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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. SFARI Annual Meeting Held at Foundation

    October 14, 2014
    SFARI held its sixth annual meeting, bringing together some 150 SFARI-supported autism researchers in an effort to advance the understanding of autism, improve its diagnosis and better …
  2. SFARI hosts Simons VIP Connect 2014 family gathering

    August 27, 2014
    The meeting brought together families with a child carrying deletions or duplications in chromosomal region 16p11.2 and researchers studying 16p11.2.
  3. SFARI’s funding priorities for the upcoming year

    August 12, 2014
    On 2 September, we plan to announce a new request for applications. Letters of intent, the short statements that precede full applications, are due no later than 10 …
  4. SFARI holds workshop on 16p11.2

    July 15, 2014
    On 12 and 13 June, the Simons Foundation Autism Research Initiative (SFARI) held its second workshop on 16p11.2 deletion and duplication. A total of 62 participants from …
  5. SFARI Aids in Mouse Model Availability

    July 3, 2014
    Mouse models provide an essential platform for studying the neural circuits underlying autism spectrum disorders.
  6. It Takes Brains: Simons Foundation, Autism Speaks and Autism Science Foundation launch Autism BrainNet registration site

    May 27, 2014
    New collaboration will collect critically needed brain tissue for autism research
  7. Autism: What we know. What is next?

    May 1, 2014
    SFARI’s chief scientist, Gerald Fischbach, provides an overview of what we know and what we need to learn about autism and related developmental disorders. We hope this …
  8. SFARI’s Wendy Chung at TED2014 Conference: What We Know About Autism

    April 25, 2014
    SFARI director of clinical research Wendy Chung presented What We Know About Autism to those gathered in Vancouver, Canada, for the TED2014 conference on March 19, 2014. The …
  9. SFARI’s priorities, funding decisions for 2014 grants cycle

    September 3, 2013
    Today, we’re announcing a new request for applications. Letters of intent, the short statements that precede full applications, are due no later than 11 October. It seems …
  10. Louis F. Reichardt to Direct Simons Foundation Autism Research Initiative

    May 16, 2013
    The Simons Foundation is pleased to announce that Louis F. Reichardt of the University of California, San Francisco (UCSF) will become the next director of the Simons Foundation …
  11. Workshop report: Online phenotyping

    April 9, 2013
    For individuals with autism, a trip to the clinic — an unfamiliar place with strange people and instruments — can be exceedingly stressful. And as many genetic databases for autism …
  12. Rho family of enzymes at crossroads of autism

    March 12, 2013
    A number of autism risk factors converge on one cellular pathway: abnormal remodeling of the cell’s structural systems through the signaling protein Rho, says SFARI’s associate …
  13. Workshop report: Glia’s role in autism

    February 12, 2013
    Glia were once thought to play a secondary role to neurons in the brain. But studies in the past few years have shown that they may be involved …
  14. Workshop report: Developmental neurobiology of autism

    November 6, 2012
    Converging lines of evidence suggest that the earliest events in brain development play a role in autism. On 12 September, the Simons Foundation Autism Research Initiative brought together …
  15. Challenging choices: How we make funding decisions

    October 30, 2012
    Which grant applications should SFARI choose to fund each year? The principles that guide that decision are nuanced and evolve as new results emerge. But there are some …
  16. Pick of the litter

    September 25, 2012
    New genetic variants that increase susceptibility to autism are emerging at a rapid pace. Given the profusion of data, it seems timely to assess the availability and usefulness …
  17. Workshop report: 16p11.2 deletions and duplications

    August 7, 2012
    The chromosomal region 16p11.2, which spans about 29 genes, is strongly linked to autism.  On 27 April, SFARI hosted a workshop to discuss the consequences of duplications …
  18. Workshop report: Regression in autism

    April 17, 2012
    Studies suggest that a subset of children with autism make significant social and language gains in the first year of life, and then experience a dramatic loss of …
  19. RAS pathway, a potentially unifying theory of autism

    March 13, 2012
    Dysregulation of the intracellular signaling pathway RAS, a risk factor for idiopathic autism, may provide a unifying theory of the disorder. Although this is not an altogether new …
  20. Celebrating a milestone in autism research

