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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. 2022 Genomics of ASD: Pathways to Genetic Therapies Awardees Announced

    March 23, 2023
    SFARI is pleased to announce that it intends to fund 15 grants in response to the 2022 Genomics of ASD: Pathways to Genetic Therapies request for applications.
  2. Simons Foundation Accepting Applications for Neuroscience Undergraduate Research Fellowships

    March 23, 2023
    The Simons Foundation is now accepting applications from undergraduate students to participate in the Simons Foundation Undergraduate Research Fellowship in Neuroscience, or SURFiN, for the 2023–2024 academic …
  3. Artificial Intelligence Discovers Secret Equation for ‘Weighing’ Galaxy Clusters

    March 23, 2023
    … equations can help us in maximizing the scientific return from these surveys.” Wadekar also hopes that this publication will be just the tip of the iceberg when …
  4. Advancing Astronomy With Statistics

    March 20, 2023
    By marrying statistical techniques with computational tools, Flatiron Institute research scientist Dan Foreman-Mackey is helping astronomers probe the atmospheres of other planets.
  5. A Novel Eye-Tracking Paradigm Identifies an Influence of Perceptual Load on Social Attention in Autism

    March 14, 2023
    A study by Caroline Robertson and her colleagues found that reduced social attention was not a static omnipresent characteristic of autism; rather, it was magnified only under certain …
  6. Why Don’t Disease-Linked Genetic Mutations Always Result in Disease? A Study in Fruit Flies Offers New Clues

    March 13, 2023
    By harnessing both experimental and computational methods, researchers have identified a significant role for randomness in disease manifestation.
  7. Dissecting social attention in autism using large-sample eye tracking over the Internet

    Funded Work
    Among the multiple cognitive processes that are atypical in people with autism, attention stands out as one of the most important.
  8. The cortical head direction system as a model for systems-level alterations in rat models of autism

    Funded Work
    In the current project, Paul Dudchenko provides a detailed neural and behavioral characterization of three rat models of autism spectrum disorder/intellectual disability (ASD/ID): Fmr1-/y, Grin2b …
  9. The COUNT project: Using multiomic profiling to identify predictors of autism traits

    Funded Work
    Autism spectrum disorder (ASD), a chronic and heterogeneous condition with many traits and co-occurring conditions, is poorly understood.
  10. Computational Model Uncovers New Insights Into How Our Brains Store Information

    March 9, 2023
    With the new model, researchers reveal how memories and learned behaviors can remain strong, even in the face of shifting neural representations.
  11. Watch: How Emily Rauscher Maps an Exoplanet’s Atmosphere

    March 8, 2023
    An astronomer at the University of Michigan and a 2022 Simons Fellow in Theoretical Physics, Emily Rauscher works to characterize the atmospheric properties of distant worlds.
  12. Stepping in the Right Direction: Optimizing Machine Learning

    March 7, 2023
    Flatiron Institute mathematician Neha Wadia is developing a new set of learning algorithms to improve machine learning optimization.
  13. A New Approach To Analyzing Genomic Association Data Finds Convergence of Both Rare and Common Genetic Influences on Autism at Chromosome 16p

    March 6, 2023
    Elise Robinson and colleagues identified a large genomic region — chromosome 16p — where a rare 16p11.2 variant associated with autism functionally converges with common polygenic variation across 16p …
  14. 2023 Simons Fellows in Mathematics Announced

    March 6, 2023
    The Simons Foundation congratulates the outstanding mathematicians who have been awarded Simons Fellowships in 2023. The Simons Fellows program extends academic leaves from one term to a full …
  15. Simons Foundation Now Accepting Applications for Second Class of Pivot Fellows

    March 1, 2023
    The Simons Foundation is now accepting applications for its second class of Pivot Fellowships. The program provides funding for today’s brightest minds to apply their talent and …
  16. New Testing Approach Diagnoses COVID-19 With Near-Perfect Accuracy

    February 27, 2023
    By monitoring the body’s molecular response to a viral attack, the new method developed by Flatiron Institute researchers and their colleagues can diagnose even asymptomatic patients with …
  17. Exploring the Role of Dopamine in Natural Behaviors

    February 27, 2023
    New research suggests that the neuromodulator plays a role in learning even in the absence of external rewards. The work also raises new questions.
  18. What Really Happens When Stars Form?

    February 27, 2023
    Guided by his longtime fascination with the cosmos, Simons Junior Fellow Lachlan Lancaster is challenging established views of how stars are born.
  19. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    February 24, 2023
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  20. Conference Spotlight: Cosyne 2023

    February 23, 2023
    Check out these talks and workshops featuring Simons Collaboration on the Global Brain investigators and fellows.
  21. Achieving More With Less: Optimizing Efficiency in Supercomputing

    February 22, 2023
    Flatiron Institute software engineer Géraud Krawezik works to minimize supercomputer energy use — with a focus on improving software performance for scientists.
  22. 2022 Awardees

    Funded Work
  23. Simons Foundation Scientists Named as Sloan Research Fellows

    February 16, 2023
    The Alfred P. Sloan Foundation has awarded its prestigious research fellowship to four past and present Simons Foundation researchers. This year’s 125 fellowship recipients “represent the most …
  24. Computational Biology Goes Under the Microscope

