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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Searching for the Secret of How Young Blood Rejuvenates the Brain

    November 10, 2020
    Researchers know that blood from young animals reverses cognitive decline, at least in mice. But to turn that into a treatment, they must first understand why.
  2. Finding Signals in the Noise With HumanBase

    November 10, 2020
    This powerful, dynamic software system is changing how scientists sift through the recent deluge of human genomic data — and deepening our knowledge of human biology, health and disease.
  3. SFARI Gene: October 2020 Data Release

    November 9, 2020
    New data were recently added to SFARI Gene. This data release included the addition of new genes associated with autism risk, new curated references of copy number variations …
  4. Next-Gen Astronomical Survey Makes Its First Observations Toward a New Understanding of the Cosmos

    November 9, 2020
    … “We are so pleased to support Juna Kollmeier and the entire SDSS team, and we are excited for this next phase of discovery.” SDSS-V will operate …
  5. Why Our Ever-Evolving Genes Sometimes Make Us Sick

    October 27, 2020
    Immunologist Maria Pokrovskii explores why some mutations in our genes lead to illness. Though still early in her career, Pokrovskii already has bold ideas about the link between …
  6. ASHG 2020 Virtual Meeting: Presentations by SFARI Investigators and Collaborators

    October 23, 2020
    A number of SFARI Investigators, collaborators and Simons Foundation scientists will present their latest research findings at the American Society of Human Genetics (ASHG) 2020 Virtual Meeting, which …
  7. Molecular Processes in Kidney Cells May ‘Prime’ Diabetics for COVID-19 Infection

    October 23, 2020
    Vulnerable kidney cells undergo similar cellular processes during diabetic kidney disease and COVID-19 infection, potentially explaining why the two illnesses together are so deadly.
  8. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    October 22, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  9. Flatiron Research Fellow Jun Wang Joins the Yau Faculty of Mathematical Sciences Center at Tsinghua University

    October 21, 2020
    Congratulations to Jun Wang, who has just moved to her new job as an assistant professor at the Yau Mathematical Sciences Center at Tsinghua University in Beijing. Wang …
  10. New Collaboration Between SFARI and Nancy Lurie Marks Family Foundation Will Generate Hundreds of iPSC Lines for Autism Research

    October 20, 2020
    A new collaboration between SFARI and the Nancy Lurie Marks Family Foundation will generate hundreds of induced pluripotent stem cells from individuals with autism and related neurodevelopmental conditions …
  11. In Olfactory System, a Balance of Randomness and Order

    October 20, 2020
    New research suggests that neural circuits underlying smell employ two favored theoretical models in succession.
  12. Molecular Mechanisms of Fragile X Syndrome

    October 19, 2020
    Kimberly Huber, Joel Richter and colleagues showed that FMRP deficiency in mice leads to changes in a key histone modification across the genome, with subsequent effects on alternative …
  13. Recent Research Lays Groundwork for New Generation of Galaxy Simulations

    October 19, 2020
    The first batch of research papers from the Simulating Multiscale Astrophysics to Understand Galaxies collaboration, or SMAUG, lays the groundwork for a transformation in the way galaxies are …
  14. Microexon Splicing and Translation in ASD

    October 15, 2020
    Benjamin Blencowe and colleagues defined the functional roles of microexons in genes encoding translation initiation factors, linking them to altered translation, synaptic plasticity and behavior.
  15. Astrophysicist Blakesley Burkhart Named a 2020 Packard Fellow

    October 15, 2020
    … postdoctoral female researchers.
  16. New Material Pushes Limits of Superconductivity’s ‘Cousin’

    October 13, 2020
    By using a sandwich structure, researchers demonstrated the quantum anomalous Hall effect at record-high temperatures.
  17. Announcing COVID-19 Microgrants for Nonprofits That Promote Science Engagement

    October 12, 2020
    Applications for organizations facing challenges related to COVID-19 will be open for two weeks.
  18. Ivan Oransky Named Editor-in-Chief of Spectrum

    October 9, 2020
    … excellence in biomedical communication from the American Medical Writers Association.
  19. Transition in SFARI Directorship: Update

    October 7, 2020
    Louis Reichardt, who has served as director of SFARI since 2013, finished his tenure here on September 28. John Spiro has been appointed interim director of SFARI until …
  20. A Conversation With SFARI Investigators Peter Kind and Loren Frank

    September 30, 2020
    Peter Kind and Loren Frank discuss their work using SFARI’s genetic rat models and their views on how these models will aid autism research.
  21. Reminder About SFARI’s Acknowledgment Policy

    September 30, 2020
    SFARI would like to remind investigators to please acknowledge SFARI funding and/or the use of SFARI resources, biospecimens and data in all relevant preprints and publications.
  22. SFARI Spring 2020 Science Meeting Goes Online

    September 29, 2020
    Due to the COVID-19 pandemic, SFARI replaced the in-person spring 2020 science meeting that was scheduled April 5–7 with a series of seven weekly webinars …
  23. How To Build a Large-Scale Neuroscience Collaboration: Lessons From the International Brain Laboratory

    September 28, 2020
    The International Brain Laboratory is a global collaboration dedicated to understanding decision-making and the mouse brain and has built a research network transcending traditional academic boundaries. Here …
  24. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    September 25, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  25. Astrophysicist Adrian Price-Whelan Receives Blavatnik Regional Award for Young Scientists

