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New data were added to SFARI Gene in November 2018. This data release included updated gene scores for candidate autism risk genes, as well as the addition of …

SFARI is pleased to announce that it has selected four awardees in response to the 2018 Bridge to Independence Award request for applications. This program helps early-career …

Genome-wide analysis the first to uncover a role for mutations in the noncoding portion of the genome in any human condition

Family-organized groups are planning a number of meetings in 2019 for individuals with rare genetic neurodevelopmental conditions, including those due to 16p11.2 copy number variants and …

On April 17, 2018, molecular neuroscientists and geneticists gathered at the Simons Foundation for a workshop on the role of chromatin-associated proteins in autism spectrum disorder. The …

SFARI is pleased to announce that it expects to have funded 22 grants in response to the Explorer Awards request for applications (RFA) this year.

On May 15, 2018, SFARI convened a workshop to revisit the excitation/inhibition (E/I) hypothesis of autism, a synaptic-based account of the disorder that has been …

The Innovative Medicines Initiative, a European public-private initiative, recently awarded a €115 million five-year grant for autism research. The Autism Innovative Medicine Studies-2-Trials (AIMS …

Paul Wang, Deputy Director of Clinical Research Associates, L.L.C. (CRA), discusses the research that CRA supports, including human and animal studies using arbaclofen, a potential drug …

New Simons VIP Phase 2 data were recently added to SFARI Base. This data release included data from individuals with 16p11.2 copy number variants, 1q21.1 CNVs …

SFARI Investigators will be giving a number of presentations at Neuroscience 2018 in San Diego, CA (November 3–7).

On January 26, 2018, SFARI held a workshop to discuss the use of zebrafish in autism research. Experts in both rodent and fish models discussed key issues in …

SFARI is pleased to announce that it intends to fund 36 grants (15 Pilot Awards and 21 Research Awards) in response to the 2018 Pilot and Research Awards …

SFARI held its thirteenth science meeting April 8–12, 2018. SFARI investigators, collaborators and foundation staff came together to discuss recent findings in autism genetics, molecular and system …

New data were added to SFARI Gene in August 2018. This data release included updated gene scores for candidate autism risk genes, as well as the addition of …

In this blog post, the SFARI science team provides insight into why SFARI’s request for applications grant programs are being revamped, which award types are being changed …

On April 10, 2018, SFARI held a workshop to discuss online platforms for visualizing and analyzing SFARI genomics data. These platforms included the Genotypes and Phenotypes in Families …

The animal models module of SFARI Gene has recently been expanded to include two new species: Drosophila melanogaster and Danio rerio. As of now, the database lists 55 …

SFARI Investigators will be giving a number of presentations at the 11th FENS Forum of Neuroscience in Berlin, Germany (July 7-11).

Two SFARI Investigators are among the 84 newly elected members of the National Academy of Sciences.

… Collaboration on the Many Electron Problem and a consultant for the Center for Computational Quantum Physics at the Flatiron Institute. Christopher Walsh is chief of the genetics …

SFARI Investigators and SFARI science staff will be giving a number of oral presentations at the International Society for Autism Research (INSAR) 2018 Annual Meeting in Rotterdam, Netherlands …

SFARI science staff will be presenting a number of posters about SFARI projects and resources at the International Society for Autism Research (INSAR) 2018 Annual Meeting in Rotterdam …

SFARI is soliciting your feedback about the utility and priority of induced pluripotent (iPS) cells from individuals with high-confidence autism risk variants. Your comments will help us …

Six current and former SFARI Investigators are among the 213 newly elected members of the American Academy of Arts & Sciences, one of the nation’s oldest and most …

SFARI’s requests for grant applications will be undergoing a number of changes in the coming months. These changes include ending the Explorer Award program, updating the Pilot …

New data were added to SFARI Gene in April 2018. This data release included updated gene scores for candidate autism risk genes, as well as the addition of …

Eleven researchers supported by the Simons Foundation have been elected as fellows of the American Academy of Arts and Sciences. The academy is one of the oldest and …

New Simons VIP Phase 2 data were recently added to SFARI Base. This data release included data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 …

Assessing network and synaptic communication in the hippocampus of behaving Fmr-1 null mice, André Fenton and colleagues showed altered network communication linked to behavioral alterations in fragile …

In comparing gene expression profiles and SNP risk across psychiatric disorders, Michael Gandal, Daniel Geschwind and colleagues found that shared genetic risk manifests in alterations in gene networks.

Using a mouse lacking brain-localized NHE9, Edwards shows that pH gradients affect neuronal communication and autism-like behaviors.

SFARI announces the launch of HumanBase, a Simons Foundation interactive web server for predictions and information about human genes, pathways and disorders.

SFARI announces that a new article summarizing the first year’s activities of SPARK — a SFARI-funded study that aims to recruit, engage and retain 50,000 individuals …

By assessing the 16p11.2 deletion autism mouse model, Ted Abel and colleagues uncover male-specific vulnerabilities in striatal signaling and reward function.

Lauren Weiss and Erik Ullian report on two studies using carrier-derived iPSC neurons to elucidate cellular phenotypes associated with 16p11.2 CNVs and a BRAF RASopathy mutation.

SFARI is happy to announce a new addition to the gene-scoring module of SFARI Gene: scores and rankings from an additional six published approaches to evaluating the …

SFARI is pleased to announce that it has awarded 13 grants in response to the Explorer Awards request for applications this year.

SFARI is pleased to announce that it has selected seven finalists in response to the 2017 Bridge to Independence Award request for applications.

SFARI Investigator David Ginty talks about the links between deficits in the sense of touch, tactile hypersensitivity, and alterations in social behaviors in autism.

Evan Eichler and Robert Darnell provide deep whole genome sequencing of 516 families with idiopathic autism, providing insights into the complex etiology of simplex autism.

Robert Malenka and colleagues find that oxytocin acts within the ventral tegmental area to increase dopamine reward neurons to reinforce the rewarding aspects of social interactions in mice.

Jun Huh, Gloria Choi and colleagues provide a link between maternal infection, gut bacteria and the risk of developing behavioral and cortical abnormalities in mice.

New data were added to SFARI Gene in October 2017. This data release included updated gene scores for candidate autism risk genes, new rodent models and new genes …

SFARI is pleased to announce that it has awarded 32 grants (19 Pilot Awards and 13 Research Awards) in response to the 2017 Pilot and Research Awards request …

A selection of presentations that will be given by past and current SFARI Investigators at Neuroscience 2017 in Washington, D.C., (November 11–15) is highlighted.

SPARK (Simons Foundation Powering Autism Research for Knowledge) is pleased to announce that whole-exome sequencing (WES) and genotyping data are available for 1,369 and 1,398 …

This blog post accompanies the “SFARI’s 2018 funding priorities” post. In it, the SFARI science team discusses the application and review process for 2018 Pilot and Research …