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SFARI Investigator Liqun Luo discusses the neurodevelopmental disorder Smith-Magenis syndrome and his lab’s efforts to understand its underlying biology.

Zebra finches use a variation of reward prediction error to evaluate how well they learn a song.

Olga Troyanskaya The Simons Foundation congratulates Olga Troyanskaya, who has been selected as an International Society for Computational Biology (ISCB) Fellow in the fellows’ class of 2017. The …

A working guide for organizing a Wikipedia edit-a-thon at a science conference

… Stability and plasticity of contextual modulation in the mouse visual cortex Adam Ranson bioRxiv posted 12 December 2016 [Abstract] [PDF] Random versus maximum entropy models of neural …

Experimental evolution enables scientists to create better calcium and voltage sensors.

As an organization dedicated to the advancement of scientific knowledge, the Simons Foundation stands united with the scientists and institutions we support in their opposition to the recently …

As an organization dedicated to the advancement of scientific knowledge, the Simons Foundation stands united with the scientists and institutions we support in their opposition to the recently …

At the Heidelberg Laureate Forum, the world’s foremost mathematicians and computer scientists offer advice and intellectual challenges to young researchers

Kevin Bender and Stephan Sanders show that ASD-associated SCN2A variants lead to impaired NaV1.2 channel activity and reduced neuronal excitability.

Amiel Rosenkranz and colleagues have identified a specific intra-amygdala circuit, from the lateral nucleus to the medial nucleus, which is critical for social learning.

Lauren Weiss and colleagues used a reverse pathway genetic approach, focused on the RAS/MAPK pathway, to show that gene-gene interactions contribute to autism.

This issue of the SFARI newsletter includes: (1) SFARI 2016 Bridge to Independence Award finalists announced, (2) SFARI 2016 Explorer awardees announced, (3) Simons Variation in Individuals Project …

New data were added to SFARI Gene in December 2016. This data release included updated gene scores for candidate autism risk genes, new animal models, and new copy …

New Simons VIP Phase 2 data have recently been added to SFARI Base. This data release includes phenotypic data from individuals with 16p11.2 copy number variants (CNVs …

New research shows that stimulating a particular brain region makes mice feel as if time is moving faster.

The finding helps explain where algae and other organisms get a vitamin that is essential to fueling marine life.

SFARI is pleased to announce that it has selected six finalists in response to the 2016 Bridge to Independence Award request for applications. This awards program is intended …

SFARI is pleased to announce that it has awarded 14 grants over the past year in response to the Explorer Awards request for applications.

The dorsal raphe nucleus, a brain region previously implicated in depression, seems to integrate motor memories.

… Pesaran. “By better understanding intelligence in the human brain, we can suggest ways to improve AI systems. Our work indicates that AI systems with multiple working memory …

… analysis of large neural populations Johannes Friedrich, Weijian Yang, Daniel Soudry, Yu Mu, Misha B Ahrens, Rafael Yuste, Darcy S Peterka, and Liam Paninski posted 2 December …

… M, Diesmann M, Donofrio DD, Frank LM, Kasthuri N, Koch C, Ruebel O, Simon HD, Sommer FT, Prabhat PubMed Neural Activity Patterns Underlying Spatial Coding in the …

… language and learning theory. Watching his four-year-old daughter grow up speaking Chinese and English has inspired Teng to think about machine learning and statistical learning …

… for Computational Quantum Physics (CCQ), in the foundation’s new Flatiron Institute, and the appointment of Antoine Georges as its director. A new era is dawning in …

Gaia Novarino and Joseph Gleeson find impaired amino acid transport into brain causes ASD-like symptoms in mice, and uncover transport mutations in individuals with ASD.

This issue of the SFARI newsletter includes: (1) SFARI 2016 Pilot and Research awardees announced, (2) SPARK Clinical Site Network – Request for applications, (3) SFARI Explorer Awards – Request …

New technologies that record the entire brain as animals think, move and make decisions could provide insight into global dynamics

A new film supported by Science Sandbox and released on Motherboard documents the rise of diabetes and the shortcomings of weight indexes

SFARI is pleased to announce that it has awarded 27 grants (21 Pilot Awards and 6 Research Awards) in response to the 2016 Pilot and Research Awards request …

The Simons Collaboration on the Global Brain (SCGB) commends the strong bipartisan effort to invest in and accelerate basic research on the brain through the 21st Century Cures …

New insights into how the brain makes decisions, recognizes novel objects and controls attention were among many areas discussed at the second annual gathering of the Simons Collaboration …

Place and grid cells do more than simply navigate the environment — new research suggests that they may construct a framework of any relevant space, including those defined by …

By examining SNPs from ASD datasets, Lauren Weiss finds that genetic mechanisms regulating general sex differences, such as height and weight, contribute to autism risk.

By assessing a Chinese autism cohort, Evan Eicher establishes the importance of de novo mutations for conferring autism risk in both European and Chinese populations.

Suitable biomarkers are needed to assess treatment outcomes in ASD. Pamela Ventola has developed fMRI biomarkers that allow accurate prediction of intervention success.

Amid an onslaught of large-scale neuroscience projects, a special issue of Neuron explores how neuroscientists can work together more effectively and how to leverage new technologies.

The Simons Foundation launches Flatiron Institute, a group of computational centers exploring galaxy formation, genomics, neuroscience and other fields

… dynamics during evidence accumulation in cortex Nature Neuroscience 2016 October 3 Morcos AS, Harvey CD PubMed Predictability and hierarchy in Drosophila behavior. Proceedings of the National Academy …

… Harris bioRxiv Linking structure and activity in nonlinear spiking networks Gabriel Koch Ocker, Krešimir Josić, Eric Shea-Brown, Michael A. Buice bioRxiv Ring attractor dynamics emerge from …

Simulations of giant, hot gas clouds and black hole binaries by Kohei Inayoshi of the Simons Society of Fellows offer insight into a key cosmological mystery

Betty Diamond reports on a method to isolate monoclonal brain-reactive antibodies from plasma obtained from mothers in the SSC, showing their in utero exposure can cause ASD.

Benjamin Cheyette finds higher rates of DIXDCI disruptions in individuals with ASD, schizophrenia or bipolar, and DIXDC1 signaling rescue improves mouse ASD-like behaviors.

Using sequencing data from the Simons Simplex Collection, Zhenglong Gu found an enrichment of predicted pathogenic mutations in mitochondrial DNA in autism.

This issue of the SFARI newsletter includes: (1) SPARK update, (2) SFARI Social at Neuroscience 2016, (3) Presentations by SFARI Investigators at Neuroscience 2016, (4) 2017 Pilot and …

The Simons Foundation’s first Wikipedia edit-a-thon brings new rigor to physics content for the online encyclopedia, laying the groundwork for the Wikipedia Year of Science …

The Simons Foundation and Math for America donate $250,000 to DonorsChoose.org for #BestSchoolDay — a “flash funding” project. The Simons Foundation and Math for America donate $250 …