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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Funded Work

Our funded projects advance discovery across mathematics, the physical and life sciences, neuroscience, and autism.

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  1. Analyzing a complex motor act at the mesoscopic scale

    Funded Work
    Our motor systems are impressive.
  2. Whole brain calcium imaging in freely behaving nematodes

    Funded Work
    How does the collective activity of individual neurons in the brain generate actions?
  3. Hidden states and functional subdivisions of fronto-parietal network

    Funded Work
    The essence of cognition is choice, and to understand choice we need to understand how neurons in the brain generate decisions in complex settings.
  4. The neural basis of Bayesian sensorimotor integration

    Funded Work
    All nervous systems must operate under conditions of uncertainty.
  5. Mechanisms of context-dependent neural integration and short-term memory

    Funded Work
    The way in which neurons process information determines how the brain functions.
  6. Network mechanisms for correcting error in high-order cortical regions

    Funded Work
    Unaided by modern technology, our very survival would depend upon our brain’s ability to accurately map external space.
  7. Computational principles of mechanisms underlying cognitive functions

    Funded Work
    The brain is composed of billions of neurons.
  8. The neural substrates of memories and decisions

    Funded Work
    The neural substrates of memories and decisions.
  9. Neural coding and dynamics for short-term memory

    Funded Work
    The brain processes sensory stimuli and uses this information in conjunction with goals and memories to generate actions.
  10. Dynamics of neural circuits, representation of information, and behavior

    Funded Work
    How the brain holds information in short-term memory is a mystery.
  11. Modulating the dynamics of human-level neuronal object representations

    Funded Work
    How does the brain give rise to the mind?
  12. Spatiotemporal structure of neural population dynamics in the motor system

    Funded Work
    Consider the simple act of reaching for a cup of coffee.
  13. Attentional modulation of neuronal variability constrains circuit models

    Funded Work
    Each time you look at a picture on a wall, even though you see the same thing, the electrical activity of neurons in your brain’s visual areas …
  14. Interaction of sensory signals and internal dynamics during decision-making

    Funded Work
    Imagine deciding whether or not to eat a piece of cake.
  15. Large-scale data and computational framework for circuit investigation

    Funded Work
    Decades of research have uncovered fundamental principles about how the eye works.
  16. Global brain states and local cortical processing

    Funded Work
    The cerebral cortex—the outermost, wrinkled layer of the brain—is involved in many cognitive processes, including sensory processing, decision-making, and movement.
  17. Searching for universality in the state space of neural networks

    Funded Work
    So-called “collective behavior” surrounds us.
  18. Catching fireflies: Dynamic neural computations for foraging

    Funded Work
    Imagine catching a firefly.
  19. Understanding neural computations across the global brain

    Funded Work
    The brain is composed of networks of thousands or millions of neurons, and modern neuroscience is just reaching the stage where researchers can observe most, if not all …
  20. Higher-level olfactory processing

    Funded Work
    How do complex patterns of activity in large populations of neurons gain meaning and guide behavior?
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