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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Principles of Microbial Ecosystems
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCB Colloquium: Thierry Emonet

    Colloquium
    Topic: Conflicts and synergies between individuality and collective behavior Cells live in communities where they interact with each other and their environment. By coordinating individuals, such interactions often …
  2. CCB Seminar: Yuhai Tu

    Seminar
    Topic: Nonequilibrium Statistical Physics of Biochemical Oscillators: Phase Accuracy, Entrainability, and Synchronization Abstract: A central question in biology is how living systems manage to process information and perform …
  3. Neuroscience Group Meeting

    Meeting
    Canonical Correlation Analysis model of the cortical microcircuit Yanis Bahroun and David Lipshutz will be leading a discussion on extensions of Canonical Correlation Analysis to more than two …
  4. CCB Colloquium: Michael Hiller

    Colloquium
    Presenter: Michael Hiller, Max Planck Institute, Dresden Topic: Linking phenotypic differences between species to differences in genes and cis-regulatory elements Identifying the DNA changes that underlie phenotypic …
  5. Neuroscience Group Meeting

    Lecture
    Topic: Clustering time series in the brain: connections to information theory, canonical correlations, and cepstra Sensory information reaches the brain as a stream with non-trivial correlations across …
  6. CCB Colloquium: Joakim Lunderberg

    Colloquium
    Title: Molecular maps in tissue and disease by data-driven analysis of spatially resolved transcriptomes in situ. Abstract: RNA-sequencing offers the possibility to analyze the expression of …
  7. Systems Biology Group Meeting

    Meeting
    Presenter: Michelle Badri, Ph.D. Candidate New York Univesity Title: Applying natural language processing methods to building models of the microbiome Integrating datasets from multiple “omic” datasets is …
  8. CCB Colloquia Schedule

    Event
  9. Brown Bag Seminar

    Lecture
    Speaker: Jamie Morton Topic: Learning representations of microbe–metabolite interactions
  10. Biophysical Modeling Group Meeting

    Meeting
    Title: Self-organisation of bidirectional microtubule networks is robust: a mathematical framework and validation in Drosophila. You and I are but a collection of trillions of cells. Why …
  11. Systems Biology Group Meeting

    Meeting
    Title: Methods for analysis of spatial transcriptomics data with application to amyotrophic lateral sclerosis Spatial genomics technologies enable new approaches to study how cells interact and function in …
  12. Neuroscience Group Meeting

    Meeting
    Speaker: Nicholas Chua Topic: Feedback on figures for the lamina paper
  13. Systems Biology Group Meeting

    Lecture
    … unexplored mechanism through which environmental influences (viral infection) and human genetics can synergize to influence human disease.
  14. Neuroscience Group Meeting

    Meeting
    Speaker: Siavash Golkar Topic: ‘Towards a biological CCA circuit’
  15. CCB Brown Bag Seminar

    Lecture
    Topic: Towards the theory of neuronal computation
  16. Biophysical Modeling Group Meeting

    Meeting
    Presenter #1: Matthew Morse Topic: Scalable Simulation of Realistic Volume Fraction Red Blood Cell Flows through Vascular Networks Presenter #2: XinXin Du Topic: Collective behaviors in tissues
  17. Systems Biology Group Meeting

    Meeting
    Presenter: Ren Yi Title: Learning from Data-Rich Problems: case studies on genetic variant calling and transcription factor binding site prediction. Highly-skewed data are commonly seen in …
  18. Neuroscience Group Meeting

    Meeting
    Speaker: Anirvan Sengupta Topic: Broad overview of kernel methods
  19. CCB Colloquium: Chao Tang

    Colloquium
    Presenter: Chao Tang, Ph.D., Center for Quantitative Biology, Peking University Topic: Bacteria, stem cells, and fruit flies: a physicist in biology It is an exciting time for …
  20. Inter-Group Workshop (BPM & Genomics)

    Workshop
  21. CCB Colloquia Schedule

    Event
  22. Biophysical Modeling Group Meeting

    Meeting
  23. Systems Biology Group Meeting

    Meeting
  24. Neuroscience Group Meeting

    Meeting
    Presenter: Charles Windolf Topic: “Segmentation-enhanced CycleGAN” and its potential use in our automated segmentation pipeline
  25. Brown Bag Seminar

