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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Towards a Structural Basis of Complex Disorders of Heart, Muscle and Brain

    Lecture
    In this lecture, Andrew Marks will present new data on the high-resolution structure of the mammalian RyR1/intracellular calcium-release channel obtained using cryogenic electron-microscopy.
  2. The Twisted Universe: The Cosmic Quest to Reveal Which End Is Up

    Lecture
    In this lecture, Brian Keating will discuss the search for the polarization of the cosmic microwave background and measurements by the POLARBEAR telescope, which pave the way for …
  3. Making up your mind: Interneurons in development and disease

    Lecture
    On 27 January 2016, Gordon Fishell described his investigations of the developmental and genetic origins of interneuron development.
  4. Making Up Your Mind: Interneurons in Development and Disease

    Lecture
    In this lecture, Gordon Fishell will describe his investigations of the developmental and genetic origins of interneuron development.
  5. Atom-interferometry Limits on Dark Energy

    Lecture
    In this lecture, Dr. Holger Müller will explain recent experimental searches for certain models of dark energy. How can it be that dark energy, which is supposedly ubiquitous …
  6. Quarks, Flux Tubes and String Theory Without Calculus

    Lecture
    … in a more mathematical context, providing a formulation of classical string dynamics that avoids calculus and does not depend on the continuous structure of spacetime.
  7. Patterns in the Primes

    Lecture
    Prime numbers have intrigued mathematicians, amateur and professional alike, for thousands of years. Some of the most pertinent questions today probably stem from classical times. In this lecture …
  8. Storming the ivory tower: How to make autism interventions work in schools

    Lecture
    On 11 November 2015, David S. Mandell talked about why autism interventions rarely are implemented in community practice and why they fail to achieve the same outcomes as …
  9. Storming the Ivory Tower: How to Make Autism Interventions Work in Schools

    Lecture
    In this lecture, David S. Mandell will talk about why autism interventions rarely are implemented in community practice and why they fail to achieve the same outcomes as …
  10. Inaugural Conference of the Simons Collaboration on Homological Mirror Symmetry

    Conference
  11. Understanding the Relationship Between Genes and Social Behavior: Lessons from the Honey Bee

    Lecture
    The study of genes and social behavior is still a young field. In this lecture, Gene E. Robinson will discuss some of the first insights to emerge that …
  12. Clinical and Translational Genomics

    Lecture
    This Biotech Symposium will focus on clinical and translational genomics and the shift to precision medicine.
  13. Molecular and neural architecture of circuits underlying social behavior in the mouse

    Lecture
    On 28 October 2015, Catherine Dulac discussed the cellular and molecular architecture of neural circuits underlying instinctive social behaviors in mice.
  14. Molecular and Neural Architecture of Circuits Underlying Social Behavior in the Mouse

    Lecture
    In this lecture, Catherine Dulac will discuss the cellular and molecular architecture of neural circuits underlying instinctive social behaviors of mice. She will describe her group’s recent …
  15. 2015 MPS Annual Meeting

    Conference
    … and applied mathematics, physics and engineering. He is known for his elegant and influential mathematical analysis of wave phenomena in diverse and important physical problems. His and …
  16. SFARI Society for Neuroscience 2015 Social

    Social
    Join the SFARI science team and leaders in the autism research community for an informal evening of food, drink, conversation and mingling on 19 October 2015 in Chicago.
  17. What Do Animals Really Learn? Adventures of Reinforcement Learning in the Real World

    Lecture
    In this lecture, Yael Niv will argue that the key to learning efficiently in real-world scenarios is to use a simplified representation of the task that includes …
  18. Timing mechanisms of critical periods in brain development

    Lecture
    On 30 September 2015, Takao Hensch discussed the biological bases of critical periods in brain development.
  19. Timing Mechanisms of Critical Periods in Brain Development

    Lecture
    This lecture explores the biological bases of critical periods in brain development. Mechanisms that open and close windows of plasticity (E/I balance and molecular brakes, respectively) are …
  20. Harnessing Hippocampal Stem Cells to Improve Mood and Cognition

    Lecture
    Recent studies have implicated adult-born hippocampal neurons in pattern separation, a process by which similar experiences or events are transformed into discrete non-overlapping representations. Impaired pattern …
  21. Visualizing Quantum Matter

    Lecture
    Everything around us — everything each of us has ever experienced and virtually everything underpinning our technological society and economy — is governed by quantum mechanics. Yet this most fundamental …
  22. Solving the 3-D Puzzle of Rotation Assignment in Single Particle Cryo-Electron Microscopy

    Lecture
    This lecture will explore algorithms for estimating the unknown pose parameters. The main focus will be on algorithms that are based on semidefinite programming relaxations that can be …
  23. Simons Collaboration on Algorithms and Geometry 2015 Annual Meeting

    Conference
    … Applied Mathematics at the Department of Mathematics, Yale University. Singer received his B.Sc. degree in Physics and Mathematics and his Ph.D. degree in applied mathematics …
  24. Extra-Solar Planets: Search, Characterization and Population Inferences

    Lecture
    David W. Hogg will explore how planets are discovered in the Kepler dataset, how the data are understood and how researchers can make inferences about the full population …
  25. Bell Labs’ Role in Programming Languages and Algorithms

    Lecture
    In this lecture, Alfred V. Aho will discuss the role that software plays in the modern world.
  26. Tracing the Unseen Majority: Insights Into the Critical Role Microbes Play in the Ocean

    Lecture
    In this lecture, Sonya Dyhrman will focus on photosynthetic microbes called phytoplankton, highlighting the critical and beneficial roles that phytoplankton play in marine systems.
  27. Climate Change and Sea Level Rise: Projecting, Reducing and Managing the Risk

