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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Mind the Gaps

    October 25, 2016
    The Wikipedia Year of Science is an unprecedented initiative to fill critical gaps in Wikipedia’s science coverage — by rethinking college class assignments and coordinating mass-editing sessions …
  2. Welcome to Science Sandbox

    October 25, 2016
    Make science part of culture. Unlock scientific thinking by engaging people with the process of science. We believe that scientific thinking is for everyone, everywhere, every day. Make …
  3. Colliding Galaxies Move From the Lab to the Movies

    October 19, 2016
    Visualizations of cosmic collisions by Chris Hayward of the Center for Computational Astrophysics prove inspirational for Terrence Malick’s Imax film Voyage of Time
  4. Neuroscience 2016: Presentations by SFARI Investigators

    October 17, 2016
    Presentations that will be given by SFARI Investigators at Neuroscience 2016 in San Diego (November 12-16) are highlighted.
  5. Microglia-like cells derived from human pluripotent stem cells

    September 30, 2016
    Rudolf Jaenisch has developed a method enabling the generation of microglia-like cells from human embryonic stem cells and induced pluripotent stem cells.
  6. Dissecting the neurobehavioral phenotypes caused by loss of RAI1 from specific cell types

    September 30, 2016
    Liqun Luo uses conditional, cell-type-specific RAI1 deletions in mice to assess how loss of RAI1 contributes to neurodevelopmental phenotypes in Smith-Magenis syndrome.
  7. Increased risk for autism is associated with mutations in genomic loci that have undergone accelerated evolution in humans

    September 30, 2016
    By assessing human accelerated regions (HARs) in healthy individuals and those with ASD, Chris Walsh shows HARs regulate human social and cognitive behavior and ASD risk.
  8. Simons Foundation, HHMI and Bill & Melinda Gates Foundation Announce Selection of Faculty Scholars

    September 22, 2016
    … new faculty appointment, a researcher’s institutional start-up funds typically come to an end. Pressure to secure federal grant money may lead to ‘safe’ grant proposals …
  9. Genome Diversity Project Reveals Faster Accumulation of Mutations in Non-Africans

    September 21, 2016
    This conclusion and others appear in a report analyzing genome sequence data from 300 individuals from diverse populations
  10. Marlow Kee Named Chief Financial Officer at Simons Foundation

    September 16, 2016
    … chance to play a role in an organization that is highly innovative and wants to push the boundaries of science and discovery. And I am inspired by …
  11. Marathon Editing

    September 16, 2016
    The Simons Foundation’s first Wikipedia edit-a-thon brings new rigor to physics content for the online encyclopedia, laying the groundwork for the Wikipedia Year of Science …
  12. Best School Day

    September 16, 2016
    The Simons Foundation and Math for America donate $250,000 to DonorsChoose.org for #BestSchoolDay — a “flash funding” project. The Simons Foundation and Math for America donate $250 …
  13. Mind the Gaps

    September 16, 2016
    The Wikipedia Year of Science is an unprecedented initiative to fill critical gaps in Wikipedia’s science coverage — by rethinking college class assignments and coordinating mass-editing sessions …
  14. SFARI’s 2017 funding priorities

    September 15, 2016
    In this blog post, the SFARI science team provides insight into SFARI’s scientific priorities. A number of experimental design issues to consider when preparing a grant application …
  15. 2017 Pilot and Research Award applications: The review process

    September 15, 2016
    This blog post accompanies the “SFARI’s 2017 funding priorities” post. In it, the SFARI science team discusses the application and review process for Pilot and Research Awards.
  16. 2017 Pilot and Research Awards – Request for applications

    September 15, 2016
    This issue of the SFARI newsletter includes: (1) 2017 Pilot and Research Awards – Request for applications, (2) Simons Variation in Individuals Project (Simons VIP): New data now available …
  17. Dating in the Dark and Other Unexpected Encounters With Science

    September 12, 2016
    Guerilla Science creates unique science experiences in the arts and music communities
  18. Physics of Feather Color Holds Clues to Diversity of Life

    September 8, 2016
    Hidden in the color of birds and their mating choices, says Rafael Maia of the Simons Society of Fellows, is information that can help elucidate the evolution of …
  19. Simons Variation in Individuals Project (Simons VIP): New data now available

    August 25, 2016
    New Simons VIP data have recently been added to SFARI Base. This data release includes phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 …
  20. Foundation Announces Simons Collaboration on Special Holonomy in Geometry, Analysis and Physics

    August 25, 2016
    … mathematical breakthroughs related to the geometric structures associated with exceptional holonomy spaces and also make use of powerful, new tools for analyzing singular spaces. More information about …
  21. Foundation Announces Simons Collaboration on the Non-Perturbative Bootstrap

    August 25, 2016
    … This strategy is called the bootstrap. The bootstrap idea has its roots in work done in the 1960s on the S-matrix approach to the strong nuclear …
  22. The Story Collider

    August 24, 2016
    August 2016 – Present
  23. SCGB Supports Preprints

    August 22, 2016
    … on preprint servers (like bioRxiv) and consider providing feedback.
  24. Update on Simons Simplex Collection whole-genome sequencing; Rat and iPSC models for autism research

