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Simons Foundation
Simons Foundation
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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Research Highlights

How an Autism-Associated Gene Keeps Synapses Stable

Confocal microscopy image showing neuronal expression of Chd1 in the Drosophila larval brain.

Epilepsy and intellectual disability often occur alongside autism spectrum disorder (ASD), and researchers have long suspected that these conditions share common biological roots.

Read full story How an Autism-Associated Gene Keeps Synapses Stable

Fragile X Syndrome Impairs Cooperation in Rats

August 5, 2026

Cis-Regulation Therapy Rescues SCN2A-Related Neurological Dysfunction

November 19, 2025

Using the Linear References From the Pangenome To Discover Missing Autism Variants

April 1, 2026
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Sad or angry toddler baby girl looking down with her arms crossed.

Genes Linked to Early Childhood Temperament Also Influence Autism and ADHD Risk

August 31, 2026
A smiling boy wearing black headphones rests his chin on his hands.

Autistic and Nonautistic Youth Successfully Leverage Same Social Learning Strategies

August 20, 2026
Confocal microscopy image of neurons in the nucleus accumbens of a mouse.

Acetylcholine Helps Dopamine Reward Hard Work

June 11, 2026
An image comparing the presence of ZBTB18 mRNA and ZBTB18 protein in germinal-zone cells shows that whilst RNA is detectable, the protein is not.

Protein Levels, Not Just Transcripts, Hold Clues to Autism

May 26, 2026
Image of the mouse superior colliculus neurons, overlaid with a color map showing the degree of plastic changes in their visual response dynamics during visual implicit learning task.

Altered Corticotectal Circuitry Shapes Contextual Sensory Processing in a Mouse Model of Autism

April 6, 2026
A little boy with Autism and his sister sitting playing together laughing and being happy, smiling and cute.

Age at Autism Diagnosis Linked to Distinct Genetic Profiles

March 11, 2026
The choroid plexus undergoing apocrine secretion.

Choroid Plexus Secretion Regulates CSF Proteome and Alters Brain Development

March 5, 2026
An image of control neurons in the dorsolateral prefrontal cortex of fetal macaque showing their many dendrites, compared to immature neurons that have few dendrites.

Multimodal Approach Reveals How Autism-Linked Genes Shape Primate Prefrontal Cortex Development

February 12, 2026
A microscopy image of a human stem cell-derived hippocampal organoid.

Human Assembloid Model Reveals Region-Specific Effects of an Epilepsy-Linked Mutation

February 5, 2026
3D digital imaging from Kinect point tracking.

Performance on a Specialized Video Game Distinguishes Children With Autism From Those With ADHD and Neurotypical Development

November 20, 2025
A photo of a boy looking at the one flat tire of the bicycle.

SINEUPs: lncRNAs With the Potential To Upregulate Haploinsufficient Autism Risk Genes

July 16, 2025
A white rat with black ears grooms itself, covering both eyes with the paws. The rat is sitting on a pink and yellow blanket.

AI-Powered Tool Maps the Fine Details of Rodent Social Behavior

April 29, 2025
Image from research by Juergen Knoblich.

Two Studies Using Brain Organoids Reveal Cell-Type-Specific Changes During the Early Stages of Human Forebrain Neuronal Development in Autism

November 9, 2023

Excessive Protein Degradation Is Identified as a New Cellular Pathology and a Potential Target for Therapeutic Intervention in Fragile X Syndrome

March 23, 2023

A Novel Eye-Tracking Paradigm Identifies an Influence of Perceptual Load on Social Attention in Autism

March 14, 2023

A New Approach To Analyzing Genomic Association Data Finds Convergence of Both Rare and Common Genetic Influences on Autism at Chromosome 16p

March 6, 2023
Ovarioles

Two Studies Clarifying the Role of FMRP in mRNA Translation in Fragile X Syndrome

October 11, 2022

Gene Expression Patterns That Underlie Functional Brain Activity Are Disrupted in Autism