    Lecture
    In this lecture, Michael Oppenheimer will describe the physical mechanisms causing observed increases in sea level.
  28. Human Neurodegenerative Disease: Insight from Drosophila

    Lecture
    The Bonini laboratory focuses on applying the extraordinary power of a very simple model organism — the fruit fly Drosophila — to the complex problem of human neurodegenerative disease.
  29. 2015 Conference on Theory & Biology

    Conference
    … cellular basis for stochastic stem cell loss and replacement has begun to be resolved. With a focus on mammalian spermatogenesis and intestinal maintenance, we review the role …
  30. Illuminating Biology at the Nanoscale with Super-Resolution Florescence Microscopy

    Lecture
    Stochastic optical reconstruction microscopy (STORM), breaks the diffraction limit on light microscopy by using selective activation of photo-switchable fluorescent probes to temporally separate the spatially overlapping images …
  31. Imaging as Exploration

    Lecture
    Advanced data generation capabilities require other enhanced abilities — with increasing data size and complexity, the development of more efficient acquisition and analysis methods is essential. In this lecture …
  32. Reproducible Research and the Common Task Method

    Lecture
    In this lecture, Mark Liberman will describe the origins and development of the ‘Common Task’ method in DARPA’s human language technology program, its broader influence on recent …
  33. Genomics in Single Cells and Microbiomes

    Lecture
    Speakers: Curtis Huttenhower, Aviv Regev, Dana Pe’er, Michael Schatz Curtis Huttenhower High-precision Functional Profiling of Microbial Communities and the Human Microbiome Aviv Regev Towards a Human …
  34. Prevalence and trends in epidemiology of autism

    Lecture
    On 25 March 2015, Maureen Durkin discussed trends in the prevalence of autism and explored some of the reasons underlying the recent rise in autism cases.
  35. Trends in Prevalence and Future Directions of the Epidemiology of Autism: The Impact of Social and Cultural Factors

    Lecture
    In this lecture, Maureen Durkin will discuss trends in the prevalence of ASD, focusing on the role of intellectual disability — both as a co-occurring condition with ASD …
  36. Light to Life

    Lecture
    All life on Earth is based on electron transfer reactions far from thermodynamic equilibrium. In this talk, Paul Falkowski will discuss the possibility that photobiochemical reactions of minerals …
  37. Geometry Over Nonclosed Fields: Geometry and Arithmetic of Holomorphic Symplectic Varieties (2015)

    Symposia
    … (PDF) Anthony Várilly-AlvaradoKodaira Dimension of Moduli of special cubic fourfolds (PDF) Wednesday Geometry of Holomorphic Symplectic Varieties Ljudmila KamenovaVanishing of the Kobayashi Pseudometric on K3 Surfaces …
  38. Online Social Systems

    Lecture
    People spend hours a day interacting in online settings, ranging from social media sites to a broad range of digital communities designed for work, education and entertainment. Such …
  39. Quantum Entanglement (2015)

    Symposia
    … Friday Horacio Casini Eva Silverstein Sean Hartnoll Liam Fitzpatrick Sun-Sik Lee → Download full agenda PDF Participants Horacio Casini Centro Atómico Bariloche Liam Fitzpatrick Stanford University Tarun …
  40. Mineral Evolution and Ecology, and the Co-evolution of Life and Rocks

    Lecture
    In this lecture, Hazen will examine how Earth’s near-surface environment has evolved as a consequence of selective physical, chemical and biological processes — an evolution that is …
  41. A Dark Matter Hunter’s Guide to the Universe

    Lecture
    Kathryn Zurek will review evidence for the presence of dark matter in our universe and the need for a new theory to describe the dark matter sector.
  42. Molecular and Neural Architecture of Circuits Underlying Social Behavior in the Mouse

    Lecture
    4:15 pm: Tea 5:00 pm: Lecture 6:15 pm: Reception More information coming soon. 4:15 pm: Tea 5:00 pm: Lecture 6:15 pm: Reception …
  43. New Directions in Approximations Algorithms (2015)

    Symposia
    … Participants Sanjeev Arora Princeton University Nikhil Bansal Eindhoven University of Technology Avrim Blum Carnegie Mellon University Moses Charikar Princeton University Shuchi Chawla University of Wisconsin Julia Chuzhoy …
  44. The Origin of Specificity in Regulated Protein Degradation

    Lecture
    One of the characteristic features of life — specificity — emerges in metabolism, information transfer from DNA to protein, embryology, immunology and virtually every other process. Its explanation on the …
  45. Simons Collaboration on the Many Electron Problem Annual Meeting 2015

    Conference
    … itself of particular use to its attendees. “I find it remarkable that, by bringing good scientists together in a great setting and in a manner which is …
  46. Cosmic Microwave Background: Observational Tests of Theories of the Early Universe

    Lecture
    In this lecture, Eiichiro Komatsu will describe the ‘cosmic microwave background,’ the light remnants of the Big Bang.
  47. Non-Archimedean and Tropical Geometry (2015)

    Symposia
    … University Matt Baker Georgia Tech Vladimir Berkovich Weizman Institute Sebastian Boucksom Paris 6 Dustin Cartwright Yale University Antoine Chambert-Loir Université Paris-Sud Johan de Jong Columbia …
  48. One Brain, Many Genomes: Somatic Mutation and Genomic Variability in the Human Cerebral Cortex

    Lecture
    Due to the winter storm, the Wednesday, January 28, 2015 5:00 p.m. Autism: Emerging Concepts lecture "One Brain, Many Genomes: Somatic Mutation and Genomic Variability in …
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