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Studies by two different research teams — one led by Ethan Greenblatt and the other by Emily Osterweil — both suggest that FXS cells under-synthesize large proteins, findings that …

To further our goal of funding the best and most transformative research on autism, SFARI strives to strike a balance between open requests for grant applications (RFAs) on …

SFARI is pleased to announce that it intends to fund 16 grants in response to the 2022 Pilot Award request for applications.

SFARI hosted a virtual workshop on March 14 and 18, 2022, to discuss the best practices for the development and use of induced pluripotent stem (iPS) cell models …

New zebrafish lines with mutations in the high-confidence autism risk genes DYRK1A and GRIN2B have been added to SFARI resources.

Genevieve Konopka and colleagues coupled brain imaging with measures of gene expression to reveal that gene expression patterns in the cortex that typically underlie functional brain activity in …

Phenotypic data from 296,307 participants enrolled in SPARK, including 117,203 individuals with ASD, are now available to approved researchers. Genomic data (whole-exome sequencing and genome …

Clinical Research Associates, L.L.C., an affiliate of the Simons Foundation, has recently launched a randomized controlled trial to test the safety, tolerability and efficacy of arbaclofen …

In a series of articles published in the journal Nature Genetics, researchers used data from the SPARK research cohort, which was created to advance our understanding of the …

Gina Turrigiano and colleagues showed that the phosphorylation state of the autism-associated synaptic scaffold protein Shank3 can bias synapses toward upward or downward homeostatic plasticity.

Vinod Menon and colleagues showed that a subregion of the auditory cortex decodes emotional cues in a communication partner’s voice and that this predicts social communication abilities …

Joshua K. Hartshorne, Stefano Anzellotti and colleagues used machine learning to disentangle variations in neuroanatomy that are specific to autism from variations common to the general population.

SFARI is pleased to announce that it has selected seven fellows in response to the 2022 Bridge to Independence Award request for applications.

Catherine Dulac and her collaborators identified a population of cells in the hypothalamus that generate fever and influence the activity of brain areas associated with behavior during sickness …

New phenotypic data from Simons Searchlight participants were recently added to SFARI Base. This release includes data from individuals with 59 gene changes and nine copy number variants …

So Hyun Kim, Catherine Lord and colleagues developed a new telehealth approach to autism assessment — the Brief Observation of Symptoms of Autism (BOSA) — for use during COVID-19 …

Daniel Geschwind and colleagues showed that Cntnap2 knockout mice exhibit alterations in brain-wide connectivity related to social behaviors and that oxytocin within the nucleus accumbens regulates changes …

SFARI is pleased to announce that it intends to fund four grants in response to the request for applications (RFA) focused on the analysis of postmortem brain tissue …

SFARI is pleased to support the Summer Undergraduate Research Program in 2022, working with SFARI Investigators and leading U.S. universities to help provide opportunities for undergraduate students …

Helen Bateup and colleagues showed that a loss of Tsc1 from striatal direct pathway neurons altered synaptic function and enhanced motor routine learning in mice. These findings suggest …

Yufeng Cheng, Wendy Chung, Chang “April” Shu and their colleagues used machine-learning models to develop a method for large-scale studies to estimate cognitive ability in individuals …

On March 25 and 28, 2022 SFARI hosted a workshop to explore the role of mitochondria in ASD risk. The workshop brought together experts in mitochondrial research spanning …

RNA-sequencing data from lymphoblastoid cell lines derived from individuals with ASD and their unaffected siblings from the Simons Simplex Collection are now available to approved researchers.

Two SFARI Investigators were elected to the American Academy of Arts & Sciences, and one SFARI Investigator was elected to the National Academy of Sciences in April 2022.

… New York University Courant Institute

Eleven Simons Foundation grantees and one board member are among the latest cohort of prominent artists, scholars, scientists and leaders elected as fellows of the American Academy of …

Ian Lipkin, Mady Hornig and colleagues showed that levels of immune molecules in mothers during pregnancy and in cord blood at birth are highly predictive of later autism …

Laura Andreae, M. Albert Basson and collaborators showed that Chd8 haploinsufficiency in mice was linked to changes in excitation/inhibition balance and disrupted homeostatic plasticity of prefrontal circuits.

SFARI is pleased to announce that it intends to fund seven grants in response to the Autism Rat Models Consortium request for applications.

SFARI Investigator Susanne Schmid and colleagues showed that loss of Cntnap2 in rats leads to immature-like delays in auditory cortex sound processing and overactive auditory neurons.

Autism BrainNet announces the recipients of the 2022 Autism BrainNet Appreciation Award, an initiative that recognizes outstanding partners and collaborators for their dedication to advancing brain tissue research …

A joint project of the Foundation for Angelman Syndrome Therapeutics (FAST) and SFARI, the International Angelman Syndrome Research Council (INSYNC-AS) held its inaugural meeting on July 9 …

Ivan Iossifov, Michael Wigler and colleagues provided a detailed comparison of simplex and multiplex families with autism, supporting the view that de novo mutations are a more frequent …

On September 27, 2021, SFARI convened a one-day virtual workshop to explore and discuss opportunities and risks for early detection of neurodevelopmental disorders through genomic sequencing.

Whole-genome sequencing data from more than 50 brains in the Autism BrainNet collection are now available for research purposes. Additional data will be released in the coming …

Anna Penn and colleagues showed that loss of the supply of the hormone allopregnanolone (ALLO) from the placenta leads to cerebellar brain and behavioral deficits in male offspring.

SFARI Investigators Lilia Iakoucheva and Alysson Muotri and colleagues utilized 3D organoid brain cultures to demonstrate how defects in neuron migration are affected in 16p11.2 deletion and …

SFARI Investigator Bruce Herring and colleagues showed that ASD-linked mutations in Trio and NLGN1 cause deficits in synapse development and function.

Hisashi Umemori and colleagues showed that X-inactivation-based patchy expression of PCDH19 causes defects in presynaptic development and signaling in the mouse hippocampus, affecting memory processes.

New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs …

The Bridge to Independence Award program serves as an overall scientific support system to help early-career scientists successfully launch their independent research positions. Fellows receive a commitment …

In October and November 2021, SFARI held the fall 2021 science meeting virtually. Across three webinars, nine SFARI-funded researchers discussed their latest findings in autism research to …

SFARI is pleased to announce that seven Director Awards were awarded in 2021. These projects include, but are not limited to, studies that aim to develop new tools …

New phenotypic and genomic data are available from participants enrolled in SPARK. Currently available data include phenotypic information from 283,520 people, including more than 111,000 individuals …

Bence Ölveczky, Jesse Marshall and colleagues developed a new method, CAPTURE, for long-term behavioral tracking in rodents and demonstrate its utility in tracking behaviors in Fmr1-KO …

Olga Troyanskaya and colleagues developed a bioinformatics framework for the identification and prioritization of disease-associated enhancers.

SFARI’s requests for grant applications (RFAs) underwent a number of changes in 2021. In 2022, we will largely continue on the course set last year. There will …

Simons Searchlight will host the CSNK2A1, HIVEP2, MED13L and SETBP1 Family and Scientific Conference on Aug 4-7, 2022, in Baltimore. Basic and clinical researchers, carriers of these …