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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. 2022 SFARI Human Cognitive and Behavioral Science Awardees Announced

    October 24, 2022
    SFARI is pleased to announce that it intends to award ten grants in response to the 2022 Human Cognitive and Behavioral Science request for applications.
  2. Science Sandbox Awardees Headed to SXSW EDU 2023

    October 20, 2022
    Three Science Sandbox awardees will be featured in a Science Sandbox-curated SXSW EDU
  3. Seeing the Early Universe Through a Simulation

    October 19, 2022
    Computational models are empowering researchers to understand observations from the James Webb Space Telescope, painting a virtual picture of the early universe.
  4. Simons and NSF-Supported Research Centers Explore the Symbiotic Relationship Between Mathematics and Biology

    October 18, 2022
    With leaps in technology and exchanges between two fields, the most exciting time in the intersection of mathematics and biology is right now.
  5. From Statistics to Gerbils: Learning About Neural Connections With Social Rodents

    October 17, 2022
    By learning the language of Mongolian gerbils, neurostatistician Alex Williams is studying the ways our brains’ neural circuits change over time.
  6. New Insight Into the Hidden States of the Brain

    October 12, 2022
    Long-term recordings of large populations of neurons reveal neural motifs representing internal states.
  7. Two Studies Clarifying the Role of FMRP in mRNA Translation in Fragile X Syndrome

    October 11, 2022
    Studies by two different research teams — one led by Ethan Greenblatt and the other by Emily Osterweil — both suggest that FXS cells under-synthesize large proteins, findings that …
  8. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    October 11, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  9. Updates to SFARI’s Requests for Grant Applications for 2023

    October 10, 2022
    To further our goal of funding the best and most transformative research on autism, SFARI strives to strike a balance between open requests for grant applications (RFAs) on …
  10. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    October 10, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  11. Three Past and Present Members of the Simons Collaboration on the Global Brain Receive NIH’s New Innovator Award

    October 5, 2022
    The National Institutes of Health (NIH) has recognized three outstanding current and former members of the Simons Collaboration on the Global Brain (SCGB) with the NIH Director’s …
  12. Nobel Prize in Physics Awarded to Alain Aspect, a Principal Investigator for the Simons Collaboration on Localization of Waves

    October 4, 2022
    Alain Aspect, a Principal Investigator for the Simons Collaboration on Localization of Waves, received the 2022 Nobel Prize in physics along with John F. Clauser and Anton Zeilinger …
  13. The Fruit Fly Photographer

    October 3, 2022
    Developmental biologist Jasmin Imran Alsous knows that it takes a village to raise an egg cell. At the Flatiron Institute, she and her collaborators are working together to …
  14. The Surprising Connection Between Hormones and Decision-Making

    September 26, 2022
    Guided by a long-held interest in brain function and behavior, Simons Junior Fellow Carla Golden is exploring the role that estrogen plays in the brain’s ability …
  15. Artificial Intelligence Reduces a 100,000-Equation Quantum Physics Problem to Only Four Equations

    September 26, 2022
    Researchers at the Flatiron Institute and their colleagues trained a machine learning tool to capture the physics of electrons moving on a lattice using far fewer equations than …
  16. Growing Insight Into COVID’s Long-Term Brain Effects

    September 23, 2022
    By examining the neuroinflammation and cognitive issues that can follow COVID infection in human studies and animal models, scientists are highlighting parallels to aging and neurodegenerative disease.
  17. CCA Research Scientist Matteo Cantiello Receives Aspen Institute Italia Award

    September 20, 2022
    … angle. Further data collected in the following months confirmed that the hypothesis supported in this work is indeed correct. Cantiello joined the foundation in 2017 as associate …
  18. New Efforts To Relate Brain Structure and Function Reveal Surprising Properties of Neural Circuits

    September 19, 2022
    Recent advances in functional connectomics are shedding new light on circuit motifs in the worm, fly and mouse brains.
  19. Physicists Present New Method for Designing Topological Metals

    September 19, 2022
    Flatiron Institute’s Jennifer Cano is part of an international team that demonstrates a design principle for predicting whether metallic compounds are likely to host topological states caused …
  20. Jellyfish and Polyps Offer New Insight Into How Groups of Neurons Coordinate Behavior

    September 19, 2022
    Novel tools for studying cnidarians’ distributed neural nets enable researchers to explore how neural ensembles form and interact.
  21. Old Problems, New Tools: Adapting Applied Mathematics for Quantum Physics

    September 19, 2022
    Flatiron applied mathematician Jason Kaye is bringing powerful new approaches to quantum physicists to help them answer big questions about small particles.
  22. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    September 14, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  23. CCQ Postdoc Aavishkar Patel Recognized With the Hermann Kümmel Early Achievement Award in Many-Body Physics

    September 14, 2022
    The International Conference on Recent Progress in Many-Body Theories has awarded the Hermann Kümmel Early Achievement Award in Many-Body Physics to quantum physicist Aavishkar Patel. The …
  24. CCQ Director Antoine Georges Awarded the Feenberg Memorial Medal

    September 14, 2022
    Antoine Georges, the director of the Flatiron Institute’s Center for Computational Quantum Physics (CCQ), received the Feenberg Memorial Medal on September 14 at the International Conference Series …
  25. Simons Collaboration on the Global Brain Announces New Class of Undergraduate Research Fellows

