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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. New SPARK Study Identifies a Novel Group of Inherited Genes of Moderate Effect and Shows Their Links to Other Behavioral Conditions

    August 18, 2022
    In a series of articles published in the journal Nature Genetics, researchers used data from the SPARK research cohort, which was created to advance our understanding of the …
  2. A Bidirectional Switch Affecting Phosphorylation of Shank3 Influences Homeostatic Synaptic Plasticity

    August 16, 2022
    Gina Turrigiano and colleagues showed that the phosphorylation state of the autism-associated synaptic scaffold protein Shank3 can bias synapses toward upward or downward homeostatic plasticity.
  3. Decoding of Emotional Vocal Cues by the Auditory Cortex Correlates With Social Communication Abilities in Children

    August 16, 2022
    Vinod Menon and colleagues showed that a subregion of the auditory cortex decodes emotional cues in a communication partner’s voice and that this predicts social communication abilities …
  4. Understanding insomnia in the autism spectrum using mouse models

    Funded Work
    Sleep problems occur at a higher rate in people with autism spectrum disorder (ASD), affecting up to 93 percent of people with ASD.
  5. COVID-19 in pregnancy and early childhood: COPE study

    Funded Work
    It is unknown how the COVID-19 pandemic affects pregnant women and their offspring.
  6. The RNA Detective

    August 9, 2022
    At the Flatiron Institute, Christopher Park studies how mutations in RNA might play a role in neuropsychiatric conditions like autism, schizophrenia and ADHD.
  7. Watch: Suzanne Staggs and the Signatures of the Primordial Universe

    August 8, 2022
    Suzanne Staggs, a physicist at Princeton University and founding member of the Simons Observatory, describes what cosmic microwave background (CMB) radiation can reveal about the early universe.
  8. One of the Universe’s Earliest Galaxies Revealed Using the James Webb Space Telescope

    August 4, 2022
    … galaxies’ evolution and create predictions for future observations. “One thing we still don’t really understand is how they formed so quickly,” says Yung. “They’re only …
  9. Enhancing reciprocal cooperation through prefrontal microstimulation

    Funded Work
    Reciprocal cooperation is a hallmark of social groups and is central to successful social interaction, playing a major role in evolutionarily shaping brain functions and enabling rich social …
  10. Tracking sensory signals across multiple cortical areas during impaired sensory perception in Cntnap2 knockout mice

    Funded Work
    Altered sensory processing is a core and predictive feature of autism spectrum disorder (ASD).
  11. The role of cortical feedback during auditory perception in a mouse model of autism

    Funded Work
    Individuals with autism spectrum disorder (ASD) perceive and experience the world differently than neurotypical individuals.
  12. Genomic variation in centromeric proximal regions and risk of autism

    Funded Work
    Like many complexly inherited conditions, autism shows high heritability, yet the inventory of identified genomic variants appears to explain only a modest portion of the risk.
  13. Neural Networks and ‘Ghost’ Electrons Accurately Reconstruct Behavior of Quantum Systems

    August 3, 2022
    Physicists at the Flatiron Institute’s Center for Computational Quantum Physics and their collaborators have created a new way to simulate quantum entanglement between interacting particles. Their approach …
  14. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    August 2, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  15. Anomalous visual integration in mouse models of autism

    Funded Work
    Autism spectrum disorder (ASD) results from alterations in the development of neural circuits in the brain and leads to a variety of clinical conditions, including insistence on sameness …
  16. A registry for clinical and functional data for variants in the GRIN gene family

    Funded Work
    GRIN disorders are rare genetic conditions that affect one of the seven GRIN genes that encode NMDA receptor subunits, which mediate excitatory synaptic transmission in the brain.
  17. Quantitative and remote methods to study early cognitive development and heterogeneity in autism

    Funded Work
    Language difficulties and intellectual disability affect approximately one-third of individuals with autism spectrum disorder (ASD) and predict quality of life for adults with ASD.
  18. High-throughput autism variant functional testing using genetic interaction technologies in model systems

    Funded Work
    Determining genotype-phenotype relationships for gene variants that increase susceptibility to autism spectrum disorder (ASD) is critical for understanding underlying mechanisms and identifying therapeutic targets.
  19. Platforms to accelerate development of antisense oligonucleotide therapeutics for haploinsufficiencies associated with autism

    Funded Work
    Food and Drug Administration (FDA) approval and clinical use of antisense oligonucleotide (ASO) therapies have demonstrated their potential for treating monogenic disorders.
  20. Stem cell models to assess antisense oligonucleotides as novel therapeutics for autism

    Funded Work
    Autism spectrum disorder (ASD) represents a group of hundreds of individually rare conditions which are in large measure due to mutations in genes produced in the brain.
  21. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    August 1, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  22. Machine Learning Reveals Autism-Specific Variation in Brain Anatomy and Its Relationship to Autism Traits

    July 28, 2022
    Joshua K. Hartshorne, Stefano Anzellotti and colleagues used machine learning to disentangle variations in neuroanatomy that are specific to autism from variations common to the general population.
  23. SFARI 2022 Bridge to Independence Fellows Announced

    July 27, 2022
    SFARI is pleased to announce that it has selected seven fellows in response to the 2022 Bridge to Independence Award request for applications.
  24. Newly Identified Hypothalamic Cells Offer Insight Into the Relationship Between Fever and Autism

    July 27, 2022
    Catherine Dulac and her collaborators identified a population of cells in the hypothalamus that generate fever and influence the activity of brain areas associated with behavior during sickness …
  25. Simons Searchlight: July 2022 Data Release