    Seminar
  26. Biophysical Modeling Group Meeting

    Lecture
    Presenter: Gokberk Kabacaoglu Topic: Machine-learning-augmented reduced model for simulations of Stokesian suspensions Particulate Stokesian flows describe the hydrodynamics of rigid or deformable particles in Stokes flows …
  27. Systems Biology Group Meeting

    Lecture
    Presenters: Claudia Skok Gibbs, Research Analyst, Systems Biology Chris Jackson, Postdoctoral Research Associate, New York University Topic: Gene Regulatory Network Inference with the Inferelator Understanding how gene expression …
  28. Geoff Goodhill Seminar

    Lecture
    Topic: The development of neural coding in the zebrafish tectum, and a new statistical model for separating evoked and spontaneous activity. Abstract: During early life, the neural code …
  29. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Quentin Brosseau, Ph.D. New York University. Topic: Janus nanorods: a recap.
  30. Neuroscience Group Meeting

    Meeting
    Title: Exploration & extension of the similarity matching framework: feature learning & nonlinear methods & transformation learning
  31. Brown Bag Seminar

    Lecture
    Title: Tissue-specific enhancer functional networks for associating distal regulatory regions to disease Abstract: Understanding disease-associated dysregulation of enhancers has the potential to reveal pathogenic signals, yet …
  32. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Yuan-nan Young Topic: Hydrodynamics of an active droplet and their suspension
  33. Neuroscience Group Seminar

    Lecture
    Talk Title: Spike-Based AI Hardware Deep Neural Networks (DNNs) replace the brain’s spike-trains with instantaneous rates that are updated once every time-step. They have …
  34. Genomics Group Meeting

    Meeting
  35. Neuroscience Group Meeting

    Meeting
    Presenter: David Lipshutz Title: Journal club presentation: Neural network learning of optimal Kalman prediction and control Description: We discuss the paper “Neural network learning of optimal Kalman prediction …
  36. Brown Bag Seminar

    Lecture
    Title: Developing sequence-based deep learning models: software and applications Abstract: Networks trained on high-throughput sequencing data (for example, ChIP-seq), or ‘sequence-based models’, have become …
  37. CCB Colloquium: David Blei, Ph.D.

    Lecture
    Topic: Scaling and Generalizing Bayesian Inference Abstract: A core problem in statistics and machine learning is to approximate difficult-to-compute probability distributions. This problem is especially important …
  38. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Brato Chakrabarti Department of Mechanical and Aerospace Engineering, University of California San Diego Title: Viscous Dynamics of Passive and Active Microfilaments
  39. Neuroscience Group Meeting

    Meeting
  40. Neuroscience Group: Guest Speaker

    Lecture
    Speaker: Romain Cosentino – Ph.D. Student at Rice University Learnable Group Transform for End-to-End Deep Learning
  41. Brown Bag Seminar

    Lecture
    Title: Computation of signal whitening by the olfactory system
  42. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Wen Yan, Ph.D. Flatiron Research Scientist
  43. 3D Nucleome Workshop

    Workshop
    The Center for Computational Biology at the Flatiron Institute in New York City will hold a two-day workshop, “The 3D Nucleome”, intended to bring together researchers working …
  44. Neuroscience Group Meeting

    Meeting
    Speaker: Jiahao Fan will be presenting a paper by Bara A. Bawan, Matthew S. Creamer, Jacob A. Zavatone-Veth and Damon A. Clark Dynamic nonlinearities enable direction opponency …
  45. CCB Colloquium: Anette Hosoi

    Colloquium
    Flexible slender structures inflow are everywhere. While a great deal is known about individual flexible fibers interacting with fluids, considerably less work has been done on fiber ensembles …
  46. BPM Seminar: Bryan Kaye

    Seminar
    Presenter: Bryan Kaye, Chief Executive Officer, CrossnoKaye An industrial automation company that develops control systems and algorithms that employ quantitative models of large facilities to optimize their energy …
  47. Brown Bag Seminar

    Lecture
    Title: Methods for Studying Evolution The origin and evolution of life on our planet is a fundamental question in biology. Aside from being a natural curiosity, evolutionary studies …
  48. CCB Brown Bag Seminar

    Lecture
    Title: Hydrodynamics and taxis of microswimmers The habitats of microswimmers are crowded with obstacles, biofilms, predators and preys. Microorganisms have evolved to thrive in these environments, however, many …
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