August 29, 2022

A Bidirectional Switch Affecting Phosphorylation of Shank3 Influences Homeostatic Synaptic Plasticity

August 16, 2022

Decoding of Emotional Vocal Cues by the Auditory Cortex Correlates With Social Communication Abilities in Children

August 16, 2022

Machine Learning Reveals Autism-Specific Variation in Brain Anatomy and Its Relationship to Autism Traits

July 28, 2022
Person's Hand Checking Fever Of Sick Girl

Newly Identified Hypothalamic Cells Offer Insight Into the Relationship Between Fever and Autism

July 27, 2022
A woman and child getting a diagnosis via video chat

New Assessment Tool Provides a Remote Telehealth Approach To Facilitate Autism Diagnosis During COVID-19 and Beyond

July 1, 2022
Molecule of oxytocin, a hormone released from the neurohypophysis

Oxytocin Regulates Changes in Social Brain Circuits Connectivity in a Cntnap2 Mouse Model of Autism

July 1, 2022

Loss of Tsc1 in Striatal Neurons May Contribute to Altered Motor Behaviors in Tuberous Sclerosis Complex and Autism

June 28, 2022

Machine-Learning Model Provides Estimates of Cognitive Ability for Large-Scale Autism Studies

June 28, 2022
A pregnant woman during a routine check up with her doctor.

Altered Immune Molecules During Pregnancy and in the Umbilical Cord at Birth Predict Later Autism Diagnoses

April 29, 2022

Synaptic Imbalance and Disrupted Homeostatic Plasticity in Cortical Circuits of Chd8 Haploinsufficient Mice

April 29, 2022

Alterations in Sound Processing in Cntnap2 Rats Provide Insights Into Mechanisms of Language-Related Disorders

April 29, 2022

New Genetic Analyses Provide Estimates of De Novo Mutations in Low– and High–Risk Families With Autism

April 18, 2022

Study Finds Placental Hormone Is Critical for Fetal Brain Development

February 24, 2022

Human Derived 3D Brain Cultures Provide Insights Into Brain Size Changes in 16p11.2 Conditions

February 24, 2022

New Study Supports Role for Disruptions in Synapse Development and Function in ASD

February 23, 2022

Patchy Expression of Pcdh19 in Female Mice Causes Defects in Hippocampal Neuron Presynaptic Development Signaling and Memory Processing

January 28, 2022

High-Resolution Rodent Movement Tracking Provides the Opportunity To Link Autism Risk Genes With Behavioral Presentations

January 26, 2022

A Machine-Learning Framework for Prioritizing Disease-Associated Enhancers

January 25, 2022

Altered Hormone Signaling in the Brainstem Causes Motor Delays in 16p11.2 Mice

November 22, 2021
Image of brain neurons

RhoA Overactivation May Underlie Smaller Brain Volumes in Cul3 Mutant Mice

November 16, 2021
Colorful abacus beads in blue and red are arranged diagonally on rods with a dark, patterned background featuring faint geometric shapes and DNA-like lines.

Tandem Repeat Mutations in Autism

November 16, 2021

Perceptual Impairments and Altered Excitatory–Inhibitory Activity in Cntnap2 Knockout Mice

September 30, 2021

Fetal Responses to Maternal Infection May Help Explain Prevalence of Autism in Males

September 30, 2021
Papers logo

From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

September 29, 2021

Probing the Neural Circuits of Social Interactions in Monkeys

September 28, 2021

Excessive Dendritic Spine Clusters in MECP2 Duplication Syndrome Mouse Model

August 25, 2021

Large Cohorts Aid in Genotype-Phenotype Analyses

August 25, 2021
Image of child

Sensory Habituation Is Reduced in Autism

August 25, 2021

Impaired Long–Range Communication and Reduced Anxiety–Related Behavior in Pogz Deficient Mice

July 20, 2021
Image of eye

Pupil Responses Predict Reward Sensitivity and Autism Status

July 19, 2021

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