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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCA Colloquium: Carl Fields

    Event
    CCA Colloquium: Carl Fields Title: Next-Generation Simulations of The Remarkable Deaths of Massive Stars.  Abstract: Core-collapse supernova explosions (CCSN) are one possible fate of a massive …
  2. CCN Cup: Latte Art & Best Espresso Competition

    Meeting
    Please join us for the Second and Third Competitions of our CCN Cup! This will be taking place on Friday, April 29th from 10-12PM in the 4th …
  3. Illusions of Perfection in the Genomic Age

    Lecture
    Our growing ability to read and manipulate the human genome has brought a dream of human perfection. Genome editing offers the tools to correct what many see as …
  4. LCV Lab Meeting

    Event
  5. Structural and Molecular Biophysics Group Meeting

    Meeting
  6. CCM Colloquium: James Bremer (U of Toronto)

    Event
    Title and abstract TBD If you would like to attend, please email [email protected] for the Zoom details.
  7. FI Computational Methods and Data Science Journal Club: Jeremy Cohen

    Seminar
    FI Computational Methods and Data Science Journal Club Flatiron Institute, 162 5th Avenue Speaker: Jeremy Cohen (CREATIS, CNRS, Villeurbanne, France) Title: Semi-supervised Low-rank Approximation, from variational …
  8. CCB Colloquium: "Short Stories of Transport Processes and Molecular Biology" (Howard A. Stone, Ph.D.)

    Colloquium
    Speaker: Howard A. Stone Donald R. Dixon ’69 and Elizabeth W. Dixon Professor in Mechanical and Aerospace Engineering, Princeton University. Title: Short Stories of Transport Processes and Molecular …
  9. Quantum Cafe: Sankar Das Sarma

    Colloquium
    Title: Superconductivity in Graphene: Twisted or not and phonons or not Abstract: I will describe a number of theoretical approaches to understanding the unexpected observation of superconductivity, seemingly …
  10. CCB Seminar: "Developmental Dynamics During Vertebrate Embryogenesis"

    Seminar
    Speaker: Alexander Schier, Ph.D., Director of the Biozentrum, University of Basel Title: Developmental dynamics during vertebrate embryogenesis Breakthroughs in single-cell genomics have begun to comprehensively identify …
  11. Developmental Dynamics Group Meeting

    Meeting
  12. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  13. Biophysical Modeling Group Meeting

    Meeting
  14. Center for Brain Immunology and Glia (BIG) Symposium 2022

    Related
    Hosted by the Center for Brain Immunology and Glia at Washington University School of Medicine Featured speakers include Maiken Nedergaard, Beth Stevens and Tony Wyss-Coray. Registration is …
  15. Origins of the Universe (2022)

    Symposia
    … Gravity View Slides (PDF) Federico Piazza Centre de Physique Théorique Understanding deviations from classicality in gravity View Slides (PDF) Eva Silverstein Stanford University MIC Overview View Slides …
  16. Flatiron Institute Seminar Series: Rachel Sommervile

    Seminar
    Title: How to fit the Universe onto a computer Abstract: The international astronomy community is building a suite of powerful new telescopes, which over the next decade will …
  17. Structural and Molecular Biophysics Group Meeting

    Meeting
  18. Genomics Group Meeting

    Meeting
  19. Constructing New Statistical Physics Theories From Big Data

    Lecture
    The glass transition is an infamous example of an emergent collective phenomenon in many-body systems that is stubbornly resistant to microscopic understanding. The transition combines three major …
  20. Constructing New Statistical Physics Theories From Big Data

    Lecture
    The glass transition is an infamous example of an emergent collective phenomenon in many-body systems that is stubbornly resistant to microscopic understanding. The transition combines three major …
  21. LCV Lab Meeting

    Meeting
  22. Quantum Cafe: Kin Fai Mak

    Colloquium
    Title: Kane-Mele-Hubbard physics in semiconductor moiré materials Abstract: Semiconductor moiré materials provide a physical realization of the Kane-Mele-Hubbard model for studies of the combined …
  23. CCM Colloquium: Brian van Koten (UMass Amherst)

    Event
    Title and abstract TBD If you would like to attend, please email [email protected] for the Zoom details.
  24. CCB Brown Bag Seminar

    Meeting
    1st speaker: Aidan Daly, Ph.D., Flatiron Research Fellow, Systems Biology Topic: Inferring cell type-specific gene expression signatures from multi-tissue spatial transcriptomics data 2nd speaker: Surya …
  25. Developmental Dynamics Group Meeting

    Meeting
  26. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  27. CCA Colloquium: Alexander Ji

    Event
    CCA Colloquium: Alexander Ji Title: Dwarf Galaxy Archaeology in the Gaia Era Abstract: The Milky Way’s satellite dwarf galaxies are powerful probes of many important astrophysical processes …
  28. CCB Seminar: "Coordinated motion of active filaments on spherical surfaces " (Eric Keaveny, Ph.D.)

