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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Simons Searchlight July 2025 Update: New Phenotypic Data Available

    July 30, 2025
    SFARI is pleased to announce that Simons Searchlight has released new data from over 5,600 individuals with autism and/or a related neurodevelopmental disorder.
  2. SINEUPs: lncRNAs With the Potential To Upregulate Haploinsufficient Autism Risk Genes

    July 16, 2025
    … stop+frameshift (c.2485dupA). To test if SINEUPs targeting CHD8 could be effective in vivo, the scientists turned toward an established zebrafish model of Chd8 haploinsufficiency, chd8p …
  3. New Study Reveals Subclasses of Autism by Linking Traits to Genetics

    July 9, 2025
    An analysis of more than 5,000 individuals with autism reveals four distinct groups that link autism-related traits with underlying genetics. The work could open the door …
  4. Applications Open for SFARI Data Analysis RFA

    July 1, 2025
    SFARI is pleased to launch a new RFA that aims to provide researchers with the support needed to allocate time and personnel toward working with and publishing from …
  5. Autism Inpatient Collection Releases Genetic, Phenotypic Data for More Than 1,500 Hospitalized Children With Autism

    June 18, 2025
    As the largest-ever collection of data from youth with autism who have high support needs, this resource will accelerate research into an understudied population.
  6. Autism BrainNet Releases Genetic Data for 27 New Brain Samples

    June 9, 2025
    Autism BrainNet is pleased to announce the release of genetic data for 27 new brain samples. The data release brings the total number of brain samples with available …
  7. SFARI To Fund 18 Patient Advocacy Group Conferences

    May 12, 2025
    SFARI will fund 18 meetings, with a focus on groups in the Simons Searchlight community, that bring together scientists and patient communities to share recent advancements and discuss …
  8. SFARI Funds 5 Projects Aiming To Understand Early Neural Circuit Development in Autism

    May 7, 2025
    SFARI is pleased to announce it will fund five projects investigating the influence of autism-associated risk genes on early neurodevelopment and links to later circuit-level functional …
  9. AI-Powered Tool Maps the Fine Details of Rodent Social Behavior

    April 29, 2025
    … high-resolution mapping of social behavior, this AI-driven approach offers new possibilities for studying autism and related neurodevelopmental disorders as well as identifying more precise interventions.
  10. SFARI Sex Differences Collaboration Gathers for Third Annual Meeting

    April 23, 2025
    On January 27–28, the Simons Foundation held the third annual meeting of the SFARI Sex Differences Collaboration (SSDC). Formed in 2021, this collaboration seeks to understand the …
  11. Announcing the Recipients of the 2024 Pilot and Pilot Progression Awards

    April 8, 2025
    The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce the funding of 23 projects as part of its 2024 Pilot and Pilot Progression awards. Awards from …
  12. Simons Sleep Project Releases Data About Sleep Behaviors and Autism

    March 27, 2025
    The Simons Foundation Autism Research Initiative (SFARI) is pleased to announce the release of data collected from its Simons Sleep Project (SSP), a study aimed at accelerating research …
  13. Paul Wang To Take on New Role in SFARI Pharmaceutical and Biotech Relations

    March 11, 2025
    Paul Wang has assumed the role of Senior Scientific Director, SFARI Pharmaceutical and Biotech Relations.
  14. 5 Simons-Supported Investigators Receive Awards From National Academy of Sciences

    January 27, 2025
    … Origins of Life (SCOL) Sutherland will receive the NAS Award in Early Earth and Life Studies — Stanley Miller Medal for advancing our understanding of the chemical origins …
  15. SFARI Researchers Gather in Edinburgh for 2024 Autism Rat Consortium Meeting

    October 30, 2024
    On September 18, 2024, the SFARI Autism Rat Consortium (ARC) held its annual meeting in the Usher Institute of the University of Edinburgh. This year’s event brought …
  16. Simons Foundation Accepting Applications for Fellows-to-Faculty Award

    October 2, 2024
    … Award will be held at 12:00 p.m. (noon) ET on Wednesday, October 16, 2024. Interested attendees can register here. A recording of the webinar will …
  17. Simons Foundation Announces 2024 Class of Neuroscience Undergraduate Research Fellows