    December 14, 2011
    More than 100 investigators and clinicians who worked together on the Simons Simplex Collection gathered in New York City to celebrate their landmark achievement in autism research.
  21. Workshop report: Biomarkers for autism research

    October 4, 2011
    Researchers can use biomarkers to diagnose individuals with autism and to hone in on the underlying causes of the disorder. In July, SFARI held an informal meeting of …
  22. The Simons Simplex Collection’s inaugural paper published in Neuron

    August 22, 2011
    SFARI scientific director Gerald Fischbach and principal investigator Catherine Lord of the University of Michigan published The Simons Simplex Collection: A Resource for Identification of Autism Genetic Risk …
  23. SFARI announces new phase for Simons Simplex Collection

    August 19, 2011
    In a milestone for the autism research community, SFARI has finished recruiting families to participate in the Simons Simplex Collection (SSC). The foundation has now shifted from recruitment …
  24. Workshop report: Oxytocin and autism

    May 19, 2011
    Preliminary studies suggest that the so-called ‘love hormone’ oxytocin could improve some of the social deficits characteristic of people with autism. On 11 April, SFARI hosted a …
  25. Workshop report: Attention deficits in autism

    May 3, 2011
    Children with autism often have behaviors that suggest problems with attention. It is unclear whether this attention deficit causes the other symptoms of autism or is a consequence …
  26. SFARI announces Explorer Awards program

    April 14, 2011
    SFARI is pleased to announce the SFARI Explorer Awards program: an initiative designed to provide timely support to innovative, high-risk experiments relevant to our mission.
  27. Difficult decisions: An inside look at SFARI’s grant-making

    April 11, 2011
    In November, the Simons Foundation Autism Research Initiative (SFARI) launched a request for applications, calling for letters of intent from individuals who will conduct bold, imaginative and rigorous …
  28. Workshop report: Assays for mouse models of autism

    March 23, 2011
    Researchers need reliable methods to interpret autism candidate genes, including rodent models to assess the impact of genes on behavior. On 4 February, SFARI hosted a workshop to …
  29. A cautionary tale, and a case for evaluating autism genes

    February 1, 2011
    A study on a SHANK3 mutation highlights the danger in using research tools to inform decision-making in the doctor’s office. This sort of concern is one …
  30. UBE3A: What the HECT goes on in the brain?

    September 29, 2010
    Several studies have shown that a micro-duplication within 15q11-13 — a region on chromosome 15 — on the maternal chromosome is associated with autism. The duplicated region contains …
  31. Workshop report: Neural circuits

    June 22, 2010
    Much of the recent advances in autism have been on the genetic and behavioral levels of dysfunction present in the disorder. Comparatively little is known about altered function …
  32. Workshop report: Fever and autism

    April 1, 2010
    On 5 February 2010, the Simons Foundation gathered a panel of experts to discuss what initially appears to be a surprising and unrelated pair of subjects: autism and …
  33. SFARI Gene launches animal model module

    March 25, 2010
    Sharmila Banerjee-Basu, founder and president of Mindspec Inc., and Alan Packer, associate director for research at SFARI, have published an article describing a new SFARI Gene module …
  34. Workshop Report: Sequencing

    January 22, 2010
    As the number of available DNA samples continues to increase and the cost of sequencing continues to drop, one can’t help but want to capture all of …
  35. Director’s column: Fever’s promising puzzle

    January 11, 2010
    Fever has benefits beyond its role in fighting infection. According to a prospective study published in 2007 and to many anecdotal reports, fever can improve cognitive function and …
  36. Director’s column: The gene-cognition gap

    October 8, 2009
    Autism research has attracted a remarkable diversity of scholars. Many of them have developed an understanding of concepts in fields that are not their own, but it is …
  37. SFARI Gene launches

    February 24, 2009
    The SFARI team is pleased to announce the launch of SFARI Gene, a new online tool for autism researchers.
  38. Workshop report: The cognitive phenotype in autism

    October 1, 2008
    Autism is a developmental disorder characterized by impaired social interaction and communication, and restricted and repetitive behavior. Because there are no biological markers for the disorder, it is …
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