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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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  • Newsletter Sign Up
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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Maternal COVID-19 As a Potential Risk for Autism: Supplemental Funding for Ongoing Pregnancy Cohorts — Request for Applications

    Funding Opportunity
    Several prospective pregnancy cohorts, across multiple continents, were recruited during the COVID-19 pandemic. These cohorts afforded the opportunity to better understand the impact of maternal infection and …
  2. SFARI Collaboration on Sex Differences in Autism - Request for Applications 2021

    Funding Opportunity
    … D.M. Biol. Sex Differ. 7, 58 (2016) PubMed Doan R.N. et al. Nat. Genet. 51, 1092–1098 (2019) PubMed Baron-Cohen S. et al. Mol …
  3. Research Award - Request for Applications 2020

    Funding Opportunity
    The goal of the Research Award was to provide support for investigation of key unresolved research questions in autism, particularly those that connect genetic etiologies to brain function …
  4. Novel Outcome Measures in ASD — Request for Applications

    Funding Opportunity
    Intervention studies for autism spectrum disorder (ASD) are hampered by a lack of reliable and sensitive measures to assess treatment response, whether the interventions are behavioral or pharmacological …
  5. SPARK Clinical Site Network — Request for Applications

    Funding Opportunity
    The overall goal of SPARK (Simons Foundation Powering Autism Research for Knowledge) is to recruit, engage and retain a research community of at least 50,000 individuals in …
  6. Genomic Analysis for Autism Risk Variants in SPARK – Request for Applications

    Funding Opportunity
    SPARK (Simons Foundation Powering Autism Research) is an autism research initiative that aims to recruit, engage and retain a community of 50,000 individuals with autism and their …
  7. NSF-Simons MathBioSys Research Centers

    Funding Opportunity
    The NSF-Simons Research Centers for Mathematics of Complex Biological Systems (MathBioSys) initiative created innovative, collaborative research centers at the intersection of mathematics and molecular, cellular and organismal …
  8. Whole-Genome Analysis for Autism Risk Variants

    Funding Opportunity
    … 400 TB) available to their academic or cloud-based computing resources. SFARI understood that validation of prioritized hits was a key part of this project and coordinated …
  9. Functional Screen of Autism-Associated Variants Request for Applications

    Funding Opportunity
    Grants awarded through this request for applications (RFA) were intended to advance our understanding of the genetic basis of autism, and in particular the potential role of missense …
  10. Innate Immune System Impact Request for Applications

    Funding Opportunity
    Grants awarded through this request for applications (RFA) were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic …
  11. Circuit Dynamics Request for Applications

    Funding Opportunity
    This request for applications (RFA) was intended to advance our understanding of the circuit basis for behavioral and cognitive alterations relevant to autism spectrum disorders (ASD). The goal …
  12. Analysis of Simons VIP Biospecimens Request for Applications

    Funding Opportunity
    The Simons Variation in Individuals Project (now known as Simons Searchlight) comprises a large cohort of individuals with a deletion or duplication of chromosomal segment 16p11.2 (approximately …
  13. NSF-Simons Research Collaborations on the Mathematical and Scientific Foundations of Deep Learning

    Funding Opportunity
    The two NSF-Simons Research Collaborations on the MoDL support research activities focused on a particular set of topics involving some of the most challenging questions in the …
  14. Simons Fellows in Theoretical Physics

    Funding Opportunity
    The Simons Fellows program in Theoretical Physics provides funds to faculty for up to a semester-long research leave from classroom teaching and administrative obligations.
  15. Mouse Phenotyping Request for Applications

    Funding Opportunity
    To maximize the ability to make direct comparisons among mouse models, this request for applications sought applications for systematic, rigorous and scalable analyses of behavioral phenotypes across multiple …
  16. Explorer Awards — Request for Applications

    Funding Opportunity
    This award program was designed to enhance our existing support of autism research by providing timely resources to enable high-risk/high-impact, exploratory experiments relevant to our …
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