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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Ben Lillie: Fostering ‘Intelligent Nightlife’

    March 1, 2018
    Caveat, a New York City venue with a speak-easy vibe, provides a new type of nightlife experience that blends academics with performing arts.
  2. Conference Spotlight: Cosyne 2018

    February 27, 2018
    Check out these talks, tutorials and workshops featuring investigators from the Simons Collaboration on the Global Brain.
  3. Artificial Intelligence Techniques Reconstruct Mysteries of Quantum Systems

    February 26, 2018
    New machine learning techniques can help experimentalists probe systems of particles exponentially faster than conventional, brute-force techniques
  4. Simons Variation in Individuals Project (Simons VIP): New Data Release

    February 23, 2018
    New Simons VIP Phase 2 data were recently added to SFARI Base. This data release included data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 …
  5. Watch: Four Minutes With Terence Tao

    February 23, 2018
    We ask the 2006 Fields Medalist to talk about his love of mathematics, his current interests and his favorite planet
  6. Alternations in Network Communication, Not Synaptic Dysfunction, Linked to Behavioral Alterations in Fragile X Syndrome

    February 23, 2018
    Assessing network and synaptic communication in the hippocampus of behaving Fmr-1 null mice, André Fenton and colleagues showed altered network communication linked to behavioral alterations in fragile …
  7. Shared Alterations in Gene Expression Networks Mirror Genetic Risk Across Neuropsychiatric Disorders

    February 23, 2018
    In comparing gene expression profiles and SNP risk across psychiatric disorders, Michael Gandal, Daniel Geschwind and colleagues found that shared genetic risk manifests in alterations in gene networks.
  8. Alterations in Cellular pH Gradients Cause Defects in Neuronal Communication and Autism-Related Behaviors in Mice Lacking NHE9

    February 23, 2018
    Using a mouse lacking brain-localized NHE9, Edwards shows that pH gradients affect neuronal communication and autism-like behaviors.
  9. For Better Vision, Independent Neurons May Be Key

    February 21, 2018
    The amount of correlated activity among groups of neurons in the visual cortex predicts how well animals will perform a visual task, suggesting this may be an important …
  10. SFARI Announces the Launch of HumanBase

    February 15, 2018
    SFARI announces the launch of HumanBase, a Simons Foundation interactive web server for predictions and information about human genes, pathways and disorders.
  11. How Natural Should Laboratory Behavior Be?

    February 13, 2018
    A bird can respond to a tone, but is that the same as responding to a birdcall? Anne Churchland and collaborators propose a framework for evaluating behavioral tasks …
  12. Neuropixels Developer James Jun Joins CCB’s Numerical Algorithm Group

    February 8, 2018
    The Flatiron Institute is pleased to announce that Jaeyoon James Jun will join the Center for Computational Biology (CCB) as a postdoctoral fellow with the Numerical Algorithms group.
  13. Technology Mashup Images Single Cells and Whole Brain Areas

    February 8, 2018
    New hybrid tools combine wide-field and two-photon imaging, as well as electrophysiology and neuromodulation.
  14. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    February 8, 2018
    Each month, SCGB scans the bioRxiv for interesting papers from the SCGB community and beyond.
  15. SPARK’s First Year: A New Paper Describes Goals and Milestones

    February 7, 2018
    SFARI announces that a new article summarizing the first year’s activities of SPARK — a SFARI-funded study that aims to recruit, engage and retain 50,000 individuals …
  16. Stratospheric Ozone at Lower Latitudes Is Not Recovering, Despite Antarctic Ozone Hole Healing

    February 6, 2018
    … developed here can be used in many scientific applications that look at complex datasets.” Information for Press For additional information, please contact [email protected]. Scientific Contact …
  17. The Danger of Boundaries in the Brain

    February 2, 2018
    Categorizing brain regions has drawbacks, argues neuroscientist Mark Humphries in a new blog post. One of the goals of the Simons Collaboration on the Global Brain is to …
  18. New Universe Simulation Reveals High-Resolution Details About Cosmological Structures

    January 31, 2018
    An international team of astrophysicists has released IllustrisTNG, the most advanced universe model of its kind.
  19. Watch: World-Class Explorers Help Scientists Collect Elusive Data

    January 17, 2018
    Adventure Scientists equips outdoor explorers — from mountaineers to surfers — with the tools to collect research-grade, hard-to-reach data in extreme environments.
  20. Male, but Not Female, 16p11.2 Deletion Mice Show Deficits in Reward Learning

    January 11, 2018
    By assessing the 16p11.2 deletion autism mouse model, Ted Abel and colleagues uncover male-specific vulnerabilities in striatal signaling and reward function.
  21. Two Studies Highlight the Utility of Carrier-Derived iPSC-Derived Neurons for the Study of Neurodevelopmental Disorders

    January 11, 2018
    Lauren Weiss and Erik Ullian report on two studies using carrier-derived iPSC neurons to elucidate cellular phenotypes associated with 16p11.2 CNVs and a BRAF RASopathy mutation.
  22. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    January 11, 2018
    Each month, SCGB scans the bioRxiv for interesting papers from the SCGB community and beyond.
  23. Neuropixels Offer New Ways To Map Cells

    January 4, 2018
    Researchers are using the mass-recording technology to answer novel questions, such as whether neurons can be classified by their action potentials or if grid cells physically adapt …
  24. The State of Computational Neuroscience