    September 30, 2024
    … University of Washington Anselmo Rivera Johns Hopkins University Gwen Roter University of Wisconsin–Madison Gloria Shen University of Washington Alishba Silat University of Texas at Dallas Ilana …
  18. SFARI Gene Workshop Touches on the Future of Autism Gene Databases

    September 13, 2024
    On January 25–26, 2024, SFARI welcomed researchers to a workshop to discuss SFARI Gene and other existing databases and other tools focused on different aspects of autism …
  19. Simons Foundation Announces 13 Recipients of 2024 Independence Awards

    August 15, 2024
    … treatment of monogenic syndromes associated with autism Cleyton Sobrinho, Ph.D. 2024 SFARI Fellow University of Connecticut Project: Disordered breathing in autism: screen for central and peripheral …
  20. Autism BrainNet: New Genetic Data Available

    August 14, 2024
    SFARI is pleased to announce the release of genetic data for 119 Autism BrainNet brain tissue samples, including whole genome and whole exome data.
  21. 2023 Summer Pilot Awards Announced

    June 6, 2024
    SFARI is pleased to announce that it intends to fund 14 grants in response to the 2023 Summer Pilot Award request for applications.
  22. SFARI Sex Differences Collaboration Shares Findings at Second Annual Meeting

    May 17, 2024
    On January 8–9, 2024, SFARI welcomed researchers to its second annual meeting of the SFARI Sex Differences Collaboration (SSDC).
  23. Applications Open for 2024–2025 Undergraduate Research Fellowships in Neuroscience

    March 26, 2024
    The Simons Foundation is now accepting applications from undergraduate students to participate in its Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) program for the 2024–2025 academic year …
  24. 2023 SFARI Human Cognitive and Behavioral Science Awardees Announced

    January 23, 2024
    SFARI is pleased to announce that it intends to fund three grants in response to the 2023 Human Cognitive and Behavioral Science request for applications.
  25. Simons Searchlight December 2023 Update: New Phenotypic Data Available

    January 19, 2024
    New phenotypic data from Simons Searchlight participants were recently added to SFARI Base. This release includes data from individuals with 94 gene changes and 15 copy number variants …
  26. 2023 SFARI Cross-Species Studies of ASD Awardees Announced

    January 18, 2024
    SFARI is pleased to announce that it intends to fund three collaborative projects in response to the 2023 Cross-Species Studies of ASD request for applications.
  27. Two Studies Using Brain Organoids Reveal Cell-Type-Specific Changes During the Early Stages of Human Forebrain Neuronal Development in Autism

    November 9, 2023
    Two studies by different research groups — one led by Flora Vaccarino and the other by Juergen Knoblich — used brain organoids derived from pluripotent stem cells of people with …
  28. Two SFARI Investigators Elected to the National Academy of Medicine

    November 9, 2023
    This year’s new cohort of National Academy of Medicine members includes two investigators funded by the Simons Foundation Autism Research Initiative (SFARI). Election to the academy “recognizes …
  29. Neuroscience 2023: Presentations by SFARI Investigators

    October 31, 2023
    A number of presentations will be given by SFARI Investigators at Neuroscience 2023, the annual meeting of the Society for Neuroscience.
  30. SFARI 2023 Winter Pilot Awardees Announced

    October 12, 2023
    SFARI is pleased to announce that it intends to fund 9 grants in response to the 2023 Winter Pilot Award request for applications.
  31. Simons Foundation Announces Next Class of Neuroscience Undergraduate Research Fellows

    September 26, 2023
    … Vy Nguyen University of Utah Ana Carolina Odebrecht Vergne de Abreu University of Essex Brenner Philbrook University of Washington Luisa Quispe Brandeis University Aya Sahib University of …
  32. Simons Foundation Announces 13 Recipients of 2023 Independence Awards

    September 12, 2023
    … corticocerebellar perturbations Daniel Pederick, Ph.D. Stanford University SFARI BTI Fellow Project: Investigating tonotopy in autism Greta Pintacuda, D.Phil. Broad Institute, Massachusetts Institute of Technology SFARI …
  33. SPARK July 2023 Update: New Phenotypic Data Available

