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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCB Brown Bag Seminar

    Seminar
  2. 2024 Simons Collaboration on Ultra Quantum Matter Annual Meeting

    Conference
    … of Emergent Collective Correlations January 19, 2024 Ruben Verresen | Gauss Law As SPT-Stabilizer: From Superconductors to Intrinsically Gapless Topological Matter January 19, 2024 Senthil Todadri | Fractional …
  3. Genomic Pillars of the Social Brain

    Lecture
    Our social brains have given rise to traits that have shaped life on our planet, enabling agriculture, construction, governance, language, manufacture and warfare. These traits are best known …
  4. Machine Learning at the Flatiron Institute Seminar: Francois Lanusse

    Seminar
    Title: Merging Deep Learning with Physical Models for the Analysis of Cosmological Galaxy Surveys Abstract: As we move towards the next generation of galaxy surveys, our field is …
  5. Structural & Molecular Biophysics Group Meeting

    Meeting
  6. Genomics Group Meeting

    Meeting
  7. Biophysical Modeling Group Meeting

    Meeting
  8. CCA Colloquium: Thebe Medupe

    Colloquium
    Title: African Astronomy in the last 400 years Abstract: African peoples created empires such as the Mali, Ghana, Great Zimbabwe and Zulu empires in the last 1000 years …
  9. CCB Colloquium: Jian Zhou, Ph.D., UT Southwestern Medical Center

    Colloquium
  10. Biophysical Modeling Group Meeting

    Meeting
  11. 2024 Simons Collaboration on Arithmetic Geometry, Number Theory, and Computation Annual Meeting

    Conference
    … describe how to recover the canonical model of a genus 4 curve from its period lattice. As an application, Schiavone will show how this can be used …
  12. Genomics Group Meeting

    Meeting
  13. Structural & Molecular Biophysics Group Meeting

    Meeting
  14. Biophysical Modeling Group Meeting

    Meeting
  15. DMFT-QE Symposium: January 8

    Symposia
    … peculiarities of the proposed approaches. While all of them rely on a selective analysis of the Schwinger-Dyson (or the Bethe-Salpeter) equation, the methodological differences originate …
  16. Biophysical Modeling Group Meeting

    Meeting
  17. Genomics Group Meeting

    Meeting
  18. Biophysical Modeling Group Meeting

    Meeting
  19. CCA Colloquium Schedule

    Colloquium
    Select Fridays From 3:00pm to 4:00pm in the 5th floor classroom, followed by a reception outside the 5th-floor conference room from 4:00pm – 5:30pm
  20. Online Community Meeting for Calcium and Voltage Imaging Analysis

    Event
    The first open Community Meeting for Calcium and Voltage Imaging Analysis using Caiman, Fastplotlib, and Mesmerize. Come and chat with developers and users about where things are, and …
  21. Online Community Meeting for Calcium and Voltage Imaging Analysis

    Event
    The first open Community Meeting for Calcium and Voltage Imaging Analysis using Caiman, Fastplotlib, and Mesmerize. Come and chat with developers and users about where things are, and …
  22. Online Community Meeting for Calcium and Voltage Imaging Analysis

    Event
    The first open Community Meeting for Calcium and Voltage Imaging Analysis using Caiman, Fastplotlib, and Mesmerize. Come and chat with developers and users about where things are, and …
  23. Structural and Molecular Biophysics Group Meeting

    Meeting
  24. Genomics Group Meeting

    Meeting
  25. Developmental Dynamics Group Meeting

    Meeting
  26. Mechanics of Life II: Models and Methods

    Workshop
    From the active metropolis inside each living cell to the vibrant dynamics of motile microorganisms, mechanical insights continue to advance our understanding of the living world. Hosted by …
  27. Online Community Meeting for Calcium and Voltage Imaging Analysis

    Event
    The first open Community Meeting for Calcium and Voltage Imaging Analysis using Caiman, Fastplotlib, and Mesmerize. Come and chat with developers and users about where things are, and …
  28. Genomics Group Meeting

    Meeting
  29. Radiation Transport in Astrophysics

    Event
  30. Structural and Molecular Biophysics Group Meeting

    Meeting
  31. Biophysical Modeling Group Meeting

    Meeting
  32. Developmental Dynamics Group Meeting

    Meeting
  33. CCA Colloquium: Raffaella Margutti

    Lecture
    CCA Colloquium stake place on select Fridays From 3:00pm to 4:00pm in the 5th floor classroom, followed by a reception outside the 5th-floor conference room …
  34. CCB Seminar: A Bayesian Framework for Cryo-EM Heterogeneity Analysis using Regularized Covariance Estimation (Marc Gilles, Ph.D., Princeton University)

    Seminar
    Speaker: Marc A. Gilles (Princeton University) Title: A Bayesian Framework for Cryo-EM Heterogeneity Analysis using Regularized Covariance Estimation Abstract: Proteins and the complexes they form are central …
  35. CCB Colloquium: Finding all our switches: biophysics at scale to globally map and understand allosteric communication in proteins (Ben Lehner, Ph.D., Wellcome Sanger Institute)

    Colloquium
    … therapeutic target. Allosteric propagation is particularly effective across the central beta sheet of KRAS and multiple surface pockets are genetically-validated as allosterically active, including a distal …
  36. Black Holes on Broadway: The Next Generation of AGN Models in Galaxy Formation 

    Conference
    … out with any specific needs you may have. You can view slides from this event HERE
  37. Human Sleep Genetics

    Lecture
    Sleep is critical for health, and chronic sleep disruption increases the risk of virtually every disease. In 2012, modern human genetics was applied to understanding the genetics and …
  38. Online Community Meeting for Calcium and Voltage Imaging Analysis

    Event
    The first open Community Meeting for Calcium and Voltage Imaging Analysis using Caiman, Fastplotlib, and Mesmerize. Come and chat with developers and users about where things are, and …
  39. Black Holes on Broadway: The Next Generation of AGN Models in Galaxy Formation 

    Conference
    … out with any specific needs you may have. You can view slides from this event HERE
  40. Structural and Molecular Biophysics Group Meeting

    Meeting
  41. Genomics Group Meeting

    Meeting
  42. Biophysical Modeling Group Meeting

    Meeting
  43. Black Holes on Broadway: The Next Generation of AGN Models in Galaxy Formation 

    Conference
    … out with any specific needs you may have. You can view slides from this event HERE
  44. Developmental Dynamics Group Meeting

    Meeting
  45. Measure Transport, Diffusion Processes and Sampling Workshop

    Workshop
    This workshop aims to foster discussions in machine learning underlying modern generative models and their role in MCMC-like sampling algorithms as well as explore how viewpoints arising …
  46. Black Holes on Broadway: The Next Generation of AGN Models in Galaxy Formation 

    Conference
    … out with any specific needs you may have. You can view slides from this event HERE December 4, 2023 Black Holes on Broadway: Day 1, Session 1 …
  47. CCA Colloquium: Meredith MacGregor

    Colloquium
    Title: How to Form a Habitable Planet Abstract: Planets form from disks of dust and gas surrounding young stars. As they grow, these new planets inherit their chemical …
  48. CCA Colloquium

    Colloquium
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