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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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  • Presidential Lectures
  • Presents
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. SPARK Research Match Expansion — Request for Applications 2026-2027

    Funding Opportunity
    The SPARK Research Match Expansion request for applications (RFA) encourages and supports applications for SPARK Research Match studies from principal investigators to increase SPARK research opportunities to individuals …
  2. Fellows-to-Faculty - 2027 Request for Applications

    Funding Opportunity
    The Fellows-to-Faculty Award program supports talented early career scientists by facilitating their transition into tenure-track faculty positions. The focus of this program is the $600 …
  3. New Ideas - 2026 Request for Applications

    Funding Opportunity
    The goal of the New Ideas Award is to provide early stage support for bold, exploratory research that tests novel hypotheses and opens new conceptual or experimental directions …
  4. Fellows-to-Faculty - 2025 Request for Applications

    Funding Opportunity
    Supports early career scientists transitioning to tenure-track positions with a $600,000 three-year research grant, mentoring, peer support and a collaborative community.
  5. Conference Support for Rare Neurodevelopmental Disorder Communities Participating in Simons Searchlight

    Funding Opportunity
    … we support partners, programs and initiatives that seek to broaden the scientific community and open pathways to science and mathematics careers. The Simons Foundation provides equal opportunities …
  6. Fellows-to-Faculty - 2026 Request for Applications

    Funding Opportunity
    The Fellows-to-Faculty Award helps early career scientists transition to tenure-track positions with a $600,000 three-year research grant, mentoring, peer support and a collaborative …
  7. Data Analysis — Request for Applications 2025

    Funding Opportunity
    … partners, programs and initiatives that seek to broaden the scientific community and open pathways to science and mathematics careers. The Simons Foundation provides equal opportunities to all …
  8. Simons Foundation Autism & Neuroscience Conferences and Courses Awards - Request for Applications 2026

    Funding Opportunity
    Supports conferences and courses advancing research across autism and neurodevelopment, healthy cognitive aging, ecological neuroscience, and systems and computational neuroscience.
  9. Autism Rat Models Consortium 2.0 RFA

    Funding Opportunity
    … awardees of this RFA will work as a consortium to use these rat models to further our understanding of the behaviors and underlying neural circuits relevant to …
  10. Linking Early Neurodevelopment to Neural Circuit Outcomes — Request for Applications

    Funding Opportunity
    … find an extended list of literature describing early developmental phenotypes here.
  11. Pilot Award — Request for Applications 2024

    Funding Opportunity
    … Investigators will include the evaluation of progress on previous or ongoing SFARI grants. Instructions for Submission Applications must be submitted via the Simons Award Manager (SAM). Please …
  12. SFARI Pilot Progression Award — Request for Applications 2024

    Funding Opportunity
    … towards the page limit. Our Commitment to Expanding Pathways to Science and Opportunities for All Many of the greatest ideas and discoveries come from a diverse mix …
  13. Human Cognitive and Behavioral Science — Request for Applications

    Funding Opportunity
    … individuals with autism; for example, machine learning approaches that could amplify measurable gains from intensive behavioral interventions would be of interest. SFARI considered the following as out …
  14. Cross-Species Studies of ASD — Request for Applications

    Funding Opportunity
    … background. While there is no rigorous way to model “idiopathic” ASD in non-human animals, we encouraged applicants to carefully consider and rationalize comparisons of humans with …
  15. Genomics of ASD: Pathways to Biological Convergence and Genetic Therapies — Request for Applications

    Funding Opportunity
    Grants awarded through this request for applications (RFA) were intended to advance our understanding of the genetic basis of ASD and the molecular and cellular consequences of genetic …
  16. Analysis of Postmortem Brain Tissue from the Autism BrainNet Collection — Request for Applications

    Funding Opportunity
    Grants awarded through this request for applications (RFA) were intended to advance the understanding of ASD through analyses of human postmortem brain tissue donated to the Autism BrainNet …
  17. Autism Rat Models Consortium — Request for Applications

    Funding Opportunity
    … circuits relevant to autism and related NDD.
  18. Maternal COVID-19 As a Potential Risk for Autism: Supplemental Funding for Ongoing Pregnancy Cohorts — Request for Applications

    Funding Opportunity
    Several prospective pregnancy cohorts, across multiple continents, were recruited during the COVID-19 pandemic. These cohorts afforded the opportunity to better understand the impact of maternal infection and …
  19. SFARI Collaboration on Sex Differences in Autism - Request for Applications 2021

    Funding Opportunity
    … D.M. Biol. Sex Differ. 7, 58 (2016) PubMed Doan R.N. et al. Nat. Genet. 51, 1092–1098 (2019) PubMed Baron-Cohen S. et al. Mol …
  20. Research Award - Request for Applications 2020

    Funding Opportunity
    The goal of the Research Award was to provide support for investigation of key unresolved research questions in autism, particularly those that connect genetic etiologies to brain function …
  21. Novel Outcome Measures in ASD — Request for Applications

    Funding Opportunity
    Intervention studies for autism spectrum disorder (ASD) are hampered by a lack of reliable and sensitive measures to assess treatment response, whether the interventions are behavioral or pharmacological …
  22. SPARK Clinical Site Network — Request for Applications

    Funding Opportunity
    The overall goal of SPARK (Simons Foundation Powering Autism Research for Knowledge) is to recruit, engage and retain a research community of at least 50,000 individuals in …
  23. Genomic Analysis for Autism Risk Variants in SPARK – Request for Applications

    Funding Opportunity
    SPARK (Simons Foundation Powering Autism Research) is an autism research initiative that aims to recruit, engage and retain a community of 50,000 individuals with autism and their …
  24. Whole-Genome Analysis for Autism Risk Variants

    Funding Opportunity
    … 400 TB) available to their academic or cloud-based computing resources. SFARI understood that validation of prioritized hits was a key part of this project and coordinated …
  25. Functional Screen of Autism-Associated Variants Request for Applications

    Funding Opportunity
    Grants awarded through this request for applications (RFA) were intended to advance our understanding of the genetic basis of autism, and in particular the potential role of missense …
  26. Innate Immune System Impact Request for Applications

    Funding Opportunity
    Grants awarded through this request for applications (RFA) were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic …
  27. Circuit Dynamics Request for Applications

    Funding Opportunity
    This request for applications (RFA) was intended to advance our understanding of the circuit basis for behavioral and cognitive alterations relevant to autism spectrum disorders (ASD). The goal …
  28. Analysis of Simons VIP Biospecimens Request for Applications

    Funding Opportunity
    The Simons Variation in Individuals Project (now known as Simons Searchlight) comprises a large cohort of individuals with a deletion or duplication of chromosomal segment 16p11.2 (approximately …
  29. Mouse Phenotyping Request for Applications

    Funding Opportunity
    To maximize the ability to make direct comparisons among mouse models, this request for applications sought applications for systematic, rigorous and scalable analyses of behavioral phenotypes across multiple …
  30. Explorer Awards — Request for Applications

    Funding Opportunity
    This award program was designed to enhance our existing support of autism research by providing timely resources to enable high-risk/high-impact, exploratory experiments relevant to our …

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