    September 12, 2022
    … Zhang Columbia University
  26. Interview: Ran Yan From the Lewis Latimer House Museum

    September 8, 2022
    Our new Science Sandbox Spotlight series aims to highlight the people behind the organizations in our grantee portfolio. In the series’ first installment, we speak with Ran Yan …
  27. Simons Foundation Announces First Pivot Fellowship Recipients

    September 7, 2022
    … approaches on a problem of high agricultural significance.
  28. SFARI 2022 Pilot Awardees Announced

    September 6, 2022
    SFARI is pleased to announce that it intends to fund 16 grants in response to the 2022 Pilot Award request for applications.
  29. The Planet Huntress

    September 6, 2022
    Is there another Earth out there? Flatiron Institute astronomer Megan Bedell is on the hunt for Earth 2.0. And she’s making new discoveries about sunlike stars …
  30. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    September 1, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  31. Simons Collaboration on Plasticity and the Aging Brain Announces New Research Awards

    September 1, 2022
    … cognitive function even late in life — a phenomenon known as cognitive resilience. While the causes of age-related cognitive degeneration are largely unknown, heritability estimates indicate a …
  32. The Simons Foundation Joins the Sloan, Moore and Templeton Foundations To Fund “Tabletop” Experiments

    September 1, 2022
    The Simons Foundation, the Alfred P. Sloan Foundation, the Gordon and Betty Moore Foundation and the John Templeton Foundation are inviting applications to a one-time call aimed …
  33. SFARI Workshop Highlights Challenges and Best Practices for Induced Pluripotent Stem (iPS) Cell Models in Autism Research

    August 31, 2022
    SFARI hosted a virtual workshop on March 14 and 18, 2022, to discuss the best practices for the development and use of induced pluripotent stem (iPS) cell models …
  34. New DYRK1A and GRIN2B Zebrafish Models Added to SFARI Resources

    August 31, 2022
    New zebrafish lines with mutations in the high-confidence autism risk genes DYRK1A and GRIN2B have been added to SFARI resources.
  35. Toward a Deeper Understanding of the Manifolds Behind Motion

    August 30, 2022
    Simons Junior Fellow Tim Large studies the mathematics underlying the spaces that control planetary orbits and the physical laws of motion.
  36. Gene Expression Patterns That Underlie Functional Brain Activity Are Disrupted in Autism

    August 29, 2022
    Genevieve Konopka and colleagues coupled brain imaging with measures of gene expression to reveal that gene expression patterns in the cortex that typically underlie functional brain activity in …
  37. SPARK August 2022 Update: New Phenotypic and Genomic Data Available

    August 23, 2022
    Phenotypic data from 296,307 participants enrolled in SPARK, including 117,203 individuals with ASD, are now available to approved researchers. Genomic data (whole-exome sequencing and genome …
  38. Clinical Trial of Arbaclofen for 16p11.2 Deletion Has Launched

    August 18, 2022
    Clinical Research Associates, L.L.C., an affiliate of the Simons Foundation, has recently launched a randomized controlled trial to test the safety, tolerability and efficacy of arbaclofen …
  39. New SPARK Study Identifies a Novel Group of Inherited Genes of Moderate Effect and Shows Their Links to Other Behavioral Conditions

    August 18, 2022
    In a series of articles published in the journal Nature Genetics, researchers used data from the SPARK research cohort, which was created to advance our understanding of the …
  40. A Bidirectional Switch Affecting Phosphorylation of Shank3 Influences Homeostatic Synaptic Plasticity

    August 16, 2022
    Gina Turrigiano and colleagues showed that the phosphorylation state of the autism-associated synaptic scaffold protein Shank3 can bias synapses toward upward or downward homeostatic plasticity.
  41. Decoding of Emotional Vocal Cues by the Auditory Cortex Correlates With Social Communication Abilities in Children

    August 16, 2022
    Vinod Menon and colleagues showed that a subregion of the auditory cortex decodes emotional cues in a communication partner’s voice and that this predicts social communication abilities …
  42. The RNA Detective

    August 9, 2022
    At the Flatiron Institute, Christopher Park studies how mutations in RNA might play a role in neuropsychiatric conditions like autism, schizophrenia and ADHD.
  43. Watch: Suzanne Staggs and the Signatures of the Primordial Universe

    August 8, 2022
    Suzanne Staggs, a physicist at Princeton University and founding member of the Simons Observatory, describes what cosmic microwave background (CMB) radiation can reveal about the early universe.
  44. One of the Universe’s Earliest Galaxies Revealed Using the James Webb Space Telescope

    August 4, 2022
    … galaxies’ evolution and create predictions for future observations. “One thing we still don’t really understand is how they formed so quickly,” says Yung. “They’re only …
  45. Neural Networks and ‘Ghost’ Electrons Accurately Reconstruct Behavior of Quantum Systems

    August 3, 2022
    Physicists at the Flatiron Institute’s Center for Computational Quantum Physics and their collaborators have created a new way to simulate quantum entanglement between interacting particles. Their approach …
  46. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    August 2, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  47. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    August 1, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  48. Machine Learning Reveals Autism-Specific Variation in Brain Anatomy and Its Relationship to Autism Traits

    July 28, 2022
    Joshua K. Hartshorne, Stefano Anzellotti and colleagues used machine learning to disentangle variations in neuroanatomy that are specific to autism from variations common to the general population.
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