    September 23, 2020
    The Blavatnik Family Foundation and the New York Academy of Sciences have named computational astrophysicist Adrian Price-Whelan as the winner of the 2020 Blavatnik Regional Award for …
  26. Think We Already Know Everything About Electrons? Think Again

    September 22, 2020
    Physicist Songtian Sonia Zhang explores how electrons work within the tiniest objects and finds that they sometimes do unexpected things.
  27. The Self-Organized Movement To Create an Inclusive Computational Neuroscience School

    September 17, 2020
    In less than three months, Neuromatch Academy developed an interactive online course catering to more than 1,750 students in more than 70 countries.
  28. First 1,000 Participants in RI-CART Study

    September 14, 2020
    Eric Morrow, Stephen Sheinkopf and colleagues reported the characteristics of the first 1,000 participants in the RI-CART study, a population-based cohort of individuals with autism …
  29. Foxp1 and the Striatum

    September 14, 2020
    Genevieve Konopka and colleagues reported important roles for Foxp1 in particular subclasses of the spiny projection neurons in the striatum, with downstream effects on striatal-dependent circuits and …
  30. Infinitely Long Chains of Hydrogen Atoms Have Surprising Properties, Including a Metallic Phase

    September 14, 2020
    Scientists with the Flatiron Institute and the Simons Collaboration on the Many Electron Problem combined cutting-edge computational methods to probe an endless line of protons surrounded by …
  31. New Rat Models Available To Study Autism Spectrum Disorder

    September 11, 2020
    SFARI is pleased to announce that eight genetic rat models of autism spectrum disorder are now available from the Medical College of Wisconsin. These models are being maintained …
  32. Simons Collaboration on Special Holonomy in Geometry, Analysis and Physics Holds 2020 Annual Meeting Online

    September 9, 2020
    The Simons Collaboration on Special Holonomy in Geometry, Analysis, and Physics met remotely on September 9 to provide research highlights from the past year. Director Robert Bryant provided …
  33. Massive Halo Finally Explains Stream of Gas Swirling Around the Milky Way

    September 9, 2020
    Astronomers have discovered that a halo of warm gas surrounding the Magellanic Clouds likely acts as a protective cocoon, shielding the dwarf galaxies from the Milky Way’s …
  34. Sandwich-Like Superlattice Structures Provide New Insight Into Materials Design

    September 9, 2020
    With newly published research, an international team of scientists lays fundamental groundwork for a new generation of electronics.
  35. To Drive Discoveries That Slow Aging, New Collaboration Will Explore How the Brain Grows Old

    September 1, 2020
    The Simons Collaboration on Plasticity and the Aging Brain (SCPAB) aims to understand the changes in the brain that unfold over the course of normal aging and contribute …
  36. MPS Announces COVID-19 Recovery Programs

    August 28, 2020
    In response to the COVID-19 crisis, the Mathematics and Physical Sciences division has created two COVID-19 Recovery Programs to stimulate the hiring of postdoctoral fellows and …
  37. Addressing Gender and Institutional Bias at Cosyne

    August 28, 2020
    Conference organizers tested out a double-blind process for reviewing abstracts. It improved some types of bias but not others.
  38. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    August 26, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  39. SFARI 2020 Bridge to Independence Award Fellows Announced

    August 25, 2020
    SFARI is pleased to announce that it has selected three fellows in response to the 2020 Bridge to Independence Award request for applications.
  40. Understanding How the Brain Works, One Model at a Time

    August 25, 2020
    Theoretical neuroscientist Guangyu Robert Yang builds elegant mathematical models that enable a new understanding of how the brain works.
  41. Taming the Data From Freely Moving Animals

    August 20, 2020
    Computer vision and machine learning technologies are creating ever more precise records of animal behavior. Now, neuroscientists must figure out how best to use these techniques to understand …
  42. Emery N. Brown Joins Simons Foundation Board of Directors

    August 12, 2020
    … underserved communities. She is a member of the board of trustees of the LearningSpring School and the East Harlem Scholars Academy in New York City. Simons received …
  43. SFARI Gene: July 2020 Data Release

    August 10, 2020
    New data were recently added to SFARI Gene. This data release included the addition of new genes associated with autism risk, new curated references of copy number variations …
  44. Paraventricular Oxytocin Neurons Support Social Behavior

    August 7, 2020
    Garret Stuber and colleagues used in vivo calcium imaging to show that a population of oxytocin-positive (OT) neurons in the paraventricular nucleus of the hypothalamus responds preferentially …
  45. USP9X Mutation Defines a Neurodevelopmental Syndrome

    August 3, 2020
    Michael Piper and colleagues confirmed and extended the association of USP9X loss-of-function mutations with a neurodevelopmental syndrome in both sexes, driven by changes in multiple signaling …
  46. Exome Sequencing Identifies New ASD Risk Genes

    July 30, 2020
    Joseph Buxbaum and colleagues in the Autism Sequencing Consortium reported the largest exome sequencing study of ASD to date, identifying 102 risk genes at a false discovery rate …
  47. A Software, a Community and a Different Way to Do Science

    July 30, 2020
    The suite of software tools collectively known as Rosetta is defined not only by what it does, but also by a community of scientists who are changing how …
  48. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    July 28, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
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