    Seminar
    Speaker: Eric E. Keaveny Faculty of Natural Sciences, Department of Mathematics Imperial College London Title: Coordinated motion of active filaments on spherical surfaces Abstract: Filaments (slender, microscopic elastic …
  29. Bayes Reading Group: Bob Carpenter

    Event
    Discussion Lead: Bob Carpenter Topic: Fu, Luo, and Zhang. 2016. Quasi-Newton Hamiltonian Monte Carlo. UAI. Abstract: The Hamiltonian Monte Carlo (HMC) method has become significantly popular in …
  30. Genomics Group Meeting

    Meeting
  31. CCB Seminar: "Mechanochemical control of nuclear positioning in Drosophila embryos " (Stefano D'Italia, Ph.D)

    Seminar
    Speaker: Stefano Di Talia, Ph.D., Duke University School of Medicine Topic: Mechanochemical control of nuclear positioning in Drosophila embryos I will describe our attempts at understanding nuclear …
  32. CCM Colloquium: David Barmherzig (CCM)

    Event
    Towards Practical X-ray Microscopy via Optimization and Deep Learning X-ray diffraction microscopy is an emerging technology with the capability of providing high-quality imaging of nanoscale …
  33. Efficiently Irrational: Unraveling the Neural Mechanisms of Human Choice Behavior

    Lecture
    Cognitive and social scientists have struggled with the irrationalities of human choice behavior; people consistently make logically inconsistent choices. Is human choice behavior evolutionarily, as widely assumed, an …
  34. CCB Colloquium: "Darwinian evolution as a principled physical process: What drives it? Where did it come from?" (Ken A. Dill, Ph.D.)

    Colloquium
    Speaker: Ken A. Dill, Distinguished Professor of Chemistry & Physics Stony Brook University Title: Darwinian evolution as a principled physical process. What drives it? Where did it come from …
  35. CCB Seminar: "Inferring entropy from structure" (Gil Ariel, Ph.D)

    Seminar
    Speaker: Gil Ariel, Associate Professor, Department of Mathematics, Bar Ilan Title: Inferring entropy from structure The thermodynamic definition of entropy can be extended to nonequilibrium systems based on …
  36. Developmental Dynamics Group Meeting

    Meeting
  37. Biophysical Modeling Group Meeting

    Meeting
  38. Black in Autism

    In Conversation
    … inclusion (DEI) roadmap and partnering across the foundation to implement an action plan. Before joining the foundation, Wesley worked in various DEI roles within the nonprofit and …
  39. CCA Colloquium: Keith Hawkins

    Event
    CCA Colloquium: Keith Hawkins Title: Galactic Archaeology Across the Milky Way Abstract: What are the processes that govern the formation evolution and assembly of galaxies, like the Milky …
  40. Bayes Reading Group: Lionel Riou-Durand

    Meeting
    Discussion Lead: Lionel Riou-Durand (Warwick) Topic: Metropolis Adjusted Langevin Trajectories: a robust alternative to Hamiltonian Monte Carlo Abstract: Hamiltonian Monte Carlo (HMC) is a widely used sampler …
  41. MathBioSys Annual Meeting 2022

    Conference
    … Embeddings — Theory and Challenges 1:00 PM Madhav Mani | Geometry as Destiny: The Language of Embryos April 7, 2022 Christine Heitsch | What Happens When Theory and Data …
  42. Cognitive Aging Conference

    Related
    The biennial Cognitive Aging Conference is the premier conference for presentation of research about aging and cognition based on experimental cognitive psychology, cognitive neuroscience of aging, human factors …
  43. The Invisible Hand of Prediction

    Lecture
    Algorithmic predictions steer markets, drive consumption, shape communities and alter life trajectories. However, the theory and practice of machine learning have long neglected the often-invisible causal forces …
  44. FI Computational Methods and Data Science Journal Club: Steve Brunton

    Seminar
    … math to engineers as co-author of three textbooks and through his popular YouTube channel, under the moniker “eigensteve.” Attendee Instructions: FI employees are welcome to attend …
  45. CCB Brown Bag Seminar

    Meeting
    1st speaker: Jasmin Alsous, Ph.D., Research Scientist, Developmental Dynamics Topic: Sperm Storage – an overlooked leg of the journey Before fertilizing the egg, sperm is typically stored in …
  46. From Neuroscience to Artificially Intelligent Systems (NAISys)

    Related
    Artificial intelligence (AI) and neural networks have long drawn on neuroscience for inspiration. However, in spite of tremendous recent advances in AI, natural intelligence is still far more …
  47. CCB Seminar: "Molecular Mechanisms and Self Organization of Subcellular Structures for Cell Division, Polarization and Motion" (Dimitrios Vavylonis, Ph.D.)

    Seminar
    … the leading edge of polarized motile cells.
  48. Developmental Dynamics Group Meeting

    Meeting
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