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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Nikolai Andreev Explains Math With Art, Animation and Toy Models

    July 5, 2022
    Through mathematically accurate animation and model-building — freely available for others around the world to use — Nikolai Andreev of the Steklov Mathematical Institute of the Russian Academy of …
  2. New Assessment Tool Provides a Remote Telehealth Approach To Facilitate Autism Diagnosis During COVID-19 and Beyond

    July 1, 2022
    So Hyun Kim, Catherine Lord and colleagues developed a new telehealth approach to autism assessment — the Brief Observation of Symptoms of Autism (BOSA) — for use during COVID-19 …
  3. Oxytocin Regulates Changes in Social Brain Circuits Connectivity in a Cntnap2 Mouse Model of Autism

    July 1, 2022
    Daniel Geschwind and colleagues showed that Cntnap2 knockout mice exhibit alterations in brain-wide connectivity related to social behaviors and that oxytocin within the nucleus accumbens regulates changes …
  4. Analysis of Autism BrainNet Postmortem Brain Tissue RFA: Awardees Announced

    June 30, 2022
    SFARI is pleased to announce that it intends to fund four grants in response to the request for applications (RFA) focused on the analysis of postmortem brain tissue …
  5. Society for Science: STEM Action Grants

    Funded Work
    This grant program supports community-driven organizations working to enhance the public’s understanding of science and to increase participation of underrepresented populations in STEM.
  6. Sing for Science

    Funded Work
    Science and music podcast where musicians talk to scientists about how their science connects to their most famous songs.
  7. APH: Abacus Bee

    Funded Work
    Friendly contest enabling students with vision loss to gain math skills while working alongside their peers.
  8. SFARI Supports 2022 Summer Undergraduate Research Program

    June 29, 2022
    SFARI is pleased to support the Summer Undergraduate Research Program in 2022, working with SFARI Investigators and leading U.S. universities to help provide opportunities for undergraduate students …
  9. The Social Lives of Birds and Mice: A Lens Into the Nature of Emotion

    June 29, 2022
    Simons Junior Fellow Jennifer Merritt began her career studying the evolution of territoriality in birds. Now, her research on monogamous mice aims to identify the neurons in the …
  10. Multimodal fingerprinting of cellular phenotypes associated with autism risk variants

    Funded Work
    While genetic studies have identified numerous risk variants and genes for autism spectrum disorder (ASD), therapeutic development requires both better understanding of the genes’ neurobiological roles and scalable …
  11. Antisense oligonucleotide therapy of X-linked protocadherin 19-related autism and epilepsy

    Funded Work
    PCDH19-clustering epilepsy (PCE) is a severe developmental and epileptic encephalopathy caused by loss-of-function variants in the PCDH19 gene on the X chromosome.
  12. A splicing code for elucidating genetic and molecular mechanisms underlying autism

    Funded Work
    Alternative splicing generates transcript variants from over 90 percent of human genes, and its disruption causes or contributes to numerous diseases and disorders.
  13. Optimization and validation of gene therapy using a patient-specific mouse model of SLC6A1-related disorders

    Funded Work
    Solute carrier family 6 membrane 1 (SLC6A1) protein is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane and removes GABA from the synaptic cleft.
  14. Genome accessibility as a high-resolution biomarker for autism gene therapy

    Funded Work
    Early intervention for autism spectrum disorder (ASD) provides the best chance for minimizing challenges that interfere with quality of life.
  15. Functional annotation of gene variants in autism risk genes using DNA methylation signatures

    Funded Work
    The role of dysregulated chromatin biology in autism spectrum disorder (ASD) has become increasingly apparent as genome sequencing has implicated numerous epigenetic regulatory genes in ASD etiology.
  16. Loss of Tsc1 in Striatal Neurons May Contribute to Altered Motor Behaviors in Tuberous Sclerosis Complex and Autism

    June 28, 2022
    Helen Bateup and colleagues showed that a loss of Tsc1 from striatal direct pathway neurons altered synaptic function and enhanced motor routine learning in mice. These findings suggest …
  17. Machine-Learning Model Provides Estimates of Cognitive Ability for Large-Scale Autism Studies

    June 28, 2022
    Yufeng Cheng, Wendy Chung, Chang “April” Shu and their colleagues used machine-learning models to develop a method for large-scale studies to estimate cognitive ability in individuals …
  18. SFARI Workshop Explores Mitochondrial Dysfunction in Autism

    June 17, 2022
    On March 25 and 28, 2022 SFARI hosted a workshop to explore the role of mitochondria in ASD risk. The workshop brought together experts in mitochondrial research spanning …
  19. Chemical characterization of acylated polysaccharides in dissolved organic matter and marine microbes

    Funded Work
  20. Simons Foundation President David Spergel Elected to the American Philosophical Society

    June 13, 2022
    The American Philosophical Society has elected astrophysicist and Simons Foundation president David Spergel as one of the newest members of its ranks. Benjamin Franklin founded the organization in …
  21. Flatiron Institute Partners With the European Space Agency for Latest Gaia Data Release

    June 13, 2022
    … galaxy’s structure and evolution over billions of years to better understand the life cycle of stars and our place in the universe. DR3 includes new information …
  22. RNA-Seq Data From Simons Simplex Collection Now Available

    June 10, 2022
    RNA-sequencing data from lymphoblastoid cell lines derived from individuals with ASD and their unaffected siblings from the Simons Simplex Collection are now available to approved researchers.
  23. Foundation Announces the Simons Collaboration on Confinement and QCD Strings

