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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCQ’s Nicolas Regnault Named American Physical Society Fellow

    January 14, 2025
    Nicolas Regnault, a research scientist at the Center for Computational Quantum Physics (CCQ) at the Flatiron Institute, has been named a Condensed Matter Physics Fellow by the American …
  2. Watch: Jim Simons’ Life, Legacy and 5 Guiding Principles

    January 9, 2025
    Jim Simons led an incredible life of mathematics, finance and philanthropy. Watch as those who knew him talk about his phenomenal legacy.
  3. Some Bacteria Evolve Like Clockwork With the Seasons, The Microbiologist

    In the News
    Like Bill Murray in the movie “Groundhog Day,” bacteria species in a Wisconsin lake are in a kind of endless loop that they can’t seem to shake …
  4. SCOPE Synthesis: Phytoplankton interaction networks along Gradients transects

    Funded Work
  5. Research Finds Vaccines Are Not Behind the Rise in Autism. So What Is?

    The New York Times
    There is no one factor that causes autism — or explains its growing prevalence. Researchers are seeking explanations for the surge. Here are some possibilities.
  6. Quasiparticle Is Seen for the First Time and Only Has Mass Moving in One Direction, Earth.com

    In the News
    For the first time, researchers have observed a type of quasiparticle that behaves in an unusual way. In one direction, it acts like it has no mass, zipping …
  7. Symmetry: A Call for Artists, Scientists and Arts Organizations

    December 10, 2024
    … trios need to join us on June 6–8, 2025, in Upstate New York. Are there requirements for how artists, scientists and arts organizations should structure the …
  8. New Datasets Will Train AI Models To Think Like Scientists

    December 2, 2024
    The Polymathic AI team has released two massive datasets for training artificial intelligence models to tackle problems across scientific disciplines. The datasets include data from dozens of sources …
  9. Science In Service of Community

    December 2, 2024
    How Futures Ignite, a community-based organization in Washington Heights, inspires youth to use STEM to problem solve in their community.
  10. First Dish Built for South Africa’s HIRAX Radio Telescope Array

    November 25, 2024
    Astronomers will use the telescope array to trace the evolution of the dark energy tearing the universe apart.
  11. The Dark Energy Pushing Our Universe Apart May Not Be What It Seems, Scientists Say, Associated Press

    In the News
    Distant, ancient galaxies are giving scientists more hints that a mysterious force called dark energy may not be what they thought.
  12. Cramped

    Funded Work
    Ten-episode limited series podcast hosted by Kate Downey, with episodes releasing weekly starting in February 2025.
  13. Math Circles of Chicago

    Funded Work
    Math organization creating meaningful and fun experiences that enable every student and educator to develop their mathematical power and build a sense of belonging in order to choose …
  14. We Finally Know Where Black Holes Get Their Magnetic Fields: Their Parents

    November 18, 2024
    Simulations of exploded highly magnetized stars collapsing into black holes reveal that they ‘pass down’ their magnetic fields to their newly formed black hole’s surrounding disk of …
  15. Microbial Nitrogen Cycling: Novel organisms and enigmatic processes

    Funded Work
  16. SCOPE Synthesis: NPSG ecosystem dynamics project

    Funded Work
  17. SCOPE Synthesis: Assessing joint impacts of viruses and nutrients on marine microbial population and macromolecular dynamics

    Funded Work
  18. SCOPE Synthesis: BEACH laboratory NPSG ecosystem dynamics project

    Funded Work
  19. SCOPE Synthesis: Constraining diversity and productivity in the North Pacific

    Funded Work
  20. SCOPE Synthesis: Cyanophage communities and their impacts on ecological processes in the North Pacific Ocean

    Funded Work
  21. SCOPE Synthesis: The impact of micronutrients on microbial community structure in the North Pacific Ocean

    Funded Work
  22. SCOPE Synthesis: Trace metal biogeochemistry of the North Pacific Subtropical Gyre

    Funded Work
  23. SCOPE Synthesis: vDarwin Initiative

    Funded Work
  24. Elucidating the function of the autism risk gene CTCF in neural differentiation-dependent chromatin organization

    Funded Work
    Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by a wide range of cognitive and behavioral alterations.
  25. When 'Squishy Space Goop' Collides, Caltech

    In the News
    Elias Most, an assistant professor of theoretical astrophysics, did not want to be an astronomer or a physicist when he grew up. He studied physics but was more …
  26. Reactivating FMR1 to treat fragile X syndrome

    Funded Work
    Fragile X syndrome (FXS) is an X-linked neurodevelopmental condition and one of the most common monogenic causes of inherited intellectual disability and autism spectrum disorder (ASD).
  27. Assessing the role of the autism risk gene Gigyf1 in astrocytic regulation of postnatal brain development in mice

    Funded Work
    Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and repetitive behavior.
  28. Piloting gene- and mutation-specific antisense oligonucleotide therapies for autism

    Funded Work
    Antisense oligonucleotides (ASOs) demonstrate promise as therapeutic approaches for treating genetic disorders of the central nervous system, as exemplified by the clinical success of nusinersen (a splice-modulating …
  29. Probing thalamo-cortico-amygdala network differences underlying sensory integration alterations in mouse models of autism