    August 18, 2016
    This issue of the SFARI newsletter includes: (1) Update on Simons Simplex Collection whole-genome sequencing data availability, (2) Rat models for autism research, (3) Induced pluripotent stem …
  25. A computational approach to predicting autism risk genes

    August 17, 2016
    Simons Center for Data Analysis scientist Olga Troyanskaya has developed a machine-learning tool that uses neural interaction networks to predict autism risk genes.
  26. Deep brain stimulation rescues neural circuit dysfunction in Rett syndrome mouse model

    August 17, 2016
    Huda Zoghbi and Stelios Smirnakis investigate how opposing molecular deficits in MeCP2 duplication and Rett syndromes lead to similar behavioral phenotypes.
  27. Update on Simons Simplex Collection whole-genome sequencing data availability

    August 12, 2016
    Plans are underway to perform whole-genome sequencing of the entire Simons Simplex Collection (SSC). Genomes from 553 families (2,174 genomes) have been sequenced and are available …
  28. Prime Numbers Reveal the Practicality of Impracticality

    August 10, 2016
    Understanding primes can lead to many applications, but overemphasizing them has its perils
  29. Human-specific BOLA2 duplication at chromosomal region 16p11.2 and the susceptibility of this locus to recurrent rearrangements

    August 5, 2016
    Evan Eichler reconstructs the evolution of chromosome 16p11.2 and finds most disease-causing rearrangements map within a H. sapiens-specific duplication containing BOLA2.
  30. Simons Collaboration on the Many Electron Problem Hosts Third Annual Summer School

    August 2, 2016
    … of the state of practical tensor-network calculations and was a unique opportunity to get practical advice on performing advanced calculations by many experts in the field …
  31. New Tool Predicts Autism Risk Genes

    August 1, 2016
    A computational technique will help scientists to better identify genes, developmental stages of the brain, and cellular functions implicated in the disorder
  32. Microglia excessively engulf synapses weakened by loss of MeCP2

    July 31, 2016
    Beth Stevens shows that, in MeCP2 null mice, microglia excessively eliminate presynaptic inputs, targeting synapses previously weakened by MeCP2 loss in other CNS cell types.
  33. Autism BrainNet begins tissue distribution

    July 29, 2016
    Autism BrainNet has begun distributing postmortem brain tissue to qualified investigators working on autism and related neurodevelopmental disorders. Initially, distributed tissue will be restricted to donations previously collected …
  34. A new resource to mine recessive disease genes

    July 29, 2016
    Joseph Gleeson and colleagues have generated a publically accessible whole-exome variome from 1,111 unrelated individuals within the Greater Middle East Variome Consortium.
  35. Autism BrainNet begins tissue distribution; SFARI Gene update

    July 29, 2016
    This issue of the SFARI newsletter includes: (1) Autism BrainNet begins tissue distribution, (2) SFARI Gene update, (3) A Conversation with Pamela Feliciano, Scientific Director of SPARK, (4 …
  36. Simons Collaboration on the Global Brain Annual Meeting

    July 28, 2016
    … 12:00 pm Break (20 minutes) AGENDA | THE SIMONS COLLABORATION ON THE GLOBAL BRAIN 6 Session 7 Moderator: Gerry Fischbach, M.D. (Simons Foundation) 12:00 – 12 …
  37. ArXiv.org Marks 25 Years of Making Scientific Preprints Accessible

    July 27, 2016
    The pre-publication server established a centralized system for distributing scholarly papers
  38. SFARI Gene update

    July 22, 2016
    New data were added to SFARI Gene in June. This data release included the addition of new human genes implicated in autism, new animal models, and new protein …
  39. Taking stock

    July 22, 2016
    Alan Packer, senior scientist at SFARI, discusses a number of recent review articles that provide interesting and complementary overviews of what we currently know about the neurobiology of …
  40. A Conversation with Pamela Feliciano, Scientific Director of SPARK

    July 22, 2016
    Pamela Feliciano discusses the motivation behind SPARK and insights gained from the initial phases of the project.
  41. Science Lives: Mathematician Endre Szemerédi

    July 21, 2016
    The 2012 Abel Prize winner, Endre Szemerédi is a Hungarian-American mathematician who has made several discoveries in combinatorics and computer science.
  42. 2016 Targeted MMLS (feature block)

    July 20, 2016
  43. PTOLEMY Detector to Hunt for Neutrinos from the Big Bang

    July 20, 2016
    The experiment will use cryogenic calorimetry to clinch the first direct detection of the relic particles
  44. MPS Awardee Spotlight: Subhash Khot

    July 13, 2016
    … interests, they can discover connections that might exist. Once in a while, one stumbles upon unexpected connections between two areas that greatly benefit both.” Much of Khot …
  45. Mathematics Elucidates Language Use in Children with Autism

    July 13, 2016
    The LENA System allows researchers to record the language an individual with autism uses in everyday life and may improve our understanding of how children with autism communicate
  46. Targeted Grants to Institutes feature block

    July 12, 2016
  47. Distinguishing True Autism Risk Genes from Red Herrings

    July 6, 2016
    SFARI Investigators have been developing statistical analyses to identify genes associated with autism
  48. Sciences at Pioneer Works

    July 1, 2016
    July 2016 – Present
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