    July 27, 2022
    New phenotypic data from Simons Searchlight participants were recently added to SFARI Base. This release includes data from individuals with 59 gene changes and nine copy number variants …
  26. Watch: John Bonini Tackles the Complexities of Quantum Machinery

    July 26, 2022
    Center for Computational Quantum Physics research fellow John Bonini is developing tools to elucidate quantum systems.
  27. David Byrne’s “Theater of the Mind” Set for Late August Debut

    July 25, 2022
    Theater of the Mind, an immersive experience that journeys “inside the human brain,” will soon premiere in Denver.
  28. What the Study of HIV Can Tell Us About the Brain

    July 25, 2022
    After uncovering new insights into how HIV hijacks the body’s innate immune system, Simons Junior Fellow Benem-Orom Davids is now exploring a possible viral component of …
  29. Strange New Phase of Matter Created in Quantum Computer Acts Like It Has Two Time Dimensions

    July 20, 2022
    By subjecting a quantum computer’s qubits to quasi-rhythmic laser pulses based on the Fibonacci sequence, physicists demonstrated a way of storing quantum information that is less …
  30. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    July 19, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  31. In Senescent Cells, a Promising Route To Slowing Brain Aging

    July 18, 2022
    As we age, our brains and bodies accumulate cells that have stopped dividing. Early studies in mice suggest that eliminating those cells might improve age-related memory loss …
  32. Church as a Venue for Powerful Experiences With STEM

    July 18, 2022
    Dr. Whitney Gaskins grew up in predominantly Black churches. Now she’s connecting these communities with STEM engagement opportunities.
  33. Simons Collaboration on Plasticity and the Aging Brain Announces Inaugural Class of Transition to Independence Fellows

    July 15, 2022
    Three talented early-career scientists in systems and computational neuroscience have been selected as the first Simons Collaboration on Plasticity and the Aging Brain Transition to Independence fellows …
  34. Seven Neuroscientists Awarded Transition to Independence Fellowships by the Simons Collaboration on the Global Brain

    July 15, 2022
    … behaviors. Ran is a postdoctoral fellow at Harvard Medical School. His research will further investigate how visceral organs are represented throughout the brain, and how viscerosensory codes …
  35. Seeing Science

    July 11, 2022
    Data visualization engineer Elizabeth Lovero combines her passions for art and computer programing to help scientists make new discoveries.
  36. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    July 8, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  37. Old Drugs Offer a New Route for Exploring Neural Dynamics

    July 8, 2022
    A recent wave of research is using pharmacology to test new hypotheses of neural coding and cognition.
  38. 2022 International Congress of Mathematicians

    Series
    The International Congress of Mathematicians 2022 (ICM 2022) took place virtually from July 6–14, 2022. These award videos premiered at the 2022 International Congress of Mathematicians in …
  39. Leelavati Prize Video: Nikolai Andreev Explains Math With Art, Animation and Toy Models

    July 5, 2022
    Through mathematically accurate animation and model-building — freely available for others around the world to use — Nikolai Andreev of the Steklov Mathematical Institute of the Russian Academy of …
  40. Gauss Prize Video: Elliott H. Lieb and the Mathematics of Physics

    July 5, 2022
    For seven decades, Elliott H. Lieb of Princeton University has made deep mathematical contributions that have shaped the fields of quantum mechanics, statistical mechanics, computational chemistry and quantum …
  41. Chern Medal Video: Barry Mazur Shapes the Landscape of Arithmetic Geometry

    July 5, 2022
    Barry Mazur of Harvard University made profound discoveries in topology, arithmetic geometry and number theory and is also known for his leadership and generosity in developing the next …
  42. Abacus Medal Video: Mark Braverman Tackles Information Complexity for More Efficient Communication

    July 5, 2022
    Mark Braverman of Princeton University made breakthroughs in the theory of information complexity, enabling the development of ingenious compression methods and noise-resilient communication protocols.
  43. Mathematicians, Including Simons Foundation Grantees, Awarded Top Honors by the International Mathematical Union

    July 5, 2022
    … Russian mathematician and recognizes revolutionary results in or with applications to mathematical physics. Jitomirskaya received the prize for her “groundbreaking work in mathematical physics, especially on the …
  44. Fields Medal Video: Maryna Viazovska

    July 5, 2022
    Maryna Viazovska of the École Polytechnique Fédérale de Lausanne (EPFL) proved that the E8 lattice provides the densest packing of identical spheres in eight dimensions while also solving …
  45. Fields Medal Video: James Maynard

    July 5, 2022
    James Maynard of the University of Oxford made major advances in number theory — in particular, the location of prime numbers and the approximation of real numbers with fractions.
  46. Fields Medal Video: June Huh

    July 5, 2022
    June Huh of Princeton University studied abstract spaces built from combinatorial objects, enabling him to make many breakthroughs, including the proof of the Dowling–Wilson conjecture for geometric …
  47. Fields Medal Video: Hugo Duminil-Copin

    July 5, 2022
    Hugo Duminil-Copin of the University of Geneva and the Institut des Hautes Études Scientifiques (IHES) solved longstanding problems in the probabilistic theory of phase transitions in statistical …
  48. New Award for Mathematical Physics, the Olga Alexandrovna Ladyzhenskaya Prize, Given to Svetlana Jitomirskaya

    July 5, 2022
    The first ever OAL Prize, celebrating the life of the noted Russian mathematician, honors outstanding contributions to the mathematics underlying previously unsolved problems in quantum physics.
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