    Funded Work
    Although much research on autism spectrum disorder (ASD) is focused on social and cognitive behaviors, recent evidence has highlighted sensory processing as a key alteration in ASD.
  30. Uncovering developmental activity biomarkers underlying autism using functional imaging in mice

    Funded Work
    Signs of autism emerge as early as 6 to 12 months of age, but the average age of diagnosis in the United States is four years.
  31. Identifying the epigenetic vulnerability of neurodevelopment

    Funded Work
    Haploinsufficiency of select chromatin regulators is frequently associated with autism.
  32. Simons Foundation Announces Third Class of Pivot Fellows

    November 5, 2024
    … analytical tools such as X-ray diffraction, microscopy and Fourier-transformed infrared spectroscopy has allowed him to explore the microstructural properties of materials in detail, contributing to …
  33. Jill Pipher Joins Simons Foundation Board of Trustees

    November 4, 2024
    The Simons Foundation is pleased to announce that mathematician Jill Pipher has joined its board of trustees. Pipher is the Elisha Benjamin Andrews Professor of Mathematics at Brown …
  34. SFARI Researchers Gather in Edinburgh for 2024 Autism Rat Consortium Meeting

    October 30, 2024
    On September 18, 2024, the SFARI Autism Rat Consortium (ARC) held its annual meeting in the Usher Institute of the University of Edinburgh. This year’s event brought …
  35. Searching Five Million Stars for Disks, Debris, and Dyson Spheres

    Sky & Telescope
    Main-sequence stars with brighter than expected mid-infrared emission can signal the presence of a debris disk, rubble from planetary collisions, or even a theorized sign of …
  36. The Surprising Reason a Classical Computer Beat a Quantum Computer at Its Own Game

    October 29, 2024
    As the battle between quantum and classical computers rages, scientists are making unexpected discoveries about quantum systems.
  37. Open Interval: The Intersection of Science and Dance

    October 28, 2024
    … continued conversation and eagerness to explore how their distinct practices might inspire and inform one another. The inaugural cohort of Open Interval consisted of a partnership between …
  38. Betelgeuse Betelgeuse? Bright Star Betelgeuse Likely Has a ‘Betelbuddy’ Stellar Companion

    October 21, 2024
    Betelgeuse has displayed brightening and dimming over the years, convincing some that it could be close to becoming a supernova. However, a new study from the Flatiron Institute …
  39. A New Benchmark To Identify the Best Solutions to the Hardest Problems in Materials Science

    October 17, 2024
    A new benchmark called the V-score can help researchers determine the best algorithms for studying complex materials, helping optimize quantum simulations leveraged in industries like pharmaceuticals and …
  40. How Building an Inclusive Workplace for Autistic Employees Benefits Everyone

    October 16, 2024
    The Simons Foundation’s Autism in the Workplace program, which increases employment for autistic candidates, was built to be replicated.
  41. Claustrophobic Cells Slow Their Own Growth, Forming Beautiful Patterns of Concentric Circles

    October 10, 2024
    Through simulations and modeling of bacterial colonies, researchers at the Flatiron Institute and collaborators have discovered how dividing cells adapt to crowded environments by slowing their growth, informing …
  42. Max Planck-New York Center on Non-Equilibrium Quantum Phenomena Renewed

    October 7, 2024
    The quantum research center will continue its international collaboration for an additional five years with Cornell University as a new partner institution.
  43. Space Probe Proposed by Team Including CCA Scientist Reaches Final Round of $1 Billion NASA Mission Selection

    October 7, 2024
    … reveal the unknown about our universe. Establishing this new line of missions — the largest our Astrophysics program has ever competed — has taken that creativity to new heights …
  44. 2024 Simons Postdoctoral Fellowships in Marine Microbial Ecology Announced

    October 3, 2024
    The Simons Foundation and Simons Foundation International have named five scientists as 2024 Simons Fellows in Marine Microbial Ecology. The fellowship program supports promising postdoctoral scientists who intend …
  45. Simons Foundation Accepting Applications for Fellows-to-Faculty Award

    October 2, 2024
    … Award will be held at 12:00 p.m. (noon) ET on Wednesday, October 16, 2024. Interested attendees can register here. A recording of the webinar will …
  46. SCOPE Investigator Benjamin Van Mooy Receives 2024 MacArthur Fellowship

    October 2, 2024
    The MacArthur Foundation has selected oceanographer Benjamin Van Mooy as a 2024 MacArthur Fellow. Known colloquially as the “genius grant”, this award provides $800,000 over five years …
  47. The Promises and Perils of a Mid-Career Pivot

    Physics Today
    Astrophysics to physical oceanography. String theory to machine learning. High energy theory to biophysics. Such leaps in research focus can be challenging—and rewarding. Learn how the Simons …
  48. Deep-Sea Discovery Shines Light on Life in the Twilight Zone, The Microbiologist

    In the News
    No sunlight reaches this region 200 to 1,000 meters below the sea surface, where levels of iron, a key micronutrient, are so low that the growth of …
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