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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Autism, Oxytocin, and Neural Signaling

    March 10, 2013
    … Institute. Dr. Tsien received both an undergraduate and graduate degree in electrical engineering from the Massachusetts Institute of Technology. He was a Rhodes Scholar, graduating with his …
  2. April 25, 2013: New Genetic Insights into the Pathophysiology of Autism Spectrum Disorders

    February 28, 2013
    … tipping point. The recent focus on de novo mutations has led to systematic, highly productive gene discovery efforts. These have begun to clarify a tremendously heterogeneous allelic …
  3. Shadows of Evidence

    February 21, 2013
    An essay on science.
  4. Probability & Intuition

    February 16, 2013
    … patents. Winkler studied Mathematics at Harvard University and received his Ph.D. in from Yale University. He has also published two books on mathematical puzzles. Homepage: http …
  5. Science Lives: Mathematician László Lovász

    February 14, 2013
    … study them.” Lovász makes contributions to essentially all facets of discrete mathematics. “And it is a big field,” Wigderson said. “But most people working in this field …
  6. Workshop report: Glia’s role in autism

    February 12, 2013
    Glia were once thought to play a secondary role to neurons in the brain. But studies in the past few years have shown that they may be involved …
  7. Event: M3 – Music, Mathematics and Malerei (Painting)

    February 7, 2013
    … prove a mathematical theorem—Fermat’s Two Square Theorem—in such a way that everybody will feel the joy of rigorous statements and arguments. The paintings, which …
  8. Mathematical Impressions: Attesting to Atoms

    February 1, 2013
    Can you combine simple observations and mathematical thinking to show that atoms exist?
  9. Mathematical Impressions: Knot Possible?

    January 3, 2013
    The mathematics of knot theory says that a simple loop and a trefoil are fundamentally different knots. But is that all there is to the question?
  10. Animation, Teeth and Skeletons: Ingrid Daubechies’ 2012 Talk on Algorithms for Biological Morphology

    December 22, 2012
    … algorithms are polynomial in nature and thus faster, making pairwise comparisons feasible for significantly larger numbers of digitized surfaces. The approach is illustrated using three datasets representing …
  11. Cathleen

    December 21, 2012
  12. Science Lives: Mathematician Cathleen Morawetz (1923–2017)

    December 20, 2012
    … her work has been very influential. Initially she was interested in applications to scattering theory of waves outside an obstacle. But her work is now being applied …
  13. Mathematical Impressions: The Surprising Menger Sponge Slice

    December 10, 2012
    The Menger Sponge, a well-studied fractal, was first described in the 1920s. The fractal is cube-like, yet its cross section is quite surprising. What happens when …
  14. Mathematical Impressions: Printing 3-D Models

    November 19, 2012
    George Hart describes in this video how to create physical models of mathematical objects, surveying some examples of surfaces and polytopes.
  15. Workshop report: Developmental neurobiology of autism

    November 6, 2012
    Converging lines of evidence suggest that the earliest events in brain development play a role in autism. On 12 September, the Simons Foundation Autism Research Initiative brought together …
  16. Challenging choices: How we make funding decisions

    October 30, 2012
    Which grant applications should SFARI choose to fund each year? The principles that guide that decision are nuanced and evolve as new results emerge. But there are some …
  17. Science Lives: Mathematician John Nash (1928–2015)

    October 24, 2012
    A video interview, conducted on Nov. 27, 2011, with the mathematician John F. Nash, Jr., who won a Nobel Prize for his contributions to game theory and who …
  18. Mathematical Impressions: Shell Games

    October 19, 2012
    A video explaining how some seemingly complex patterns on sea shells can be created by simple, one-dimensional, two-state cellular automata.
  19. Shell Games

    October 19, 2012
  20. Mathematical Impressions: Regular Polylinks

    October 8, 2012
    A video illustrating the beautiful geometry behind symmetrical linkages of regular polygons.
  21. Regular Polylinks

    October 8, 2012
  22. Yuri Tschinkel Joins the Simons Foundation

    October 2, 2012
    … Simons, foundation president, said, “Yuri was the clear choice for us as an experienced leader and administrator of similar programs, with years of experience in the areas …
  23. A Research Institute in the Cradle of Humanity

    October 1, 2012
    … University, which has extended faculty positions to Louise, Meave and Richard Leakey, operates as TBI’s center of research, hiring, development of facilities and fundraising in the …
  24. Tackling the Complexity of the Social Brain

    October 1, 2012
    … attended. The workshop aimed to inform scientists about the state of the art in autism research, and to generate excitement about the project among scientists outside the …
  25. Geometry of Spaghetti Code