    August 15, 2023
    Phenotypic data from 328,973 participants enrolled in SPARK, including 132,138 individuals with autism spectrum disorder (ASD), are now available to approved researchers. Genomic data are also …
  34. New Research Clarifies Connection Between Autism and the Microbiome

    June 26, 2023
    A SFARI initiated and funded reanalysis of previous studies reveals consistent biological signals in the human microbiome and other physiological signals associated with autism and highlights the need …
  35. SFARI Sex Differences Collaboration Gather To Share Their Progress

    June 1, 2023
    On January 30–31, SFARI convened its first annual meeting of the SFARI Sex Differences Collaboration (SSDC). Funded in 2021, the SSDC collaboration consists of five groups of …
  36. Postponing the Launch of the Upcoming RFA on Genomics of ASD

    June 1, 2023
    Earlier this year we announced here that this summer we would be issuing a request for applications (RFA) for the Genomics of ASD grants. However, as we have …
  37. Simons Foundation Renames Neuroscience Undergraduate Research Fellowship Program in Honor of Krishna Shenoy

    May 5, 2023
    … collaboration and mentorship of early-career researchers will live on in SURFiN, Picchini Schaffer says.
  38. Approaches for Measuring Sensory Function in ASD/NDD

    April 25, 2023
    On February 10, 2023, SFARI hosted an in-person meeting focused on measuring sensory system function in humans with autism spectrum disorder (ASD) and other neurodevelopmental disorders (NDD).
  39. Excessive Protein Degradation Is Identified as a New Cellular Pathology and a Potential Target for Therapeutic Intervention in Fragile X Syndrome

    March 23, 2023
    In a mouse model of fragile X syndrome, Emily Osterweil and her colleagues show that excessive protein synthesis drives a pathological compensatory rise in protein degradation (by the …
  40. 2022 Genomics of ASD: Pathways to Genetic Therapies Awardees Announced

    March 23, 2023
    SFARI is pleased to announce that it intends to fund 15 grants in response to the 2022 Genomics of ASD: Pathways to Genetic Therapies request for applications.
  41. Simons Foundation Accepting Applications for Neuroscience Undergraduate Research Fellowships

    March 23, 2023
    The Simons Foundation is now accepting applications from undergraduate students to participate in the Simons Foundation Undergraduate Research Fellowship in Neuroscience, or SURFiN, for the 2023–2024 academic …
  42. A Novel Eye-Tracking Paradigm Identifies an Influence of Perceptual Load on Social Attention in Autism

    March 14, 2023
    A study by Caroline Robertson and her colleagues found that reduced social attention was not a static omnipresent characteristic of autism; rather, it was magnified only under certain …
  43. A New Approach To Analyzing Genomic Association Data Finds Convergence of Both Rare and Common Genetic Influences on Autism at Chromosome 16p

    March 6, 2023
    Elise Robinson and colleagues identified a large genomic region — chromosome 16p — where a rare 16p11.2 variant associated with autism functionally converges with common polygenic variation across 16p …
  44. January 2023 Update: New Simons Searchlight Data Added to SFARI Base

    January 25, 2023
    New Simons Searchlight data were recently added to SFARI Base. The data released included phenotypic data from individuals with 16p11.2 copy number variant (CNVs), 1q21.1 CNVs …
  45. SPARK December 2022 update: New Phenotypic Data Available

    January 4, 2023
    Phenotypic data from 310,649 participants enrolled in SPARK, including 123,444 individuals with ASD, are now available to approved researchers. Genomic data (whole-exome sequencing and genome …
  46. Simons Foundation Opens Applications for Independence Awards

    November 29, 2022
    … from candidates with backgrounds in neuroscience, molecular biology, genetics, immunology, cell biology and the physical and information sciences. Applications are open to individuals from racial, ethnic and …
  47. Simons Searchlight Gathers Families and Researchers for Conference on CSNK2A1 and SETBP1–Related Conditions

    November 28, 2022
    On August 4, 2022, SFARI and Simons Searchlight helped to host two scientific workshops focused on neurodevelopmental disorders (NDDs) that are linked to mutations in the CSNK2A1 and …
  48. 2022 SFARI Human Cognitive and Behavioral Science Awardees Announced

    October 24, 2022
    SFARI is pleased to announce that it intends to award ten grants in response to the 2022 Human Cognitive and Behavioral Science request for applications.
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