    June 9, 2022
    … gravitational theories. The generalization of QCD from 3 to N colors, and the subsequent large N limit of gauge theories, offer a particularly good vantage point on …
  24. Foundation Announces the Simons Collaboration on New Structures in Low-Dimensional Topology

    June 9, 2022
    … lead to the resolution of fundamental open problems extending far beyond the localized study of low-dimensional topology. The Simons Collaborations on New structures in Low-Dimensional …
  25. The Secret Lives of Stars

    June 8, 2022
    Massive stars are key players in the universe. They explode as supernovae, affect the evolution of galaxies, and even create the elements in our DNA. Through computer modeling …
  26. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    June 7, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  27. Exploring How Young Blood Helps Reverse Signs of Aging in Old Brains

    June 6, 2022
    Scientists are zeroing in on the ways that parabiosis — treating old animals with young blood — alters gene activity, shining light on its rejuvenating effects.
  28. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    May 27, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  29. In Mapping Mistakes, a Window to the Inner Mind

    May 26, 2022
    New efforts explore how internal states influence decision-making.
  30. Watch: The SCGB Undergraduate Research Fellowship

    May 23, 2022
    The Simons Collaboration on the Global Brain (SCGB) Undergraduate Research Fellowship (SURF) program is designed to spark and sustain interest in systems and computational neuroscience among undergraduate students …
  31. Shedding Light on Wave Physics in Dynamical Metamaterials

    May 20, 2022
    By exploring how waves move through artificially engineered metamaterials, structured in space and modulated in time, physicist and first-year Simons Junior Fellow Emanuele Galiffi is obtaining fundamental …
  32. Quanta Magazine Wins 2022 Webby People’s Voice Award for Best Writing

    May 17, 2022
    Quanta Magazine was honored with a People’s Voice award for Best Writing (Editorial) yesterday at the 26th Annual Webby Awards, hosted by the comedian Roy Wood Jr …
  33. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    May 12, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  34. New Map of Brain Vasculature Reveals Unexpected Diversity

    May 12, 2022
    Tracking gene expression in individual cells uncovers new cellular subtypes within the blood vessels that irrigate and protect the brain.
  35. SFARI Investigators Elected to the American Academy of Arts and Sciences and National Academy of Sciences in 2022

    May 12, 2022
    Two SFARI Investigators were elected to the American Academy of Arts & Sciences, and one SFARI Investigator was elected to the National Academy of Sciences in April 2022.
  36. Quanta Magazine‘s Natalie Wolchover and Staff Awarded the 2022 Pulitzer Prize for Explanatory Writing

    May 9, 2022
    … Berkeley, and co-authored several academic papers in nonlinear optics. Her writing has been featured in The Best American Science and Nature Writing and The Best Writing …
  37. Characterizing the convergent molecular mechanisms of common and rare autism-associated genetic variation

    Funded Work
    The additive effects of thousands of common genetic variants explain most genetic risk for autism spectrum disorder (ASD) in the population.
  38. Math and Dance Collide at ‘Dance of the Diagram’

    May 9, 2022
    A contemporary dance performance inspired by the groundbreaking cohomology research by mathematicians Jim Simons and Dennis Sullivan
  39. A human stem cell-based neuronal network platform for functional validation of autism-linked variants

    Funded Work
    Genome-wide analyses of large cohorts of people with autism spectrum disorder (ASD) have enabled the identification of numerous de novo and inherited rare DNA variants linked to …
  40. Development of a CRISPR base editing gene therapy for Rett syndrome

    Funded Work
    Rett syndrome (RTT), which is caused by loss-of-function mutations in the gene MECP2, is the leading cause of complex autism spectrum disorders (ASD).
  41. Gene therapies for GRIN disorder

    Funded Work
    Several forms of syndromic autism have as a common feature changes in N-methyl-D-aspartate (NMDA) receptors.
  42. CCB Director Michael Shelley and Simons-Supported Researchers Elected to National Academy of Sciences

    May 6, 2022
    … New York University Courant Institute
  43. American Academy of Arts and Sciences Elects 11 Simons Research Grantees

    May 6, 2022
    Eleven Simons Foundation grantees and one board member are among the latest cohort of prominent artists, scholars, scientists and leaders elected as fellows of the American Academy of …
  44. The Quantum Plumber

    May 6, 2022
    Sitting at the juncture of quantum physics and fluid dynamics, Flatiron Institute physicist Nikita Kavokine has been called a “quantum plumber” for having discovered the specifics of how …
  45. Science Sandbox Holds Inaugural Awardee Summit

    May 3, 2022
    For the first time, the community of Science Sandbox awardees convened for a two-day summit at the Simons Foundation
  46. Quanta Magazine’s New Podcast, ‘The Joy of Why,’ Ponders the Big Questions

    May 2, 2022
    … Powers and The Joy of x. Quanta Magazine is an award-winning, editorially independent publication launched by the Simons Foundation to illuminate big ideas in science and …
  47. Integration of electrophysiological and transcriptomic signatures of cognitive resilience in the hippocampus using patch-seq

    Funded Work
    As we age, most individuals will experience normal declines in cognitive abilities, including memory.
  48. Altered Immune Molecules During Pregnancy and in the Umbilical Cord at Birth Predict Later Autism Diagnoses

    April 29, 2022
    Ian Lipkin, Mady Hornig and colleagues showed that levels of immune molecules in mothers during pregnancy and in cord blood at birth are highly predictive of later autism …
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