    October 1, 2012
  26. Science Lives: Mathematician Jim Simons (1938–2024)

    September 28, 2012
    … Simons, now 76, has also found time to return to his first love, mathematical research. About a decade ago, he started thinking about mathematical objects called differential …
  27. Systems Biology Takes Center Stage

    September 28, 2012
    … postdocs and other researchers. The goal is to build up a dynamic group trained not only in genetics and neuroscience, but also mathematics and physics. One recent …
  28. Simons Investigators

    September 26, 2012
    … classified in terms of the momentum space topology of the electronic states, and that as a consequence there exist protected states at interfaces between topologically nontrivial crystals …
  29. Pick of the litter

    September 25, 2012
    New genetic variants that increase susceptibility to autism are emerging at a rapid pace. Given the profusion of data, it seems timely to assess the availability and usefulness …
  30. 2013 RFA Announcement

    September 21, 2012
  31. Analysis of Boolean Functions: New Directions and Applications

    September 21, 2012
  32. Knot Homologies and BPS States

    September 20, 2012
  33. The Mathematics of Mind and Brain

    September 19, 2012
    … people, and constructing intuitive theories of core domains, such as intuitive physics, psychology, biology, or social structure. Homepage: http://web.mit.edu/cocosci/josh.html
  34. Visualizing Apoptosis

    August 28, 2012
    … cellular processes, such as cell death and the control of cell cycle and growth. Endosomes are membrane-bound compartments that underlie intracellular membrane trafficking. Early endosomes regulate …
  35. Mathematical Impressions: Geometry of Spaghetti Code

    August 16, 2012
    A sculpture project built entirely with right angles combines math and art in subtle and surprising ways.
  36. Workshop report: 16p11.2 deletions and duplications

    August 7, 2012
    The chromosomal region 16p11.2, which spans about 29 genes, is strongly linked to autism.  On 27 April, SFARI hosted a workshop to discuss the consequences of duplications …
  37. Science Lives: Mathematician Pierre Deligne

    June 19, 2012
    … of Deligne’s contributions to the theory. “What is a 1-motive?” Tate asks himself, reiterating what turns out to be a question difficult to answer using …
  38. Science Lives: Mathematician Robert D. MacPherson

    May 30, 2012
    … give his students a full hearing, on issues that can range far beyond math. "I spent my early graduate career being unsuccessfully mentored by straight white guys …
  39. Science Lives: Mathematician Egbert Brieskorn (1936–2013)

    May 15, 2012
    A video interview, conducted on Dec. 8, 2010, with the German mathematician Egbert Brieskorn. The videos for this Science Lives feature are temporarily unavailable. A video interview, conducted …
  40. Paul Sally

    April 30, 2012
    A video interview, conducted on Oct. 26, 2010, with the mathematician Paul Sally. A video interview, conducted on Oct. 26, 2010, with the mathematician Paul Sally.
  41. Network Solutions

    April 24, 2012
    A new breed of ultrafast computer algorithms offers computer scientists a novel tool to probe the structure of large networks.
  42. What Has the Brain Evolved to Know About the Natural Olfactory World?

    April 18, 2012
    … the fruit fly Drosophila as a model for investigating neural circuit function. Homepage: http://www.hhmi.org/research/ecs/wilson_bio.html
  43. Workshop report: Regression in autism

    April 17, 2012
    Studies suggest that a subset of children with autism make significant social and language gains in the first year of life, and then experience a dramatic loss of …
  44. New Technologies for Measuring Neural Circuit Dynamics

    March 14, 2012
    … http://genomics.princeton.edu/tank/Index.html
  45. RAS pathway, a potentially unifying theory of autism

    March 13, 2012
    Dysregulation of the intracellular signaling pathway RAS, a risk factor for idiopathic autism, may provide a unifying theory of the disorder. Although this is not an altogether new …
  46. Taking the Universe’s Baby Picture

    February 22, 2012
    … of the NAS Committee on Astronomy and Astrophysics. Spergels research in theoretical astrophysics ranges from the search for planets around nearby stars to the shape of the …
  47. Hitting a Nerve

    February 10, 2012
    … according to the direction of strongest diffusion. In the lower left image, for instance, the corpus callosum (the portion of the brain joining the right and left …
  48. Science Lives: Mathematician Yuri Manin (1937–2023)

    January 27, 2012
    … year before as part of a competition prize. The meeting with Igor Shafarevich at his seminar was the most formative influence in Yuri’s mathematical life. However …
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