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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCB Colloquium: Ramin Golestanian

    Colloquium
    Presenter: Ramin Golestanian, Ph.D. Max Planck Institute for Dynamics and Self-Organization in Göttingen and Oxford University Title: A classical analogue of Bose-Einstein condensation in active …
  2. Systems Biology Group Meeting

    Meeting
    Presenter: Sonya Hanson, Ph.D., Structural & Molecular Biophysics Collaboration, Center for Computational Biology Title: Elucidating mechanisms of biological temperature sensing Abstract: Despite the existence of engineered thermometers since …
  3. Drosophila Journal Club

    Meeting
    Discussion Leads: Hayden Nunley & Binglun Shao Paper: Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs
  4. CCB Brown Bag Seminar

    Seminar
    1st Speaker: Jaspreet Singh, Ph.D., Flatiron Research Fellow, Developmental Dynamics Title: Biophysics of Arrested Furrows Absrtact: Cell division is often incomplete in early-stage gametogenesis: instead of …
  5. Systems Biology Group Meeting

    Meeting
    Presenter: Lingdi Zhang, Ph.D. Candidate, New York University Title: Characterization of the respiratory tract microbiome in influenza infection Abstract: Recent studies have shown that the microbiome of …
  6. CCB Colloquium: Benjamin B. Machta

    Colloquium
    Presenter: Dr. Benjamin B. Machta, Ph.D. Assistant Professor of Physics Yale University Title: Surface densities prewet a nearly critical membrane. Abstract: Proteins and nucleic acids can phase …
  7. Systems Biology Group Meeting

    Meeting
    Presenter: Lingdi Zhang
  8. Drosophila Journal Club

    Meeting
    Speaker: Rohit Supekar, MIT Paper: https://arxiv.org/pdf/2101.06568.pdf
  9. Brown Bag Seminar

    Seminar
    Speaker: Richard Bonneau, Ph.D., Group Leader, Systems Biology Topic: “Mad max-pool beyond thunder-matrix: biology in a post alignment world.”
  10. Systems Biology Group Meeting

    Meeting
    Presenter: Ren Yi, Ph.D. Candidate, New York University Title: Multitask learning methods for efficient learning of data poor problems in biology Abstract: The recent advancement in computational …
  11. CCB Colloquium: James Zou

    Colloquium
    Guest Presenter: James Zou, Ph.D. Assistant Professor, Biomedical and Data Science Stanford University Title: Computer vision to phenotype human diseases across physiological and molecular scales. Abstract: I …
  12. Systems Biology Group Meeting

    Meeting
    Presenter: Ren Yi
  13. Drosophila Journal Club

    Meeting
    Speaker: Sayantan Dutta, Princeton University
  14. Brown Bag Seminar

    Meeting
    Speaker: Maria Avdeeva, Ph.D, Associate Research Scientist, DevDy Topic: A data fusion approach to developmental patterning
  15. Systems Biology Group Meeting

    Meeting
    Presenter: Aaron Watters, Ph.D., Senior Software Engineer, Flatiron Institute Title: Landscapes of Binary Classification Ranking Abstract: This talk informally explores and compares methods for evaluating binary classification …
  16. Systems Biology Group Meeting

    Meeting
    Presenter: Andreas Tjarnberg, Postdoctoral Associate, New York University Title: Translating gene regulatory network inference into a white-box deep learning framework Abstract: Gene regulatory network (GRN) inference is …
  17. Drosophila Journal Club

    Meeting
  18. Brown Bag Seminar

    Lecture
    Speaker: Wen Yan, Ph.D. Research Scientist, Biophysical Modeling Topic: From pairwise crosslinker kinetics to collective bundling in active assemblies.
  19. Systems Biology Group Meeting

    Meeting
    Presenter: Claudia Skok Gibbs, Research Analyst, Systems Biology Group, Center for Computational Biology, Flatiron Institute Title: Learning cell-type-specific single-cell gene regulatory networks in the developing …
  20. Drosophila Journal Club

    Meeting
  21. Drosophila Journal Club

    Meeting
    Speaker: Elizabeth T. Ables, Ph. D., Associate Professor, Dept. of Biology, East Carolina University Topic: Counting cell divisions in the Drosophila germline.
  22. Brown Bag Seminar

    Seminar
    Presenter: Aaron Wong, Ph.D., Data Scientist & Project Leader, Genomics Topic: HumanBase – a platform for data-driven predictions in human molecular biology
  23. Systems Biology Group Meeting

