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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Simons Foundation Summer Interns Explore Science and Self-Discovery

    October 19, 2026
  2. Mysteries of Fruit Fly Sperm Untangled by Mathematical Models

    July 22, 2026
  3. Beyond the Cryo-EM Resolution Revolution

    June 23, 2026
  4. How Mathematical Modeling Identified Subclasses of Autism

    June 23, 2026
  5. Alumni Spotlight: Gokberk Kabacaoglu

    May 15, 2026
  6. Alumni Spotlight: Jamie Morton

    May 6, 2026
  7. Pilar Cossio: Reconstructing RNA’s Shapeshifting Behavior

    April 28, 2026
  8. The Machinery That Helps Divide Your Cells Self-Organizes Like an Active Liquid Crystal

    Watch
    February 12, 2026
  9. A Tug-of-War Explains a Decades-Old Question About How Bacteria Swim

    January 8, 2026
  10. From Ring to Keyhole: Modeling How Tissues Mold the Fruit Fly’s Gut

    Watch
    November 17, 2025
  11. New Study Reveals Subclasses of Autism by Linking Traits to Genetics

    July 9, 2025
  12. New Model Predicts How Bacteria Navigate Obstacles To Spread

    March 21, 2025
  13. Claustrophobic Cells Slow Their Own Growth, Forming Beautiful Patterns of Concentric Circles

    Watch
    October 10, 2024
  14. Physics-Informed AI Method Could Help Make CRISPR Safer

    May 20, 2024
  15. Researchers Crack Mystery of Swirling Vortexes in Egg Cells

    Watch
    April 17, 2024
  16. CCB Flatiron Research Fellow Miro Astore Awarded Young Biophysicist Award

    January 26, 2024
  17. All 5 Flatiron Centers Represented at the Conference on Neural Information Processing Systems (NeurIPS)

    December 8, 2023
  18. Experiments and Mathematical Model Uncover the Mechanisms Behind Wrinkles in Cell Nuclei

    November 3, 2023
  19. Moving in Harmony

    June 21, 2023
  20. Cutting-Edge Computational Study Provides ‘Gut Check’ to How We Thought Proteins Function

    April 28, 2023
  21. Going With the Flow: Mapping Vascular Systems in Fruit Flies

    April 3, 2023
  22. Why Don’t Disease-Linked Genetic Mutations Always Result in Disease? A Study in Fruit Flies Offers New Clues

    March 13, 2023
  23. New Testing Approach Diagnoses COVID-19 With Near-Perfect Accuracy

    February 27, 2023
  24. Simons Foundation Scientists Named as Sloan Research Fellows

    February 16, 2023
  25. Computational Biology Goes Under the Microscope

    February 14, 2023
  26. Small Cell, Big Picture: Fundamental Biology Through the Lens of Simplified Models

    January 26, 2023
  27. Big Data and Powerful Computing Join Forces To Link DNA Sequence and Function

    January 24, 2023
  28. The Fruit Fly Photographer

    October 3, 2022
  29. The RNA Detective

    August 9, 2022
  30. CCB Director Michael Shelley and Simons-Supported Researchers Elected to National Academy of Sciences

    May 6, 2022
  31. New Model Shows How Cilia Make Waves

    March 17, 2022
  32. A Machine-Learning Framework for Prioritizing Disease-Associated Enhancers

    January 25, 2022
  33. A ‘Forest Fire’ Model of Cell Division Can Explain Clonal Dominance in Developing Tissue

    December 14, 2021
  34. NetQuilt: A Powerful Computational Approach for Predicting Protein Function

    October 5, 2021
  35. Fruit Fly Egg Takes an Active Hand in Its Own Growth, Highlighting Parallels to Mammals

    March 22, 2021
  36. CCB and CCM Collaborate To Create the New Structural and Molecular Biophysics Team

    February 4, 2021
  37. Mathematics Explains How Giant Whirlpools Form in Developing Egg Cells

    January 13, 2021
  38. Unveiling the Forces Behind Millions of Years of Cell Division

    December 1, 2020
  39. Finding Signals in the Noise With HumanBase

    November 10, 2020
  40. Molecular Processes in Kidney Cells May ‘Prime’ Diabetics for COVID-19 Infection

    October 23, 2020
  41. A Software, a Community and a Different Way To Do Science

    July 30, 2020
  42. Computing the Egg: The Effort To Calculate Biological Development

    July 10, 2020
  43. Plasticity May Make Neurons Vulnerable to Alzheimer’s Disease

    June 29, 2020
  44. Mutations in Uncharted Territory

    April 29, 2020
  45. Deciphering the Brain’s Algorithms

    April 9, 2020
  46. The Flatiron Institute: A Home for Computational Sciences

    March 9, 2020
  47. Beauty and the Brain

    February 5, 2020
  48. You’re Not All Human: The Wonder of Gut Microbes

    January 30, 2020
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