    February 14, 2023
    A new facility at the Flatiron Institute’s Center for Computational Biology (CCB) bridges the gap between experimental and theoretical biology, allowing researchers to take big steps toward …
  25. Interview: Suzanne Pierre From Critical Ecology Lab

    February 14, 2023
    The second edition of our Science Sandbox Spotlight series features Dr. Suzanne Pierre, founder and principal investigator of Critical Ecology Lab.
  26. A New Era of Perception Research

    February 10, 2023
    How we perceive the world is an age-old question. Flatiron Institute researcher Jingyang Zhou is part of a new generation of scientists tackling it from a different …
  27. Topology of cortical and thalamic gene expression changes in autism

    Funded Work
    In work that began nearly 15 years ago, Daniel Geschwind and collaborators identified a shared pattern of transcriptomic and epigenetic dysregulation in postmortem brain tissue of people with …
  28. CCM Director Leslie Greengard Awarded ICIAM Pioneer Prize

    January 31, 2023
    … applications, from chip simulation to molecular modeling. In 2000, the Institute of Electrical and Electronics Engineers recognized the FMM as one of the top ten algorithms of …
  29. Neuroscientists Grapple With New Data Management Rules

    January 30, 2023
    New grant applications to the National Institutes of Health must include a plan for data-sharing and management. Researchers hope the broad requirement will boost development and adoption …
  30. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    January 30, 2023
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  31. Quarks, Wormholes and a New Understanding of the Physical World

    January 30, 2023
    By building models of the subatomic world, theoretical physicist Fedor Popov is working to strengthen our knowledge of the universe’s underlying principles.
  32. Small Cell, Big Picture: Fundamental Biology Through the Lens of Simplified Models

    January 26, 2023
    The nucleus of a cell may only be one-thousandth of a centimeter in diameter, but that doesn’t stop biophysicist Alex Rautu from seeing the big picture.
  33. January 2023 Update: New Simons Searchlight Data Added to SFARI Base

    January 25, 2023
    New Simons Searchlight data were recently added to SFARI Base. The data released included phenotypic data from individuals with 16p11.2 copy number variant (CNVs), 1q21.1 CNVs …
  34. Using human innervated intestinal organoids to study enteric glial dysfunction in autism

    Funded Work
    Gut disturbances are unusually common in individuals with autism spectrum disorder (ASD), but the basis of these gut irregularities is not yet known.
  35. Simons Foundation Providing Support to Researchers in Ukraine

    January 25, 2023
    … other members of the Simons Foundation staff. Ultimately, the Simons Foundation accepted every application it received and extended the application period as many scientists lost power and …
  36. Neural basis for observational learning in autism mouse models

    Funded Work
    Autism spectrum disorder (ASD) is a pervasive neurodevelopmental condition with core characteristics that are broadly categorized as problems with social engagement that are proposed, in part, to emanate …
  37. The role of the superior colliculus in tactile sensory processing in mouse models of autism

    Funded Work
    More than 90 percent of individuals diagnosed with autism spectrum disorder (ASD) exhibit sensory alterations, with 60 percent displaying altered tactile sensitivity.
  38. Zebrafish functional analysis of autism risk genes

    Funded Work
    The goal of this project is to investigate genes that increase risk for autism spectrum disorder (ASD) by characterizing mutant zebrafish.
  39. Colin Hill and Oliver Philcox Among Winners of Buchalter Cosmology Prize

    January 24, 2023
    First place for this year’s Buchalter Cosmology Prize went to a paper co-authored by Colin Hill, until recently a Flatiron Institute associate research scientist and currently …
  40. ‘Fire of Love’ Nominated for the Academy Award for Best Documentary

    January 24, 2023
    … nominations. “Fire of Love” was produced by Sandbox Films, Intuitive Pictures and Cottage M and distributed by National Geographic Documentary Films and Neon. “Fire of Love” is …
  41. The Calculus Project

    Funded Work
    Math organization that helps schools and school districts create a middle and high school pathway for success in advanced mathematics.
  42. ART±BIO Collaborative

    Funded Work
    Integrating art, science and nature and broadening participation through public engagement, outreach, activism and public art.
  43. SciLine

    Funded Work
    On-deadline service connecting reporters to expert sources and research-backed evidence for use in their stories.
  44. Make the Road New York

    Funded Work
    Community based organization creating a science learning initiative dedicated to engaging Spanish speaking immigrants and their children with New York City math and science learning institutions.
  45. Seattle Universal Math Museum

    Funded Work
    Math museum providing math enrichment activities for students that parents can replicate at home.
  46. Big Data and Powerful Computing Join Forces To Link DNA Sequence and Function

    January 24, 2023
    Built from one of the world’s largest collections of epigenetic data, the newly developed model Sei predicts how DNA sequence variation alters gene expression, advancing our understanding …
  47. Classifying axon pathology in autism using machine learning and deep neural network analyses

    Funded Work
    Axon pathology is at the core of disruptions in cortical connectivity in autism spectrum disorder (ASD).
  48. Astrophysicist Chiara Mingarelli Awarded the 2023 HEAD Early Career Prize

    January 19, 2023
    … International Outgoing Fellow at the California Institute of Technology and the Max Planck Institute for Radio Astronomy. She completed her Ph.D. at the University of Birmingham …
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