autism science while promoting diversity in the …
  36. Robbert Dijkgraaf Joins Simons Foundation Board of Directors

    June 22, 2021
    The Simons Foundation is pleased to announce that mathematical physicist Robbert Dijkgraaf has joined its board of directors. Dijkgraaf is director of and Leon Levy Professor at the …
  37. CCQ Hosts Virtual Electronic Structure Conference: July 12–July 15

    June 10, 2021
    The 33rd Annual Workshop on Recent Developments in Electronic Structure Methods (ES21) will be hosted online by the Center for Computational Quantum Physics (CCQ), Flatiron Institute, July 12 …
  38. Connecting the Family Tree of Mathematics: A Profile of Andrei Okounkov

    June 10, 2021
    Known for his extraordinary ability to bridge disparate fields, mathematician Andrei Okounkov finds connections everywhere he goes.
  39. 2021 Autism BrainNet Appreciation Award: Recipients Announced

    June 9, 2021
    SFARI announces the recipients of the Autism BrainNet Appreciation Award, a new honor that recognizes outstanding partners and collaborators for their dedication to advancing brain tissue research in …
  40. 10 Years of Simons Searchlight: Advancing Research on Autism and Genetic Neurodevelopmental Conditions

    June 7, 2021
    Ten years after its launch, Simons Searchlight counts a community of 4,000 families, encompassing more than 150 genetic neurodevelopmental conditions. Thanks to the dedicated, highly motivated families …
  41. The Challenges of Proving Predictive Coding

    June 3, 2021
    Despite renewed attention, definitive conclusions remain elusive for a decades old theory of how the visual system may work in reverse.
  42. Regulation and reversibility of DNA methylation changes associated with autism spectrum disorders

    Funded Work
    Accumulating evidence indicates that autism spectrum disorder (ASD) susceptibility mutations are frequently found within genes encoding chromatin regulators that control the expression of genes across the genome.
  43. SFARI Presentations at INSAR 2021 Virtual Annual Meeting

    May 26, 2021
    The International Society for Autism Research (INSAR) Virtual 2021 Annual Meeting was held May 3–7, 2021. A selection of presentations by SFARI Investigators, SFARI staff and collaborators …
  44. The Arcane Research That Prepared Us for COVID-19

    May 25, 2021
    … medical and technological breakthroughs now central to the world’s pandemic response. With support from the Kavli Foundation and the Simons Foundation, the Science Philanthropy Alliance has …
  45. Decoding How We Make Quick Decisions

    May 25, 2021
    Simons Junior Fellow Michael Waskom studies what happens in the brain when we need to decide something quickly, like whether to cross the street against a red light …
  46. Mitochondrial Deficiency and Fragile X Syndrome

    May 24, 2021
    Elizabeth Jonas and colleagues identified a molecular mechanism underlying the contributions of mitochondrial dysfunction to the synaptic and behavioral features associated with fragile X syndrome.
  47. Neural Circuitry of Sociability in Mice

    May 24, 2021
    Hirofumi Morishita and colleagues showed that juvenile social isolation leads to deficits in adult mouse sociability via reduced activation of a prefrontal-paraventricular thalamus circuit.
  48. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    May 24, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
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