    Meeting
    Presenter: Douglas Renfrew
  24. CCB Colloquium: Stefano Di Talia

    Colloquium
    Guest Presenter: Stefano Di Talia, Ph.D. Associate Professor of Cell Biology Duke University School of Medicine Topic: Waves and flows in embryogenesis and regeneration Abstract: Embryonic development …
  25. Systems Biology Group Meeting

    Meeting
    Presenter: Anders Rasmussen, Associate Software Engineer, Systems Biology Group, Center for Computational Biology. Title: Inferring Regulatory Dynamics from Pseudotemporally Ordered Single Cell Data Abstract: Single-cell RNA-seq …
  26. CCB Seminar: Dr. Madhav Mani

    Seminar
    Presenter: Madhav Mani, Ph.D., Assistant Professor of Engineering Sciences and Applied Mathematics Northwestern University Topic: Descartes’ Duck and Picasso’s Bull Abstract: The Duck of Vaucanson served …
  27. CCB Colloquium: Justin Kinney

    Colloquium
    Presenter: Justin B. Kinney, Ph.D., Assistant Professor Simons Center for Quantitative Biology Cold Spring Harbor Laboratory Topic: Massively Parallel Reporter Assays, Machine Learning, and the Biophysics of …
  28. Systems Biology Group Meeting

    Meeting
    Presenter: Julia Kohler Leman, Ph.D., Systems Biology Group, Center for Computational Biology Title: Mapping the microbiome by large-scale structure and function prediction Abstract: The microbiome consists …
  29. Systems Biology Group Meeting

    Meeting
  30. Brown Bag Seminar

    Lecture
    Topic: Cilia, collectively
  31. Systems Biology Group Meeting

    Meeting
    Presenter: Jamie Morton, Ph.D., Systems Biology Group, Center for Computational Biology Inferring Principal Components in the Simplex with Multinomial Variational Autoencoders Covariance estimation on high-dimensional data …
  32. Brown Bag Seminar

    Lecture
  33. CCB Colloquium: Sushmita Roy

    Lecture
    Speaker: Dr. Sushmita Roy, Ph.D., Assistant Professor, Department of Biostatistics and Medical Informatics Wisconsin Institue for Discovery / University of Wisconsin, Madison Topic: Network-based approaches for examining …
  34. CCB Special Lecture Series with Michael Chertkov

    Lecture
    Machine learning and artificial intelligence play an increasingly critical role in modern science. This lecture series will provide an introductory tutorial on these methods for researchers interested in …
  35. Biophysical Modeling Group Meeting

    Meeting
  36. Special Seminar: Evelyn Tang

    Seminar
    Guest Presenter: Evelyn Tang, Ph.D., Group Leader, Department of Living Matter Physics Max Planck Institute of Dynamics and Self-Organization Title: Surfacing robust function in living matter …
  37. Brown Bag Seminar

    Lecture
    Speaker: Pilar Cossio, Ph.D., Tandem Group Leader, Max Planck Institute of Biophysics & and University of Antioquia Topic: Recovering the rates from metadynamics simulations Abstract: Metadynamics enables the …
  38. Biophysical Modeling Group Meeting

    Meeting
  39. Biophysical Modeling Group Meeting

    Meeting
  40. Brown Bag Seminar

    Lecture
    Topic: Machine learning approaches for disease genomics
  41. Biophysical Modeling Group Meeting

    Meeting
  42. CCB Colloquium: Elena F. Koslover

    Colloquium
    Guest Presenter: Dr. Elena F. Koslover, Ph.D., Assistant Professor, Department of Physics University of California, San Diego
  43. Biophysical Modeling Group Meeting

    Lecture
    Talk Topic: A Higher-Order Spectral Analysis of Active Suspensions
  44. Brown Bag Seminar

    Lecture
    Topic: Modeling single-cell gene regulatory networks with the Inferelator.
  45. Biophysical Modeling Group Meeting

    Meeting
    Lab meeting is canceled today
  46. Systems Biology Group Meeting

    Lecture
    A Graph Interpretation of the Cyclic Peptoid Conformational Energy Landscape Cyclic peptoids are known to adopt various stable conformations, but the details of their complex energy landscape have …
  47. Biophysical Modeling Group Meeting

    Meeting
    Topic: General Discussion
  48. Brown Bag Seminar

    Lecture
    Title: Biologically plausible circuits for segmenting time-series data
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