    January 2, 2018
    Adrienne Fairhall, a computational neuroscientist at the University of Washington, reflects on how the field has evolved and on the biggest issues yet to be solved.
  25. On the Road With a Brand-New BioBus

    December 18, 2017
    The second mobile lab to teach kids about biology takes a cross-country trip home — and creates fans along the way.
  26. Third-Party Gene Scores Added to SFARI Gene

    December 14, 2017
    SFARI is happy to announce a new addition to the gene-scoring module of SFARI Gene: scores and rankings from an additional six published approaches to evaluating the …
  27. In Basal Ganglia, a Map of Movement

    December 14, 2017
    A brain region called the striatum may house abstract representations of different actions, which could eventually help scientists understand how the striatum selects among many potential behaviors
  28. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    December 12, 2017
    Each month, SCGB scans the bioRxiv for interesting papers from the SCGB community and beyond.
  29. SFARI 2017 Explorer Awardees Announced

    December 6, 2017
    SFARI is pleased to announce that it has awarded 13 grants in response to the Explorer Awards request for applications this year.
  30. Newly Discovered Goliath Galaxies From Early Universe Hint at Massive Dark Matter Trove

    December 6, 2017
    The colossal clump of dark matter is nearly as large as physically possible at the time
  31. SFARI Announces 2017 Bridge to Independence Award Finalists

    December 5, 2017
    SFARI is pleased to announce that it has selected seven finalists in response to the 2017 Bridge to Independence Award request for applications.
  32. Teaching Computational Neuroscience Across the Globe

    December 5, 2017
    SCGB helps support summer courses designed to train the next generation of neuroscientists in computational and systems neuroscience
  33. Simons Investigators Awarded 2018 Breakthrough Prize, New Horizons Prize

    December 4, 2017
    Three Simons Investigators were honored at the sixth annual Breakthrough Prizes on December 3. Mathematicians Christopher Hacon of the University of Utah and James McKernan of the University …
  34. Flatiron Institute’s David Spergel Awarded 2018 Breakthrough Prize for Mapping the Early Universe

    December 3, 2017
    … about the universe, such as the nature of dark energy,” Spergel says. Spergel and Page are currently part of the Simons Observatory project, which will look for …
  35. A Conversation with SFARI Investigator David Ginty

    December 1, 2017
    SFARI Investigator David Ginty talks about the links between deficits in the sense of touch, tactile hypersensitivity, and alterations in social behaviors in autism.
  36. CCQ Distinguished Research Scientist Angel Rubio Awarded Max Born Medal and Prize

    November 29, 2017
    The Institute of Physics and the German Physical Society have awarded the 2018 Max Born Medal and Prize to theoretical physicist Angel Rubio. Rubio is a distinguished research …
  37. Gravitational Waves From Merging Supermassive Black Holes Will Be Spotted Within 10 Years, New Study Predicts

    November 13, 2017
    Survey of fast-spinning pulsar stars offers better estimate of when astronomers will first detect the strongest gravitational waves in the universe, which dwarf those previously detected from …
  38. ‘Neuropixels’ Expand Access to the Brain

    November 9, 2017
    The novel probes can simultaneously track hundreds to thousands of individual neurons in different parts of the brain.
  39. SFN 2017 Presentations by SCGB Investigators and Collaborators

    November 9, 2017
    Traveling to the annual meeting in DC? Check out these talks.
  40. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    November 9, 2017
    Each month, SCGB scans the bioRxiv for interesting papers from the SCGB community and beyond.
  41. Building Trust in Science via ‘Cultural Brokers’

    November 8, 2017
    The leaders of the New York Hall of Science adapt its hands-on museum approach to serve its largely immigrant community.
  42. Inner Workings of the Brain Explored at 2017 SCGB Annual Meeting

    November 8, 2017
    Insights into how dopamine directs learning and new techniques for imaging and tracing cells were just some of the advances described at the third annual gathering of the …
  43. Genomic Patterns of De Novo Mutation in Simplex Autism

    November 2, 2017
    Evan Eichler and Robert Darnell provide deep whole genome sequencing of 516 families with idiopathic autism, providing insights into the complex etiology of simplex autism.
  44. Gating of Social Reward by Oxytocin in the Ventral Tegmental Area

    October 30, 2017
    Robert Malenka and colleagues find that oxytocin acts within the ventral tegmental area to increase dopamine reward neurons to reinforce the rewarding aspects of social interactions in mice.
  45. Maternal Gut Bacteria Provide a Link Between Maternal Infection and Autism Risk

    October 30, 2017
    Jun Huh, Gloria Choi and colleagues provide a link between maternal infection, gut bacteria and the risk of developing behavioral and cortical abnormalities in mice.
  46. SFARI Gene: New Data Release

    October 30, 2017
    New data were added to SFARI Gene in October 2017. This data release included updated gene scores for candidate autism risk genes, new rodent models and new genes …
  47. SFARI 2017 Pilot and Research Awardees Announced

    October 30, 2017
    SFARI is pleased to announce that it has awarded 32 grants (19 Pilot Awards and 13 Research Awards) in response to the 2017 Pilot and Research Awards request …
  48. M. Lisa Manning, MMLS Investigator and PI in the Cracking the Glass Problem Collaboration, Awarded American Physical Society’s Maria Goeppert Mayer Prize

    October 30, 2017
    Professor M. Lisa Manning, MMLS Investigator and PI of the Simons Collaboration on Cracking the Glass Problem, has been awarded the Maria Goeppert Mayer Prize of the American …
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